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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw ali Khan Mohsin ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Can the Bass innovation diffusion model describe adsorption breakthrough curves of pharmaceutical contaminants?

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Green Chemical Engineering 2024年第2期5卷 145-149页

作者： Khim Hoong Chu Mohd ali Hashim Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

*** Fixed bed adsorption is a widely used separation process in the chemical industry for the processing of liquids and *** performance of fixed bed adsorption systems is often evaluated by analyzing the breakthrough curves,which represent the variation of the solute concentration in the effluent stream as a function of time or bed volume.

关键词： adsorption breakthrough curves

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Intelligent algorithm-based maximum power point tracker for an off-grid photovoltaic-powered direct-current irrigation system

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Clean Energy 2024年第3期8卷 48-61页

作者： Hussain Attia Maen Takruri ali Al-Ataby Department of Electrical Electronics and Communications EngineeringAmerican University of Ras Al KhaimahRas Al KhaimahUnited Arab Emirates

This research aims to enhance the performance of photovoltaic(PV)systems on a 2-fold ***,it introduces an advanced deep artificial neural network algorithm for accurate and fast maximum power point tracking,ensuring optimal extraction of electrical power from PV ***,it proposes the use of 96-V,2.98-kW direct-current(DC)water pumps for farm irrigation,aiming to improve efficiency,reduce cost and complexity,and overcome challenges associated with connecting faraway farm irrigation systems to the utility *** this study,it has been demonstrated that the use of DC pumps greatly improves system performance and efficiency by eliminating the need for isolation transformers,power passive filters and inverters,therefore simplifying the architecture of the *** efficacy of the proposed methodology is confirmed by MATLAB®/Simulink®simulation results,whereby the proposed algorithm attains a mean squared error of 6.5705×10^(-5)and a system efficiency approaching 99.8%,ensuring a steady voltage under varying load conditions.

关键词： artificial neural network photovoltaic arrays maximum power point tracking buck converter direct-current irrigation systems MATLAB/Simulink

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Winding Function Model-based Performance Evaluation of a PM Transverse Flux Generator for Applications in Direct-drive Systems

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 216-226页

作者： Mehrage Ghods Jawad Faiz ali A Pourmoosa IEEE School of Electrical and Computer Engineering College of Engineeringthe University of Tehran

The magnetic flux in a permanent magnet transverse flux generator(PMTFG) is three-dimensional(3D), therefore, its efficacy is evaluated using 3D magnetic field analysis. Although the 3D finite-element method(FEM) is highly accurate and reliable for machine simulation, it requires a long computation time, which is crucial when it is to be used in an iterative optimization process. Therefore, an alternative to 3DFEM is required as a rapid and accurate analytical technique. This paper presents an analytical model for PMTFG analysis using winding function method. To obtain the air gap MMF distribution, the excitation magneto-motive force(MMF) and the turn function are determined based on certain assumptions. The magnetizing inductance, flux density, and back-electro-magnetomotive force of the winding are then determined. To assess the accuracy of the proposed method, the analytically calculated parameters of the generator are compared to those obtained by a 3D-FEM. The presented method requires significantly shorter computation time than the 3D-FEM with comparable accuracy.

关键词： Index Terms—Permanent magnet transverse flux generator Winding function 3D-FEM Cogging torque Prototyping

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Green hydrogen energy production:current status and potential

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Clean Energy 2024年第2期8卷 1-7页

作者： ali O.M.Maka Mubbashar Mehmood The Libyan Centre for Research and Development of Saharian Communities MurzuqLibya School of Engineering and Physical Sciences Heriot-Watt UniversityEdinburghEH144ASUK

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen ***,by implementing this technique,hydrogen will become a sustainable and clean energy source by lowering greenhouse gas emissions and reducing our reliance on fossil *** key benefit of producing green hydrogen by utilizing green energy is that no harmful pollutants or greenhouse gases are directly released throughout the ***,to guarantee all of the environmental advantages,it is crucial to consider the entire hydrogen supply chain,involving storage,transportation and end *** is a promising clean energy source and targets plan pathways towards decarbonization and net-zero emissions by *** paper has highlighted the techniques for generating green hydrogen that are needed for a clean environment and sustainable energy ***,it summarizes an overview,outlook and energy transient of green hydrogen ***,its perspective provides new insights and research directions in order to accelerate the development and identify the potential of green hydrogen production.

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen

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Tubular Heat Enhancement Using Twisted Tape Inserts with Large Holes

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Energy Engineering 2024年第2期121卷 273-290页

作者： ali Jaber Abdulhamed Aws Al-Akam Wisam J.Khudhayer ali Sabri Allw Faculty of Engineering-Al-Mussayib University of BabylonHillaBabylon15001Iraq

Heat augmentation techniques play a vital role in the heating and cooling processes in industries,including solar collectors and many applications that utilize heat *** studies are based on inserting fillers inside the tubes to enhance heat *** investigation considered the effects of twisted tapes with large holes on a tubular heat exchanger’s(HX)heat transmission,pressure drop,and thermal boosting *** the experimental section,counter-swirl flow generators used twisted tapes with pairs of 1.0 cm-diameter holes and changes in porosity(Rp)at 1.30%and 2.70%.In the experiments,air was utilized as a working fluid in a tube with a circular *** turbulent flow was considered,with Reynolds numbers(Re)domain from 4800 to 9500,and a boundary condition with a uniform wall heat flux was *** findings expound that when the number of holes rose,the Nusselt number(Nu),the factor of friction(f),and the thermal enhancement factor(η)all increased as ***,as the friction factor increased,the Nusselt number of the tape-equipped tube was noticeably ***,it was discovered that the friction factor was between 70%and 94%lower than the values of the tube without tape,while the(Nu)was between 87%and 97%higher than the conventional tube *** maximum value ofηis 89%.According to the experimental results,empirical correlations for Nu,f,andηwere also generated.

