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Sr,Nd,Pb and trace element systematics of the New Caledonia harzburgites:Tracking source depletion and contamination processes in a SSZ setting

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Geoscience Frontiers 2020年第1期11卷 37-55页

作者： arianna Secchiari Alessandra Montanini Delphine Bosch Patrizia Macera Dominique Cluzel Dipartimento di Scienze Chimiche della Vita e della SostenibilitàAmbientaleUniversitàdi ParmaItaly Geosciences Montpellier Universitéde MontpellierFrance Dipartimento di Scienze della Terra Universitàdi PisaItaly Institut des Sciences Exactes et Appliquées Universitéde la Nouvelle-CalédonieNew Caledonia

The New Caledonia ophiolite(Peridotite Nappe)consists primarily of harzburgites,locally overlain by mafic-ultramafic cumulates,and minor spinel and plagioclase *** this study,a comprehensive geochemical data set(major and trace element,Sr-Nd-Pb isotopes)has been obtained on a new set of fresh harzburgites in order to track the processes recorded by this mantle section and its *** studied harzburgites are low-strain tectonites showing porphyroclastic textures,locally grading into protomylonitic *** exhibit a refractory nature,as attested by the notable absence of primary clinopyroxene,very high Fo content of olivine(91-93 mol.%),high Mg#of orthopyroxene(0.91-0.93)and high Cr#of spinel(0.44-0.71).The harzburgites are characterised by remarkably low REE concentrations(<0.1 chondritic values)and display"U-shaped"profiles,with steeply sloping HREE(DyN/YbN=0.07-0.16)and fractionated LREE-MREE segments(LaN/SmN=2.1-8.3),in the range of modern fore-arc *** modelling shows that the HREE composition of the harzburgites can be reproduced by multi-stage melting including a first phase of melt depletion in dry conditions(15%fractional melting),followed by hydrous melting in a subduction zone setting(up to 15%-18%).However,melting models fail to explain the enrichments observed for some FME(***,Sr,Pb),LREE-MREE and *** enrichments,coupled with the frequent occurrence of thin,undeformed films of Al2 O3,and CaO-poor orthopyroxene(Al2O3=0.88-1.53 wt.%,CaO=0.31-0.56 wt.%)and clinopyroxene with low Na2 O(0.03-0.16 wt.%),Al2 O3(0.66-1.35 wt.%)and TiO2(0.04-0.10 wt.%)contents,point to FME addition during fluid-assisted melting followed by late stage metasomatism most likely operated by subductionrelated melts with a depleted trace element *** isotopic ratios range from unradiogenic to radiogenic(-0.80<εNdi≤+13.32)and negatively correlate with Sr isotopes(0.70257≤87Sr/86Sr≤0.70770).Pb isotopes cover a wide range,trendi

关键词： Intra-oceanic arcs Depleted mantle sections Fore-ac harzburgites New Caledonia ophiolite Sr-Nd-Pb isotopes Subduction zones

Velocity profiles description and shape factors inclusion in a hyperbolic,one-dimensional,transient two-fluid model for stratified and slug flow simulations in pipes

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Petroleum 2019年第2期5卷 191-198页

作者： arianna Bonzanini Davide Picchi Marco Ferrari Pietro Poesio Dipartimento di Ingegneria Meccanica ed Industriale Universita degli Studi di BresciaVia Branze3825123BresciaItaly Energy Resources Engineering Stanford UniversityStanford94305CAUnited States Department of Mathematics Politecnico di Milanop.zza Leonardo da Vinci3220133MilanItaly

In a previous work it has been shown that a one-dimensional,hyperbolic,transient five equations twofluid model is able to numerically describe stratified,wavy,and slug flow in horizontal and nearhorizontal *** statistical characteristics can be numerically predicted with results in good agreement with experimental data and well-known empirical *** this model some approximated and simplified assumptions are adopted to describe shear stresses at wall and at phase *** this paper,we focus on the possibility to account for the cross sectional flow by inserting shape factors into the momentum balance equations of the aforementioned *** profiles are obtained by a pre-integrated model and they are computed at each time step and at each computational *** that the velocity profiles are known,the obtained shape factors are inserted in the numerical *** this way it is possible to recover part of the information lost due to the one-dimensional flow *** profiles computed in stratified conditions are compared against experimental profiles measured by PIV technique;a method to compute the velocity profile during slug initiation and growth has been developed and the computed velocity distribution in the liquid phase was compared against the one-seventh power law.

