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Possible Application of the Medicinal Plant Hyoscyamus albus in Phytoremediation: Excess Copper Compensates for Iron Deficiency, Depending on the Light Conditions

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American Journal of Plant Sciences 2014年第26期5卷 3812-3822页

作者： Noriko Tamari Akemi Mine ari sako Seiya Tamagawa Yasuhiro Tabira Yoshie Kitamura Graduate School of Science and Technology Nagasaki University Nagasaki Japan Faculty of Environmental Studies Nagasaki University Nagasaki Japan Graduate School of Fisheries and Environmental Studies Nagasaki University Nagasaki Japan Environmental Management Center Nagasaki University Nagasaki Japan

Seedlings of the medicinal plant Hyoscyamus albus were supplied with an excess of Cu to examine the possible application in phytoremediation. The seedlings were cultured in B5 medium supplied with basal 0.1 μM Cu and 200 μM Cu under various light conditions: short day (SD);long day (LD);and continuous light (CL). In addition, the effect of supplying 200 μM Cu under Fe deficiency was determined, in order to elucidate the interaction between Cu and Fe. Interestingly, Fe-deficiency symptoms that developed in plants grown with basic levels of Cu under LD almost disappeared when excess Cu was supplied. Plant growth mainly depended on the photo irradiation period (SD < LD^CL);and 200 μM Cu did not inhibit growth at all when Fe was available, whereas in the absence of Fe, CL caused damage to growth. Analysis of the Cu and Fe contents of the plants revealed that Cu was distributed equally in both the aerial parts and roots, whereas most of the Fe was found in the roots;under Fe deficiency, Cu accumulation in the roots apparently increased. Cu was mainly distributed in the soluble fraction, which included vacuoles and the cell-wall fraction. These results provide evidence indicating that H. albus seedlings are tolerant of Cu present in excess. Furthermore, excess Cu was able to compensate for Fe deficiency, depending on the light conditions. Continuous light inhibited this effect, probably as a result of the induction of Mn deficiency. The possible applications of this newly discovered cuprophyte are discussed.

关键词： Copper Accumulator Medicinal Plant Hyoscyamus albus

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Investigation of micro-scale shear response of sand–rubber granule mixture in terms of particle shape and grain scale deformability effects

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Particuology 2024年第7期90卷 452-469页

作者： Abdulmuttalip ari Suat Akbulut Department of Civil Engineering Yildiz Technical UniversityIstanbul34220Turkey

In this study,the effects of particle shape of rigid sand and soft rubber materials on macro-scale shear response were reasoned based on micro-scale *** this purpose,first,the shape properties of three different sand and two different rubber samples were quantified using image processing techniques,and the contact model parameters were calibrated through physical *** direct shear test was simulated in a two-dimensional discrete element software with realistic particle *** soft nature of rubber particles was reflected using body-centered cubic packing with a linear-parallel bond contact *** a result,coordination number,distribution of contact forces(i.e.,strong contact,and fabric anisotropy),and contact sliding were derived by the numerical *** has been observed that the particle shape leads to distinctive micro-scale responses due to the variations in the stiffness of the contacts.

关键词： Particle shape Sand Rubber Shear response Micro-scale response Discrete element method

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Ophthalmic exam and ophthalmology residents’ subspecialty preference

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 359-364页

作者： ari Leshno Daf Shalev Daphna Landau Prat Goldschleger Eye Institute Sheba Medical CenterTel Hashomer 5262000Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel Department of Ophthalmology Edith Wolfson Medical CenterHolon 5822012Israel

AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career ***:This is a cross-sectional study.A questionnaire on the perception of the ophthalmic exam was sent via SurveyMonkey to ophthalmology residents throughout *** of them(one-half of all ophthalmology residents in 2019)completed *** first part related to how they perceived each component of the ophthalmic *** second part related to their future fellowship *** Chi-squared test was used to compare categorical variables and Student’s t-test and One-way ANOVA were used to compare continuous *** logistic regression analysis was applied as needed to detect interactions between variables and to exclude confounder ***:Slit-lamp examination of the anterior and posterior segments ranked as the most likeable aspects,whereas gonioscopy,ocular motility examination and visual acuity assessment were least *** segment and retina subspecialties were the ones most sought ***-nine respondents(61.3%)noted a direct correlation between their preferred parts of comprehensive ophthalmic evaluations and their choice of *** of selected components of those evaluations were significantly associated with responders’intentions to pursue anterior segment,retina,or oculoplastic fellowships(P<0.05).CONCLUSION:Perspectives of residents toward the ophthalmic examination,and most specifically its individual components,play an important role in their choice of subspecialty training.