关键词： Tubular heat exchanger tape inserts twisted tape

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Internet of Things Enabled DDoS Attack Detection Using Pigeon Inspired Optimization Algorithm with Deep Learning Approach

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Computers, Materials & Continua 2024年第9期80卷 4047-4064页

作者： Turki ali Alghamdi Saud S.Alotaibi Department of Computer Science and Artificial Intelligence College of ComputingUmm Al-Qura UniversityMakkah21955Saudi Arabia

Internet of Things(IoTs)provides better solutions in various fields,namely healthcare,smart transportation,home,*** Denial of Service(DoS)outbreaks in IoT platforms is significant in certifying the accessibility and integrity of IoT *** learning(DL)models outperform in detecting complex,non-linear relationships,allowing them to effectually severe slight deviations fromnormal IoT activities that may designate a DoS *** uninterrupted observation and real-time detection actions of DL participate in accurate and rapid detection,permitting proactive reduction events to be executed,hence securing the IoT network’s safety and ***,this study presents pigeon-inspired optimization with a DL-based attack detection and classification(PIODL-ADC)approach in an IoT *** PIODL-ADC approach implements a hyperparameter-tuned DL method for Distributed Denial-of-Service(DDoS)attack detection in an IoT ***,the PIODL-ADC model utilizes Z-score normalization to scale input data into a *** handling the convolutional and adaptive behaviors of IoT,the PIODL-ADCmodel employs the pigeon-inspired optimization(PIO)method for feature selection to detect the related features,considerably enhancing the recognition’s ***,the Elman Recurrent Neural Network(ERNN)model is utilized to recognize and classify DDoS ***,reptile search algorithm(RSA)based hyperparameter tuning is employed to improve the precision and robustness of the ERNN method.A series of investigational validations is made to ensure the accomplishment of the PIODL-ADC *** experimental outcome exhibited that the PIODL-ADC method shows greater accomplishment when related to existing models,with a maximum accuracy of 99.81%.

关键词： Internet of things denial of service deep learning reptile search algorithm feature selection

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Seasonal variations in dissolved organic matter concentration and composition in an outdoor system for bank filtration simulation

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Journal of Environmental Sciences 2024年第1期135卷 252-261页

作者： Muhammad Zeeshan Omamah ali Shamas Tabraiz Aki Sebastian Ruhl German Environment Agency Section II 3.3Schichauweg 5812307BerlinGermany Technische Universitat Berlin Water TreatmentKF4Str.des 17.Juni 13510623BerlinGermany Natural and Applied Sciences Section School of Psychology and Life SciencesCanterbury Christ Church UniversityCanterburyCT11QUUK

Dissolved organic matter(DOM)in surface waters can vary markedly in character depending on seasonal variations such as rainfall intensity,UV radiations and *** in DOM as well as temperature and rainfall intensity over the year can affect the biochemical processes occurring in bank filtration(BF).Identification and characterization of DOM in the surface water could help to optimize the water treatment and provide stable and safe drinking *** study investigated year-long variations of DOM concentrations and compositions in a surface water of a circulated outdoor pond(research facility)connected to a BF *** was dominated by humic substances and a changing pattern of DOM in surface water was observed throughout the year.A significant increase of DOM(~38%)in surface water was noted in August compared to *** fluorescent DOM showed that DOM in summer was enriched with the degradable fraction whilst non-degradable fraction was dominated in winter.A constant(1.7±0.1 mg/L)effluent DOM was recirculated in the system throughout the *** removal through BF varied between 4%to 39%and was achieved within a few meters after infiltration and significantly correlated with influent DOM concentration(R^(2)=0.82,p0.05)change in the removal of DOM was observed in two subsurface layers(upper and lower).This study highlights the presence of a constant non-degradable DOM in the bank filtrate,which was not affected by temperature,redox conditions and UV radiations.

关键词： Bank filtration Dissolved organic matter Dissolved oxygen Fluorescence spectroscopy Excitation-emission matrix

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Study of bending angle and shadow in a new Schwarzschild-like black hole affected by plasma and non-plasma mediums

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Chinese Physics C 2024年第5期48卷 309-318页

作者： Riasat ali Tiecheng Xia Muhammad Awais Rimsha Babar Department of Mathematics Newtouch Center for Mathematics of Shanghai UniversityShanghai 200444China Department of Mathematics University of Engineering and Technology Lahore-54890Pakistan Department of Mathematics GC University Faisalabad Layyah CampusLayyah-31200Pakistan

In this study,we analyze the models of the deflection angle of a new Schwarzschild-like black hole(BH)and employ the optical metric of the *** achieve this,we use the Gaussian curvature of the optical metric and the Gauss-Bonnet theorem,known as the Gibbons-Werner technique,to determine the deflection ***,we examine the deflection angle in the presence of a plasma medium and the effect of the plasma medium on the deflection *** deflection angle of the BH solution in the gauged super-gravity is computed using the Keeton-Petters *** the ray-tracing technique,we investigate the shadow of the corresponding BH and analyze the plots of the deflection angle and shadow to verify the influence of the plasma and algebraic thermodynamic parameters on the deflection angle and shadow.

关键词： new Schwarzschild-like black hole Gibbons-Werner and Keeton-Petters techniques deflection angle ray-tracing approach shadow

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Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2275-2296页

作者： