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英国医学杂志中文版 2015年第3期18卷 126-127页

作者： Peter M c Klein Irene j Zaal cristian Spitoni David S Y Ong Arendina W van der Kooi Marc j M Bonten arjen j c slooter Olaf L cremer 朱玉王玉平 Department ofIntensive careMedicine UniversityMedical Centre Utrecht 3508 GAUtrecht Netherlands Department ofMathematics UtrechtUniversity UtrechtNetherlands Department of MedicalMicrobiology University MedicalCentre UtrechtUtrecht Netherlands 首都医科大学宣武医院

目的明确在危重症患者中因谵妄而导致的病死率。设计前瞻性队列研究。背景2011年1月至2013年7月，荷兰一个有32张混合床位的重症医疗病房（IcU）。研究对象连续收住IcU至少24小时的1112例成人患者。暴露由受过培训的观察人员使用经过验... 详细信息

目的明确在危重症患者中因谵妄而导致的病死率。设计前瞻性队列研究。背景2011年1月至2013年7月，荷兰一个有32张混合床位的重症医疗病房（IcU）。研究对象连续收住IcU至少24小时的1112例成人患者。暴露由受过培训的观察人员使用经过验证的评估工具每天评估患者的谵妄状态。应用Logistic回归分析和竞争风险生存分析校正基线变量，应用边际结构模型分析校正谵妄发作前疾病严重程度进展造成的混杂因素影响。

关键词：队列研究危重病人死亡归因

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An open compute and data federation as an alternative to monolithic infrastructures for big Earth data analytics

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Big Earth Data 2023年第3期7卷 812-830页

作者： Björn Backeberg ZdeněkŠustr Enol Fernández Gennadii Donchyts arjen Haag j.B.Raymond Oonk Gerben Venekamp Benjamin Schumacher Stefan Reimond charis chatzikyriakou Deltares DelftThe Netherlands Nansen Environmental and Remote Sensing center BergenNorway cESNET PragueCzech Republic EGI Foundation AmsterdamThe Netherlands SURF/SURFsara AmsterdamThe Netherlands Earth Observation Data centre for Water Resources Monitoring GmbH ViennaAustria

An adequate compute and storage infrastructure supporting the full exploitation of copernicus and Earth Observation datasets is currently not available in *** paper presents the cross-disciplinary open-source technologies being leveraged in the c-ScALE project to develop an open federation of compute and data providers as an alternative to monolithic infrastructures for processing and analysing copernicus and Earth Observation *** critical aspects of the federation and the chosen technologies are elaborated upon:(1)federated data discovery,(2)federated access and(3)software *** these technologies the open federation aims to provide homogenous access to resources,thereby enabling its users to generate meaningful results quickly and *** will be achieved by abstracting the complexity of infrastructure resource access provisioning and orchestration,including discovery of data across distributed archives,away from the *** is needed because end-users wish to focus on analysing ready-to-use data products and models rather than spending their time on the setup and maintenance of complex and heterogeneous IT *** open federation will support processing and analysing the vast amounts of copernicus and Earth Observation data that are critical for the implementation of the Destination Earth *** Twins vision for a high precision digital model of the Earth to model,monitor and simulate natural phenomena and related human activities.

关键词： Open compute and data federation big Earth data analytics federated data discovery federated access software distribution

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胰岛素样生长因子Ⅰ启动子的多态性、卒中风险及卒中后存活情况:鹿特丹研究

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 42-43页

作者： Van Rijn M.j.E slooter A.j.c Bos M.j c.M. Van Duijn 郭中孟 Department of Epidemiology and Biostatistics Erasmus Medical Center PO Box 1738 3000 DR Rotterdam NetherlandsProf.

Background and purpose: Low levels of insulin-like growth factor I (IGF- I) predispose to atherosclerosis and may therefore increase the risk of stroke. Low levels have also been found to influence the outcome of cardiovascular and cerebrovascular disease. A polymorphism in the promoter region of the IGF-I gene influences IGF-I levels. Non-carriers of the 192 bp allele have lower levels of IGF-I compared with 192 bp allele carriers. We studied the IGF-I polymorphism in relation to the risk of stroke and survival after stroke. Methods: We studied 6808 subjects of the Rotterdam Study, who were followed for the occurrence of stroke and death after stroke. Subjects were grouped according to the 192 bp allele of IGF-I into non-carriers, heterozygotes, and homozygotes. The risk of stroke and survival after stroke was studied using cox regression analysis, adjusting for age and sex, with homozygotes for the wildtype allele as the reference. Results: Non-carriers had a relative risk of 0.8 (95% cl: 0.6 to 1.0) for the occurrence of any stroke and 0.7 (95% cl: 0.5 to 1.0) for ischaemic stroke. For non-carriers, the relative risk of death after any stroke was 1.5 (95% cl: 1.0 to 2.2). After an ischaemic stroke, this relative risk was 1.5 (95% cl: 0.9 to 2.6) and after a haemorrhagic stroke 5.2 (95% cl: 1.3 to 21.5). conclusions: Our study suggests that IGF-I is a significant determinant of survival after stroke.

关键词：基因启动子区域相对风险胰岛素样生长因子I 存活情况卒中后多态性鹿特丹胰岛素样生长因子Ⅰ 基因携带者 cox回归分析

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Differences in sensitivity of native and exotic fish species to changes in river temperature

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current Zoology 2011年第6期57卷 852-862页

作者： R.S.E.W. LEUVEN A.j. HENDRIKS M.A.j. HUIjBREGTS H.j.R. LENDERS j. MATTHEWS VAN DER VELDE Radboud University Nijmegen Institute for Water and Wetland Research Department of Environmental Science Heyendaal- seweg 135 NL-6525 AJ Nijmegen The Netherlands Radboud University Nijmegen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology Heyendaalseweg 135 NL-6525 AJ Nijmegen The Netherlands Netherlands centre for Biodiversity Naturalis P.O. Box 9517 NL-2300 RA Leiden The Netherlands

This paper describes the effects that temperature changes in the Rhine river distributaries have on native and exotic fish diversity. Site-specific potentially affected fractions （PAFs） of the regional fish species pool were derived using species sensitivity distributions （SSDs） for water temperature. The number of fish species in the river distributaries has changed remarkably over the last century. The number of native rheophilous species declined up until 1980 due to anthropogenic disturbances such as commercial fishing, fiver regulation, migration barriers, habitat deterioration and water pollution. In spite of progress in river re- habilitation, the native rheophilous fish fauna has only partially recovered thus far. The total number of species has strongly in- creased due to the appearance of more exotic species. After the opening of the Rhine-Main-Danube waterway in 1992, many fish species originating from the Ponto-caspian area colonized the Rhine basin. The yearly minimum and maximum river tempera- tures at Lobith have increased by circa 4 ~c over the period 1908-2010. Exotic species show lower PAFs than native species at both ends of the temperature range. The interspecific variation in the temperature tolerance of exotic fish species was found to be large. Using temporal trends in river temperature allowed past predictions of PAFs to demonstrate that the increase in maximum river temperature negatively affected a higher percentage of native fish species than exotic species. Our results support the hy- pothesis that alterations of the river Rhine＇s temperature regime caused by thermal pollution and global wanning limit the full recovery of native fish fauna and facilitate the establishment of exotic species which thereby increases competition between native and exotic species. Thermal refuges are important for the survival of native fish species under extreme summer or winter temperature conditions

关键词： Aquatic invaders Global warming Heat discharges Lethal temperature River Rhine Thermal heterogeneity

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