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Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up

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Bioactive Materials 2022年第11期7卷 439-456页

作者： Barzi Gareb Nico Bvan Bakelen Leon Driessen Pieter Buma Jeroen Kuipers Dirk W.Grijpma arjan vissink Ruud R.M.Bos Baucke van Minnen University of Groningen University Medical Center GroningenDepartment of Oral and Maxillofacial SurgeryHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands Radboud University Medical Center Radboud Institute for Molecular Life SciencesOrthopaedic Research LabHoutlaan 46525 XZP.O.Box 91026500 HCNijmegenthe Netherlands University of Groningen University Medical Center GroningenDepartment of Biomedical Sciences of Cells and SystemsHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands University of Twente TechMed CentreDepartment of Biomaterials Science and TechnologyDrienerlolaan 57522 NBP.O.Box 2177500 AEEnschedethe Netherlands

pplying biodegradable osteosyntheses avoids the disadvantages of titanium osteosyntheses. However, foreign-body reactions remain a major concern and evidence of complete resorption is lacking. This study compared the physico-chemical properties, histological response and radiographs of four copolymeric biodegradable osteo-synthesis systems in a goat model with 48-months follow-up. The systems were implanted subperiosteally in both tibia and radius of 12 Dutch White goats. The BioSorb FX [poly(70LLA-co-30DLLA)], Inion CPS [poly([70–78.5] LLA-co-[16–24]DLLA-co-4TMC)], SonicWeld Rx [poly(DLLA)], LactoSorb [poly(82LLA-co-18GA)] systems and a negative control were randomly implanted in each extremity. Samples were assessed at 6-, 12-, 18-, 24-, 36-, and 48-month follow-up. Surface topography was performed using scanning electron microscopy (SEM). Differential scanning calorimetry and gel permeation chromatography were performed on initial and explanted samples. Histological sections were systematically assessed by two blinded researchers using (polarized) light microscopy, SEM and energy-dispersive X-ray analysis. The SonicWeld Rx system was amorphous while the others were semi-crystalline. Foreign-body reactions were not observed during the complete follow-up. The SonicWeld Rx and LactoSorb systems reached bone percentages of negative controls after 18 months while the BioSorb Fx and Inion CPS systems reached these levels after 36 months. The SonicWeld Rx system showed the most predictable degradation profile. All the biodegradable systems were safe to use and well-tolerated (i.e., complete implant replacement by bone, no clinical or histological foreign body reactions, no [sterile] abscess formation, no re-interventions needed), but nanoscale residual polymeric fragments were observed at every system’s assessment.

关键词： Biocompatible materials Absorbable implants Polymers Orthopaedic fixation devices Reconstructive surgical procedures Fracture fixation

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功能负荷下骨内种植体周围牙槽骨嵴的变化:对无牙[牙合]患者口内不同种植系统进行比较的影像学评价

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中国口腔医学继续教育杂志 2014年第6期17卷 347-352页

作者： Nynke Tymstra Henny J.A.Meijer Gerry M.Raghoebar arjan vissink 索超(译) 徐莉(审) 不详北京大学口腔医院牙周科北京市100081

对120位无牙[牙合]患者的下颌骨颏孔间区域植入的240颗离子喷涂钛种植体周围边缘骨的变化,进行了5年以上的随访观察,重点关注微间隙和粗糙/光滑面交界的位置的影响.在标准化根尖放射线片上对边缘骨的变化进行测量.结果显示微间隙和粗糙... 详细信息

对120位无牙[牙合]患者的下颌骨颏孔间区域植入的240颗离子喷涂钛种植体周围边缘骨的变化,进行了5年以上的随访观察,重点关注微间隙和粗糙/光滑面交界的位置的影响.在标准化根尖放射线片上对边缘骨的变化进行测量.结果显示微间隙和粗糙/光滑面交界的位置不是决定种植体周围边缘骨位置的主要因素.

关键词：牙槽骨钛种植体骨内种植体光滑面颏孔影像学评价微间隙下颌骨

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