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Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?

Hepatobiliary Surgery and Nutrition 2020年第5期9卷 577-586,I0001页

作者： ariella m.altman Scott Kizy Schelomo marmor Jane Y.C.Hui Todd m.Tuttle Eric H.Jensen Jason W.Denbo Department of Surgery University of MinnesotaMinneapolisMNUSA Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFLUSA

Background:Intrahepatic cholangiocarcinoma(ICC)is rare with limited evidence-based *** retrospective study evaluates the use of chemotherapy in patients with resected ***:The Surveillance Epidemiology and End Results(SEER)program database was used to identify patients with resected *** were stratified by date of diagnosis(2000-2004,2005-2009,2010-2014),T,and N *** logistic regression models identified predictors of chemotherapy ***-meier and Cox proportional hazard models were used to identify survival ***:One thousand and two hundred twenty-three patients met inclusion *** utilization increased over time(33%to 41%,P≤0.05).Chemotherapy use increased in lymph node(LN)positive patients[32%to 60%in 2010-2014;(P≤0.05)and T3/T4 disease(40%to 60%in 2010-2014;P≤0.01)],but not in patients with LN negative or T1/T2 *** positivity was associated with utilization of chemotherapy in 2005-2009 and *** survival increased from 32 to 41 months(P≤0.05).In LN positive patients,chemotherapy was associated with a decreased hazard ratio of death(P≤0.05)and T3/T4 disease was associated with an increased hazard ratio of death(P≤0.05).Conclusions:Adjuvant chemotherapy use in ICC has *** LN positive or patients with T3/T4 tumors are receiving chemotherapy,which may explain the improvement in overall survival.

关键词： Cholangiocarcinoma adjuvant chemotherapy survival lymph node(LN) surgical procedures

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Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 296-303页

作者： Scott Kizy ariella m.altman Keith m.Wirth Schelomo marmor Jane Y.C.Hui Todd m.Tuttle Emil Lou Khalid Amin Jason W.Denbo Eric H.Jensen Division of Surgical Oncology Department of SurgeryUniversity of MinnesotaMinneapolisMNUSA Division of Hematology and Oncology Department of Internal MedicineUniversity of MinnesotaMinneapolisMNUSA Department of Laboratory medicine and Pathology University of MinnesotaMinneapolisMNUSA

Background:The utility of neoadjuvant treatment for resectable pancreas cancer is yet to be determined,but has commonly included *** evaluated outcomes in patients with radiographically resectable pancreatic adenocarcinoma treated with neoadjuvant chemotherapy without ***:A retrospective review of patients in our institutional pancreatic cancer registry was performed,which identified 36 patients who received neoadjuvant chemotherapy alone for resectable pancreatic adenocarcinoma between 2012 and ***:median age at diagnosis was 66.3 *** regimens included gemcitabine(n=17),gemcitabine/nab-paclitaxel(n=8),or 5-FU/leucovorin/irinotecan/oxaliplatin(FOLFIRINOX)(n=11).Surgical resection was performed in 69%of patients(n=25),with an R0 resection rate of 92%(n=23 patients).During chemotherapy,distant disease became apparent in 19%of patients(n=7),while no patients had evidence of local *** rates were similar between chemotherapy regimens(single agent=59%,multiple agent=79%).median overall survival for all patients who received neoadjuvant chemotherapy was 30.3 and 34.4 months for those who underwent surgical *** was no difference in median survival for patients treated with gemcitabine(31.3 months)or multi-agent chemotherapy(29.7 months).Conclusions:A short course of neoadjuvant chemotherapy without chemoradiation may improve patient selection prior to surgical resection for pancreas ***,local disease progression did not limit surgical resection in this small series.

