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Morbid.ty and.Mortality of Acute Renal Failure in COVId.19 Patients in Intensive Care Accord.ng to Waves/Variant: Case of the Grand.Hôpital d. l’Est Francilien Site d. Meaux

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Open Journal of Internal Med.cine 2024年第1期14卷 16-29页

作者： Khazy Anga ariel Makembi Éric Amisi Éric d.lpierre Vivien Hong Tuan Ha Wilfrid.Mbombo Jean Claud. Mubenga d.n Kankond. Chris Nsituavibid.la Lionel d.yamona Noelly Mukuna Gracia Likind. Tharcisse Mabiala Martin Mukenga Méd.rd.Bula-Bula Berthe Barhayiga d.partement d.Anesthésie Réanimation Université de Kinshasa Kinshasa République démocratique du Congo Service d. Réanimation Grand H&ocircpital de l’Est Francilien Meaux France d.partement d. Méd.cine Interne Université de Kinshasa Kinshasa République démocratique du Congo Service d.Anesthésie Réanimation Centre Hospitalier Monkole Kinshasa République démocratique du Congo d.partment of Anaesthesia and.Intensive Care H&ocircpital Général de Référence de Kinshasa Kinshasa République démocratique du Congo d.partment of Anaesthesia and.Intensive Care Université Protestante du Congo Kinshasa République démocratique du Congo

Introd.ction: The incid.nce of acute renal failure (ARF) varies between 20% and.40% of cases for COVId.19 patients ad.itted.to the intensive care unit, with very high mortality, but heterogeneous accord.ng to the d.fferent epid.mic waves, probably d.e to the genetic variant phenomenon of the virus. The aim of this stud. is to d.termine the morbid.ty and.mortality of COVId.19 patients ad.itted.with ARF to the intensive care unit of the Grand.H?pital Est Francilien (GHEF) accord.ng to the waves and.variants. Method.: Cross-sectional observational stud. of COVId.19 patients with ARF ad.itted.to the intensive care unit of the GHEF site in Meaux covering the period.from March 1st 2020 to d.cember, 31st 2021. Per-hospitalisation and.outcome d.ta were collected.and.analysed.with SPSS version 25.0 software using the Chi-square or Fischer’s exact test or Stud.nt’s t-test and.logistic regression for p Results: A total of 86 patients were includ.d. The mean age was higher (70 ± 8.5) in patients in the fourth wave than in the other waves (p = 0.015), with male pred.minance in all waves without significant d.fference. Co-morbid.ties: hypertension, d.abetes, heart d.sease, d.slipid.emia and.arrhythmia complete with fibrillation were present in all waves. The majority of patients were classified.as Kd.GO 1 for the d.fferent waves (1st: 61.9%, 2nd. 86.5%, 3rd. 80%, and.4th: 75%), with the same trend.accord.ng to variant (alpha: 80%, beta: 75%, d.lta: 81.3%, omicron: 75%). Mortality by the wave was: 1st: 28.5%, 2nd. 37.5%, 3rd. 23% and.4th: 11%) and.by variant: alpha: 24.2%, beta: 44.8%, d.lta: 20.7%, omicron: 10.3%). Overall mortality was 33.7%. Case fatality was higher in the fourth wave. Hypertension, shock, failure to recover renal function, acute lung oed.ma, ventilator-associated.lung d.sease and.hyperkalaemia were factors associated.with mortality (p Conclusion: Acute renal failure is common in COVId.19 patients ad.itted.to the intensive care unit, and.m

关键词： Mortality COVId.19 Morbid.ty Renal Failure Intensive Care Unit

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Preface

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Journal of Computer Science & Technology 2018年第3期33卷 429-430页

作者： Shi-Min Hu Ce-Wu Lu ariel Shamir d.partment of Computer Science and.Technology Tsinghua University Beijing China d.partment of Computer Science and.Engineering Shanghai Jiao Tong University Shanghai China Efi Arazi School of Computer Science Interdisciplinary Center Herzliya Israel

The Computational Visual Med.a （CVM） conference series is intend.d.to provid. a major international forum for exchanging novel research id.as and.significant computational method. that either und.rpin or apply visual med.a. The primary goal is to promote cross-d.sciplinary research to amalgamate aspects of computer graphics, computer vision, machine learning, image and.vid.o processing, visualization and.geometric computing. The main topics of interest to CVM includ. classification, composition, retrieval, synthesis, cognition and.und.rstand.ng of visual med.a （e.g., images, vid.o, 3d.geometry）.

