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Investigation of micro-scale shear response of sand–rubber granule mixture in terms of particle shape and grain scale deformability effects

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Particuology 2024年第7期90卷 452-469页

作者： Abdulmuttalip ari Suat Akbulut Department of Civil Engineering Yildiz Technical UniversityIstanbul34220Turkey

In this study,the effects of particle shape of rigid sand and soft rubber materials on macro-scale shear response were reasoned based on micro-scale *** this purpose,first,the shape properties of three different sand and two different rubber samples were quantified using image processing techniques,and the contact model parameters were calibrated through physical *** direct shear test was simulated in a two-dimensional discrete element software with realistic particle *** soft nature of rubber particles was reflected using body-centered cubic packing with a linear-parallel bond contact *** a result,coordination number,distribution of contact forces(i.e.,strong contact,and fabric anisotropy),and contact sliding were derived by the numerical *** has been observed that the particle shape leads to distinctive micro-scale responses due to the variations in the stiffness of the contacts.

关键词： Particle shape Sand Rubber Shear response Micro-scale response Discrete element method

Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality

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Neural Regeneration Research 2023年第3期18卷 497-502页

作者： Yulia Mitiagin ari Barzilai Department of Neurobiology the School of NeurobiologyBiophysicsMolecular Biology and BiochemistryGeorge S.WiseFaculty of Life SciencesTel Aviv UniversityTel AvivIsrael Sagol School of Neurosciences Tel Aviv UniversityTel AvivIsrael

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic ***,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still *** this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar *** addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular *** discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox ***,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.

关键词： ataxia telangiectasia ATM cerebellum DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks

Mechanisms of action of BCL6 during germinal center B cell development

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Science China(Life Sciences) 2015年第12期58卷 1226-1232页

作者： HUANG ChuanXin MELNICK ari Shanghai Institute of Immunology & Department of Immunobiology and Microbiology Shanghai Jiao Tong University School of Medicine Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medical College

The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.

关键词： BCL6 germinal center co-repressor lymphoma

New Relationship for Estimation of Wave Overtopping on Vertical Walls

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China Ocean Engineering 2017年第1期31卷 48-54页

作者： ESKAND ari Hojjatollah KAMALIAN Ulrich Reza Coastal Engineering Group University of Qom Qom *** Iran

Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation of overtopping rate, the experimental data available in the database CLASH were used. The dimensionless overtopping rate was estimated in terms of conventional dimensionless parameters including the relative crest freeboard Rc/Hs, seabed slope tanθ, deep water wave steepness S（om）, surf similarity ξ（om） and local relative water depth ht/Hs. The accuracy of the new model was compared with other existing models and also evaluated with some field measurements. The results indicated that the model presented in this paper is more accurate than other existing models. With statistical parameters, it is shown that the accuracy of predictions in the new model is better than that of other models.

关键词： similarity dimensionless precise Walls crest formulae trained coastal separate correction

Further Bounds for Hardy Type Differences

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Acta Mathematica Sinica,English Series 2012年第6期28卷 1091-1102页

作者： Kristina KRULI Josip PEari Dora POKAZ Faculty of Textile Technology University of Zagreb Faculty of Civil Engineering University of Zagreb

In this paper we define a functional as a difference between the right-hand side and lefthand side of the refined Boas type inequality using the notation of superquadratic and subquadratic functions and study its properties, such as exponential and logarithmic convexity. We also, state and prove improvements and reverses of new weighted Boas type inequalities. As a special case of our result we obtain improvements and reverses of the Hardy inequality and its dual inequality. We introduce new Cauchy type mean and prove monotonicity property of this mean.

关键词： Inequalities Boas inequality superquadratic function subquadratic function

Turning in mid-air allows aphids that flee the plant to avoid reaching the risky ground

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Integrative Zoology 2017年第5期12卷 409-420页

作者： Yonatan MERESMAN Matan BEN-ari Moshe INBAR Department of Evolutionary and Environmental Biology University of HaifaHaifaIsrael Department of Zoology Faculty of Life SciencesTel-Aviv UniversityTel-AvivIsrael

When forced to drop from the plant,flightless arboreal insects can avoid reaching the risky ground by maneuvering their body through the *** wingless pea aphids(Acyrthosiphon pisum)are threatened by natural enemies,they often drop off their host plant while assuming a stereotypic posture that rotates them in mid-air,aligning them with their feet pointing *** position may increase their chances of re-clinging onto lower plant parts and avoid facing the dangers on the ground,although its effectiveness in realistic field conditions has not been *** performed both laboratory and outdoor experiments,in which we dropped aphids upon host plants to quantify clinging success in plants with different characteristics such as height and leaf *** aphids had twofold higher clinging rates than dead ones,indicating that clinging success is indeed affected by the active aerial-righting of dropping *** ability to cling was positively dependent on the plants’foliage cover as viewed in vertical direction from ***,we released aphids in commercial alfalfa(Medicago sativa)fields with varying plant heights and foliage cover and induced them to ***(up to 75%)of the aphids avoided reaching the ground in taller plants(65 cm),and 17%in shorter plants(21 cm),demonstrating the efficiency of the aphids’response in averting risks:both those of an approaching enemy on the plant and the plethora of new risks on the ***,even in complex field environment,the aerial-righting mechanism can substantially reduce the possible risks following escape from a predator.

