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Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

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World Journal of Gastroenterology 2023年第6期29卷 997-1010页

作者： armando Rojas Cristian Lindner Iván Schneider Ileana González Miguel Angel Morales Biomedical Research Laboratories Medicine FacultyCatholic University of MauleTalca 34600000Chile Medicine Faculty Catholic University of MauleTalca 34600000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori *** the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and ***,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关键词： Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products Alarmins Helicobacter pylori Chronic inflammation

Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider

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World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Miguel Angel Morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

Linking sedimentary provenance,climate and tectonics in the Neoproterozoic SeridóBelt,Borborema Province(NE Brazil)

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Geoscience Frontiers 2023年第6期14卷 414-431页

作者： Carlos V.A.Ribeiro Marcos C.C.Sales armando L.S.de Oliveira Ricardo Sallet Programa de Pós-graduação em Geologia Instituto de GeociênciasUniversidade de Brasília(UnB)CEP 70910-900 BrasíliaDFBrazil Programa de Pós-Graduação em Geociências Universidade Federal de PernambucoDepartamento de GeologiaCentro de Tecnologia e GeociênciasAv.da ArquiteturaCEP 50740-530 RecifePEBrazil Departamento de Geologia Universidade Federal do Rio Grande do NorteCEP 59078-970 NatalRNBrazil

The SeridóBelt,at the extreme northeast of Brazil,is one of the several Neoproterozoic mobile belts related to the Brasiliano/Pan-African Orogeny in Western *** lithostratigraphy of the SeridóBelt comprises basal quartzites and metaconglomerates(Equador Formation)overlain by hornblende-bearing paragneisses,calc-silicate rocks and marbles(Jucurutu Formation)and biotiteschists(SeridóFormation).We investigated the sedimentary provenance of these rocks based on an integration of compiled whole-rock geochemistry,Sm-Nd isotopes,U-Pb detrital zircon ages and a new set of whole-rock trace elements *** Formation quartzites have major and trace elements patterns that resemble cratonic sandstones,with a typical felsic provenance consistent with the isotopic composition of plutonic Archean to Paleoproterozoic basement *** proxies suggest that these rocks were deposited in fresh waters under anoxic conditions and moderate to intense weathering conditions(CIA=58–79).A shift in provenance led to an increase in intermediate-mafic sources during the deposition of the Jucurutu and Seridó*** elements from rock types in these units are nearly identical,yet they differ on the contents of some high field-strength elements(e.g.,Sc,V and Ni),which are higher in the SeridóFormation than average *** proxies show similar depositional environments,with brackish to marine conditions for the Jucurutu and Seridóformations under anoxic to euxinic *** conditions are consistently lower in the Jucurutu Formation(CIA=58–66)in comparison with the SeridóFormation(CIA=60–88).Compiled U-Pb data suggest maximum depositional ages of 633±11 Ma and 633±6 Ma for Jucurutu and Seridóformations,respectively,suggesting deposition following the ca.645–635 Ma Marinoan *** compared the geochemistry of the SeridóFormation schists with currently exposed basement rocks and showed a strong affinity with Neoproterozoic arc-related

关键词： Whole-rock geochemistry Marinoan Glaciation U-Pb detrital zircon Brasiliano Orogeny

Dictionary,Thesaurus or Ontology? Disentangling Our Choices in the Semantic Web Jungle

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Journal of Integrative Agriculture 2012年第5期11卷 710-719页

作者： armando Stellato Department of Enterprise Engineering University of Tor VergataRome 00133Italy

The Semantic Web seems finally close to maintaining its promise about a real world-wide graph of interconnected resources. The SPARQL query language and protocols and the Linked Open Data initiative have laid the way for endless data endpoints sparse around the globe. However, for the Semantic Web to really happen, it does not suffice to get billions of triples out there： these must be shareable, interlinked and conform to widely accepted vocabularies. While more and more data are converted from already available large knowledge repositories of companies and organizations, the question whether these should be carefully converted to semantically consistent ontology vocabularies or find other shallow representations for their content naturally arises. The danger is to come up with massive amounts of useless data, a boomerang which could result to be contradictory for the success of the web of data. In this paper, I provide some insights on common problems which may arise when porting huge amount of existing data or conceptual schemes （very common in the agriculture domain） to resource description framwork （RDF）, and will address different modeling choices, by discussing in particular the relationship between the two main modeling vocabularies offered by W3C： OWL and SKOS.