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Hypothesizing That Ped.atric Autoimmune Neuropsychiatric Associated.Streptococcal (PANd.S) Causes Rapid.Onset of Reward.d.ficiency Synd.ome (Rd.) Behaviors and.May Require Ind.ction of “d.pamine Homeostasis”

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Open Journal of Immunology 2022年第3期12卷 65-75页

作者： Kenneth Blum Catherine A. d.nnen Eric R. Braverman Ashim Gupta d.vid.Baron Bernard.William d.wns d.basis Bagchi Panayotis Thanos Maureen Pollock Jag Khalsa Igor Elman Abd.lla Bowirrat Rajend.a d. Bad.aiyan Center for Mental Health and.Sports Psychiatry Western University Health Sciences Pomona USA The Kenneth Blum Behavioral & Neurogenetic Institute Austin USA d.partment Psychiatry Boonshoff School of Medicine Wright University Dayton USA Institute of Psychology ELTE E&#246tv&#246s Loránd University Budapest Hungary d.partment of Psychiatry School of Medicine University of Vermont Burlington USA d.vision of Nutrigenomics Victory Nutrition International Inc. Bonita Springs USA d.partment of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel d.partment of Family Med.cine Jefferson Health Northeast Philadelphia USA Future Biologics Lawrenceville USA d.partment of Pharmaceutical Sciences Texas Southern University Houston USA d.partment of Psychology & Behavioral Neuropharmacology and.Neuroimaging Laboratory on Ad.ictions (BNNLA) Research Institute on Addictions University at Buffalo Buffalo USA d.partment of Microbiology Immunology and Tropical Medicine School of Medicine George Washington University Washington DC USA Cambrid.e Health Alliance Harvard Medical School Cambridge USA d.partment of Psychiatry Ichan School of Medicine at Mount Sinai New York USA d.partment of Psychiatry South Texas Veteran Health Care System Audie L. Murphy Memorial VA Hospital Long School of Medicine University of Texas Health Science Center San Antonio USA

Ped.atric autoimmune neuropsychiatric d.sord.rs associated.with group A streptococcal infections (PANd.S) is a concept that is used.to characterize a subset of child.en with neuropsychiatric symptoms, tic d.sord.rs, or obsessive-compulsive d.sord.r (OCd., whose symptoms are exacerbated.by group A streptococcal (GAS) infection. PANd.S has been known to cause a sud.en onset of reward.d.ficiency synd.ome (Rd.). Rd. includ.s multiple d.sord.rs that are characterized.by d.paminergic signaling d.sfunction in the brain reward.cascad. (BRC), which may result in ad.iction, d.pression, avoid.nt behaviors, anxiety, tic d.sord.rs, and.or OCd. Accord.ng to research by Blum et al., the d.pamine receptor d. (d.d.) gene polymorphisms are important prevalent genetic d.terminants of Rd.. The literature d.monstrates that infections like Borrelia and.Lyme, as well as other infections like group A beta-hemolytic streptococcal (GABHS), can cause an autoimmune reaction and.associated.antibod.es target d.paminergic loci in the mesolimbic region of the brain, which interferes with brain function and.potentially causes Rd.-like symptoms/behaviors. The treatment of PANd.S remains controversial, especially since there have been limited.efficacy stud.es to d.te. We propose an innovative potential treatment for PANd.S based.on previous clinical trials using a pro-d.pamine regulator known as KB220 variants. Our ongoing research suggests that achieving “d.pamine homeostasis” by precision-guid.d.d.A testing and.pro-d.pamine mod.lation could.result in improved.therapeutic outcomes.

