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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： Guillermo Valenzuela Mauricio Burotto Katherine Marcelain Jaime gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine Liquid biopsy Cetuximab Panitumumab

Effect of application rate and irrigation on the movement and dissipation of indaziflam

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Journal of Environmental Sciences 2017年第1期29卷 111-119页

作者： Amir M.gonzalez-Delgado Manoj K.Shukla Jamshid Ashigh Russ Perkins Plant and Environmental Sciences Department New Mexico State UniversityLas CrucesNM 88003-8003USA Department of Entomology Plant Pathology and Weed ScienceNew Mexico State UniuersityLas CrucesNM 88003-8003USA Bayer CropScience LP Field Development-SouthernIdalouTX 79329USA

Indaziflam is a new preemergence herbicide for the control of annual grass and broadleaf weeds in various cropping systems including pecan *** objectives of this study were to（1） determine the mobility and dissipation of indaziflam and（2） evaluate herbicide efficacy in a flood-irrigated pecan orchard in southern New Mexico,*** was applied at 0,35.5,and 73.1 g/ha in areas with（impacted） and without（unimpacted） tree injury *** samples were collected at 0-15,15-30,and 30-46 cm depths 25,63,90,and 125 days after the first herbicide *** soil samples were collected 4,30,and 55 days after the second *** was detected in soil samples collected at each depth,suggesting movement with irrigation *** concentrations decreased with increasing soil depth and *** mass recoveries were greater in the unimpacted area than in the impacted area after the first and second *** half-lives of indaziflam in the soil ranged from 30 to 85 days for total indaziflam recovered from the entire soil profile after the first and second applications in both *** percent weed control was similar in the impacted and unimpacted areas for both rates of indaziflam on 25 and 53 days after application;however,on 90 days after the application,percent weed control was lower in the impacted than unimpacted area.

关键词： Indaziflam Half-life Sorption Soil properties Dissipation Persistence

Multi-objective optimization design of bridge piers with hybrid heuristic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： Francisco J. MARTINEZ-MARTIN Fernando gonzalez-VIDOSA Antonio HOSPITALER Víctor YEPES Department of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Department of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid multi- objective simulated annealing (SA) algorithm with a neighborhood move based on the mutation operator from the genetic algorithms (GAs), namely MOSAMO1, MOSAMO2 and MOSAMO3. The procedure is applied to three objective functions: the economic cost, the reinforcing steel congestion and the embedded CO 2 emissions. Additional results for a random walk and a descent local search multi-objective algorithm are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The methodology was applied to a typical bridge pier of 23.97 m in height. This example involved 110 design variables. Results indicate that algorithm MOSAMO2 outperforms other algorithms regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures Multi-objective optimization Simulated annealing (SA) Structural design

Learning Reactive Power Control Polices in Distribution Networks Using Conditional Value-at-Risk and Artificial Neural Networks

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 201-211页

作者： Krishna Sandeep Ayyagari Reynaldo gonzalez Yufang Jin Miltiadis Alamaniotis Sara Ahmed Nikolaos Gatsis Department of Electrical and Computer Engineering University of Texas at San AntonioSan AntonioUSA

Scalable coordination of photovoltaic(PV)inverters,considering the uncertainty in PV and load in distribution networks(DNs),is challenging due to the lack of real-time *** PV inverter setpoints can be achieved to address this issue by capitalizing on the abundance of data from smart utility meters and the scalable architecture of artificial neural networks(ANNs).To this end,we first use an offline,centralized data-driven conservative convex approximation of chance-constrained optimal power flow(CVaR-OPF)in which conditional value-at-risk(CVaR)is used to compute reactive power setpoints of PV inverter,taking into account PV and load uncertainties in *** that,an artificial neural network(ANN)controller is trained for each PV inverter to emulate the optimal behavior of the centralized control setpoints of PV inverter in a decentralized ***,the voltage regulation performance of the developed ANN controllers is compared with other decentralized designs(local controllers)developed using model-based learning(regressionbased controller),optimization(affine feedback controller),and case-based learning(mapping)*** tests using real-world feeders corroborate the effectiveness of ANN controllers in voltage regulation and loss minimization.