关键词： ontologies thesauri knowledge modeling linked open data

Meteorological indicators of dengue epidemics in non-endemic Northwest Argentina

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Infectious Disease Modelling 2022年第4期7卷 823-834页

作者： Javier armando Gutierrez Karina Laneri Juan Pablo Aparicio Gustavo Javier Sibona Departamento de Física-FCE-Universidad Nacional de Salta SaltaArgentina Grupo de Física Estadística e Interdisciplinaria CONICETCentro Atòmico Bariloche-CNEASan Carlos de BarilocheRío NegroArgentina Instituto de Investigaciones en Energía no Convencional(INENCO)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Salta Av.Bolivia 51004400SaltaArgentina Simon A.Levin Mathematical Computational and Modeling Sciences Center Arizona State UniversityPO Box 871904TempeAZ85287-1904USA IFEG-CONICET and Fa.M.A.F.-Universidad Nacional de Cordoba CordobaArgentina

In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin *** the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller *** pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic *** develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic *** variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological *** mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole *** tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to *** assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic *** found that the number of vectors per host and the effective reproductive number are proxies for large *** proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.

关键词： Mathematical modelling Dengue Outbreak Mosquitoes population

JNKs,insulin resistance and inflammation:A possible link between NAFLD and coronary artery disease

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World Journal of Gastroenterology 2011年第33期17卷 3785-3794页

作者： Giovanni Tarantino armando Caputi Department of Clinical and Experimental Medicine FedericoⅡUniversity Medical School of NaplesVia Sergio Pansini580131 NaplesItaly Department of Clinical Medicine Cardiovascular&Immunological SciencesFederico Ⅱ University Medical School of NaplesVia Sergio Pansini580131 NaplesItaly

The incidence of obesity has dramatically increased in recent ***,obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious ***,the contribution of adipose tissue to metabolic homeostasis has become a focus of *** this review,we discuss the latest discoveries that support the role of lipids in nonalcoholic fatty liver *** describe the common mechanisms(cJun aminoterminal kinases,endoplasmic reticulum stress,unfolded protein response,ceramide,lowgrade chronic inflammation)by which lipids and their derivatives impair insulin responsiveness and contribute to inflammatory liver and promote plaque instability in the arterial *** the molecular mechanism of lipid activation of proinflammatory pathways,we attempt to find a link between nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular *** the common mechanisms by which lipid derivatives,through modulation of macrophage function,promote plaque instability in the arterial wall,impair insulin responsiveness and contribute to inflammatory liver and discussing the molecular mechanism of lipid activation of proinflammatory pathways,the key roles played by the proliferatoractivated receptor and liver X receptorα,nuclear receptorslipid sensors that link lipid metabolism and inflammation,should be *** studies are warranted of antiinflammatory drugs such as aspirin,antiinterleukin6 receptors,immunemodulators(calcineurin inhibitors),substances enhancing the expression of heat shock proteins(which protect cells from endoplasmic reticulum stressinduced apoptosis),and anticJun aminoterminal kinases in welldesigned trials to try to minimize the high impact of these illnesses,and the different expressions of the diseases,on the whole population.