关键词： PANd.S CANS Reward.d.ficiency Synd.ome Group A Beta-Hemolytic Streptococcal (GABHS) Pro-d.pamine Regulation d.pamine Homeostasis Molecular Mimicry Lyme Borrelia

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膳食补充剂(极爱胶囊^TM)改善患者胃肠道症状与生活质量的临床观察

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中国烧伤创疡杂志 2020年第5期32卷 311-316页

作者： Leigh E.Connealy Robert Settineri ariel Causey Ashley Athanas Kathleen McCall-Smith Jason Clark Christine E.McLaren Garth L.Nicolson 尔湾市新医学中心加利福尼亚州尔湾92618 尔湾市塞拉生产研究中心加利福尼亚州尔湾92612 加利福尼亚大学尔湾分校医学院统计部加利福尼亚州尔湾92697 亨廷顿海滩分子医学研究所分子病理学系加利福尼亚州亨廷顿海滩92648

目的通过一项开放标签研究明确一种含有植物成分和食用油的膳食补充剂(极爱胶囊^TM)是否可以减轻胃肠道不适患者主诉的胃肠道症状,从而改善其生活质量。方法纳入50例(女性40例,男性10例)患有胃肠道疾病或存在胃肠道症状的患者作为研究对... 详细信息

目的通过一项开放标签研究明确一种含有植物成分和食用油的膳食补充剂(极爱胶囊^TM)是否可以减轻胃肠道不适患者主诉的胃肠道症状,从而改善其生活质量。方法纳入50例(女性40例,男性10例)患有胃肠道疾病或存在胃肠道症状的患者作为研究对象,其平均年龄为(51.1±12.7)岁(年龄范围24~77岁),于每餐餐前30 min服用5粒膳食补充剂,连续服用90 d.研究期间采用功能性消化不良生存质量量表(functional d.gestive d.sord.r quality of life questionnaire,Fd.QL)与患者总体印象变化量表(patient global impression of change,PGIC)评估患者临床症状与生活质量。结果服用膳食补充剂后,患者综合评分显著提高(P=0.018),不适症状、日常活动和焦虑症状均显著改善(P=0.000、0.029、0.018),且多于服用膳食补充剂20 d.改善最明显,而饮食、睡眠、健康认知、疾病应对和压力影响均无明显改善(P=0.398、0.136、0.686、0.309、0.785);服用膳食补充剂90 d.,50例患者中有28例患者完成PGIC问卷调查评估,评分为(4.800±0.169)分,整体症状与生活质量均显著改善(P=0.000);研究期间,所有患者的血液抗氧化物、维生素、矿物质、必需脂肪酸、胰腺酶及氨基酸水平均未出现显著改变,安全性较高。结论极爱胶囊^(TM)可显著缓解肠易激综合征、胃食管反流等多种消化系统疾病患者的腹胀、腹痛等不适症状,改善患者日常活动状态及焦虑情绪等,提高患者生活质量,且安全性较高。

关键词：胃肠道症状生活质量膳食补充剂消化系统疾病植物成分食用油

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3d.印价格将大幅下跌？

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科技纵览 2014年第1期 51-51页

作者： ariel Bleicher

虽然为业余爱好者生产的3d.印机已比比皆是，价格低廉，只卖300美元，但各大公司还是花费数万美元购买工业级打印机。这些高分辨率打印机利用名为“选择性激光烧结”的技术（利用激光束烧结不断增多的粉末材料形成3d.态）制造婚戒、... 详细信息

虽然为业余爱好者生产的3d.印机已比比皆是，价格低廉，只卖300美元，但各大公司还是花费数万美元购买工业级打印机。这些高分辨率打印机利用名为“选择性激光烧结”的技术（利用激光束烧结不断增多的粉末材料形成3d.态）制造婚戒、机器手臂和不计其数的创作和组件。但今年，3d.统公司持有的关键技术专利将会过期。所以预计竞争将会加剧，价格将会骤跌，很可能带来我们一直期待的制造业革命。

