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World Journal of Clinical Cases 2022年第29期10卷 10435-10450页

作者： Moises Rodriguez-gonzalez Ana Castellano-Martinez Division of Pediatric Cardiology Puerta del Mar University HospitalCadiz 11009Spain Division of Pediatric Nephrology Puerta del Mar University HospitalCadiz 11009Spain

BACKGROUND Multisystem inflammatory syndrome in children(MIS-C) has emerged as a new disease associated with COVID-19 that presents in acute critically ill children with acute cardiovascular *** To determine whether the age-adjusted N-terminal pro-brain natriuretic peptide(NT-proBNP) value(Z-log-NT-proBNP) is associated with severe MIS-C and myocardial *** A retrospective study was conducted which included children with MIS-C managed at our institution between April 1,2020,and February 28,*** divided the population into groups depending on severity based on pediatric intensive care unit(PICU) *** compared Z-log-NT-proBNP values across these groups and analyzed Z-log-NT-proBNP dynamics during the onemonth *** We included 17 participants [median age 3(2-9) years] and seven(41%) required PICU ***(100%) of these cases presented very high(Z-log > 4) levels of NT-proBNP at the time of admission compared to only 5(50%) patients with non-severe MIS-C(P = 0.025).NT-proBNP was significantly correlated with highsensitive Troponin I levels(P = 0.045),Ross modified score(P = 0.003) and left ventricle ejection fraction(P = 0.021).CONCLUSION Raised NT-proBNP,specifically very high values(Z-log-NT-proBNP > 4) could help in the early identification of MIS-C patients with myocardial dysfunction requiring inotropic support and PICU admission.

关键词： Multisystem inflammatory syndrome associated with COVID-19 COVID-19 SARS-CoV-2 NT-proBNP Echocardiography Myocardial dysfunction Children

Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

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World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez Perez Rocio gonzalez Grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

Predicting outcomes after kidney transplantation: Can Pareto’s rules help us to do so?

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World Journal of Transplantation 2024年第1期14卷 9-11页

作者： Fernando M gonzalez Francisca gonzalez Cohens Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesSantiago 7500922Chile

Kidney transplantation is the best option for kidney replacement therapy,even considering that most of the times the grafts do not survive as long as their *** the Khalil et al's experience,published in this issue of the Journal,they analyze their second kidney graft survival and describe those significant predictors of early *** editorial comments on the results and put in perspective that most of the times,long-term graft survival could be inadvertently jeopardized if the immunosuppressive therapy is reduced or withdrawn for any reason,and that it could happen frequently if the transplant physician intends to innovate with the clinical care without proper evidence-based data.

关键词： Kidney transplantation Graft survival Acute rejection Interstitial fibrosis and tubular atrophy Immunosuppression

Is the near coming xenotransplantation era relieving us from needing to look for more non-living organ donors?

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World Journal of Transplantation 2022年第12期12卷 388-393页

作者： Fernando M gonzalez Francisca del Rocío gonzalez Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile

Despite organ transplantation being the most successful treatment for end-stage organ dysfunction,the number of annual solid organ transplantations is much lower than that required to satisfy the demand of patients on waiting *** explanation for this phenomenon is the relative scarcity of non-living organ donors due to several factors,such as:(1)Late arrival of patients with a neurocritical condition to an emergency service;(2)lack of detection of those patients as possible organ donors by health professionals dedicated to procurement or by clinicians at emergency and intensive care units,for instance;(3)late transfer of the patient to an intensive care unit to try to recover their health and to provide hemodynamic,ventilatory,and metabolic support;(4)lack of confirmation of the physiological status of the possible donor;(5)late or incorrect positive diagnosis of the subject’s death,either due to brain or cardiac death;(6)difficulty in obtaining legal authorization,either by direct relatives or by the authority,for the extraction of organs;and(7)deficient retrieval surgery of the organs actually *** recent reports of relatively successful xenotransplants from genetically modified pigs open the possibility to fix this mismatch between supply and demand,but some technical(organ rejection and opportunistic infections),and economic issues,still remain before accepting a progressive replacement of the organ sources for *** approximate economic cost analysis suggests that the hypothetical acquisition cost of any genetically modified pig derived organ is high and would not even satisfy the solid organ demand of the wealthiest countries.

