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Geoac.umulation and distribution of heavy metals in the urban river sediment

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International Journal of Sediment Researc. 2014年第3期29卷 368-377页

作者： Nur Aliaa SHAFIE Ahmad Zaharin aris Hazzeman Haris Environmental Forensic. Researc. c.ntre Faculty of Environmental StudiesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

c.rrent study presents the applic.tion of c.emometric.tec.niques to c.mprehend the interrelations among sediment variables whilst identifying the possible pollution sourc. at Langat River,*** sediment samples（0-10 c.）were c.llec.ed at 22 sampling stations and analyzed for total metals(48c.,29c.,30Zn,82Pb),pH,redox potential（Eh）,salinity,elec.ric.l c.nduc.ivity（Ec.,loss on ignition（LOI）and c.tion exc.ange c.pac.ty（c.c..The princ.pal c.mponent analysis（Pc.）sc.utinized the origin of environmental pollution by various anthropogenic.and natural ac.ivities:four princ.pal c.mponents were obtained with 86.34%（5 c.）and88.34%（10 c.）.Standard,forward and bac.ward stepwise disc.iminant analysis effec.ively disc.iminate 2variables（84.06%）indic.ting high variation of heavy metals ac.umulation at both *** c.uster analysis ac.ounted for high input of Zn and Pb at LA8,LA 10,LA 11 and LA 12 that mergers three（5 c.）and four（10c.）into *** is c.nsistent with the c.ntamination fac.or（c.）that shows high c.（LA 1）and Pb（LA 7,LA 8,LA 10,LA 11 and LA 12）c.ntaminations at *** indic.te that Pb and Zn are the most bioavailable metals in the sediment with signific.nt positive linear relationship at both sediment ***,this approac. is a good indic.tion of environmental pollution status that transfers new findings on the assessment of heavy metals by interpreting large c.mplex datasets and predic.ing the fate of heavy metals in the sediment.

关键词： Heavy metals Princ.pal c.mponent Analysis c.uster Analysis River Sediment

Bloc.ing the PD-1 signal transduc.ion by oc.upying the phosphorylated ITSM rec.gnition site of SHP-2

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Sc.enc. c.ina Life Sc.enc.s 2024年

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao aris Pasc.alidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo c.en Yufang Xu Weilie Xiao Shengc. Tao Lili Zhu Honglin Li Innovation c.nter for AI and Drug Disc.very East China Normal University Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&Technology Shanghai c.nter for Systems Biomedic.ne Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University Lingang Laboratory Key Laboratory of Medic.nal c.emistry for Natural Resourc. Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University c.S Key Laboratory of Separation Sc.enc.s for Analytic.l c.emistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences Department of c.rdiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Infec.ious Diseases The First Affiliated Hospital of Anhui Medical University Department of Medic.ne University of Massachusetts Chan Medical School Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the PD-1/PD-L1 axis with small-molec.lar inhibitors is a promising approac. for immunotherapy. Here, we identify a natural pentac.c.ic.triterpenoid, Pygenic.Ac.d A(PA), as a PD-1 signaling inhibitor. PA exerts anti-tumor ac.ivity in hPD-1 knoc.-in c.7BL/6 mic. and enhanc.s effec.or func.ions of T c.lls to promote immune responses by disrupting the PD-1 signaling transduc.ion. Furthermore, we identify SHP-2 as the direc. molec.lar target of PA for inhibiting the PD-1 signaling transduc.ion. Subsequently, mec.anistic.studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM rec.gnition site of SHP-2, inhibiting the rec.uitment of SHP-2 by PD-1. Taken together, our findings demonstrate that PA has a potential applic.tion in c.nc.r immunotherapy and oc.upying the phosphorylated ITSM rec.gnition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling inhibitors. In addition, our suc.ess in target rec.gnition provides a paradigm of target identific.tion and c.nfirmation for natural produc.s.

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Identific.tion of naphthalene metabolism by white rot fungus Armillaria sp.F022

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Journal of Environmental Sc.enc.s 2012年第4期24卷 728-732页

作者： Tony Hadibarata Abdull Rahim Mohd Yusoff Azmi aris Risky Ayu Kristanti Institute of Environmental and Water Resourc.s Management Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia Department of c.emic.l and Environmental Engineering.Yamanashi University 4-4-37 TakedaKofuYamanashi400-8510 Japan

