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作者： CHRISTINE CHARLOTTE AYABA BAMIDELE dos-reis 中南大学

学位级别：硕士

背景:重性抑郁障碍(Major Depressive disorder,MDD)是一种常见的精神障碍,也是全球疾病负担的主要原因之一。尽管MDD突出的特征是显著而持久的心境低落与快感缺失等情绪症状,但也普遍存在明显的认知功能如注意、记忆、执行功能等的损... 详细信息

背景:重性抑郁障碍(Major Depressive disorder,MDD)是一种常见的精神障碍,也是全球疾病负担的主要原因之一。尽管MDD突出的特征是显著而持久的心境低落与快感缺失等情绪症状,但也普遍存在明显的认知功能如注意、记忆、执行功能等的损害。值得注意的是,即使在临床缓解的情况下,患者的某些认知损伤也有可能持续存在,并对其日常生活及社会功能产生明显影响。因此,对抑郁症患者认知功能损伤的研究近年来越来越受到研究者的关注。事件相关电位(Event-related potentials,ERP)由脑电图(EEG)衍生而来,是外加的特定刺激(给予或者撤销刺激)作用于人脑所引起的脑区电位变化,通常运用平均叠加技术从头颅表面记录。由于ERP反映了认知过程中大脑的神经电生理改变,与认知过程有密切关系,也被称为认知电位。当ERP用于测量精神疾病患者大脑的认知功能受损时,可提供比传统神经心理学测试更丰富的信息。特别是ERP技术具有出色的时间精度,在考察大脑的认知功能障碍相关神经活动时可达到毫秒级的分辨率,因此常用于以认知功能损害为主的神经精神疾病的研究,并从中筛选有临床意义的生物标志物。ERP实验范式通常可诱发出多种成分,而在ERP的各种成分当中,由区分标准刺激与罕见的偏差刺激所诱发的大脑后部P3成分(峰值通常在300-600ms之间),以及额-中央区的P2成分(峰值通常在200ms左右),分别与目标识别、概念更新和认知过程,以及注意力分配、刺激的早期识别有关,是常见的与精神疾病患者认知功能受损有关的脑电生理指标。例如,在经典的听觉Oddball任务范式中诱发的P3成分,其波幅和潜伏期分别反映了对预期目标刺激的注意力分配,以及刺激信息处理及分类速度。而通常在额-中央区和顶枕区观察到的在刺激后约150-250ms出现的P2成分,则反映了早期注意力资源的分配和调节,参与对刺激的加工、识别和分类,代表对任务相关刺激和无关刺激的区分。抑郁障碍患者的认知功能异常通常表现为注意力较难集中,执行任务时所需时间更长等。而在脑电生理方面与临床表现较一致地发现,抑郁障碍患者的P3的波幅较健康被试显著降低,潜伏期显著延长,提示抑郁障碍患者的注意认知加工速度和认知资源分配可能存在损伤。当前对于在抑郁症患者中P2成分的损害尚存争议,有研究发现在Oddball范式中,MDD患者在标准刺激和目标刺激下的P2波幅较健康被试更大,认为前者可能反映了患者在感觉加工中有过度抑制的表现,而后者可能反映了患者对认知任务加工的早期注意分配和调控存在困难。据此有研究者提出,P3、P2、N1成分等脑电指标,在抑郁障碍患者中存在特异性的损伤,因而可能在抗抑郁治疗反应预测和治疗选择方面具有一定价值。但是,目前少有研究对MDD患者在治疗前后不同疾病状态的脑电成分异常及变化规律进行考察,已有的几项研究也尚未取得一致。一些关注抗抑郁药物治疗后P3变化的研究指出,MDD患者在治疗后虽未恢复至健康被试的水平,但P3的波幅和潜伏期有所改善;也有研究得出相反的结论,发现经抗抑郁药治疗后MDD患者的P3波幅并没有显著改变。但总体来说,当前对MDD患者的认知相关ERP研究大多为横断面研究,缺乏纵向追踪报道;而且抑郁障碍临床表现复杂多样,患者具有高度异质性,研究中被试的纳入标准、抑郁严重程度、共病、病程不同等因素也会对研究结果的一致性产生较大影响。值得注意的是,抑郁障碍患者的认知功能损害与其情绪症状存在密切的联系,如形成负性偏向的认知图式,对正性或积极情绪的反应变慢,对奖赏的动机缺失等,而基于情绪的认知损伤有可能是抑郁障碍患者的认知功能障碍区别于其他疾病的特异性表现形式,在进行经典的脑电生理研究中如能结合考察与情感相关的认知功能的任务,更有可能探测到抑郁障碍的特异性认知表现。综上所述,本研究将结合情绪识别行为学任务及经典的听觉Oddball任务范式脑电实验,对首发未服药MDD患者进行纵向追踪研究,在接受 SSRI(Selective Serotonin Reuptake Inhibitor)类抗抑郁药物治疗8周前后评估患者的认知功能特征,并进行听觉Oddball任务过程中的脑电数据采集,比较患者与健康对照在基线时的差异,并寻找患者在不同疾病状态(首发、临床缓解或未缓解)下的变化规律,进一步探索脑电生理特征、行为和情绪认知表现之间的联系。材料与方法:研究共纳入116名被试,其中首发未服药MDD患者56人,健康对照被试60人。所有被试均完成量表、情绪认知评估以及听觉oddball范式的脑电数据采集。在使用SSRI类药物进行8周的抗抑郁治疗后,MDD患者再次进行评估和脑电数据采集,经8周治疗后HAMD-17得分≤7分为缓解组(remitted MDD,RM),否则为未缓解组(non-remitted MDD,

