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Plant type effect overweighs seasonal variation in n-alkanoic acid biomarker on regional Loess Plateau of China

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science China Earth sciences 2024年第8期67卷 2547-2562页

作者： Jinzhao LIU s.Nemiah LADD Jiaju ZHAO Dongna YAN Ding HE Yunning CAO Zhisheng AN state Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China CAs Center for Excellence in Quaternary science and Global Change Xi’an 710061China Department of Environmental sciences University of BaselBasel 4056Switzerland Department of Ocean science and Center for Ocean Research in Hong Kong and Macao The Hong Kong University of Science and TechnologyHong Kong 999077China

The effect of plant type on n-alkane biomarker has been widely studied,but the influence of plant type on n-alkanoic acids(n-fas)has received less *** the effect of the distribution of n-fas and their hydrogen isotope composition(δ^(2)H_(FA))is critical for interpreting sedimentaryδ^(2)H_(FA)values as proxies of hydroclimate and/or vegetation *** this study,we systematically investigated the distribution ofn-fas andδ^(2)H_(FA)values across seasons on the Chinese Loess Plateau(CLP).Our results showed that there were no significant seasonal differences in n-fas distribution andδ^(2)H_(FA)values,but there were significant differences inδ^(2)H_(FA)values across plant ***δ^(2)H_(FA)values ranged from-185‰to-125‰in dicots(-161‰±28‰),and from-215‰to-170‰in monocots(-196‰±22‰)on the *** fractionation betweenδ^(2)H_(FA)values and precipitationδ^(2)H(ε_(FA-P))was also^(2)H-enriched in dicots relative to *** the regional scale of the CLP,δ^(2)H_(FA)values were not correlated withδ^(2)H values of ***,δ^(2)H_(FA)values from the CLP were similar to expectations from a global comparison,both in terms of their mean values and high variability among plants growing in sites with similarδ^(2)H values of *** some of this variability inεFA-Pis due to the effect of plant type,a careful assessment of the likely sources of waxes in terrestrial sediments is critical when usingδ^(2)H_(FA)values for paleohydroclimate reconstruction.

关键词： n-Alkanoic acid Hydrogen isotope Plant type Paleohydroclimate Chinese Loess Plateau

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幻想空间——优等生

大众软件 2004年第15期 124-125页

作者： fas 北京

如今，冒险类游戏的景况颇为不好，它们似乎已经被大多数玩家淡忘了。尽管如此，提起雪乐山（sisrra Entertainment)的《幻想空间》系列，也和《神秘岛》（Myst）系列和《国王密使》（King‘s Quest）系列一样，足以在经典冒险游戏中占... 详细信息

如今，冒险类游戏的景况颇为不好，它们似乎已经被大多数玩家淡忘了。尽管如此，提起雪乐山（sisrra Entertainment)的《幻想空间》系列，也和《神秘岛》（Myst）系列和《国王密使》（King‘s Quest）系列一样，足以在经典冒险游戏中占有一定地位，能够唤起玩家心中的美好回忆。记得当初《幻想空间》系列推出第一款游戏《幻想空间——休闲蜥蜴之地》（Leisure suit Larry1:In the Land of the Lounge Lizards)时，玩家便对这个游戏史上最为古怪精灵的家伙之——拉瑞的种种幽默出轨的举动张开了双臂。

关键词：冒险类游戏《幻想空间》系列《优等生》游戏介绍游戏背景

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哥特王朝3 Gothic3

大众软件 2006年第4期 119-120页

作者： fas 北京

如果说起欧美角色扮演游戏，相信大家马上想到的就是《暗黑破坏神》系列（Diablo）、《博德之门》系列（Baldur＇s Gate 11）以及《上古卷轴》系列（Elder scrolls）。这些经典之作无论何时拿来重玩，都能给人带来无穷的游戏乐趣。

关键词：角色扮演游戏《暗黑破坏神》网络游戏《上古卷轴》

幽灵行动3——先锋战士 Tom Clancy＇s Ghost Recon Advanced Warfighter

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大众软件 2005年第21期 130-131页

作者： fas 北京

熟悉“汤姆·克莱西”系列游戏的玩家都知道，该系列游戏着重强调战斗的真实性而非战斗的激烈性，它能让喜好军事行动的玩家从中获得很多现实生活中无法感受到的真实体验，战争不是慢节怕的事情，也不是能被周密计划的。有鉴于此。在“... 详细信息

熟悉“汤姆·克莱西”系列游戏的玩家都知道，该系列游戏着重强调战斗的真实性而非战斗的激烈性，它能让喜好军事行动的玩家从中获得很多现实生活中无法感受到的真实体验，战争不是慢节怕的事情，也不是能被周密计划的。有鉴于此。在“汤姆·克莱西”系列新近推出的一些游戏中，我们可看出战斗的真实模拟化和动作电影中的紧张刺激元素正在逐渐结合到一起，但紧密程序似乎还有所欠缺。