关键词： Multi-phase pipeline transport Oil&gas Hyperbolic two-fluid model Velocity profiles Shape factors

Role of KOL in Social Media——Case from Instagram and Red

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Role of KOL in Social Media——Case from Instagram and Red

作者： Fengyi arianna CHEN 上海交通大学

学位级别：硕士

With the advancement in technology and emergence of internet together with online platforms especially social platforms such as Instagram and Red,online virtual communities are formed and e-WOM is *** this process,people who present themselves to have in-depth knowledge in a specific field online will gather a group of followers with similar *** parties will interact on the interested topic and relationship is built between *** with in-depth knowledge are considered to be *** to their in-depth knowledge in certain field and their relationship with their followers,their followers view the KOL as one of them and the content shared by the KOLs to be more credible and *** such,this gives the KOLs the power to influence their followers and brands start to see the value in engaging KOLs to communicate with their potential *** marketing has gained popularity quickly in recent years as they are seen as a cost-efficient marketing strategy to reach *** the success of influencer marketing and critical factors that will contribute to the success of such campaigns become *** researches focus on understanding influencer marketing,the theories behind it and factors that contributes to the success of such *** though many articles and research papers do acknowledge that relationship of the 2 parties is important and essential for influencer marketing,however,very few or no researches directly conduct empirical analysis on whether relationship between KOLs and their followers indeed influence and to what magnitude influence the success of influencer marketing campaigns and eventually impacting brand’s choice of marketing tactic or KOLs to *** study in the form of case study with KOLs on Instagram and Red platform will help to fill this void by addressing this issue which is underexplored currently and provide a deep-dive into the relationship between influencers and its

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ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation

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Journal of Molecular Cell Biology 2011年第2期3卷 123-131页

作者： Elisabetta Donzelli Caterina Lucchini Elisa Ballarini arianna Scuteri Fabrizio Carini Giovanni Tredici Mariarosaria Miloso Department of Neuroscience and Biomedical Technologies University of Milano-BicoccaVia Cadore 48-20052Monza(MB)Italy Reproductive Medicine Nuova Villa Claudia ClinicVia Flaminia Nuova 280RomeItaly

Adipocytes’biology and the mechanisms that control adipogenesis have gained importance because of the need to develop therapeutic strategies to control obesity and the related *** mesenchymal stem cells(hMSCs),undifferentiated stem cells present in the bone marrow that are physiological precursors of adipocytes,were induced to adipogenic *** molecular mechanisms on the basis of the adipogenesis were evaluated,focusing on the MAPKinases ERK1 and ERK2,which are involved in many biological and cellular ***1 and ERK2 phosphorylation was reduced with different timing and intensity for the two isoforms in treated hMSCs in comparison with control cells until day 10 and then at 14–28 days,it reached the level of untreated *** total amount of ERK1 was also decreased up to day 10 and then was induced to the level of untreated cultures,whereas the expression of ERK2 was not changed following adipogenic *** with the specific ERK1/2 inhibitor U0126 during the whole differentiation period hampered hMSCs’adipogenic differentiation,as lipid droplets appeared in very few cells and were reduced in number and *** U0126 was administered only during the initial phase of differentiation,the number of hMSCs recruited to adipogenesis was reduced while,when it was administered later,hMSCs did not acquire a mature adipocytic ***1 and ERK2 are important for hMSC adipogenic differentiation since any alteration to the correct timing of their phosphorylation affects either the recruitment into the differentiation program and the extent of their maturation.

关键词： mesenchymal stem cells ERK adipogenesis MAPK obesity differentiation

Hepatitis delta virus: From infection to new therapeutic strategies

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World Journal of Gastroenterology 2021年第24期27卷 3530-3542页

作者： Grazia A Niro arianna Ferro Francesca Cicerchia Isabella Brascugli Marilena Durazzo Department of Gastroenterology IRCCS Casa Sollievo della Sofferenza Hospital FoundationSan Giovanni Rotondo 71013Italy Department of Medical Sciences University of TurinTurin 10126Italy

The hepatitis delta virus(HDV)is a small RNA virus that encodes a single protein and which requires the hepatitis B virus(HBV)-encoded hepatitis B surface antigen(HBsAg)for its assembly and ***/HDV co-infections exist worldwide and show a higher prevalence among selected groups of HBV-infected populations,specifically intravenous drug users,practitioners of high-risk sexual behaviours,and patients with cirrhosis and hepatocellular *** chronic form of HDV-related hepatitis is usually severe and rapidly *** of the viral infection itself,including the status of co-infection or super-infection,virus genotypes(both for HBV and HDV),and persistence of the virus’replication,influence the outcome of the accompanying and manifested liver ***,disease severity is burdened by the lack of an effective cure for either virus *** decades,the main treatment option has been interferon,administered as mono-therapy or in combination with nucleos(t)ide *** its efficacy has been reported for different doses,durations and courses,only a minority of patients achieve a sustained response,which is the foundation of eventual improvement in related liver *** need for an efficient therapeutic alternative *** efforts towards this end have led to new treatment options that target specific steps in the HDV life cycle;the most promising among these are myrcludex B,which inhibits virus entry into hepatocytes,lonafarnib,which inhibits farnesylation of the viral-encoded LHDAg large hepatitis D antigen,and REP-2139,which interferes with HBsAg release and assembly.

关键词： Hepatitis delta virus Hepatitis B virus Myrcludex Lonafarnib REP 2139

Autoimmune hepatitis treatment in the elderly: A systematic review

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作者： arianna Betti.