关键词：重性抑郁障碍抗抑郁药物情绪认知功能 Oddball 脑电图

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Automatic method for the estimation of li-ion degradation test sample sizesrequired to understand cell-to-cell variability

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能源与人工智能(英文) 2022年第3期9卷 139-147页

作者： Calum Strange Michael Allerhand Philipp Dechent Gonçalo dos reis School of Mathematics University of EdinburghThe Kings buildingsEdinburghEH93JFScotlandUnited Kingdom Institute for Power Electronics and Electrical Drives(ISEA) RWTH Aachen UniversityAachenGermany Centro de Matematica e Aplicacoes(CMA) Faculdade de Ciencias e TecnologiaCampus da CaparicaCaparica2829-516Portugal

The testing of battery cells is a long and expensive process, and hence understanding how large a test set needsto be is very useful. This work proposes an automated methodology to estimate the smallest sample size ofcells required to capture the cell-to-cell variability seen in a larger population. We define cell-to-cell variationbased on the slopes of a linear regression model applied to capacity fade curves. Our methodology determinesa sample size which estimates this variability within user specified requirements on precision and *** sample size is found using the distributional properties of the slopes under a normality assumption, andan implementation of the approach is available on *** the five datasets in the study, we find that a sample size of 8–10 cells (at a prespecified precision andconfidence) captures the cell-to-cell variability of the larger datasets. We show that prior testing knowledge canbe leveraged with machine learning models to operationally optimise the design of new cell-testing, leadingup to a 75% reduction in experimental costs.

关键词： Battery Testing Lithium-ion Degradation Statistics Manufacturing Machine learning

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Water availability drives gradients of tree diversity,structure and functional traits in the Atlantic-Cerrado-Caatinga transition,Brazil

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Journal of Plant Ecology 2018年第6期11卷 803-814页

作者： Marcela de Castro Nunes Santos Terra Rubens Manoel dos Santos Jamir Afonso do Prado Júnior José Marcio de Mello José Roberto Soares Scolforo Marco Aurélio Leite Fontes Ivan Schiavini Aliny Aparecida dos reis Inacio Thomaz Bueno Luiz Fernando Silva Magnago Hans ter Steege Departamento de Ciências Florestais Universidade Federal de LavrasCampus UniversitárioPO Box 3037LavrasMinas Gerais 37200-000Brazil Instituto de Biologia Universidade Federal de UberlândiaCampus Umuarama-Bloco 2DPO Box 593UberlândiaMinas Gerais 38400-902Brazil Applied Ecology and Conservation Lab Programa de Pós‐graduação Ecologia e Conservação da BiodiversidadeUniversidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Naturalis Biodiversity Center Vondellaan 55Postbus 95172300 RA LeidenThe Netherlands Coordenação de Botânica Museu Paraense Emílio GoeldiAv.Magalhães Barata 376PO Box 399BelémPara´66040-170Brazil

Aims Climate and soil are among the most important factors determin-ing variation in tree communities,but their effects have not been thoroughly elucidated to date for many vegetation *** this study,we evaluate how climate and soil gradients affect gradients of vegetation composition,species diversity and dominance,structure and functional traits(seed mass and wood density)using over 327000 trees in 158 sites distributed along environmental gradients in the transitions among the Atlantic forest,Cerrado and Caatinga in Minas Gerais State(MG),Brazil(nearly 600000 km2).Methods Gradients in species,genus and family abundance in addition to basal area,stem density,species diversity(Fisher’s alpha),domin-ance percentage,seed mass and wood density were correlated using multiple regressions with environmental variables,as summarized in four principal component analysis axes(two climatic-precipi-tation seasonality and temperature range-and two edaphic-soil fertility and soil moisture).Additionally,ordinary kriging maps were used to better illustrate the *** Findings Multiple regression models indicate that all variables but domin-ance percentage were affected by one or more of the environmental gradients,but the average R2 was low(26.25%).Kriging maps rein-forced the patterns observed in the regression *** seasonality and soil moisture gradients were the most important gra-dients affecting vegetation *** finding suggests that water availability is an important determinant of vegetation features in these vegetation transitions.

