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Stage-Specific Changes on <i>Plasmodium yoelii yoelii </i>Following Treatment with <i>Hintonia latiflora</i>Stem Bark Extract and Phytochemical-Antioxidant Evaluation

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Pharmacology & Pharmacy 2017年第12期8卷 381-395页

作者： Elba Carrasco-Ramírez Perla Y. López-Camacho armando zepeda-rodríguez Patricia Bizarro-Nevares Filiberto Malagón-Gutiérrez Gustavo Basurto-Islas Norma Rivera-Fernández Laboratorio de Malariología Departamento de Microbiología y Parasitología Facultad de Medicina Universidad Nacional Autónoma de México CDMX México Departamento de Ciencias Naturales e Ingeniería Universidad Autónoma Metropolitana CDMX México Deparatmento de Biología Celular y Tisular Facultad de Medicina Universidad Nacional Autónoma de México CDMX México Departamento de Ingenierías Química Electrónica y Biomédica División de Ciencias e Ingeniería Universidad de Guanajuato Campus León Guanajuato México

Malaria endemic zones are mostly located on third world countries, where antimalarials are not easily found or patients cannot afford them, and in consequence, they must turn toward natural products or phytomedicines. In the present study, the effect of Hinotnia latiflora (Hl) methanolic stem bark extract (HlMeOHe) on the ultrastructure of the asexual intraerythrocytic stages of Plasmodium yoelii yoelii (Pyy) after a Peters’ four-day oral treatment was assessed by transmission electron microscopy (TEM), as well as the parasite development on blood smears, analyzed by light microscopy. Likewise, extract was subjected to qualitative tests adopting standard procedures for identification of phytoconstituents;its antioxidant activity was evaluated according to the method of Brand-Williams and by the radical cation decolorization assay. Results showed higher percentage of rings and lower percentage of trophozoites and schizonts in the treated animals, in comparison with those of the control groups, which demonstrated lower percentage of rings and trophozoites, and schizonts in higher number. Images of TEM showed in some treated parasites, mild parasite membranes, organelle swelling and ribosomal depletion. The phytochemical profile demonstrated that the extract contains alkaloids, tannis, steroids, terpenoids, flavonoids, phenolics and saponins. The obtained values of the half maximal inhibitory concentration (IC50) in μg/mL, for both antioxidant assays were of 423.83 and 202.95 respectively. It is concluded that HlMeOHe altered the development of the intraerythrocytic asexual stages and the ultrastructure of Pyy, and due to its phytochemical constituents, showed an in vitro antioxidant activity.

关键词： Hintonia latiflora Plasmodium yoelii yoelii Malaria Ultrastructural Changes Phytochemicals Antioxidant Natural Products

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Do new neurons contribute to functional reorganization after brain damage?

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Neural Regeneration Research 2018年第12期13卷 2083-2084页

作者： Clorinda Arias Angelica zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México

The finding that adult neurogenesis occurs constitutively in the brain was a breakthrough in neuroscience and soon gained attention as a possible mechanism for neurorepair after brain damage. In a recent study we show that the dentate gyrus （DG） reorganizes anatomically over neurons undergo maturation time after damage, while new and activate in response to a contextual fear memory recall （Aguilar-Arredondo and zepeda, 2018）. These findings provide new evidence on the possible role of neurogenesis in cognitive recovery after brain injury.

关键词： Do new neurons contribute to functional reorganization after brain damage

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The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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Neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio J.Galván Angelica zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

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Learning the Mapping x→Σi=1^d xi^(2):the Cost of Finding the Needle in a Haystack

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Communications on Applied Mathematics and Computation 2021年第2期3卷 313-335页

作者： Jiefu Zhang Leonardo zepeda-Nunez Yuan Yao Lin Lin Department of Mathematics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mathematics University of Wisconsin-MadisonMadisonWI 53706USA Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