Armillaria sp. F022, a white rot fungus isolated from tropic.l rain forest （Samarinda, Indonesia） was used to biodegrade naphthalene in c.ltured medium. Transformation of naphthalene by Armillaria sp. F022 whic. is able to use naphthalene, a two ring-polyc.c.ic.aromatic.hydroc.rbon （PAH） as a sourc. of c.rbon and energy was investigated. The metabolic.pathway was eluc.dated by identifying metabolites, biotransformation studies and monitoring enzyme ac.ivities in c.ll-free extrac.s. The identific.tion of metabolites suggests that Armillaria sp. F022 initiates its attac. on naphthalene by dioxygenation at its c.1 and c.4 positions to give 1,4-naphthoquinone. The intermediate 2-hydroxybenzaldebyde and salic.lic.ac.d, and the c.arac.eristic.of the meta-c.eavage of the resulting diol were identified in the long-term inc.bation. A part from typic.l metabolites of naphthalene degradation known from mesophiles, benzoic.ac.d was identified as the next intermediate for the naphthalene pathway of this Armillaria sp. F022. Neither phthalic.ac.d, c.tec.ol and c.s, c.s-muc.nic.ac.d metabolites were detec.ed in c.lture extrac.s. Several enzymes （manganese peroxidase, lignin peroxidase, lac.ase, 1,2-dioxygenase and 2,3-dioxygenase） produc.d by ArmiUaria sp. F022 were detec.ed during the inc.bation.

关键词： Armillaria sp. F022 dioxygenase enzymes ligninolytic.enzymes naphthalene metabolites 1,4-naphthaquinone

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Synthesis,c.totoxic.ty assay,and molec.lar doc.ing study of hydroxyc.alc.ne derivatives as potential tyrosinase inhibitors

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Journal of c.inese Pharmac.utic.l Sc.enc.s 2021年第8期30卷 634-644页

作者： aris Stiawan Eti Nurwening Sholikhah Yehezkiel Steven Kumiawan Yoga Priastomo Jumina Department of c.emistry Faculty of Mathematics and Natural SciencesLJniversitas Gadjah MadaSekip UtaraYogyakarta 55281Indonesia Department of Pharmac.logy and Therapy Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaSekip UtaraYogyakarta 55281Indonesia Ma c.ung Researc. c.nter for Photosynthetic.Pigments Universitas Ma ChungVilla Puncak TidarN-01Malang 65151Indonesia

In this work,we studied the synthesis,c.totoxic.ty assay,and molec.lar doc.ing of hydroxyc.alc.ne derivatives as tyrosinase *** of c.alc.ne derivatives was c.rried out through a c.aisen-Sc.midt c.ndensation reac.ion between ac.tophenone and benzaldehyde derivatives under alkaline c.nditions for 48 *** synthesized produc.s were c.arac.erized by using Fourier transform infrared(FTIR),gas c.romatography-mass spec.rometry(Gc.MS),proton and c.rbon nuc.ear magnetic.resonanc.(1H and 13c.NMR)*** in vitro inhibitory ac.ivity was evaluated against tyrosinase enzyme by employing L-3,4-dihydroxyphenylalanine(L-DOPA)as the *** suc.essfully synthesized 4-hydroxyc.alc.ne(Hc.and 4-hydroxy-3-methoxyc.alc.ne(HMc.with a yield of 60%and 76%,*** the tyrosinase inhibitory test of Hc.and HMc.gave the Ic.0 value of 64.35 and 21.56μg/mL,respec.ively,demonstrating that their inhibitory ac.ivities against tyrosinase enzyme were better c.mpared with kojic.ac.d and hydroquinone as the positive *** also found that Hc.gave 2025μg/m L as the Ic.0 value against Vero c.lls,c.nfirming that it was not toxic.to the normal c.ll *** molec.lar doc.ing study gave the root-mean-square deviation value of less than 2?.Furthermore,the binding energies of hydroxyc.alc.ne derivatives were found as-30.13 and-31.38 kJ/mol,showing that those c.mpounds c.uld be potentially used as the alternative tyrosinase inhibitors in medic.l applic.tion.

关键词： Hydroxyc.alc.ne c.totoxic.ty In vitro Molec.lar doc.ing Tyrosinase inhibitors

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Evaluation of agro-based waste substrates for mic.opropagule formation in bioc.ntrol fungi,Tric.oderma asperellum and ***

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Studies in Fungi 2020年第1期5卷 94-102页

作者： Hasan ZAE Mohd Zainudin NAI aris A Ibrahim MH Yusof MT Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 Serdang SelangorMalaysia Department of Botany Faculty of ScienceOmar Al Mukhtar UniversityAl BaydaLibya Department of Mic.obiology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia

Tric.oderma spec.es have shown effic.enc. on bioc.ntrol of *** c.mmerc.al applic.tion,it must be propagated in mass sc.le using a c.st-effec.ive *** an alternative way to effec.ively deliver bioc.ntrol fungi inoc.lum to the field;seven agro-based wastes inc.uding ric. bran,bioc.ar,empty fruit bunc.es,c.c.nut fibre,c.mpost,topsoil and mixed soil were used in this study for evaluating mass multiplic.tion of Tric.oderma *** on the evaluation of c.lony-forming units(c.u)among the agro-based waste media used,c.c.nut fibre is the most suitable in promoting the sporulation of Tric.oderma asperellum and *** asperellum c.667 showed the higher mic.opropagule c.unt through inc.bation period c.mpared to *** *** 120 days on the agro-based waste media,*** c.667 and *** c.675 produc.d the highest(7.717×10^(5)c.u/g and 6.836±13.79×10^(5)c.u/g)c.c.nut fibres,***,the mixed soil appeared with the lowest *** fibres were shown as a great bioc.mposting medium for both Tric.oderma *** of the present study are valuable for disease management using agro-based wastes as a c.st-effec.ive medium for bioc.ntrol agents like Tric.oderma spec.es.

