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Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes:A single-center experience

World Journal of Diabetes 2021年第1期12卷 56-68页

作者： Sari Krepel Volsky Shlomit Shalitin Elena Fridman Michal Yackobovitch-Gavan Liora Lazar Rachel Bello Tal Oron ariel tenenbaum Liat de Vries Yael Lebenthal National Center for Childhood Diabetes The Jesse Z and Sara Lea Shafer Institute for Endocrinology and DiabetesSchneider Children's Medical Center of IsraelPetach-Tikva 4920235Israel Sackler School of Medicine Tel Aviv UniversityTel Aviv 6997801Israel

BACKGROUND Type 1 diabetes(T1D)contributes to altered lipid profiles and increases the risk of cardiovascular disease(CVD).Youth with T1D may have additional CVD risk factors within the first decade of *** To examine risk factors for dyslipidemia in young subjects with *** Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D(86 males;baseline mean age 12.2±5.6 years and hemoglobin A1c 8.4%±1.4%)were followed in a single tertiary diabetes center for a median duration of 15 *** for outcomes of lipid profiles at last visit(total cholesterol[TC],triglycerides[TGs],low-density lipoprotein-cholesterol[LDL-c],and highdensity lipoprotein-cholesterol[HDL-c])were analyzed by stepwise linear regression *** At baseline,79.5%of the patients had at least one additional CVD risk factor(borderline dyslipidemia/dyslipidemia[37.5%],pre-hypertension/hypertension[27.6%],and overweight/obesity[16.5%])and 41.6%had multiple(≥2)CVD risk factors.A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1%of the *** of elevated TC:family history of CVD(β[SE]=23.1[8.3],P=0.006);of elevated LDL-c:baseline diastolic blood pressure(DBP)(β[SE]=11.4[4.7],P=0.003)and family history of CVD(β[SE]=20.7[6.8],P=0.017);of elevated TGs:baseline DBP(β[SE]=23.8[9.1],P=0.010)and family history of CVD(β[SE]=31.0[13.1],P=0.020);and of low HDL-c levels:baseline DBP(β[SE]=4.8[2.1],P=0.022]).CONCLUSION Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of *** is of utmost importance to prevent and control modifiable risk factors such as these,as early as childhood,given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia.

关键词： Type 1 diabetes Children and adolescents Cardiovascular disease risk factors Dyslipidemia Hypertension Family history of cardiovascular disease risk factors

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