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Binding of circulating autoantibodies in breast cancer to native and peroxynitrite-modified RNA

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 40-46页

作者： Sheereen TARANNUM Zarina arif Khursheed ALAM Department of Biochemistry Faculty of MedicineAligarh Muslim University Rajiv Gandhi Centre for Diabetes and Endocrinology Faculty of MedicineAligarh Muslim University

Peroxynitrite （ONOO-） is a powerful oxidant and nitrosative agent and has in vivo existence. The half life of ONOO- at physiological pH is less than 1 s. It can react with nucleic acids, proteins, lipoproteins, saccharides, cardi- olipin, etc., and can modify their native structures. Action of ONOO-, synthesized in the authors＇ laboratory by a rapid quenched flow process, on structural changes of commercially available RNA was studied by ultraviolet （UV）, fluo- rescence, and agarose gel electrophoresis. Compared to native RNA, the ONOO--modified RNA showed hyper- chromicity at 260 nm. Furthermore, the ethidium bromide （EtBr） assisted emission intensities of ONOO--modified RNA samples were found to be lower than the emission intensity of native RNA-EtBr complex. Agarose gel electrophoresis of ONOO--modifled RNA showed a gradual decrease in band intensities compared to native RNA, an observation clearly due to the poor intercalation of EtBr with ONOO--modified RNA. Native and ONOO--modified RNA samples were used as an antigen to detect autoantibodies in sera of patients with clinically defined breast cancer. Both direct binding and inhibition enzyme-linked immunosorbent assay （ELISA） confirmed the prevalence of native and 0.8 mmol/L ONOO--modified RNA specific autoantibodies in breast cancer patients. Moreover, the progressive retarda- tion in the mobility of immune complexes formed with native or 0.8 mmol/L ONOO--modified RNA and affinity purified immunoglobulin G （IgG） from sera of breast cancer patients supports the findings of the direct binding and inhibition ELISAs. The peroxynitrite treatment to RNA at a higher concentration appears to have damaged or destroyed the typical epitopes on RNA and thus there was a sharp decrease in autoantibodies binding to 1.4 mmol/L ONOO--modified RNA. It may be interpreted that cellular nitrosative stress can modify and confer immunogenicity on RNA molecules. Higher concentrations of nitrogen reactive species can be detrimental t

关键词： RNA Peroxynitrite ELISA Breast cancer Band shift assay

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An Active Image Forgery Detection Approach Based on Edge Detection

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Computers, Materials & Continua 2023年第4期75卷 1603-1619页

作者： Hüseyin Bilal Macit arif Koyun Department of IT Systems and Technologies Mehmet Akif Ersoy UniversityBucak Z.T.School of Applied Technology and BusinessBurdur15300Türkiye Department of Computer Engineering Suleyman Demirel UniversityEngineering FacultyIsparta32200Türkiye

Recently, digital images have become the most used data, thanks tohigh internet speed and high resolution, cheap and easily accessible digitalcameras. We generate, transmit and store millions of images every *** of these images are insignificant images containing only personal ***, in many fields such as banking, finance, public institutions,and educational institutions, the images of many valuable objects like IDcards, photographs, credit cards, and transaction receipts are stored andtransmitted to the digital environment. These images are very significantand must be secured. A valuable image can be maliciously modified by anattacker. The modification of an image is sometimes imperceptible even by theperson who stored the image. In this paper, an active image forgery detectionmethod that encodes and decodes image edge information is proposed. Theproposed method is implemented by designing an interface and applied on atest image which is frequently used in the literature. Various tampering attacksare simulated to test the fidelity of the method. The method not only notifieswhether the image is forged or not but also marks the tampered region ofthe image. Also, the proposed method successfully detected tampered regionsafter geometric attacks, even on self-copy attacks. Also, it didn’t fail on JPEGcompression.

关键词： Image forgery image tampering edge detection

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Small Signal Stability of Three-phase and Six-phase Synchronous Motors:A Comparative Analysis

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Chinese Journal of Electrical Engineering 2020年第1期6卷 22-40页

作者： G.K.Singh arif Iqbal Department of Electrical Engineering Indian Institute of TechnologyRoorkee 247667India Department of Electrical Engineering Rajkiya Engineering College Ambedkar NagarAkbarpur 224122India

Small signal stability analysis is conducted for an asymmetrical six-phase synchronous motor in comparison with its equivalent three-phase *** this purpose,a linearized model of the six-phase synchronous motor is developed using the dq0 approach,which is used in eigenvalue criteria to determine absolute stability in comparison with its equivalent three-phase *** analysis includes a comparison of the variation in evaluated eigenvalues associated with the stator and rotor sides according to changes in both the three and six-phase machine parameters and working *** analytical results are experimentally investigated and validated on a test rig.