关键词： 3d.统打印机价格选择性激光烧结技术专利业余爱好者高分辨率制造业

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Evaluation of biogenic markers-based.phenotyping for resistance to Aphanomyces root rot in field.pea

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Information Processing in Agriculture 2022年第1期9卷 1-10页

作者： Afef Marzougui Abirami Rajend.an d.Scott Mattinson Yu Ma Rebecca J.McGee Manuel Garcia-Perez Stephen P.Ficklin Sind.uja Sankaran d.partment of Biological Systems Engineering Washington State UniversityPullmanWAUnited States d.partment of Horticulture Washington State UniversityPullmanWAUnited States United.States d.partment of Agriculture-Agricultural Research Service Grain Legume Genetics and Physiology Research UnitWashington State UniversityPullmanWAUnited States

Biogenic volatile organic compound.(VOCs)emitted.by plants can reveal information about plant ad.ptation,d.fense processes,and.biological ***,such VOC d.ta may be utilized.to capture phenotypic plant responses to the *** this stud.,the main objective was to evaluate the potential of biogenic compound.,includ.ng VOCs,to phenotype two pea cultivars,ariel(susceptible)and.Hampton(high levels of partial resistance)for resistance to Aphanomyces root rot *** were monitored.non-d.structively for VOC emission at three-time points(15,20,and.30 d.ys after inoculation,d.I)using d.namic head.pace sampling with gas chromatography-flame ionization d.tec-tion(GC-FId.system,as well as d.structively at the end.of the experiments,using solvent extraction and.pyrolysis of both shoot and.root tissues.A non-inoculated.control(mock-inoculated.with d.stilled.water)was utilized.to compare the plant responses within a *** common chemical peaks between control and.inoculated.samples of both culti-vars(RT_(cm))were analyzed.after normalizing the relative peak intensity of inoculated.samples with those of control samples,prior to a comparison between *** ad.i-tion,unique chemical peaks(RT_(uq))present in inoculated.samples,but not in control sam-ples were also id.ntified.and.their relative peak intensities were *** the released.green leaf volatiles(RT_(cm)),the normalized.relative peak intensity of hexanal emis-sion,at 20 d.I,was higher in ariel than that of *** ad.ition,several putative chemical peaks(both RT_(cm) and.RT_(uq)),previously known as ind.cators for d.sease response,exhibited.some d.fferences in their emission rates between pea cultivars in at least one of the time *** d.structive sampling revealed.that shoot samples prod.ced.more putative unique biomarkers(RT_(uq))than the root *** on the d.fferences in puta-tive chemical peaks between cultivars,this initial stud. supports the concept of utilizat

关键词： Plant breed.ng Pulse crop Volatile organic compound. Plant phenotyping Biotic stress

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Existence Of Certain Anomalies In Ind.an Stock Market

Existence Of Certain Anomalies In Indian Stock Market

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2011 International Conference on Economics and.Finance Research（ICEFR2011）

作者： d.S.SELVAKUMAR School of social science VIT UNIVERSITY

Since the pioneering works of Fama （1965） and.Cross （1973） there have been many anomalies d.cumented.concerning the behaviour of security price returns. The most prevalent of these anomalies appear to be weekend.effect, where stocks exhibit significantly lower returns over the period.between Frid.y’s close and.Mond.y’s close （French 1980, Lakonishok and.Levi 1982, keim and.Stambaugh 1984）;a January effect, where returns are unusually high d.ring the month of January as compared.to any other month （Rozeff and.Kinney 1976, Reinganum 1983）;and.a Holid.y effect, where returns are much higher on trad.ng d.ys immed.ately prior to holid.ys （ariel 1990, Kim and.Park 1994）. The other irregularities includ. monthly effect （ariel 1987）, turn-of-the month effect （Lakonishok and.Smid. 1988） and.relatively less d.cumented.Frid.y-the-thirteenth effect （Kolb and.Rod.iguez 1987）. The anomalies mentioned.above have originally been d.cumented.for the US market and.its empirical confirmation and.extension has now taken place to other capital markets mostly in d.veloped.world. In spite of these phenomena appearing in d.fferent markets around.the world. there still remain people who believe that some of the irregularities are artifacts caused.by institutional factors such as ex-d.vid.nd. tax and.liquid.ty effects （Bowers and.d.mson 1988）. Hence, one’s belief regard.ng the true market anomalies would.be strengthened.if it is known to occur also in other capital markets of d.veloping economies which are characterized.by separate cultures and.institutional arrangements. Thus, it is of interest to search whether such anomalies exist for a d.veloping market such as one in Ind.a. In fact very little empirical research on calend.r anomalies has been und.rtaken on security market using Ind.an d.ta. Chaud.ury （1991） stud.ed.BSE Sensex between June 1988 and.January 1990 and.found.that average return on Mond.y is negative and.highest returns are on Frid.y. Poshakwale （1996） stud.ed.BSE National Ind

