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Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin

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World Journal of gastroenterology 2006年第21期12卷 3410-3415页

作者： Stelios F Assimakopoulos Constantine E Vagianos aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa Department of Internal Medicine School of Medicine University of PatrasPatrasGreece Department of Surgery School of Medicine University of PatrasPatrasGreece Section of Histology Center for Basic Research Foundation of Biomedical Research of the Academy of AthensAthensGreece Department of Microbiology School of Medicine University of PatrasPatrasGreece Department of Internal Medicine Division of gastroenterology School of MedicineUniversity of PatrasPatrasGreece Department of Pathology School of Medicine University of PatrasPatrasGreece

AIM： To investigate the influence of experimental obstructive jaundice and exogenous bombesin （BBS） and neurotensin （NT） administration on the expression of the tight junction （TJ）-protein claudin-4 in intestinal epithelium of rats. METHODS： Forty male Wistar rats were randomly divided into five groups： Ⅰ = controls, Ⅱ = sham operated,Ⅲ = bile duct ligation （BDL）,Ⅳ = BDL＋BBS （30μg/kg per d）, V = BDL＋NT （300μg/kg per d）. At the end of the experiment on d 10, endotoxin was measured in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and immunohistochemically for evaluation of claudin-4 expression in intestinal epithelium. RESULTS： Obstructive jaundice led to intestinal barrier failure demonstrated by significant portal and aortic endotoxemia. Claudin-4 expression was significantly increased in the upper third of the villi in jaundiced rats and an upregulation of its lateral distribution was noted. Administration of BBS or NT restored claudin-4 expression to the control state and significantly reduced portal and aortic endotoxemia. CONCLUSION： Experimental obstructive jaundice increases claudin-4 expression in intestinal epithelium,which may be a key factor contributing to the disruption of the mucosal barrier. gut regulatory peptides BBS and NT can prevent this alteration and reduce portal and systemic endotoxemia.

关键词： Obstructive jaundice Tight junctions Claudin-4 Intestinal permeability Intestinal barrier Regulatory peptides Bombesin Neurotensin

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Rainfall Measurements Due to Radio Frequency Signal Attenuation at 2 gHz

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Journal of Signal and Information Processing 2018年第3期9卷 192-201页

作者： Vasilis Christofilakis giorgos Tatsis Constantinos T. Votis Spyridon K. Chronopoulos Panos Kostarakis Christos J. Lolis aristides Bartzokas Physics Department Electronics-Telecommunications and Applications Laboratory University of Ioannina Ioannina Greece Physics Department Laboratory of Meteorology University of Ioannina Ioannina Greece

In this paper we present an experimental validated system for measuring rainfall due to radio frequency (RF) signal attenuation at 2 gHz. Measurements took place in Ioannina, NW greece, starting in April 2015 and lasting for twelve months. The primary acquired extensive results have shown reliable and accurate measurements for rainfall amounts smaller than 1 mm for 5 min periods. The very important innovation is that this paper presents significant earth-to-earth measurements due to rainfall attenuation (at 2 gHz) in order to act as a map for future investigation and as a prior knowledge for the behavior of other systems operating at frequencies around S-band.

关键词： Remote Sensing Rain Attenuation S-Band Measurements

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润滑条件对304L钢丝拉拔参数的影响

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金属制品 2004年第B5期30卷 35-36页

作者： gustavo aristides Santana Martínez Sérgio Tonini Button Roger N.Wright 赵玉兰

1试验设备试验使用可调速的单卷筒拉丝机.直流电机功率14.7 kW,最大转速为2 000 r/min.拉丝速度1～22m/s,由数字调速器控制.拉丝模和润滑剂的温度变化由热电偶检测控制,额定值为500 N的测压元件和敏感度为2 mV/V的压力传感器测量拉拔力.

关键词：润滑剂 304L 拉拔速度影响

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The Role of Synthetic Biology in Atmospheric greenhouse gas Reduction: Prospects and Challenges

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BioDesign Research 2020年第1期2020卷 1-8页

作者： Charles DeLisi aristides Patrinos Michael MacCracken Dan Drell george Annas Adam Arkin george Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang Department of Biomedical Engineering and Program in Bioinformatics College of EngineeringBoston UniversityBoston MA 02215USA The NOVIM group Kohn HallUC Santa BarbaraCA 93106USA Climate Institute WashingtonDCUSA Department of Energy WashingtonDCUSA Center for Health Law Ethics&Human Rights at the Boston University School of Public HealthSchool of MedicineBoston UniversityUSA Department of Bioengineering University of CaliforniaBerkeley CAUSA Department of genetics Harvard Medical SchoolCambridge MAUSA School for the Future of Innovation in Society Arizona State UniversityBarrett&O’Connor Washington Center1800 I StreetNWWashingtonDC 20006USA Sloan School of Management MITCambridge MAUSA Department of Chemical Engineering University of WashingtonSeattle WashingtonUSA The Ecosystems Center of the Marine Biological Laboratory in Woods Hole MAUSA Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovotIsrael Department of Soil and Crop Sciences Colorado State UniversityFort Collins CO 80523USA MIT Joint Program on the Science and Policy of global Change MITCambridge MAUSA New England Biolabs Beverly MAUSA Department of Biology and Program in Bioinformatics Boston UniversityBoston MA 02215USA Department of Earth Atmospheric and Planetary SciencesMITCambridge MAUSA Soil and Crop Sciences Section School of Integrated Plant SciencesCornell UniversityIthaca NYUSA Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA

The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory *** and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric *** participants(in attendance:Christina Agapakis,george Annas,Adam Arkin,george Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard ***,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and *** include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed.

关键词： Synthetic Roberts enable

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