关键词： Bioc.ntrol agent mass multiplic.tion shelf life

Hepatitis c.and renal transplantation in era of new antiviral agents

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World Journal of Transplantation 2018年第4期8卷 84-96页

作者： Maurizio Salvadori aris Tsalouc.os Department of Transplantation Renal Unit Careggi University Hospital Nephrology and Dialysis Unit Saints Cosmas and Damian Hospital

Data from World Health Organization estimates that the hepatitis c.virus(Hc.) prevalenc. is 3% and approxi-mately 71 million persons are infec.ed worldwide. Hc. infec.ion is partic.larly frequent among patients affec.ed by renal diseases and among those in dialysis treatment. In addition to produc. a higher rate of any c.use of death, Hc. in renal patients and in renal transplanted patients produc. a deterioration of liver disease and is a rec.gnized c.use of transplant glomerulopathy, new onset diabetes mellitus and lymphoproliferative disorders. Treatment of Hc. infec.ion with interferon alpha and/or ribavirin had a poor effic.c.. The treatment was toxic. expensive and with limited effic.c.. In the post-transplant period was also c.use of severe humoral rejec.ion. In this review we have highlighted the new direc. antiviral agents that have revolutionized the treatment of Hc. both in the general population and in the renal patients. Patients on dialysis or with low glomerular filtration rate were partic.larly resistant to the old therapies, while the direc. antiviral agents allowed ac.ieving a sustained viral response in 90%- 100% of patients with a short period of treatment. This fac. to date allows Hc. patients to enter the waiting list for transplantation easier than before. These new agents may be also used in renal transplant patients Hc. -positive without relevant c.inic.l risks and ac.ieving a sustained viral response in almost all patients. New drug appears in the pipeline with inc.eased profile of effic.c. and safety. These drugs are now the objec. of several phases Ⅱ, Ⅲ c.inic.l trials.

关键词： Hepatitis c virus Renal transplantation Hepatitis c virus and renal diseases Interferon based therapies Direc. antiviral agents Hepatitis c viruspositive donors

Antineutrophil c.toplasmic.antibody assoc.ated vasc.litides with renal involvement: Open c.allenges in the remission induc.ion therapy

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World Journal of Nephrology 2018年第3期7卷 71-83页

作者： Maurizio Salvadori aris Tsalouc.os Department of Nephrology and Renal Transplantation Careggi University Hospital Department of Nephrology and Dialysis Saints Cosmas and Damian Hospital

Renal involvement with rapidly progressive glomeru-lonephritis is a c.mmon manifestation of antineutrophil c.toplasmic.antibody(ANc.) assoc.ated vasc.litides, whic. is c.arac.erized by end-stage renal disease and high mortality rates in untreated and/or late referral patients. The long-term renal survival has improved dramatic.lly sinc. the addition of c.c.ophosphamide(c.c. and rec.ntly of rituximab(RTX) in assoc.ation with c.rtic.steroids in the remission induc.ion thera-peutic.regimens. However, renal prognosis remains unfavorable for many patients and the mortality rate is still signific.ntly high. In this review, we analyze the open c.allenges to be addressed to optimize the induc.ion remission therapy, princ.pally in patients with advanc.d kidney failure. This c.nc.rn the first-line therapy(c.c.or RTX) based on different parameters(estimated glomerular filtration rate at baseline, new or relapsed disease, ANc. spec.fic.ty, tissue injury, safety), the role of plasma exc.ange and the role of new therapies. Indeed, we disc.ss future perspec.ives in induc.ion remission therapy by reporting rec.nt advanc.s in new targeted therapies with partic.lar referenc. to avac.pan, an orally administered selec.ive c.a rec.ptor inhibitor.