关键词： Chance constraint decentralized control distributed energy resource(DER) data-driven control neural network voltage regulation

Green Synthesis of Silver Nanoparticles from Abronia villosa as an Alternative to Control of Pathogenic Microorganisms

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Journal of Renewable Materials 2020年第1期8卷 69-78页

作者： Ali Abdelmoteleb Benjamin Valdez-Salas Ernesto Beltran-Partida Daniel gonzalez-Mendoza Botany Department Faculty of AgricultureMenoufia UniversityShebin El-Kom32511Egypt Instituto de Ingeniería de la Universidad Autónoma de Baja California MexicaliBaja California21100México Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC) Ejido Nuevo LeónBaja California21705México

The aim of this study was to evaluate the antibacterial and antifungal activities of eco-friendly synthesized silver *** silver nanoparticles were synthesized by biological method using aqueous extract of Abronia *** of silver nanoparticles was confirmed by color change and characterized using UV-visible spectroscopy,scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLS),and zeta potential *** SEM analysis revealed the presence of spherical silver nanoparticles of the size range 21 to 33 *** silver nanoparticles were used to evaluate their antibacterial effects at different concentrations(25,50,75 and 100μg/ml)on gram negative and gram positive *** biggest halo zone was observed at 75 and 100μg/ml concentrations of silver nanoparticles against both gram positive and gram negative *** activity of biosynthesized silver nanoparticles was evaluated against seven different phytopathogenic *** showed high inhibition of radial growth toward all tested *** highest inhibition of fungal growth by AgNPs was recorded against Macrophomina phaseolina(86.06±0.92%).Biosynthesized AgNPs using plant extract are a promising to use safety for various biomedical and agricultural applications.

关键词： Antibacterial activity antifungal activity green synthesis

Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats

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World Journal of Gastroenterology 2011年第7期17卷 898-905页

作者： Glasiella gonzalez Perez da Silva Jacqueline Nelisis Zanoni Nilza Cristina Buttow Department of Morphological Sci-ences Universidade Estadual de Maringá Av. Colombo 5790Bloco H-79 CEP 87020-900 Maringá PR Brazil

AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats.

关键词： Diabetes mellitus Ginkgo biloba Myenteric plexus Submucous plexus Neuroprotection

Approach to Simplify the Development of IoT Systems that Interconnect Embedded Devices Using a Single Program

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Computers, Materials & Continua 2023年第11期77卷 2463-2480页

作者： Enol Matilla Blanco Jordán Pascual Espada Rubén gonzalez Crespo Department of Computer Science University of OviedoOviedo33007Spain Department of Computer Science and Technology Universidad Internacional de La RiojaLogroño26006Spain

Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized ***,there are several commercial and research platforms available to simplify the creation of such IoT ***,developing these systems can often be a tedious *** address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices *** approach is based on an abstraction,integrating the control of the devices in a single program through a programmable ***,the proposal processes the unified script to generate the centralized system code and a controller for each *** adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.

关键词： IoT interconnected devices IoT platform programing devices devices coordination and communication

Characterization of a 3-Phase a.c. Free Burning Arc Plasma

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Plasma Science and Technology 2006年第2期8卷 156-163页

作者：夏维东 Laurent FULCHERI Jose gonzalez-AGUILAR 李辉 Thomas M. GRUENBERGER University of Science" and Technology of China Hefei 230027 China. Centre for Energy Studies Ecole des Mines de Paris Rue Claude Daunesse F-06904 Sophia Antipolis France University of Science and Technology of China Hefei 230027 China.