关键词： Linearized modeling stability analysis six-phase synchronous motor three-phase synchronous motor

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Deciphering codon usage patterns and evolutionary forces in chloroplast genes of Camellia sinensis var. assamica and Camellia sinensis var. sinensis in comparison to Camellia pubicosta

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Journal of Integrative Agriculture 2019年第12期18卷 2771-2785页

作者： Sophiarani Yengkhom arif Uddin Supriyo Chakraborty Department of Biotechnology Assam UniversitySilchar 788011AssamIndia Department of Zoology Moinul Hoque Choudhury Memorial Science CollegeAlgapurHailakandi 788150AssamIndia

Codon usage bias(CUB) is a unique property of genome which refers to non-random usage of synonymous codons in coding sequences. The present study makes an attempt to find out the pattern of CUB in chloroplast(cp) genes among three tea species, i.e., Camellia sinensis var. assamica(Assam tea), Camellia sinensis var. sinensis(Chinese tea) and Camellia pubicosta(wild tea species) as no work on CUB was reported earlier. To understand the patterns of codon usage among the cp genes of three tea groups, we used bioinformatic tools to investigate the protein coding sequences of cp genes. In our present study, the mean nucleobase T was the highest whereas C was the lowest in all the three tea groups. The overall AT content was more than GC content, i.e., genes were AT rich. The scaled chi-square(SCS) value indicated that the CUB of cp genes was low. The codon CGT(Arg) was over-represented in C. sinensis var. sinensis whereas GGA(Pro) was over-represented in C. pubicosta species. Heatmap study revealed that most of the GC ending codons showed positive correlations between codon usage and GC3 while AT ending codons exhibited negative correlations. From neutrality plot analysis, it was evident that natural selection had played a major role, while mutation pressure exerted a minor effect in the CUB of cp genes in three tea groups. Highly significant(P<0.01) positive correlation was found between SCS and synonymous codon usage order(SCUO) of cp genes which suggested that high expression of cp genes was associated with high degree of CUB.

关键词： Camellia sinensis var.assamica Camellia sinensis var.sinensis Camellia pubicosta chloroplast genes codon usage bias mutation natural selection

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Dealing with hepatic artery traumas:A clinical literature review

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World Journal of Clinical Cases 2021年第28期9卷 8425-8440页

作者： Osman Nuri Dilek arif Atay Department of General Surgery Division of Hepatopancreatobiliary Surgeryİzmir Katip Celebi University School of Medicineİzmir 35150Turkey Department of Surgery İzmir Katip Celebi University School of Medicineİzmir 35150Turkey

BACKGROUND The hepatic artery(HA)is one of the most threatened vascular structures during hepatopancreatobiliary(HPB)surgeries and interventional *** can be affected by many clinical pictures,especially tumors,due to its anatomical position and *** To reveal the evolution and recent developments in the management of HA traumas in the light of the *** In this article,100 years of MEDLINE(PubMed)literature and articles including cases and series of HA injuries were reviewed,and the types of injury occurrence,treatment,and related complications and their management were *** The risk of HA injury increases during cholecystectomies and pancreatoduodenectomies,among the most common *** anatomy shows anomalies in approximately 15%-25%of the cases,further increasing this *** incidence of HA injury is not precisely *** that have evolved in recent years in managing patients with HA injury(laceration,transection,ligation,resection)with severe morbidity and mortality risk are reviewed in light of the current *** In conclusion,complications and deaths due to HA injury are less common *** risk of complications increases in patients with hemodynamic instability,jaundice,cholangitis,and *** the variations in the preoperative radiological evaluation will reduce the *** cases where HA injury is detected,arterial flow continuity should be tried to maintain with primary anastomosis,arterial transpositions,or *** cases where bile duct injury develops,patients should be directed to HPB surgery centers,considering the possibility of accompanying HA ***-scale and multicentric studies are needed to understand better the early and long-term results of HA ligation and determine preventive procedures.

