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COVID-19 infection and liver injury:Clinical features,biomarkers,potential mechanisms,treatment,and management challenges

引用

World Journal of Clinical Cases 2021年第22期9卷 6178-6200页

作者： Gholam Reza Sivandzadeh Hassan Askari Ali Reza Safarpour Fardad Ejtehadi Ehsan Raeis-Abdollahi armaghan vaez lari Mohammad Foad Abazari Firoozeh Tarkesh Kamran Bagheri Lankarani Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran Department of Medical Sciences Qom Medical BranchIslamic Azad UniversityQom ***Iran Department of Physiology School of MedicineAhvaz Jundishapur University of Medical ScienceAhvaz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Health Policy Research Center Shiraz University of Medical SciencesShiraz 71348-45794Iran

It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical *** injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 *** addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current ***,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver *** monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver *** purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver *** review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.

关键词： Liver injury COVID-19 SARS-CoV-2 Inflammation Management

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