关键词： Pancreatic adenocarcinoma chemotherapy survival neoadjuvant chemotherapy resection

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Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth

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Bioactive materials 2024年第2期32卷 292-303页

作者： Claire E.Nason-Tomaszewski Emily E.Thomas Daniel L.matera Brendon m.Baker ariella Shikanov Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Department of Chemical Engineering University of MichiganAnn ArborMI 48109USA Department of Obstetrics and Gynecology University of MichiganAnn ArborMI 48109USA Cellular and molecular Biology Program University of MichiganAnn ArborMI 48109USA

Synthetic matrices which mimic the extracellular composition of native tissue create a comprehensive model for studying development and ***,we have engineered a composite material which retains cell-secreted ECm for the culture of ovarian follicles by embedding electrospun dextran fibers functionalized with basement membrane binder(BmB)peptide in PEG *** the presence of ECm-sequestering fibers,encapsulated immature primordial follicles and ovarian stromal cells aggregated into large organoid-like structures with dense deposition of laminin,perlecan,and collagen I,leading to steroidogenesis and significantly greater rates of oocyte survival and *** determined that cell aggregation restored key cell-cell interactions critical for oocyte survival,whereas oocyte growth was dependent on cell-matrix interactions achieved in the presence of *** we have shown that sequestration and retention of cell-secreted ECm along synthetic fibers mimics fibrous ECm structure and restores the cell-cell and cell-matrix interactions critical for engineering an artificial ovary.

关键词： Biomimetic matrix Ovarian follicle Fibrous hydrogels

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大堡礁和大峡谷世界遗产区的适应性管理

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AmBIO－人类环境杂志 2007年第B11期36卷 553-558页

作者： Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona ariella Helfgott Heather Leslie Jon Norberg magnus Nystrm Per Olsson Henrik sterblom marten Scheffer Heidi Schuttenberg Robert S.Steneck maria Teng max Troell Brian Walker James Wilson Boris Worm 丁莉澳大利亚研究委员会(ARC)珊瑚礁研究卓越中心大峡谷监测和研究中心科学顾问委员会瑞典皇家科学院Beijer国际生态经济研究所澳大利亚研究委员会卓越中心詹姆斯库克大学马尼托巴大学自然资源研究所阿德莱德大学普林斯顿大学斯德哥尔摩大学斯德哥尔摩恢复力中心斯德哥尔摩大学系统生物学系瓦赫宁根大学水生态和水质管理研究组缅因大学斯德哥尔摩大学系统生态学系澳大利亚联邦科学工业研究组织达尔豪斯大学

关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基... 详细信息

关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。

关键词：世界遗产地适应性管理大峡谷大堡礁自然资源管理产区传统观念生态景观

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草菇病毒——一种新的食用菌ds-RNA病毒

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微生物学报 1988年第1期 19-23页

作者：陈开英梁平彦张树庭尤美莲中国科学院微生物研究所香港中文大学

自草菇(Volvariella volvacea)子实体中分离到一种等轴对称直径为35nm左右的病毒颗粒。病毒样品经琼脂糖电泳显示一条区带,并具有典型核蛋白的紫外吸收光谱。最大吸收为E257,最低吸收为E230,A260/280=1.96。经SDS-不连续聚丙烯酰胺凝胶... 详细信息

自草菇(Volvariella volvacea)子实体中分离到一种等轴对称直径为35nm左右的病毒颗粒。病毒样品经琼脂糖电泳显示一条区带,并具有典型核蛋白的紫外吸收光谱。最大吸收为E257,最低吸收为E230,A260/280=1.96。经SDS-不连续聚丙烯酰胺凝胶电泳解离病毒,出现一条主要衣壳多肽的电泳带,分子量为60,000道尔顿。病毒核酸的最大吸收在258nm,最低吸收在232nm,A260/280=2.0,琼脂糖电泳为一个组分。以产黄青霉病毒(Penicillium chrysogenum virus)ds-RNA和枯草杆菌噬菌体DNA作参照物,对草菇病毒核酸的性质进行了鉴定。病毒核酸抗DNase(5μg/ml),并在高离子强度(2×SSC)下抗RNase(20μg/ml)。但经过106℃ 10分钟处理,变性后样品对RNase敏感,结果表明草菇病毒是ds-RNA病毒。

关键词：草菇病毒衣壳多肽免疫双扩散

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