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World Journal of Gastroenterology 2019年第22期25卷 2809-2818页

作者： Marilena Durazzo Giulia Lupi Michela ScANDella arianna Ferro Gabriella Gruden Department of Medical Sciences University of Turin

BACKGROUND Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease with a high risk of progression to liver cirrhosis. The initial treatment for AIH usually includes a steroid, with or without azathioprine. AIH can present at any age;however, the most effective and safe induction treatment for AIH in the elderly remains unclear. AIM To systematically review available data on both effectiveness and safety of AIH treatments in elderly subjects. METHODS To identify studies on AIH induction treatment in elderly patients (≥ 60 years of age), an electronic research was performed (PubMed, EMBASE and Cochrane Library databases) until February 2019. Eligible studies were selected through screening of titles and abstracts, followed by full-text critical evaluation. After risk of bias assessment, data on study designs, interventions, and outcomes were extracted and reviewed. RESULTS Among the 1736 retrieved papers, 15 studies were selected. Out of them, eight studies were excluded because of a critical risk of bias. The remaining seven studies included 789 patients and out of them 239 subjects were elders. First-line treatment was a steroid either alone or in combination with azathioprine in most patients (87.6%) and only one study investigated the effect of combined steroid and mycophenolate mofetil therapy. Standard therapy was effective in inducing remission in the elderly. Moreover, treatment failure and relapses occurred less often in the elderly compared to younger *** Treatment of AIH is challenging in elderly patients. This systematic review confirms the efficacy and safety of standard induction treatment for AIH in the elderly. Available evidence is insufficient to draw any conclusion on the effect of novel AIH treatments in elderly subjects.

关键词： Autoimmune hepatitis Elderly patients Aged Steroids Azathioprine Mycophenolate mofetil

Highly selective sorting of semiconducting single wall carbon nanotubes exhibiting light emission at telecom wavelengths

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Nano Research 2016年第8期9卷 2478-2486页

作者： Francesco Sarti Francesco Biccari Federica Fioravanti Ughetta Torrini Anna Vinattieri Vincent Derycke Massimo Gurioli arianna Filoramo Department of Physics and LENS University of Florence Via Sansone 1 50019 Sesto Fiorentino Italy LICSEN NIMBE CEA CNRS University Paris-Saclay CEA Saclay 91191 Gif sur Yvette CEDEX France

Single wail carbon nanotubes （SWNTs） are known for their exceptional electronic properties. However, most of the synthesis methods lead to the production of a mixture of carbon nanotubes having different chiralities associated with metallic （m-SWNTs） and semiconducting （s-SWNTs） characteristics. For application purposes, effective methods for separating these species are highly desired. Here, we report a protocol for achieving a highly selective separation of s-SWNTs that exhibit a fundamental optical transition centered at 1,550 nm. We employ a polymer assisted sorting approach, and the influence of preparation methods on the optical and transport performances of the separated nanotubes is analyzed. As even traces of m-SWNTs can critically affect performances, we aim to produce samples that do not contain any detectable fraction of residual m-SWNTs.

关键词： single wall carbonnanotube (SWNT) sorting optical properties field effect transistors

Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements

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Particuology 2018年第2期16卷 99-106页

作者： Alessia Nicosia Laura Manodori arianna Trentini Isabella Ricciardelli Dimitri Bacco Vanes Poluzzi Lorenza Di Matteo Franco Belosi Institute of Atmospheric Sciences and Climate (ISAC)-CNR Bologna Italy Department of Physics and Earth Sciences University of Ferrara 44122 Ferrara Italy ECSIN - European Center for the Sustainable Impact ofNanotechnology Veneto Nanotech Scpa Rovigo Italy d Regional Agency for Prevention Environment and Energy of Emilia-Romagna (ARPAE) Bologna Italy Regional Agency for Prevention Environment and Energy of Emilia-Romagna (ARPAE) Bologna Italy University of Eastern Piedmont "A. Avogadro" Department of Science and Technology Innovation Alessandria Italy

Most conventional aerosol neutralizers are based on radioactive sources, which are controlled by strict regulations restricting their handling, transport, and storage. The TSI 3087 soft X-ray （SXR） neutralizer circumvents these legal restrictions. The aim of the present work is to compare the performance of a standalone SXR aerosol neutralizer with that of conventional radioactive aerosol neutralizers based on 85Kr （TSI 3077） and 241Am （Grimm 5522） by performing field tests in a real environmental scenario. The results obtained when the SXR neutralizer was connected to a mobility particle sizer spectrometer （MPS）, different from the device suggested by the manufacturer, were comparable with those obtained with the use of radioactive aerosol neutralizers. In changing the neutralizer, the particle number concentrations, measured with the MPS connected to the SXR neutralizer, almost remained within the 10% uncertainty bounds for the particle size interval 10-300 nm, when diffusion losses inside the SXR tube were considered. Based on our comparisons, the SXR neutralizer can be regarded as a standalone instrument that could solve the problems associated with legal restrictions on radioactive neutralizers and fulfil the need for a portable instrument for different field test purposes.

关键词： Aerosol neutralizer Soft X-ray non-radioactive charger Mobility particle sizer spectrometer Particle size distribution Diffusion losses