A 3-phase a.c. arc plasma reactor with large volume plasma has been developed for the synthesis of new carbon nano-structures. One of the main characteristics of the plasma system is related to the absence of a fixed neutral point. This gives rise to a rich and complex phenomenology related to instabilities and arc motion since the arcs are ＂burning＂ freely in the gas flow between the three electrodes. This paper is dedicated to the analysis of the behavior of such a system under typical conditions using argon and nitrogen as plasma gases. A classification of are configuration, arc commutating, arc interaction, arc motion and arc instabilities are discussed based on ultra high-speed cine camera analysis. A simple model describing the time evolution of the system is also presented and compared with the experimental measurements. The results show that an adequate control could allow the improvement of the overall system.

关键词： 3-phase AC arc plasma free arc arc motion arc commutating arc instabilities

Effects of obstructive sleep apnea and its treatment over the erectile function： a systematic review

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Asian Journal of Andrology 2017年第3期19卷 303-310页

作者： Felix Campos-Juanatey Marcos Fernandez-Barriales Monica gonzalez Jose A Portillo-Martin Urology Department Marques de Valdecilla University Hospital Santander 39008 Spain Institute of Investigation Marques de Valdecilla Santander 39011 Spain Oral and Maxillofacial Surgery Department Araba University Hospital Araba 01004 Spain Sleep and Ventilation Unit Marques de Valdecilla University Hospital Santander 39008 Spain Medical and Surgical Sciences Department School of Medicine University of Cantabria Santander 39011 Spain.

Erectile dysfunction （ED） is considered a condition with a broad range of etiologies. Obstructive sleep apnea （OSA） syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors （iPDE5） on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.

关键词： continuous positive airway pressure erectile dysfunction obstructive sleep apnea operative surgical procedures phosphodiesterase type 5 inhibitors

Assessing a novel modelling approach with high resolution UAV imagery for monitoring health status in priority riparian forests

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Forest Ecosystems 2021年第4期8卷 810-830页

作者： Juan Guerra-Hernandez Ramon A.Diaz-Varela Juan Gabriel Avarez-gonzalez Patricia Maria Rodriguez-gonzalez edata Centro de iniciativas empresariaisFundacion CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonInstituto Superior de Agronomia(ISA)Tapada da Ajuda1349-017 LisbonPortugal Biodiversity and Applied Botany Unit(GI BIOAPLIC 1809) Department of BotanyEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus Universitario27002 LugoSpain Sustainable Forest Management Unit(UXFS) Department of Agroforestry EngineeringEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus UniversitarioE-27002 LugoSpain

Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different types of damages caused by the disease is challenging in high density ecosystems in which spectral variability is high due to canopy *** obtained by unmanned aerial vehicles(UAVs)may be particularly useful for such tasks due to the high resolution,flexibility of acquisition and cost efficiency of this type of *** this study,*** decline was assessed by considering four categories of tree health status in the field:asymptomatic,dead and defoliation above and below a 50% threshold.A combination of multispectral Parrot Sequoia and UAV unmanned aerial vehicles-red green blue(RGB)data were analysed using classical random forest(RF)and a simple and robust three-step logistic modelling approaches to identify the most important forest health indicators while adhering to the principle of parsimony.A total of 34 remote sensing variables were considered,including a set of vegetation indices,texture features from the normalized difference vegetation index(NDVI)and a digital surface model(DSM),topographic and digital aerial photogrammetry-derived structural data from the DSM at crown ***:The four categories identified by the RF yielded an overall accuracy of 67%,while aggregation of the legend to three classes(asymptomatic,defoliated,dead)and to two classes(alive,dead)improved the overall accuracy to 72% and 91% *** the other hand,the confusion matrix,computed from the three logistic models by using the leave-out cross-validation method yielded overall accuracies of 75%,80% and 94% for four-,three-and two-level classifications,***:The study findings provide forest managers with an alternative robust classification method for the rapid,effective assessment of area

关键词： Alder RPAS Multi-spectral Defoliation Texture variables 3D point cloud Tree health monitoring