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Comparison of Interfacial and Foaming Properties of Soy and Whey Protein Isolates

Journal of Food Science and Engineering 2012年第7期2卷 376-381页

作者： Cecilia Abirached claudia Alejandra Medrano aria claudia araujo Patrick Moyna Maria Cristina Anon Luis Alberto Panizzolo Food Science and Technology Departament Facultad de Quimica Universidad de la Republiea Montevideo 11800 Uruguay DEPTEQ Facultad de Quimica Universidad de la Republica Montevideo 11800 Uruguay CIDCA-CONICET- UNLP La Plata 1900 Argentina

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Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki Mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

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On Real-rootedness of Independence Polynomials of Rooted Products of Graphs

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应用数学学报:英文版 2023年第4期39卷 854-867页

作者： aria Ming-yue ZHU Bao-xuan ZHU School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China

An independent set in a graph G is a set of pairwise non-adjacent vertices. The independence polynomial of G is the polynomial AΣx^(|A|), where the sum is over all independent sets A of G. In 1987, Alavi,Malde, Schwenk and Erd os conjectured that the independence polynomial of any tree or forest is *** this unimodality conjecture has attracted many researchers’ attention, it is still open. Recently, Basit and Galvin even asked a much stronger question whether the independence polynomial of every tree is ordered log-concave. Note that if a polynomial has only negative real zeros then it is ordered log-concave and *** this paper, we observe real-rootedness of independence polynomials of rooted products of graphs. We find some trees whose rooted product preserves real-rootedness of independence polynomials. In consequence, starting from any graph whose independence polynomial has only real zeros, we can obtain an infinite family of graphs whose independence polynomials have only real zeros. In particular, applying it to trees or forests, we obtain that their independence polynomials are unimodal and ordered log-concave.

关键词： independence polynomials unimodality real zeros rooted products claw-free graphs

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Journal of Materials Science & Technology 2022年第1期96卷 248-261页

作者： Seyedmohammad Tabaie Farhad Rézaï-aria Bertrand C.D.Flipo Mohammad Jahazi Department of Mechanical Engineering École de Technologie Supérieure(ÉTS)H3C 1K3 MontrealQCCanada Institut Clément Ader(ICA) Universitéde ToulouseCNRSIMT Mines AlbiINSAUPSISAECampus Jarlard81013 AlbiFrance TWI Ltd Granta ParkGreat AbingtonCambridge CB216ALUnited Kingdom

The continuous growth in the manufacture of aerospace components such as blisks has led to an increase in the application of different hybrid materials fabricating methods,and thus the requirements for joining and strengthening of dissimilar *** to this goal,selective laser melted(SLM)Inconel718 was joined with forged AD730^(TM)Nickel-based superalloy through linear friction welding(LFW)in this *** variation,specifically with respect to secondary phases precipitation was *** microhardness and strengthening mechanisms of the weldment were also *** precipitation(volume fraction and size of particles)at different regions of both sides of the weld line was *** to the weld line,the dissolution ofγ’/γ"and Laves phases and grain refinement occurred which reveals the effects of both compression strain and high temperature on recrystallization and high degree of elemental diffusion in the weld zone(WZ).It is shown that the size,volume fraction,and shape of secondary phases increased and changed(from spherical to long-striped for Laves particles)as we went from the WZ toward the base ***,the measured microhardness indicated that the strength of AD730^(TM)alloy depends significantly on the grain size,while strength in SLM Inconel 718 was dominated by shape(or size)and the presence of secondary phases(γ’/γ"and Laves).

关键词： Additive manufacturing Linear friction welding Ni-based superalloy Precipitation Microhardness Strengthening mechanisms

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How long does the recovery of corneal sensitivity in different corneal regions take after LASEK?

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2056-2062页

作者： Ali Mirzajani aria Bouyeh Fatemeh Khezri Ebrahim Jafarzadehpur Farid Karimian Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Ophthalmic Research Center Research Institute for Ophthalmology and Vision ScienceShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To determine the corneal sensitivity recovery period after laser-assisted sub-epithelial keratectomy(LASEK)refractive surgery and investigate the effects of ablation depth on ***:In this study examinations were performed on 90 right eyes of 90 people(34 males and 56 females)with an age range of 20-35 and an average of 22.26±3.8 years old.A sensation of 5 corneal regions,including the center and 4 mid-peripheral regions,i.e.,nasal,inferior,temporal,and superior,each at a distance of 2 mm from the center of the cornea were measured with a Cochet-Bonnet esthesiometer device in 3-time points including before LASEK,1 and 3mo after the surgery,*** was performed on individuals with stabilized myopia of -1.00 to -7.00 diopters and astigmatism of less than 2.00 ***,the individuals were divided into three groups regarding ablation ***:The highest level of corneal sensitivity before surgery was related to the center of the cornea(59.1±7.76),and the highest level of corneal sensitivity loss was also related to this *** sensation of all measured corneal regions significantly reduced 1mo postoperatively and returned to their preoperative levels 3mo after surgery(mean of 5 corneal regions in levels of preoperation:58.2±6.48,1mo postoperation:57.3±5.84,3mo postoperation:58.2±5.49;P<0.05).A significant relationship was found between ablation depth and corneal sensitivity changes in the center and temporal regions(P<0.05).CONCLUSION:Corneal sensitivity in myopia and low astigmatism decreases after LASEK and reaches the preoperative level within *** depth of ablation during surgery affected the recovery of corneal sensitivity.