关键词： residency subspecialty ophthalmic examination career choice ophthalmology

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Assessment of corrected time-step method for nominal ionospheric gradient calculation: A comparative analysis with spatial approaches

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Earth and Planetary Physics 2024年第4期8卷 641-649页

作者： Slamet Supriadi Prayitno Abadi Susumu Saito Harry Bangkit Dwiko Unggul Prabowo Adi Purwono Ginaldi ari Nugroho Research Center for Smart Mechatronics National Research and Innovation Agency(BRIN)BandungIndonesia Research Center for Climate and Atmosphere BRINBandungIndonesia School of Electrical Engineering Telkom UniversityKab.BandungIndonesia Electronic Navigation Research Institute National Institute of MaritimePort and Aviation TechnologyTokyoJapan Research Center for Space BRINBandungIndonesia

The effect of ionospheric delay on the ground-based augmentation system under normal conditions can be mitigated by determining the value of the nominal ionospheric gradient(σvig).The nominal ionospheric gradient is generally obtained from Continuously Operating Reference Stations data by using the spatial single-difference method(mixed-pair,station-pair,or satellite-pair)or the temporal single-difference method(time-step).The time-step method uses only a single receiver,but it still contains ionospheric temporal *** introduce a corrected time-step method using a fixed-ionospheric pierce point from the geostationary equatorial orbit satellite and test it through simulations based on the global ionospheric *** also investigate the effect of satellite paths on the corrected time-step method in the region of the equator,which tends to be in a more north–south direction and to have less coverage for the east–west ionospheric *** study also addresses the limitations of temporal variation correction coverage and recommends using only the correction from *** processes are developed under simulations because observational data are still difficult to *** findings demonstrate that the corrected time-step method yieldsσvig values consistent with other approaches.

关键词： ground-based augmentation system nominal ionospheric gradient time-step correction global ionospheric model

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协同创新模式、网络嵌入与协同创新绩效:中国自动驾驶汽车产业fsQCA研究

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科技进步与对策 2024年

作者：周菲刘颖琦 ari Kokko 北京交通大学经济管理学院哥本哈根商学院国际经济政府与商业系

自动驾驶汽车在推动全球汽车产业颠覆性变革的同时,其技术前沿性、复杂性、跨学科性等特征使得跨界融合和协同创新成为带动产业发展的必然选择,而协同创新模式高度影响协同创新效果。利用专利工具和社会网络分析法,结合自动驾驶协同创... 详细信息

自动驾驶汽车在推动全球汽车产业颠覆性变革的同时,其技术前沿性、复杂性、跨学科性等特征使得跨界融合和协同创新成为带动产业发展的必然选择,而协同创新模式高度影响协同创新效果。利用专利工具和社会网络分析法,结合自动驾驶协同创新网络创新主体类型及其合作关系,将中国自动驾驶汽车产业协同创新模式划分为四大类:亲缘型、地缘型、业缘型和混合型。同时,不同协同创新网络存在不同的网络嵌入特征,与协同创新模式共同影响协同创新绩效。为研究不同自动驾驶产业协同创新模式和网络嵌入特征组态匹配对协同创新绩效的影响,利用fsQCA方法进行实证检验。研究发现:可将实现自动驾驶汽车产业高协同创新绩效和低协同创新绩效的协同创新模式分别概括为4类,其中亲缘型和亲缘地缘混合型协同创新模式对于自动驾驶汽车产业协同创新影响最大,且目前业缘型模式难以产生较高的协同创新绩效,而低协同创新绩效路径存在业缘关系占比较高等显著特征。基于此,对自动驾驶汽车产业协同创新发展提出4点建议。

关键词：自动驾驶汽车协同创新网络嵌入 fsQCA

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3D micro-devices for enhancing the lateral resolution in optical microscopy

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Light(Advanced Manufacturing) 2024年第2期5卷 50-63页

作者： Gordon Zyla Goran Maconi Anton Nolvi Jan Marx Dimitra Ladika ari Salmi Vasileia Melissinaki Ivan Kassamakov Maria Farsari Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklionGreece Electronics Research Laboratory Department of PhysicsUniversity of HelsinkiHelsinkiFinland Applied Laser Technologies Ruhr University BochumBochumGermany