The task of using the machine learning to approximate the mapping x→Σi=1^d xi^(2)with Xi∈[-1,1]seems to be a trivial *** the knowledge of the separable structure of the function,one can design a sparse network to represent the function very accurately,or even *** such structural information is not available,and we may only use a dense neural network,the optimization procedure to find the sparse network embedded in the dense network is similar to finding the needle in a haystack,using a given number of samples of the *** demonstrate that the cost(measured by sample complexity)of finding the needle is directly related to the Barron norm of the *** only a small number of samples are needed to train a sparse network,the dense network trained with the same number of samples exhibits large test loss and a large generalization *** control the size of the generalization gap,we find that the use of the explicit regularization becomes increasingly more important as d *** numerically observed sample complexity with explicit regularization scales as G(d^(2.5)),which is in fact better than the theoretically predicted sample complexity that scales as 0(d^(4)).Without the explicit regularization(also called the implicit regularization),the numerically observed sample complexity is significantly higher and is close to 0(d^(4.5)).

关键词： Machine learning Sample complexity Generalization error

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Exploring kidney biopsy findings in congenital heart diseases:Insights beyond cyanotic nephropathy

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World Journal of Nephrology 2024年第1期13卷 25-32页

作者： Jose Daniel Juarez-Villa Iván zepeda-Quiroz Sebastián Toledo-Ramírez Victor Hugo Gomez-Johnson Francisco Pérez-Allende Brian Ricardo Garibay-Vega Francisco E rodríguez Castellanos Bernardo Moguel-González Edgar Garcia-Cruz Salvador Lopez-Gil Department of Nephrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico Congenital Heart Disease Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BACKGROUND The association between congenital heart disease and chronic kidney disease is well *** mechanisms of kidney damage associated with congenital heart disease have been *** etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical *** To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our *** This is a retrospective observational study conducted at the Nephrology Depart-ment of the National Institute of Cardiology“Ignacio Chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the *** Ten patients with congenital heart disease and kidney biopsy were *** average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 *** most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)*** the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement *** remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific *** Determining the cause of chronic kidney disease can help in delaying the need for kidney replacement *** 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was *** studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.

关键词： Renal biopsy Congenital heart disease Chronic kidney disease Focal segmental glomerulosclerosis

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Alcoholism and liver disease in Mexico:Genetic and environmental factors

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World Journal of Gastroenterology 2013年第44期19卷 7972-7982页

作者： Sonia Roman Eloy Alfonso zepeda-Carrillo Laura Eugenia Moreno-Luna Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and Health Sciences Center University of GuadalajaraGuadalajara Jalisco 44280 Mexico Universidad Autónoma de Nayarit and Hospital Civil Tepic "Antonio González Guevara" Tepic Nayarit 63000 Mexico

Alcoholism and cirrhosis,which are two of the most serious health problems worldwide,have a broad spectrum of clinical *** diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each *** contrast to other regions around the world,Mexicans present the highest drinking score and a high mortality rate for alcoholic liver disease with an intermediate category level of per capita alcohol *** has a unique history of alcohol consumption that is linked to profound anthropological and social *** Mexican population has an admixture genome inherited from different races,Caucasian,Amerindian and African,with a heterogeneous distribution within the ***,genes related to alcohol addiction,such as dopamine receptor D2 in the brain,or liver alcoholmetabolizing enzymes,such as alcohol dehydrogenase classⅠpolypeptide B,cytochrome P450 2E1 and aldehyde dehydrogenase class 2,may vary from one individual to ***,they may be inherited as risk or non-risk haplogroups that confer susceptibility or resistance either to alcohol addiction or abusive alcohol consumption and possibly liver ***,in this era of genomics,personalized medicine will benefit patients if it is directed according to individual or population-based *** association studies will be required to establish novel strategies for the prevention,care and treatment of liver disease in Mexico and worldwide.