关键词： Organ donation Xenotransplantation Procurement Kidney transplantation Costs

A biologically inspired model for pattern recognition

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第2期11卷 115-126页

作者： Eduardo gonzalez Hans LILJENSTROM Yusely RUIZ Guang LI Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China Department of Energy and Technology Swedish University of Agricultural Sciences Box 7013 SE-750 Sweden National Laboratory of industrial Control Technology Institute of Cyber-Systems and Control Zhejiang University Hangzhou 310027 China

In this paper, a novel bionic model and its performance in pattern recognition are presented and discussed. The model is constructed from a bulb model and a three-layered cortical model, mimicking the main features of the olfactory system. The olfactory bulb and cortex models are connected by feedforward and feedback fibers with distributed delays. The Breast Cancer Wisconsin dataset consisting of data from 683 patients divided into benign and malignant classes is used to demonstrate the capacity of the model to learn and recognize patterns, even when these are deformed versions of the originally learned patterns. The performance of the novel model was compared with three artificial neural networks (ANNs), a back-propagation network, a support vector machine classifier, and a radial basis function classifier. All the ANNs and the olfactory bionic model were tested in a benchmark study of a standard dataset. Experimental results show that the bionic olfactory system model can learn and classify patterns based on a small training set and a few learning trials to reflect biological intelligence to some extent.

关键词： Olfactory system Neural network Bionic model Pattern recognition

DNA replication components as regulators of epigenetic inheritance---lesson from fission yeast centromere

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Protein & Cell 2014年第6期5卷 411-419页

作者： Haijin He Marlyn gonzalez Fan Zhang Fei Li Department of Biology New York University New York NY 10003 USA Clinical Translational-Research Center shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China

Genetic information stored in DNA is accurately copied and transferred to subsequent generations through DNA replication. This process is accomplished through the concerted actions of highly conserved DNA replication components. Epigenetic information stored in the form of histone modifications and DNA methylation, constitutes a second layer of regulatory information important for many cellular processes, such as gene expression regulation, chromatin organization, and genome stabil- ity. During DNA replication, epigenetic information must also be faithfully transmitted to subsequent generations. How this monumental task is achieved remains poorly understood. In this review, we will discuss recent advances on the role of DNA replication components in the inheritance of epigenetic marks, with a particular focus on epigenetic regulation in fission yeast. Based on these findings, we propose that specific DNA replication components function as key regulators in the replication of epigenetic information across the genome.

关键词： epigenetic inheritance DNA replication,centromere histone modification heterochromatin,euchromatin

Declining metabolic scaling parallels an ontogenetic change from elongate to deep-bodied shapes in juvenile Brown trout

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Current Zoology 2023年第3期69卷 294-303页

作者： Jorge-Ruben Sanchez-gonzalez Alfredo G.Nicieza Department of Organisms andSystems Biology University of Oviedo33006O OviedoSpain Biodiversity Research Institute(IMIB) University of Oviedo-Principality of Asturias-CSIC33600 MieresSpain Department of Animal Science-Wildlife Section University of Lleida25006 LleidaSpain