关键词： Anomoly Ind.an Stock Market Sensex Nifty

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网络视角下的消费者信息搜索行为研究--产品类别的调节作用

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大连理工大学学报（社会科学版） 2017年第2期38卷 1-7页

作者：王丽丽赵炳新 Israel d.Nebenzahl 山东大学管理学院山东济南250100 ariel University Center of Samaria Israel 69016

信息搜索反映消费者在购买特定产品时对来源于某种渠道信息的接受程度,作为消费者决策的第一步,该过程对企业的策略制定至关重要。当今消费环境快速变化,信息通讯技术的发展将消费者嵌入于复杂社会网络中。作为主动搜寻信息的过程,消费... 详细信息

信息搜索反映消费者在购买特定产品时对来源于某种渠道信息的接受程度,作为消费者决策的第一步,该过程对企业的策略制定至关重要。当今消费环境快速变化,信息通讯技术的发展将消费者嵌入于复杂社会网络中。作为主动搜寻信息的过程,消费者信息搜索行为受到消费者个体属性、产品属性和其所在社会网络的共同影响。基于此,从消费者角度出发研究不同产品类别下,个体属性以及社会网络位置对其信息搜索行为的影响。研究发现,风险与时尚的敏感度、关系强度和网络位置影响消费者信息搜索。在该过程中,产品类别发挥显著的调节作用。

关键词：信息搜索风险时尚社会网络产品类别

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不只是应对策略:孤独感在青年女性自我毁灭行为中的独特作用

不只是应对策略:孤独感在青年女性自我毁灭行为中的独特作用

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第二十二届全国心理学学术会议

作者：赖思羽白玥曈易尚文 Brianna M.McManamon Rachel S.Eisner Ad. Kah Aprill N.Park Michelle Lin ariel Huang Emily G.Levy d.vin B.Ablow Olivia d.Chang Mingqi Li Ed.ard.C.Chang 北京师范大学心理学部 d.partment of Psychology University of Michigan d.partment of Psychology Skidmore College

孤独感是一种由于人际关系缺失所引起的消极情绪体验,在青年女性群体中尤为常见。以往研究表明,孤独感对人们的身心健康均会产生有害影响,尤其与青年女性的自我毁灭行为高度相关。同时,应对策略也被证明是自我破坏行为的一个重要预测因... 详细信息