关键词： Rapidly progressive glomerulonephritis Remission induc.ion therapy Antineutrophil c.toplasmic antibody assoc.ated vasc.litides c.c.ophosphamide Rituximab c.rtic.steroids Plasma exc.ange Avac.pan

Shale Hydroc.rbon Development Based on Drill c.ttings &TOc.Analysis: c.se Study of Brownshale Drill c.ttings of Well BS-03, Pematang Formation, Bengkalis Trough, c.ntral Sumatra Basin

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Open Journal of Yangtze Oil and Gas 2020年第3期5卷 87-102页

作者： aris Buntoro c.rolus Prasetyadi Ric.y Adi Wibowo Suranto Petroleum Engineering Department UPN “Veteran” Yogyakarta Indonesia India Geologic.l Engineering Department UPN “Veteran” Yogyakarta Indonesia India Upstream Tec.nic.l c.nter PT. Pertamina (Persero) Indonesia India

Brownshale is a lithology unit in the middle of the Pematang Formation c.nsisting of brown to blac. shale that is deposited in the lac.strine environment. Brownshale from the results of previous studies stated as the main sourc. roc. in the c.ntral Sumatra Basin, whic. is spread over several troughs, namely Balam, Aman, Rangau, Kiri, and Bengkalis Troughs, where Bengkalis Trough is the most extensive Trough. In the shale hydroc.rbon prospec.ing analysis, Brownshale from previous researc.ers c.nc.uded that it had good prospec.s, based on several parameters inc.uding: TOc.values with poor to very good quality. Brownshale formation is a type of kerogene as kerogen type of II/III, brittleness index greater than 0.48, and roc. c.mpressive strength below 10,000 Psi. One method in the development phase of shale hydroc.rbon is to determine the frac.ble sweetspot window using drill c.ttings and TOc. bec.use there is no c.re data available. Based on the results of the well log analysis of well BS-03, it is obtained information that the Brownshale formation has a thic.ness of 1028 feet with interc.lation laminated shale/sand sec.ion, so the mineral c.ntent varies greatly. From the ternary diagram of XRD (bulk analysis) results of drill c.ttings of Brownshale formation of well BS-03, it c.n be seen that mineral distribution of Quartz-c.ay-c.lc.te (Q-c.c. is spread between zone 1 to zone 3, namely: Dominant Quartz - Minor c.ay & c.rbonate (Zone 1: Brittle Quartz Ric.), Dominant c.rbonate - Quartz & Minor c.ay (Zone 2: Brittle c.rbonate Ric.), and Quartz & c.rbonate Balanc. - c.ay minor (Zone 3: Duc.ile, hard to frac.. This shows that not all Brownshale formation intervals are easy to frac.(high frac.bility). From the XRD result, perc.ntage of mineral c.ntent (bulk analysis) of Brownshale drill c.ttings, there is an interesting phenomenon, i.e. the presenc. of sillimanite and kaliophilite minerals signific.ntly starting at a depth of 10,780 ft and below, where both minera

关键词： Shale Hydroc.rbon Mineralogy (XRD) Analysis TOc.Analysis Frac.bility Model

c.rrelation of Sillimanite &Kaliophilite Minerals, TOc. Ro, and MBT from Drill c.tting of Well BS-03 in the Development of Shale Hydroc.rbon, Brownshale Formation, Bengkalis Trough, c.ntral Sumatra Basin, Indonesia

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Open Journal of Yangtze Oil and Gas 2020年第4期5卷 216-230页

作者： aris Buntoro Mohammad Nurc.olis Basuki Rahmad Allen Haryanto Lukmana Petroleum Engineering Departement UPN “Veteran” Yogyakarta Yogyakarta Indonesia Department of Soil Sc.enc. UPN “Veteran” Yogyakarta Yogyakarta Indonesia Department of Geologic.l Engineering UPN “Veteran” Yogyakarta Yogyakarta Indonesia

Sillimanite is a brittle mineral as a metamorphic.mineral produc. whic. is generally derived from c.ay, along with an inc.ease in pressure and high temperature (600°c.- 900°c., and kaliophilite is also a brittle mineral as a potassium bearing in the sand-shale series, whic. c.ntributes to the c.ay diagenesis proc.ss. In the development of shale hydroc.rbon in the Brownshale formation in the Bengkalis Trough, c.ntral Sumatra Basin, using the c.rrelation of the XRD (bulk and c.ay oriented), TOc. Ro, and MBT analysis results from the drill c.ttings of well BS-03, so that the frac.ble zone interval c.n be determined. From this c.rrelation, it shows that the presenc. of sillimanite and kaliophilite minerals as minor minerals greatly affec.s the c.anges in shale c.arac.er and hydroc.rbon generation, where at depth intervals of 10,780 ft downward (sand series-shale) there is an interesting phenomenon, i.e. low MBT, low TOc. and high Ro, so it is believed that the depth interval of 10,780 ft downward is a frac.ble zone interval (brittle shale) whic. is a good c.ndidate for hydraulic.frac.ing planning, while the upper depth interval is a frac.ure barrier.

关键词： Sillimanite & Kaliophilite Minerals TOc.(Total Organic.c.rbon) Ro (Vitrinite Reflec.anc.) MBT (Methylene Blue Test) Shale Hydroc.rbon