Body shape and metabolic rate can be important determinants of animal performance,yet often their effects on influential traits are evaluated in a non-integrated *** creates an important gap because the integration between shape and metabolism may be crucial to evaluate metabolic scaling ***,we measured standard metabolic rate in 1-and 2-years old juvenile brown trout Salmo trutta,and used a geometric morphometrics approach to extricate the effects of ontogeny and size on the link between shape and metabolic *** evidenced near-isometric ontogenetic scaling of metabolic rate with size,but also a biphasic pattern driven by a significant change in metabolic scaling,from positive to negative ***,the change in metabolic allometry parallels an ontogenetic change from elongate to deep-bodied *** is consistent with the dynamic energy budget(DEB)and surface area(SA)theories,but not with the resource transport network theory which predicts increasing allometric exponents for trends towards more robust,three-dimensional *** addition,we found a relationship between body shape and size independent metabolic rate,with a positive correlation between robustness and metabolic rate,which fits well within the view of Pace-of-Life Syndromes(POLS).Finally,our results align with previous studies that question the universality of metabolic scaling exponents and propose other mechanistic models explaining the diversity of metabolic scaling relationships or emphasizing the potential contribution of ecological factors.

关键词： biphasic allometric scaling metabolic rate ontogenetic allometry shape surface-area trout

Detecting stable phase structures in EEG signals to classify brain activity amplitude patterns

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1483-1491页

作者： Yusely RUIZ Guang LI Walter J.FREEMAN Eduardo gonzalez Department of Biomedical Engineering Zhejiang University Hangzhou 310027China National Lab of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China Department of Molecular&Cell Biology 101 Donner University of California at BerkeleyCA 94720-3206USA

Obtaining an electrocorticograms(ECoG)signal requires an invasive procedure in which brain activity is recorded from the cortical *** contrast,obtaining electroencephalograms(EEG)recordings requires the non-invasive procedure of recording the brain activity from the scalp surface,which allows EEG recordings to be performed more easily on healthy *** this work,a technique previously used to study spatial-temporal patterns of brain activity on animal ECoG was adapted for use on *** main issues are centered on solving the problems introduced by the increment on the interelectrode distance and the procedure to detect stable *** results showed that spatial patterns of beta and gamma activity can also be extracted from the EEG signal by using stable frames as time markers for feature *** adapted technique makes it possible to take advantage of the cognitive and phenomenological awareness of a normal healthy subject.

关键词： Electroencephalograms(EEG) Spatial-temporal pattem Stable phase structure Frames

A 3R-Tau-mediated mechanism in oligodendrocytes:could it be the key for neuroprotection after stroke?

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Neural Regeneration Research 2021年第12期16卷 2401-2402页

作者： Mario Villa gonzalez Maria JoséPérez-Álvarez Departamento de Biología(Fisiología Animal) Facultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Biología Molecular“Severo Ochoa” Departamento de Neuropatología Molecular CSIC-UAMMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Anoverview of cerebral ischemia:Cerebrovascular accident or stroke have a high global *** most common types of stroke are ischemic,accounting for 87%of the total number,and they are triggered by a reduction or interruption of blood flow to the central nervous system,usually caused by a thrombus,embolus or atherosclerotic *** severity of brain damage caused by this kind of stroke is directly related to the size of the vessel that is occluded and the duration of occlusion.

关键词： cerebral ischemia damage

Preliminary Experimental Results of Deep Levels for Dielectronic Recombination in He—Like High—Z Ions at Heidelbreg Electron Beam Ion Trap

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Chinese Physics Letters 2003年第5期20卷 657-659页

作者： ZHANGXue-Mei GUOPan-Lin A.gonzalez J.CRESPO AppliedIonBeamPhysicsLaboratory InstituteofModernPhysicsFudanUniversityShanghai200433 ShanghaiInstituteofNuclearResearch ChineseAcademyofSciencesShanghai201800 Max-Planck-InstitutfurKernphysik Saupfercheckweg1D-69117HeidelbergGermany

An experimental system for dielectronic recombination was set-up on H-EBIT in order to carry out dielectronic recombination study. Some preliminary results of He-like Ge32+ and Cu27+ are obtained. Space charge shift on determination of the resonance position for Ge32+ at 100mA is around 18% and that for Cu27+ is around 38%. Further analysis of experimental data is in progress.

关键词：实验研究二次电子再结合离子捕获电子束自由电子