关键词： climate environmental gradient soil southeastern Brazil vegetation

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Spatial Statistics and Age Structure of Leaf Cutting Ant Nests

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Open Journal of Statistics 2019年第2期9卷 196-217页

作者： Debora Maria Ferreira Canuto Sergio Furtado dos reis Wesley Augusto Conde Godoy Departamento de Entomologia e Acarologia Escola Superior de Agricultura Luiz de Queiroz Universidade de Sao Paulo Piracicaba Brazil Departamento de Biologia Animal Universidade Estadual de Campinas Campinas Brazil

In this study, we investigated the spatial aggregation of old and incipient nests of Atta sexdens rubropilosa by fitting Poisson and Negative binomial models to nest abundance data. Our aim is to analyse the distribution of ant nests in eucalypt regrowth, Cerrado and native forest fragment. We also investigated the correlation between nest abundance and climatic factors, as well as different nest ages. When comparing nests of different ages we observed an aggregated pattern for both old and incipient nests. On the other hand, analysing the distribution of nests separately, only taking into account the different areas and respective borders, old nests exhibited an aggregated pattern and incipient nests showed a random pattern, except for native forest with ants exhibiting only an aggregated pattern. The levels of aggregation changed in response to different areas and border gradients, with more external borders showing higher aggregation than more internal borders. Temperature was the variable showing the highest correlation with nest abundance and the correlation between nests of different ages was totally depending on the different areas.

关键词： Spatial Statistics Leaf Cutting Ant Nest Aggregation Nest Age Forest Landscapes

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Verification of Applicability of the Polyurethane Adhesive Based on Castor Oil in the Manufacture of Glued Laminated Bamboo

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Journal of Chemistry and Chemical Engineering 2014年第9期8卷 898-905页

作者： Flavio Cardoso Ventura Bruno Perazzelli Farias Ramos Marco Antonio dos reis Pereira FATEC JAHU Faculty of Technology Jahu Jahu 17212-599 Brazil School of Architecture Arts and Communication Sao Paulo State University Bauru 17033-360 Brazil Department of Mechanical Engineering Sao Paulo State University Bauru 17033-360 Brazil

The current concern with the environment promotes the development of new technologies for production with use of alternative materials, from renewable resources, and changes in production processes, having as main objective the reduction of environmental impact. One of the alternatives for cleaner production is the use of castor oil derivatives instead of non-renewable sources, such as adhesives based on PVA （polyvinyl acetate）, applied in the manufacturing process of glued laminated bamboo. Based on the versatility of the bamboo laminate and the castor oil, and from the perspective of sustainability, this study aims to contribute to the application of new materials and processes, used in the manufacturing industry, by proposing the use of the polyurethane adhesive based on castor oil for glued laminated bamboo manufacturing, which can later be used in the manufacture of several products. To verify the applicability of the polyurethane adhesive based on castor oil in the glued laminated bamboo manufacture, mechanical tests of traction and shearing of the glue sheet were performed in specimens of the said material, and the results were compared with the Cascorez 2590 and Waterbond adhesives. The results showed that the polyurethane adhesive based on castor oil, in the traction test, has superior performance than the Waterbond adhesive and slightly below than the Cascorez 2590 adhesive, but in the shear test, the polyurethane adhesive based on castor oil presented a slightly inferior performance than the other two adhesives used in the comparison.

关键词： Design castor oil glued laminated bamboo sustainable development PVA adhesives.