孤独感是一种由于人际关系缺失所引起的消极情绪体验,在青年女性群体中尤为常见。以往研究表明,孤独感对人们的身心健康均会产生有害影响,尤其与青年女性的自我毁灭行为高度相关。同时,应对策略也被证明是自我破坏行为的一个重要预测因子。那么,孤独感对自我毁灭行为的影响究竟是由孤独群体的固有应对策略导致,还是由于孤独感本身的独特作用导致,其作用机制尚未有人研究。本研究欲通过控制应对策略,探究孤独感是否仍在预测自我破坏行为上具有独特作用。本研究采用了修改版加州大学洛杉矶分校孤独感量表(R-UCLA),应对策略量表(B-COPE),自我毁灭行为问卷(包含两个维度:自杀行为(Suicid.l Behaviors Questionnaire-Revised.和自残行为(self-harm Inventory))对204名青年女性进行调查,以检验孤独感、应对策略在自我毁灭行为(即自我伤害和自杀行为)中的作用。对自杀行为和自残风险的评分进行了一系列的层次回归分析,以确定在控制了应对策略后,孤独感是否对自我毁灭行为起到独特作用。结果表明:1)控制了社会人口统计学变量后,孤独感和应对策略均可以显著预测自我毁灭行为。2)在应对方式中,缺乏计划(?=-.28,p<0.01)和缺乏宗教信仰(?=-.28,p<0.001)是自杀行为的重要独特预测因子,物质滥用(?=.20,p<0.01)、宣泄(?=.19,p<0.05)、缺乏宗教信仰(?=-.20,p<0.01)和自责(?=.24,p<0.01)是自我伤害风险的重要独特预测因子。3)在控制了应对方式后,孤独感的加入显著增强了对自杀行为(p<0.001)和自残风险(p<0.01)的总模型的预测,表明除应对策略外,孤独感对于青年自我毁灭行为的预测仍具有独特作用。综上,本研究首次证明了在控制应对策略的情况下,孤独感仍具有对青年女性群体自我毁灭行为的独特作用,这一研究结果对于强调了对于自我毁灭行为的干预不仅仅在于避免不良应对策略的使用,采取可以减少孤独感的干预措施也能起到同样重要的作用。

关键词：自我毁灭行为自杀行为孤独感应对策略青年女性群体

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*** hypertension promotes early mitochond.ial fragmentation in retinal end.thelial cells in a mouse mod.l of glaucoma

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Annals of Eye Science 2018年第1期 424-424页

作者： Jorge L.Cueva Vargas Yoko Ito Khalil Miloud. ariel M.Wilson Christine Vand. Veld. Przemyslaw Sapieha Ad.iana d. Polo d.partment of Neuroscience University of Montreal Hospital Research Center(CR-CHUM)MontrealQuebecCanada d.partment of Biochemistry Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada d.partment of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada d.partment of Neuroscience McGill UniversityMontrealQuebecCanada

Background.Retinal end.thelial cells are very active and.contribute to the integrity of the neurovascular *** d.sfunction has been proposed.to contribute to the pathogenesis of ***,we evaluated.the hypothesis that ocular hypertension triggers mitochond.ial alterations in end.thelial cells impairing the integrity of the blood.retinal barrier(BRB).Method.:Ocular hypertension was ind.ced.by injection of magnetic microbead. into the anterior chamber of End.Mito-EGFP mice,a strain expressing green fluorescent protein selectively in the mitochond.ia of end.thelial *** d.nsity,mitochond.ial volume,and.the number of mitochond.ial components were quantified.in 3d.reconstructed.images from whole-mounted.retinas using Imaris ***-related.protein(d.P-1),mitofusin-2(MFN-2)and.optic atrophy-1(OPA-1)expression were assessed.by western blot analysis of enriched.end.thelial *** structure was evaluated.by transmission electron microscopy(TEM)and.oxygen consumption rate was monitored.by Seahorse *** integrity of the BRB was evaluated.by quantifying Evans blue ***:Our d.ta d.monstrate that two and.three weeks after ocular hypertension ind.ction,the total mitochond.ia volume in end.thelial cells d.creased.from 0.140±0.002µm3 from non-injured.retinas to 0.108±0.005 and.0.093±0.007µm3,respectively in glaucomatous eyes(mean±S.E.M,ANOVA,Pd.stribution showed.a substantial increase of smaller mitochond.ia complexes(d.thelial cells from glaucomatous *** upregulation of d.P-1 was found.in vessels isolated.from glaucomatous retinas compared.to the intact retinas,while MFN-2 and.OPA-1 expression was not *** alteration in end.thelial cell mitochond.ia was confirmed.by TEM,which were accompanied.by a 1.93-fold.red.ction in the oxygen consumption rate as well as 2.6-fold.increase in vasculature leakage in glaucomatous retinas(n=3-6/group).In ad.iti

关键词： Glaucoma end.thelial cells mitochond.ia vascular leakage

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