关键词：冠状动脉疾病胰岛素抵抗慢性炎症内质网应激代谢综合征热休克蛋白脂肪组织分子机制

It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation

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Molecular Plant 2021年第11期14卷 1779-1781页

作者： Miguel Daniel-Mozo armando Albert Instituto de Quimica Ffsica Rocasolano Consejo Superior de Investigaciones Cientificas(IQFR-CSIC)Calle Serrano 11928006 MadridSpain

Protein kinases are a conserved superfamily of proteins that play an essential role in signal transduction by attaching a phosphoryl group to serine,threonine,or tyrosine residues of a protein,hence converting them to *** process,which can be reversed by protein phosphatases,regulates vital cellular processes in plants,including metabolism,proliferation,and *** is also key to trigger response mechanisms to drought,increased salinity,and other abiotic stresses(Zhu,2016).

关键词： hence reversed translational

Utilization of online systems to promote youth participation in research:A methodological study

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World Journal of Methodology 2023年第4期13卷 210-222页

作者： Marie Salem Lance Pollack Alex zepeda Kathleen P Tebb Institute for Health Policy Studies University of California San FranciscoSan FranciscoCA 94158United States Division of Prevention Science University of California San FranciscoSan FranciscoCA 94105United States Research Los Angeles Trust for Children's HealthLos AngelesCA 90017United States Department of Pediatrics University of California San FranciscoSan FranciscoCA 94143United States

BACKGROUND Online surveys can align with youth’s increased use of the internet and can be a mechanism for expanding youth participation in *** is particularly important during the coronavirus disease 2019(COVID-19)pandemic,when inperson interactions are ***,the advantages and drawbacks of online systems used for research need to be carefully considered before utilizing such *** To describe and discuss the strengths and limitations of an online system developed to recruit adolescent girls for a sexual health research study and conduct a three-month follow up *** This methodology paper examines the use of an online system to recruit and follow participants three months after their medical visit to evaluate a mobile sexual and reproductive health application,Health-E You/Salud iTuTM,for adolescent girls attending school-based health centers(SBHCs)across the United *** staff gave adolescent girls a web link to an online eligibility and consent *** were then asked to complete two online surveys(baseline and 3-month follow-up).Surveys,reminders,and incentives to complete them were distributed through short message service(SMS)text *** completing each survey,participants were also sent an email with a link to an electronic gift card as a thank-you for their *** to implementing this system were discussed with clinicians and staff at each participating *** This online recruitment and retention system enabled participant recruitment at 26 different SBHCs in seven states across the United *** September 2021 and June 2022,415 adolescent girls were screened using the Qualtrics online survey platform,and 182 were eligible to *** those eligible,78.0%(n=142)completed the baseline *** were racially,geographically,and linguistically *** of the participants(89.4%)were non-White,and 40.8%spoke Spanish.A total of 62.0%(n=88)completed

关键词： Online recruitment Adolescents Sexual and reproductive health Mobile data Methodology paper Data security

Learning the Mapping x→Σi=1^d xi^(2):the Cost of Finding the Needle in a Haystack

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Communications on Applied Mathematics and Computation 2021年第2期3卷 313-335页

作者： Jiefu Zhang Leonardo zepeda-Nunez Yuan Yao Lin Lin Department of Mathematics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mathematics University of Wisconsin-MadisonMadisonWI 53706USA Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

The task of using the machine learning to approximate the mapping x→Σi=1^d xi^(2)with Xi∈[-1,1]seems to be a trivial *** the knowledge of the separable structure of the function,one can design a sparse network to represent the function very accurately,or even *** such structural information is not available,and we may only use a dense neural network,the optimization procedure to find the sparse network embedded in the dense network is similar to finding the needle in a haystack,using a given number of samples of the *** demonstrate that the cost(measured by sample complexity)of finding the needle is directly related to the Barron norm of the *** only a small number of samples are needed to train a sparse network,the dense network trained with the same number of samples exhibits large test loss and a large generalization *** control the size of the generalization gap,we find that the use of the explicit regularization becomes increasingly more important as d *** numerically observed sample complexity with explicit regularization scales as G(d^(2.5)),which is in fact better than the theoretically predicted sample complexity that scales as 0(d^(4)).Without the explicit regularization(also called the implicit regularization),the numerically observed sample complexity is significantly higher and is close to 0(d^(4.5)).

关键词： Machine learning Sample complexity Generalization error