关键词： Alcohol Genes Alcoholism Alcohol dependence Alcohol addiction Alcohol abuse Alcoholic liver cirrhosis Anthropology

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Gastric infiltration of diffuse large B-cell lymphoma: Endoscopic diagnosis and improvement of lesions after chemotherapy

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World Journal of Gastroenterology 2008年第27期14卷 4407-4409页

作者： Sergio zepeda-Gómez Jesús Camacho Edgar Oviedo-Cárdenas Carmen Lome-Maldonado Department of Gastrointestinal Endoscopy Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" Department of Pathology Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"

Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL with infiltration to the stomach in a 39-year-old female. She had a 6-mo history of lumbar and left upper quadrant pain with intermittent episodes of melena. A computer tomograghy (CT) scan showed mural thickening of the gastric antrum. Endoscopic examination revealed multiple gastric ulcers. Definite diagnosis could be made by endoscopic biopsies and the patient had a good response to chemotherapy. This response correlated well with a further endoscopic follow-up. A follow-up endoscopic examination could be considered to evaluate a good response to chemotherapy in DLBCL patients with secondary gastric dissemination.

关键词： Diffuse large B-cell lymphoma Non-Hodgkin's lymphoma Gastric infiltration

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Magnetic imaging-assisted colonoscopy vs conventional colonoscopy: A randomized controlled trial

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World Journal of Gastroenterology 2014年第36期20卷 13178-13184页

作者： Christopher W Teshima Sergio zepeda-Gómez Suliman H AlShankiti Gurpal S Sandha Division of Gastroenterology University of Alberta Edmonton Alberta T6G 2X8 Canada

AIM: To compare magnetic imaging-assisted colonoscopy (MIC) with conventional colonoscopy (CC).

关键词： Colonoscopy Conscious sedation Magnetic endoscope imaging Pain measurement Randomized controlled trial

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The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-Domínguez Evangelina ávila-Mu?oz Eduardo Domínguez-Rivas Angélica zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

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Diversity, frequency, and geographic distribution of facultative bacterial endosymbionts in introduced aphid pests

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Insect Science 2017年第3期24卷 511-521页

作者： Daniela A. Sepulvedat Francisca zepeda-Paulo Claudio C. Ramfrez Bias Lavandero Christian C. Figueroa Facultad de Ciencias Agrarias Universidad de Talca Instituto de Ciencias BiolSgicas Universidad de Talca Millennium Nucleus Centre in Molecular Ecology and Evolutionary Applications in the Agroecosystems Universidad de Talca 2 Norte 685 Talca Chile

Facultative bacterial endosymbionts in insects have been under intense study during the last years. Endosymbionts can modify the insect＇s phenotype, conferring adap- tive advantages under environmental stress. This seems particularly relevant for a group of worldwide agricultural aphid pests, because endosymbionts modify key fitness-related traits, including host plant use, protection against natural enemies and heat tolerance. Aimed to understand the role of facultative endosymbionts on the success of introduced aphid pests, the distribution and abundance of 5 facultative endosymbionts （Hamiltonella defensa, Regiella insecticola, Serratia symbiotica, Rickettsia and Spiroplasma） were stud- ied and compared in 4 cereal aphids （Sitobion avenae, Diuraphis noxia, Metopolophium dirhodum and Schizaphis graminium） and in the pea aphid Acyrthosiphon pisum complex from 2 agroclimatic zones in Chile. Overall, infections with faeultative endosymbionts exhibited a highly variable and characteristic pattern depending on the aphid species/host race and geographic zone, which could explain the success of aphid pest populations after their introduction. While S. symbiotica and H. defensa were the most frequent endosym- bionts carried by the A. pisum pea-race and A. pisum alfalfa-race aphids, respectively, the most frequent facultative endosymbiont carried by all cereal aphids was R. insecticola. Interestingly, a highly variable composition of endosymbionts carried by S. avenae was also observed between agroclimatic zones, suggesting that endosymbionts are responding differentially to abiotic variables （temperature and precipitations）. In addition, our findings constitute the first report of bacterial endosymbionts in cereal aphid species not screened before, and also the first report of aphid endosymbionts in Chile.

关键词： cereal aphids facultative bacterial endosymbionts grain aphid introduced aphids pea aphid

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