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Chemical Composition of the Edible Part and the Waste of Brachyuras

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Journal of Agricultural Science and Technology(A) 2012年第5期2卷 690-695页

作者： Tiago Viana da Costa Lidia Miyako Yoshii Oshiro Helaine dos reis Flor Institute of Social Science Education and Animal Science Federal University of Amazon Parintins Amazonas Brazil Institute of Animal Science Federal Rural University of Rio de Janeiro Serop~dica Rio de Janeiro Brazil Federal Rural University of Rio de Janeiro Seropedica Rio de Janeiro Brazil

Flavorful meat and great economic importance, crabs and swimming crabs are appreciated throughout the Brazilian coast, where its waste is discarded by fishermen and consumers. In order to verify the centesimal composition, these animals caught in Sepetiba Bay （Rio de Janeiro, Brazil）, 20 samples of Ucides cordatus, Cardisoma guanhumi, Menippe nodifrons, Callinectes danae and C. exaperatus had their edible and waste parts （shells and hepatopancreas） analyzed in the Laboratory of Bromatology of the UFRRJ. The analysis revealed that the meat of crustaceans is protein （12.68% to 25.56%） and low in fat （0.37% to 0.67%）, sticking to a more demanding consumer market for thin products; the waste has already presented a protein content ranging from 15.75% to 27.64% and fat from 0.75% to 3.27%, with values of calcium （17.96% to 25.23%） and phosphorus （0.93% to 1.55%）, setting a precedent for use in animal feed through future studies in area.

关键词： Crustaceans byproduct commercialization crabs.

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Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection

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World Journal of Hepatology 2021年第1期13卷 109-119页

作者： Jóice Teixeira de Bitencorte Tássia Flores Rech Vagner Ricardo Lunge Deivid Cruz dos Santos Mário reisÁlvares-da-Silva Daniel Simon PPG Biologia Celular e Molecular AplicadaàSaúde Universidade Luterana do BrasilCanoas 92425-900Rio Grande do SulBrazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)infection is a public health concern *** factors,including genetic polymorphisms,may be evolved in the progression of HCV infection to liver *** lambdas(IFNLs)modulate the immune response during viral *** induce antiviral activity,interfering in the viral replication by promoting the expression of several genes that regulate immunological *** interferon lambda-4(IFNL4)rs12979860 polymorphism,which is characterized by a C to T transition in intron 1,is associated with spontaneous and treatment-induced clearance of HCV infection and may play a role in the development of HCV-associated liver diseases,including hepatocellular carcinoma(HCC).AIM To investigate the association of IFNL4 rs12979860 polymorphism with fibrosis,cirrhosis,and HCC in patients with chronic HCV *** This study was comprised of 305 chronic HCV-infected patients(53 fibrosis,154 cirrhosis,and 98 HCC cases).The control group was comprised of 260 HCVnegative healthy *** IFNL4 rs12979860 polymorphism was genotyped using the TaqMan *** was diagnosed based on liver biopsy findings,while cirrhosis was diagnosed through clinical,laboratory,anatomopathological,and/or imaging *** was diagnosed through imaging tests,tumor,and/or anatomopathological *** The T allele was observed in the three groups of patients(fibrosis,cirrhosis,and HCC)at a significantly higher frequency when compared with the control group(P=0.047,P<0.001,and P=0.01,respectively).Also,genotype frequencies presented significant differences between the control group and cirrhosis patients(P<0.001)as well as HCC patients(P=0.002).The risk analysis was performed using the codominant and dominant T allele *** the codominant model,it was observed that the CT genotype showed an increased risk of developing cirrhosis in comparison with the CC genotype[odds ratio(OR)=2.53;95%confidence interval(CI):1.55-4.15;

关键词： Hepatitis C Hepatitis C virus Cirrhosis Hepatocellular carcinoma Genetic polymorphism Interferon-lambda

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Cochlear Implant in a Patient with Arnold-Chiari Syndrome

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Case Reports in Clinical Medicine 2018年第2期7卷 162-167页

作者： Maria Stella Arantes do Amaral Daniela Soares Fonseca Antonio Carlos dos Santos Henrique Furlan Pauna Eduardo T. Massuda Ana Cláudia Mirandola barbosa reis Miguel Angelo Hyppolito Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Postgraduate Program in Oftalmology Otorrhinolaryngology and Head and Neck Surgery of the FMRP/USP-Medical Sciences Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of Clinical Medicine (Center of Image Sciences and Medical Physics) Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of Health Sciences RCS—Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil

Objective: To verify the efficacy of cochlear implantation in a patient with Arnold-Chiari syndrome. Design: Review of a medical chart from a patient with Arnold-Chiari syndrome that underwent to cochlear implant surgery. Case report: A 6 year-old female, with meningomyelocele and congenital hydrocephalus, deaf in the past 3 years, after meningitis. At that time, she used oral language with adequate speech development. Tone audiometry revealed bilateral profound sensorineural hearing loss. The MRI was compatible with the Arnold-Chiari syndrome. Cochlear implantation was performed on the left ear with MED-EL? Implant (model SONATATi100). Currently, the child is 12 year-old, performs speech therapy three times a week, with good hearing and language development. Conclusion: Despite the presence of Arnold-Chiari syndrome (Chiari type II) with neurological disorders and with ventriculoperitoneal shunt, patient had good hearing results after cochlear implant surgery.