关键词：《幽灵行动3》军事行动战斗游戏网络游戏

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Brabanthallen综合体

世界建筑导报 2010年第3期25卷 60-61页

作者： fas keuzenkamp jannes linders

地点：荷兰diezekade 2＇s-hertogenbosch业主：maatschappij tot exploitatie van industriegebouwen‘s-hertogenbosch面积：总面积28,900m2;新建筑16,525m2;改建3,443m2;整修8,932m2完工：2005年该项目是对曾经是欧洲最大的牲畜市场大厅进行彻底的结构调整、恢复、以及扩建。现在,部分Brabanthallen已经上了保护建筑的名单,大厅完全定位为贸易展览会、集会和其他活动的场所。最初,这项工作只涉及几个大厅的整修,但随着制订一个发展计划,

关键词：综合体贸易展览会结构调整保护建筑 tot van 新建筑大厅

High Resolution MR Angiography of the Posterior Cerebral Circulation: Variants, Incidence and Clinical Impact

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Open Journal of Radiology 2013年第4期3卷 209-214页

作者： argyro Mazioti Nikolaos Economopoulos Olympia Papakonstantinou Christina Kontopoulou Dimitrios Filippiadis Aristodimos Maratsos Nikolaos Kelekis Efthymia Alexopoulou 2nd Radiology Department General University Hospital “Attikon” Chaidari-Athens Greece

Objective: In the embryonic period, several developmental anomalies of the posterior cerebral circulation might occur. Digital subtractive angiography used to be the imaging technique of choice for the illustration of such variations. Nowadays, the development of MR imaging has led to a new entry in the diagnostic archer’s quivery, the MR an- giography, with which most of these variations may be diagnosed. Purpose of this study is to illustrate these anatomic variants, their incidence and their potential clinical significance. Materials and Methods: We retrospectively reviewed 282 MR angiographies performed in our institution, in order to assess the posterior cerebral circulation. The imaging findings (including both normal development and variations) were depicted. Results: In our study 61/282 (21.63%) MR angiographies were positive for imaging findings concerning variations of the vertebrobasilar system. These variations included abnormal origin of the vertebral artery (0.7%), unilateral aplasia or hypoplasia (8.86%), unilateral aplasia or hypoplasia of the distal part of the vertebral artery (3.85%), and unilateral or bilateral fetal posterior cerebral artery (7.7%). These results show that anatomic variations of the posterior cerebral circulation are not very uncommon in the population. Conclusion: High resolution Magnetic Resonance Angiography provides excellent interpretation of the vertebral arteries, allowing depiction of all anatomic variations. Knowing these anatomic variations is important, espe- cially for clinicians and patients planning a surgical operation or an interventional radiology technique. Furthermore, it contributes to avoiding potential diagnostic pitfalls or to explaining unusual acute vascular cerebral events.

关键词： MRA Vertebral Arteries Variants

Biology and Treatment of skeletal Manifestations in Multiple Myeloma

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Journal of Cancer Therapy 2014年第4期5卷 387-402页

作者： Nikolaos A. stavropoulos argyro Papadoyiannis Dimitris Maltezas Petros stavrou George C. Babis Panayiotis J. Papagelopoulos Gerasimos A. Pangalis Marie-Christine Kyrtsonis 1st Department of Orthopaedics Attikon University General Hospital University of Athens Medical School Haidari Athens Greece 2nd Department of Orthopaedics Konstantopouleio General Hospital N. Ionia University of Athens Medical School N. Ionia Athens Greece Hematology Clinic Athens Medical Center Psychiko Branch Psychiko Athens Greece Hematology section of First Department of Propedeutic Internal Medicine National and Kapodistrian University of Medicine Laikon University Hospital Athens Greece section of Internal Medicine General Hospital of Lakonia Sparti Greece spine Clinic American Medical Center Nicosia Cyprus