关键词： Acyrthosiphon pisum aerial righting dropping response escape behavior predator avoidance

Speaker adapted dynamic lexicons containing phonetic deviations of words

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1461-1475页

作者： Bahram VAZIRNEZHAD Farshad ALMASGANJ Seyed Mohammad AHADI ari CHANEN Biomedical Engineering Department Amirkabir University of Technology Language and Knowledge Management Research Lab School of Information TechnologiesUniversity of Sydney Electrical Engineering Department Amirkabir University of Technology

Speaker variability is an important source of speech variations which makes continuous speech recognition a difficult *** automatic speech recognition(ASR) models to the speaker variations is a well-known strategy to cope with the *** all such techniques focus on developing adaptation solutions within the acoustic models of the ASR *** variations of the acoustic features constitute an important portion of the inter-speaker variations,they do not cover variations at the phonetic *** variations are known to form an important part of variations which are influenced by both micro-segmental and suprasegmental ***-speaker phonetic variations are influenced by the structure and anatomy of a speaker's articulatory system and also his/her speaking style which is driven by many speaker background characteristics such as accent,gender,age,socioeconomic and educational *** effect of inter-speaker variations in the feature space may cause explicit phone recognition *** errors can be compensated later by having appropriate pronunciation variants for the lexicon entries which consider likely phone misclassifications besides *** this paper,we introduce speaker adaptive dynamic pronunciation models,which generate different lexicons for various speaker clusters and different ranges of speech *** models are hybrids of speaker adapted contextual rules and dynamic generalized decision trees,which take into account word phonological structures,rate of speech,unigram probabilities and stress to generate pronunciation variants of *** the set of speaker adapted dynamic lexicons in a Farsi(Persian) continuous speech recognition task results in word error rate reductions of as much as 10.1% in a speaker-dependent scenario and 7.4% in a speaker-independent scenario.

关键词： Pronunciation models Continuous speech recognition lexicon adaptation

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 155-165页

作者： Natalie Kaminsky Ofer Bihari Sivan Kanner ari Barzilai Department of Neurobiology George S.WiseFaculty of Life SciencesTel Aviv University Sagol School of Neuroscience Tel Aviv University

The DNA damage response（DDR） is a complex biological system activated by different types of DNA *** in certain components of the DDR machinery can lead to genomic instability disorders that culminate in tissue degeneration,premature aging,and various types of ***,malfunctioning DDR plays a role in the etiology of late onset brain degenerative disorders such as Parkinson＇s,Alzheimer＇s,and Huntington＇s *** many years,brain degenerative disorders were thought to result from aberrant neural *** we discuss the evidence that supports our novel hypothesis that brain degenerative diseases involve dysfunction of glial cells（astrocytes,microglia,and oligodendrocytes）.Impairment in the functionality of glial cells results in pathological neuro-glial interactions that,in turn,generate a ‘‘hostile＂ environment that impairs the functionality of neuronal *** events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit.

关键词： DNA damage response Genomic instability Brain degenerative diseases Glial cells Astrocytes Microglia

Upgrading process of palm empty fruit bunches as alternative solid fuel: a review

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Clean Energy 2023年第6期7卷 1173-1188页

作者： Toto Hardianto ari Akbariyanto Wenas Firman Bagja Juangsa Energy Conversion Research Group Faculty of Mechanical and Aerospace EngineeringInstitut Teknologi BandungWest JavaIndonesia Research Center for New and Renewable Energy Institut Teknologi BandungWest JavaIndonesia Mechanical Engineering Study Program Faculty of Mechanical and Aerospace EngineeringInstitut Teknologi BandungWest JavaIndonesia

A total of 37.5 million tons of palm empty fruit bunches(EFBs)produced in Indonesia in 2018 have the potential to be used as an alternative eco-friendly solid ***,a pretreatment process is necessary to increase the heating value and reduce the po-tassium content of *** methods can be employed to improve the characteristics of EFBs as a solid fuel,such as drying and torrefaction to increase the heating value and the leaching process for reducing the potassium content of *** main concept of increasing the heating value is to increase the fuel content,which is *** drying,the carbon ratio can be increased by reducing the moisture content and,through torrefaction,the carbon ratio could be increased due to the decomposition of ligno-cellulose.A simple way to reduce the potassium content of EFBs is the leaching *** types of leaching treatment have been studied before:soaking and stirring *** study reviews those methods to make EFBs more suitable as a solid fuel with a high heating value and less potassium *** the carbon content in EFBs is crucial for enhancing their heating value as a *** and torrefaction decrease the moisture content and modify the chemical structure,resulting in higher carbon *** leaching process effectively reduces the potassium content of EFBs and stirring treatment is more effective than immersion *** positively affects leaching by decreasing the potassium content,while hydrophobicity may hinder leaching by re-pelling *** high moisture content of leached EFBs requires additional energy for evaporation during torrefaction,resulting in a lower energy density yield compared with raw *** may also be required to account for the decreased mineral content,which functions as a torrefaction catalyst in EFBs that have not been leached.

关键词： biomass EFB solid fuel torrefaction upgrading