Although optical microscopy is a widely used technique across various multidisciplinary fields for inspecting small-scale objects,surfaces or organisms,it faces a significant limitation:the lateral resolution of optical microscopes is fundamentally constrained by light *** micro-spheres,however,offer a promising solution to this issue as they are capable of significantly enhancing lateral resolution through extraordinary phenomena,such as a photonic *** upon the potential of dielectric micro-spheres,this paper introduces a novel approach for fabricating 3D micro-devices designed to enhance lateral resolution in optical *** proposed 3D micro-device comprises a modified coverslip and a micro-sphere,facilitating easy handling and integration into any existing optical *** manufacture the device,two advanced femtosecond laser techniques are employed:femtosecond laser ablation and multi-photon *** laser ablation was employed to create a micro-hole in the coverslip,which allows light to be focused through this ***-photon lithography was used to fabricate a micro-sphere with a diameter of 20μm,along with a cantilever that positions the above the processed micro-hole and connect it with the *** this context,advanced processing strategies for multi-photon lithography to produce a micro-sphere with superior surface roughness and almost perfect geometry(λ/8)from a Zr-based hybrid photoresist are *** performance of the micro-device was evaluated using Mirau-type coherence scanning interferometry in conjunction with white light illumination at a central wavelength of 600 nm and a calibration grid(Λ=0.28μm,h>50 nm).Here,the 3D micro-device proved to be capable of enhancing lateral resolution beyond the limits achievable with conventional lenses or microscope objectives when used in ***,it maintained the high axial resolution characteristic of Mirau-type coherenc

关键词： Photonic nanojet Multi-photon lithography Optical microscopy Micro-optics Multi-photon grayscale lithography Extreme manufacturing

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数字支付垄断中的银行竞争与家庭隐私

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新金融 2024年第3期 36-43页

作者： Itai Agur Anil ari Giovanni Dell'ariccia 李丽丽(翻译) 周正铭(翻译) 国际货币基金组织不详

贷款人可以利用家庭的支付数据来推断他们的信誉。当家庭重视隐私时,他们就会在保护隐私和信贷条件之间做出权衡。本文研究了引入更具信息入侵性的数字支付工具是如何对家庭的现金使用、信贷获取和福利产生影响,以及私人和社会最优是如... 详细信息

贷款人可以利用家庭的支付数据来推断他们的信誉。当家庭重视隐私时,他们就会在保护隐私和信贷条件之间做出权衡。本文研究了引入更具信息入侵性的数字支付工具是如何对家庭的现金使用、信贷获取和福利产生影响,以及私人和社会最优是如何分化的。新技术正在从根本上改变支付和信贷提供的方式,并为数据垄断创造了前所未有的空间。技术垄断者控制着新支付方式的入侵性,操纵家庭和寡头垄断银行之间的信息不对称,以获取比自己放贷更有利可图的数据合同。自由放任的均衡需要一种比最优状态更具入侵性的数字支付工具,为监管提供窗口。本刊编译此篇国际货币基金组织的工作论文,以期为读者带来启示。

关键词：数字支付家庭隐私金融中介大数据数据监管

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遥遥领先！超越西方数百年的中国古代数学

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环球人文地理 2024年第11期 100-103页

作者：汪洋 ari 摄影师Sean Wikipedia 摄图网

以盈补虚、因木望山、幻方、珠算、隙积术……华夏沃土不仅绽放着多彩的文化之花，也厚植了无数启迪心智的智慧之树。我们的祖先在长期生产劳动中掌握了丰富且实用的数学知识，应用在天文历法、土地测量、买卖交易、器物制作与织绣纹样...

以盈补虚、因木望山、幻方、珠算、隙积术……华夏沃土不仅绽放着多彩的文化之花，也厚植了无数启迪心智的智慧之树。我们的祖先在长期生产劳动中掌握了丰富且实用的数学知识，应用在天文历法、土地测量、买卖交易、器物制作与织绣纹样等领域，不仅解决了许多生存与生活难题，也在世界数学史上留下瞩目成就。

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Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality

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Neural Regeneration Research 2023年第3期18卷 497-502页

作者： Yulia Mitiagin ari Barzilai Department of Neurobiology the School of NeurobiologyBiophysicsMolecular Biology and BiochemistryGeorge S.WiseFaculty of Life SciencesTel Aviv UniversityTel AvivIsrael Sagol School of Neurosciences Tel Aviv UniversityTel AvivIsrael

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic ***,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still *** this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar *** addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular *** discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox ***,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.

关键词： ataxia telangiectasia ATM cerebellum DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks

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Mechanisms of action of BCL6 during germinal center B cell development

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Science China(Life Sciences) 2015年第12期58卷 1226-1232页

作者： HUANG ChuanXin MELNICK ari Shanghai Institute of Immunology & Department of Immunobiology and Microbiology Shanghai Jiao Tong University School of Medicine Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medical College

The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.

关键词： BCL6 germinal center co-repressor lymphoma

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