关键词： refractive surgery laser-assisted subepithelial keratectomy corneal sensitivity ablation depth refractive error

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Making sense of spike D614G in SARS-CoV-2 transmission

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Science China(Life Sciences) 2021年第7期64卷 1062-1067页

作者： aria C.Shi Xuping Xie School of Medicine Johns Hopkins UniversityBaltimoreMD 21205USA Department of Biochemistry and Molecular Biology University of Texas Medical BranchGalvestonTX 77550USA

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiologic agent of the current coronavirus disease 2019(COVID-19)pandemic,has evolved to adapt to human host and transmission over the past 12 *** prominent adaptive mutation is the asparagine-to-glycine substitution at amino acid position 614 in the viral spike protein(D614G),which has become dominant in the currently circulating virus *** spike protein determines host ranges,tissue tropism,and pathogenesis through binding to the cellular receptor of angiotensin converting enzyme 2(ACE2),the D614G mutation is hypothesized to enhance viral fitness in human host,leading to increased transmission during the global *** we summarize the recent progress on the role of the D614G mutation in viral replication,pathogenesis,transmission,and vaccine and therapeutic antibody *** findings underscore the importance in closely monitoring viral evolution and defining their functions to ensure countermeasure efficacy against newly emerging variants.

关键词： SARS-CoV-2 D614G COVID-19

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Improving Evidence-Based Practice in Forensic Medicine:Validation of INtegration of Forensic Epidemiology and the Rigorous EvaluatioN of Causation Elements and Principles of Evidence-Based Reporting in FORensic Medicine-Pathology version in Indonesia

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Journal of Forensic Science and Medicine 2023年第3期9卷 236-249页

作者： Putri Dianita Ika Meilia Herkutanto Agus Purwadianto Budi Sampurna Murdani Abdullah Diantha Soemantri aria Kekalih Doctoral Program in Medical Sciences Faculty of Medicine Universitas IndonesiaJakartaIndonesia Department of Forensic Medicine and Mortuary Persahabatan General HospitalJakartaIndonesia Department of Forensic Medicine and Medicolegal Studies Dr.Cipto Mangunkusumo General HospitalFaculty of Medicine Universitas IndonesiaJakartaIndonesia Department of Internal Medicine Dr.Cipto Mangunkusumo General HospitalFaculty of Medicine Universitas IndonesiaJakartaIndonesia Department of Medical Education Faculty of Medicine Universitas IndonesiaJakartaIndonesia Department of Community Medicine Faculty of Medicine Universitas IndonesiaJakartaIndonesia

Introduction: Expert opinions presented in legal proceedings should be scientifically accountable, which is known as evidence-based practice (EBP). Although forensic medical expert opinions are essential in legal proceedings, the methods used to formulate them are not always evidence based or based on standard methods. In forensic medicine, EBP has not been explicitly applied, including in Indonesia. One potential approach to formulate evidence-based expert opinions is called INtegration of Forensic Epidemiology and the Rigorous EvaluatioN of Causation Elements (INFERENCE). In addition, there is also no universal guideline for making forensic pathological reports. One prospective guideline is named the Principles of Evidence-based Reporting in FORensic Medicine-Pathology version (PERFORM-P). Methods: This article describes the validation process of INFERENCE and PERFORM-P in Indonesia. This study uses a mixed method through three interrelated phases, i.e., (1) a cross-sectional survey to determine the characteristics of Indonesian forensic doctors and their current practice, (2) the adaptation and validation process of the two tools through a review by the Indonesian College of Forensic Medicine, and (3) a one-group pre-postintervention study to assess the validity and reliability of forensic medical expert opinions formulated using Indonesian-INFERENCE (i-INFERENCE) and reported using Indonesian-PERFORM-P (i-PERFORM-P). Results and Discussion: In general, both tools received a positive reception and can potentially be used in the Indonesian setting with some additions/clarifications in the user manuals. Participants envision that both tools will be most useful in complex cases. Conclusions: By obtaining the i-INFERENCE and the i-PERFORM-P, it is hoped that Indonesian forensic medical doctors are better equipped in analyzing and reporting complex cases, and the implementation of EBP can be improved.

