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Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

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World Journal of Diabetes 2022年第6期13卷 434-441页

作者： arjun jain Kristof Bozovicar Vidhi Mehrotra Tomaz Bratkovic Martin H Johnson Ira Jha ET-Traps Limited Cambridge CB30JEUnited Kingdom Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB23DYUnited Kingdom Accelerate Cambridge Judge Business SchoolUniversity of CambridgeCambridge CB21AGUnited Kingdom Department of Pharmaceutical Biology Faculty of PharmacyUniversity of LjubljanaSlovenia 1000Slovenia

BACKGROUND Endothelin(ET)-traps are Fc-fusion proteins with a design based on the physiological receptors of *** work has shown that use of the selected ET-traps potently and significantly reduces different markers of diabetes pathology back to normal,non-disease *** To demonstrate the selected ET-traps potently and significantly bind to *** We performed phage display experiments to test different constructs of ET-traps,and conducted bio-layer interferometry binding assays to verify that the selected ET-traps bind specifically to ET-1 and display binding affinity in the double-digit picomolar range(an average of 73.8 rM,n=6).RESULTS These experiments have confirmed our choice of the final ET-traps and provided proof-of-concept for the potential use of constructs as effective biologics for diseases associated with pathologically elevated *** There is increased need for such therapeutics as they could help save millions of lives around the world.

关键词： Endothelin-1 Endothelin-traps Diabetes Heart failure Chronic kidney disease Novel therapeutic

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Artificial neural network based modeling of liquid membranes for separation of dysprosium

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Journal of Rare Earths 2023年第3期41卷 440-445,I0005页

作者： Jawad Iqbal arjun Tyagi Manish jain Department of Applied Chemistry Delhi Technological UniversityDelhi110042India

In recent years,the liquid membrane process has been widely investigated to remove rare earth ***,transport modeling of this process requires the accurate values of several parameters,which are difficult to ***,the accurate simulation of this process is a challenging *** this study,the artificial neural network(ANN)based approach is used to model the liquid membrane process for removing *** results from a previous study were used to train the ***,the number of neurons in the hidden layer was *** minimum mean squared error between experimental results and model predictions is found with ten *** predictions were successfully validated with experimental results with correlation factor(R)of 0.9987,which confirms the authenticity of the trained *** ANN was then used to study the effects of different operating parameters on transport *** higher volume ratio of membrane solution to feed solution(3-4)with 50-60 min of operation,higher feed pH(5),HCl concentration in stripping solution of 2 mol/L,and moderate concentration of carrier species(0.5 mol/L)with 0.5×10^(-4) mol/L dysprosium initial concentration are found to be optimum values of operating conditions for maximizing the transport rate.

关键词： Rareearth metal separation Artificial neural network Dysprosium separation Liquid membranes

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Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease:A systematic review

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World Journal of Nephrology 2025年第1期14卷 127-137页

作者： Jaydeep jain Mahendra Singh Shashank Kumar Om Kumar Yadav Ankit Shettar Shiv Charan Navriya Deepak Prakash Bhirud Gautam Ram Choudhary arjun Singh Sandhu Department of Urology All India Institute of Medical SciencesJodhpur 342008RājasthānIndia

BACKGROUND End-stage renal disease(ESRD)is associated with a multitude of physical,psychological,and social health challenges,including a profound impact on sexual and reproductive *** males with ESRD,erectile dysfunction(ED)is highly prevalent due to factors such as underlying comorbidities,including diabetes and hypertension,and the physiological effects of long-term *** transplantation(KTx)has been proposed as a potential intervention to mitigate the effects of ED by restoring renal function and improving hormonal ***,the evidence surrounding the effectiveness of KTx in improving sexual function,specifically erectile function(EF),remains *** systematic review and meta-analysis aim to evaluate the effects of KTx on sexual dysfunction(SexDys),particularly ED,in male ESRD *** To evaluate the benefits and potential harms of KTx compared to other forms of renal replacement therapy in improving EF in adult males with ESRD,assessed using the international index of EF(IIEF),to survey the prevalence of SexDys in this population,and to assess the correlation between various factors and SexDys through regression *** A systematic search of PubMed,EMBASE,Cochrane Library,Scopus,***,and Google Scholar was conducted,following the PRISMA 2020 *** and retrospective cohort studies,as well as cross-sectional studies assessing EF pre-and post-transplantation,were *** studies used validated tools such as the IIEF to measure ***-analyses were performed using a random-effects model to estimate standardized mean differences(SMD)and hazard ratios(HR)with 95%confidence intervals(CI).Heterogeneity was assessed using the I²statistic,and publication bias was evaluated with a funnel plot and the Egger’s *** A total of 2419 studies were identified,with 362 abstracts screened and 193 full-text articles ***,11 studies were included for qualitative analys

关键词： Kidney transplantation Sexual dysfunction Erectile dysfunction International index of erectile function Syste-matic review Meta analyses

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Exploring one material for dual applications:A red-emitting Mg_(2)GeO_(4):Eu^(3+)nanophosphor for future generation energy efficient WLEDs and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay arjun G.P.Darshan S.C.Sharma H.Nagabhushana D.V.Sunitha H.B.Premkumar Department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India Honorary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India C.N.R.Rao Centre for Advanced Materials Tumkur UniversityTumkur572103India School of Applied Sciences(Physics) REVA UniversityBengaluru560064India

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was estimated and obtained to be~4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at^(5)79,589,610,661,and 707 nm,which are due to characteristic^(5)D_(0)→^(7)F_(0),^(5)D_(0)→^(7)F_(1),^(5)Do→^(7)F_(2),^(5)D_(0)→^(7)F_(3)and^(5)D_(0)→^(7)F_(4)transitions of Eu^(3+)ions,*** Commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peaks showcase excellent super-linear response at low doses ofγ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes(WLEDs)and personal dosimetric applications.

关键词： Nanophosphors Photoluminescence Thermoluminescence Dosimetry Photometric properties Rare earths

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