MM is frequently associated with the development of osteolytic bone lesions, osteoporosis and pathological fractures. Bone destruction in MM is caused by osteoclasts recruited in areas adjacent to myeloma plasma cells;their contact triggers both cell types to secrete soluble factors sustaining one each other’s activation and proliferation. Osteoclasts differentiate and maturate upon binding of the receptor activator of NF-kappaB ligand (RANKL), secreted by bone marrow microenvironmental cells, to its receptor (RANK) on osteoclast progenitors, while osteoprotegerin (OPG), a natural decoy receptor, can block the aforementioned ligation. At the same time osteoblasts are inactivated by the Wnt/β-catenin signaling pathway inhibitor, Dickkopf-1 protein (DKK-1), secreted by malignant plasma cells. Furthermore, DKK-1 deregulates the OPG/RANKL equilibrium, promoting osteoclastogenesis. Myeloma bone disease (MBD) can be treated with myeloma-directed chemotherapy and agents inhibiting bone resorption such as aminobisphosphonates, although new promising biology driven monoclonal antibodies targeting osteoclastogenesis mechanisms are emerging. Palliative MBD treatment includes analgesics, orthotics, radiation therapy, vertebroplasty and kyphoplasty. In case of spinal cord compression, radiation therapy or surgical decompression, should be instantly performed, along with steroid administration. surgery may also be an option especially in case of weight-bearing bone fractures. MBD is a morbid complication and should be carefully managed because it deteriorates patients’ quality of life and worsens disease outcome.

关键词： Multiple Myeloma skeletal Manifestations Biology Treatment

Automatic Liver Tumor segmentation in CT Modalities Using MAT-ACM

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Computer systems science & Engineering 2022年第12期43卷 1057-1068页

作者： s.Priyadarsini Carlos Andrés Tavera Romero Abolfazl Mehbodniya P.Vidya sagar sudhakar sengan Department of Computer science and Engineering P.S.R.Engineering CollegeSivakasiTamil Nadu626123India COMBA R&D Laboratory Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Department of Electronics and Communications Engineering Kuwait College of Science and TechnologyKuwait Department of Computer science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramAndhra Pradesh522502India Department of Computer science and Engineering PSN College of Engineering and TechnologyTirunelveliTamil Nadu627152India

In the recent days, the segmentation of Liver Tumor (LT) has beendemanding and challenging. The process of segmenting the liver and accuratelyspotting the tumor is demanding due to the diversity of shape, texture, and intensity of the liver image. The intensity similarities of the neighboring organs of theliver create difficulties during liver segmentation. The manual segmentation doesnot provide an accurate segmentation because the results provided by differentmedical experts can vary. Also, this manual technique requires a large numberof image slices and time for segmentation. To solve these issues, the Fully Automatic segmentation (fas) technique is proposed. In this proposed Multi-AngleTexture Active Contour Model (MAT-ACM) method, the input Computed Tomography (CT) image is preprocessed by Contrast Enhancement (CE) with Non-Linear Mapping Technique (NLMT), in which the liver is differentiated from itsneighbouring soft tissues with related strength. Then, the filtered images are givenas the input to Adaptive Edge Modeling (AEM) with Canny Edge Detection(CED) technique, which segments the Liver Region (LR) from the given CTimages. An AEM with a CED model is implemented, which increases the convergence speed of the iterative process for decreasing the Volumetric Overlap Error(VOE) is 6.92% rates when compared with the traditional segmentation Techniques (sT). Finally, the Liver Tumor segmentation (LTs) is developed by applyingthe MAT-ACM, which accurately segments the LR from the segmented LRs. Theevaluation of the proposed method is compared with the existing LTs methodsusing various performance measures to prove the superiority of the proposedMAT-ACM method.

关键词： Computed tomography contrast enhancement adaptive edge modeling multi-angle texture active contour liver tumor segmentation

EXPREssION OF FLIP IN HUMAN COLON CARCINOMAs: A NEW MECHANIsM OF IMMUNE EVAsION

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Chinese Journal of Cancer Research 2005年第3期17卷 193-198页

作者：邢宝才 s. Wimmenauer EH. Farthmann Department of surgery Peking University School of Oncology Beijing Cancer Hospital Beijing Institute for Cancer Research Department of surgery University Hospital of Freiburg

Objective： It has been proposed that fas ligand （fasL） may play an important role in immune escape of tumors and FLIP is an important mediator of fas/fasL pathway. In this study, the expression of FLIP was determined in human colon carcinoma cell lines and tissue to investigate the new mechanism of immune evasion of human colon carcinomas. Methods： RT-PCR and immunohistochemistry （IHC） were performed to investigate the expression of FLIP in human colon carcinoma cell lines sW480, Ls174 and twenty human primary colon carcinoma specimens. Results： It was shown that sW480 cells, Ls174 cells and primary colon carcinoma specimen constitutively expressed FLIP at the mRNA and protein level. The expression of FLIP was not found in the epithelial cells of normal colon mucosa. Conclusion： FLIP was expressed in human primary colon carcinoma specimens but not in the normal counterpart. It suggested that the expression of FLIP may occur during the malignant transformation from normal colon epithelial cells to colon carcinoma cells. Tumor cells might obtain the ability to resist the fas-mediated apoptosis by expressing FLIP. The expression of FLIP might contribute to the formation of colon carcinomas.

关键词： Colon carcinoma fas/fasL FLIP Immune evasion