关键词： Evidence-based practice forensic medicine forensic pathology INFERENCE Principles of Evidence-based Reporting in FORensic Medicine-Pathology version

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Testing and numerical simulation of a medium strength rock material under unconfined compression loading

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 197-211页

作者： aria Mardalizad Riccardo Scazzosi Andrea Manes Marco Giglio Politecnico di Milano Department of Mechanical Engineering

This study aims to numerically and experimentally investigate the response of a medium strength rock material under unconfined compression loading up to failure. The unconfined compressive strength(UCS) is one of the most important parameters in characterising rock material behaviour. Hence the UCS is crucial in understanding the failure mechanism of fractured rocks. An effective approach to determine the UCS and to investigate the behaviours of rock materials under unconfined compression is essential in the majority of research fields of rock mechanics. The experimental configuration for the unconfined compression test, suggested by the protocols of the ASTM standard, has some limitations which affect the accuracy in determination of the real UCS. Among several alternative configurations proposed, the Mogi’s configuration seems to be the most appropriate one. Therefore, the ASTM and Mogi’s configurations were used to perform the tests on a medium strength rock material, i.e. Pietra Serena sandstone. The results using two configurations were discussed in terms of the differences. The tests were also replicated in LSDYNA using a finite element method(FEM) coupled smooth particle hydrodynamics(SPH) *** technique is employed in this study due to its capabilities to cope with large deformation issues related to the rocks. An advanced material model, called the Karagozian and Case Concrete(KCC) model,is implemented in the numerical simulations. The KCC model consists of three independent fixed failure surfaces and it can consider the damage accumulation based on the current state of stress among these failure surfaces. An equation-of-state(EOS) is used in conjunction with KCC material model for decoupling the volumetric and deviatoric responses. The numerical and experimental results were finally compared with the focus on the stress-strain diagram and the failure patterns. The comparison shows that the numerical results are in good agreement with the experime

关键词： Pietra Serena sandstone Unconfined compression Mogi's configuration Karagozian and Case Concrete(KCC) model Finite element method(FEM) Smooth particle hydrodynamics(SPH)

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Investigation of mechanical behaviour of a quasi-brittle material using Karagozian and Case concrete (KCC) model

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第6期11卷 1119-1137页

作者： aria Mardalizad Marco Caruso Andrea Manes Marco Giglio Politecnico di Milano Department of Mechanical EngineeringMilanItaly Politecnico di Milano Material Testing LaboratoryMilanItaly

The mechanical behaviour of a quasi-brittle material,*** Serena sandstone,was investigated both numerically and experimentally in order to build a reliable numerical modelling system applicable to more complex *** Karagozian and Case concrete(KCC)model was exploited as the material constitutive law and a new method to utilise this model for efficient and accurate simulation of quasibrittle materials is *** capability of this model is evaluated by comparing the results of the numerical simulations with the corresponding experimental results,and the method itself is critically assessed.

关键词： Finite element method (FEM) Triaxial compression test Brazilian disc test Quasi-brittle behaviour Karagozian and Case concrete (KCC) model

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Tribology in metal forming at elevated temperatures

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Friction 2015年第1期3卷 1-27页

作者： Kuniaki DOHDA Christine BOHER Farhad REZAI-aria Numpon MAHAYOTSANUN Department of Mechanical Engineering Northwestern University2145 Sheridan RoadEvanstonIL 60208-3111USA Universitéde Toulouse Mines AlbiICA(Institut Clément Ader)Campus JarlardF-81013 Albi cedex 09France Department of Mechanical Engineering Faculty of EngineeringKhon Kaen University123 Moo 16 Mittraphap RoadNai-MuangMuang DistrictKhon Kaen40002Thailand

The tribo-characteristics of metal forming at high temperatures have not yet been well understood due to the complex nature of thermal,microstructural,interaction,and process *** is a review paper on the effects of temperature,coating,and lubrication to the tribological characteristics in hot forming as well as the tribometers for different metal forming processes at elevated temperatures mainly based on the experimental *** tribological behaviors of oxides in hot forming,such as rolling and stamping,were reviewed and *** commonly used surface coatings and lubricants in hot forming were *** types of tribometer were selected and presented and some of them provided a great potential to characterize friction and wear at elevated ***,more testing conditions should be further investigated by developing new ***,experimental results obtained from reliable tribometers could be used in theory and model developments for different forming processes and materials at high *** review also showed the great potential in further investigations and innovation in tribology.

关键词： elevated temperature hot forming oxidation tribometer tribology

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