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ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation

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Journal of Molecular Cell Biology 2011年第2期3卷 123-131页

作者： Elisabetta Donzelli Caterina Lucchini Elisa Ballarini arianna scuteri Fabrizio Carini Giovanni Tredici Mariarosaria Miloso Department of Neuroscience and Biomedical Technologies University of Milano-BicoccaVia Cadore 48-20052Monza(MB)Italy Reproductive Medicine Nuova Villa Claudia ClinicVia Flaminia Nuova 280RomeItaly

Adipocytes’biology and the mechanisms that control adipogenesis have gained importance because of the need to develop therapeutic strategies to control obesity and the related *** mesenchymal stem cells(hMSCs),undifferentiated stem cells present in the bone marrow that are physiological precursors of adipocytes,were induced to adipogenic *** molecular mechanisms on the basis of the adipogenesis were evaluated,focusing on the MAPKinases ERK1 and ERK2,which are involved in many biological and cellular ***1 and ERK2 phosphorylation was reduced with different timing and intensity for the two isoforms in treated hMSCs in comparison with control cells until day 10 and then at 14–28 days,it reached the level of untreated *** total amount of ERK1 was also decreased up to day 10 and then was induced to the level of untreated cultures,whereas the expression of ERK2 was not changed following adipogenic *** with the specific ERK1/2 inhibitor U0126 during the whole differentiation period hampered hMSCs’adipogenic differentiation,as lipid droplets appeared in very few cells and were reduced in number and *** U0126 was administered only during the initial phase of differentiation,the number of hMSCs recruited to adipogenesis was reduced while,when it was administered later,hMSCs did not acquire a mature adipocytic ***1 and ERK2 are important for hMSC adipogenic differentiation since any alteration to the correct timing of their phosphorylation affects either the recruitment into the differentiation program and the extent of their maturation.

关键词： mesenchymal stem cells ERK adipogenesis MAPK obesity differentiation

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Dual role of extracellular vesicles in neurodegenerative diseases

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World Journal of Stem Cells 2024年第12期16卷 1002-1011页

作者： arianna scuteri Elisabetta Donzelli Experimental Neurology Unit and Milan Center for Neuroscience School of Medicine and SurgeryUniversity of Milano-BicoccaMonza 20900Italy

Extracellular vesicles(EVs)are cell-to-cell interaction tools that are attracting increasing interest in the literature in two opposing *** addition to their role in physiological development,there is growing evidence of their involvement in healing and protective ***,EVs also mediate pathological conditions,particularly contributing to the progression of several chronic diseases,such as neurodegenerative *** the other hand,EVs also form the core of a new therapeutic strategy for neuroprotection,which is based on the administration of EVs derived from a wide range of donor *** particular,the possibility of obtaining numerous EVs from stem cells of different origins,which is feasible for therapeutic aims,is now under *** this review,we focused on neurodegenerative diseases,in which EVs could have a propagative detrimental effect or could also be exploited to deliver protective *** review explores the different hypotheses concerning the dual role of EVs,with the aim of shedding light on the following question:Can vesicles be used to fight vesicle-propagated diseases?

关键词： Extracellular vesicles Neurodegenerative diseases Induced pluripotent stem cells Mesenchymal stem cells Neuroprotection Cellular communication Biomarkers

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