关键词： Audiometry Cochlear Implant Sensorineural Hearing Loss Arnold-Chiari Syndrome Deafness Central Nervous System Malformation

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Preparation of High Purity Neodymium Oxide from Brazilian Monazite by Ion Exchange

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Journal of Energy and Power Engineering 2015年第7期9卷 616-621页

作者： Carlos Alberto da Silva Queiroz Jose Antonio Seneda Walter dos reis Pedreira Filho IPEN/CNEN-SP (Instituto de Pesquisas Energeticas e Nucleares/Comissao Nacional de Eneergia Nuclear-Sao Paulo) Cidade Universitaria Sao Paulo 05508-000. Brazil Fundacao Jorge Duprat Figueiredo de Seguranca e Medicina do Trabalho-FUNDACENTRO Sao Paulo 05409-002 Brazil

A simple and economical chemical process for obtaining high purity neodymium oxide is discussed. The raw material in the form of RE （rare earth） carbonates is produced industrially in Brazil from monazite. Using this concentrate as the feed material, ion exchange with a strong cationic resin, commonly used for water treatment, and without the use of retention ions was used for the fractionating of the REE （rare earth elements）. The eluent was ammonium salt of EDTA （ethylenediaminetetraacetic acid） at pH 4.0. The complex of EDTA-neodymium was transformed into neodymium oxides via oxalate precipitation. We produced 99.9% pure Nd203 in yields greater than or equal to 80%. Molecular absorption spectrophotometry was used to monitor the neodymium content during the process and sector field inductively coupled plasma mass spectrometry was used to certify the purity of the neodymium oxides. The typical neodymium oxides obtained contained the followings contaminants in micrograms per gram： Sc （4.09）; Y （0.39）; La （0.78）; Ce （5.62）; Pr （4.56）; Sm （11.10）; Eu （1.10）; Gd （14.30）; Tb （29.3）; Dy （4.15）; Ho （8.39）; Er （13.80）; Tm （0.23）; Yb （2.29）; Lu （0.39）. High purity neodymium oxides obtained from this procedure replaced the imported product used in research and development work on rare earth at IPEN/CNEN-SP （Instituto de Pesquisas Energeticas e Nucleares/Comissfio Nacional de Eneergia Nuclear-Sao Paulo）.

关键词： Neodymium oxide elemental rare earths separation rare earths.

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Root Canal Treatment Outcome and Restorative Condition of Teeth Treated by Undergraduates—A Clinical and Radiographic Evaluation

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Open Journal of Stomatology 2023年第9期13卷 257-270页

作者： Gabriela Tonet Bassani Bartelle Dianeia Miranda dos reis Thiago Oliveira Gamba Fabiana Vieira Vier-Pelisser School of Dentistry UCS—Caxias do Sul University Caxias do Sul Brazil School of Dentistry UFRGS—Federal University of Rio Grande do Sul Porto Alegre Brazil

Background: The aim was to evaluate the nonsurgical Root Canal Treatment (nRCT) outcome, the restorative condition and the relationship between the coronal restoration quality and the outcome of teeth endodontic treated by undergraduates at the University of Caxias do Sul School of Dentistry (UCS-SD), Brazil, between 2019 and 2021. Materials and Methods: Data from the endodontically treated cases were retrieved, and the patients were recalled for a follow-up appointment at the university. The endodontic diagnosis, radiographs, and the presence of definitive restorations were analyzed in the clinical records. During the follow-up appointment, endodontically treated teeth were classified as present or absent. The nRCT was classified as successful (complete or incomplete healing) or failure (uncertain or unsatisfactory healing). Coronal restoration was classified as absent or present. When it was present, it was classified as permanent or temporary, and its quality as adequate or inadequate restoration. The results were presented as percentages. Results: A total of 257 teeth were endodontically treated. The most prevalent diagnosis was Chronic Apical Periodontitis (33.33%) and the most commonly treated teeth were premolars (46.15%). A total of 52 (21%) treated teeth were clinically and radiographically reexamined. The success rate for the nRCT was 98.08%. About 61.54% of this sample had a definitive composite resin restoration. Conclusion: The nRCT success rate was high. Special attention should be given to the presence and quality of the definitive restoration. Clinical Implications: There was no statistically significant impact between the coronal restoration and the nRCT success (P > 0.05).

关键词： Periapical Periodontitis Permanent Dental Restoration Permanent Dental Filling Root Canal Obturation Treatment Outcome

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