关键词： Hepatic artery Injury Anomaly Ligation Resection Reconstruction

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A Computational Investigation of the Thermohydraulics of an EGS Project

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Journal of Thermal Science 2018年第5期27卷 405-412页

作者： BENIM Ali Cemal CICEK Aydin EKER arif Mert Department of Mechanical and Process Engineering Center of Flow Simulation (CFS) Düsseldorf University of Applied Sciences Department of Energy Raw Materials and Survey General Directorate of Mineral Research and Exploration HD Energy Inc.

A numerical analysis of the thermohydraulics of an enhanced geothermal system project is presented. The rock structures are modelled as porous medium, based on the computationally obtained hydraulic fracturing data of other authors. The influence of the domain size, grid resolution, temporal resolution and the discretization scheme is assessed to obtain a highly accurate numerical solution under the prevailing modelling assumptions. Based on the numerical model, different production scenarios are investigated and discussed. The relative positioning of the injection and production ports is also analyzed. It is shown that there is a considerable potential for optimizing the production rate and the port configuration to obtain the most favorable results for the production temperature, investment costs and operation costs.

关键词： enhanced geothermal system hot dry rock thermohydraulics numerical analysis

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SUFFICIENT CONDITION FOR FUNCTIONS TO BE IN A CLASS OF MEROMORPHIC MULTIVALENT SAKAGUCHI TYPE SPIRAL-LIKE FUNCTIONS

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Acta Mathematica Scientia 2014年第2期34卷 575-578页

作者： Muhammad arif Janusz SOK Muhammad AYAZ Department of Mathematics Abdul Wali Khan University Mardan Department of Mathematics Rzeszw University of Technology

In this article, we define a subclass of meromorphic multivalent Sakaguchi type functions and obtain certain sufficient conditions for functions to be in this class. The main result presented here includes a number of... 详细信息

关键词： Sakaguchi type functions spirallike functions meromorphic functions

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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi Pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil Sharma Amos Lal Rahul Kashyap Vikas Bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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Robowler:Design and development of a cricket bowling machine ensuring ball seam position

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Journal of Central South University 2014年第11期21卷 4142-4149页

作者： RAZA Ali DIEGEL Olaf arif Khalid Mahmood Mechatronics and Control Engineering University of Engineering & TechnologyLahore 54890 Pakistan School of Engineering and Advanced Technology Massey UniversityAuckland 0632 New Zealand

The art of cricket bowling is complex and arduous owing to the run-up and ball release time energy requirement to achieve speed and variations. Therefore, human bowlers cannot bowl for extended periods and numerous mechanical bowling machines have been built to help batsmen improve their skills during practice sessions. However, most of these existing machines are designed for spherical balls ignoring the distinguishing physical feature of a cricket ball: the raised equatorial seam, which makes it less of a sphere. The bowlers are known to often benefit from this seam in their pursuit to taking the batsmen's wicket by imparting swing, spin and bounce variations along-with other bowling variables. This lack of the seam consideration creates a void between human and mechanical bowling. In this work, we present design and development of an automatic bowling machine termed as ROBOWLER to make mechanical bowling more realistic. This machine ensures ball seam position as well as fulfills other constraints. Ball pitching and seam position accuracy results underscore the suitability of this design to enhance the capabilities of mechanical bowling.

关键词： robowler bowling machine cricket bowling ball seam bowling variables

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Problems of Lifts in Symplectic Geometry

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Chinese Annals of Mathematics,Series B 2019年第3期40卷 321-330页

作者： arif SALIMOV Manouchehr BEHBOUDI ASL Sevil KAZIMOVA Department of Algebra and Geometry Baku State University Department of Mathematics Salmas Branch Islamic Azad University

Let(M,ω)be a symplectic *** this paper,the authors consider the notions of musical(bemolle and diesis)isomorphisms ω~b:T M→T~*M and ω~?:T~*M→TM between tangent and cotangent *** authors prove that the complete lifts of symplectic vector field to tangent and cotangent bundles is ω~*** consequence of analyze of connections between the complete lift ~cω_(T M )of symplectic 2-form ω to tangent bundle and the natural symplectic 2-form dp on cotangent bundle,the authors proved that dp is a pullback o f^cω_(TM)by ω~?.Also,the authors investigate the complete lift ~cφ_T~*_M )of almost complex structure φ to cotangent bundle and prove that it is a transform by ω~?of complete lift^cφ_(T M )to tangent bundle if the triple(M,ω,φ)is an almost holomorphic *** transform of complete lifts of vector-valued 2-form is also studied.

关键词： Symplectic manifold Tangent bundle Cotangent bundle Transform of tensor fields Pullback Pure tensor Holomorphic manifold

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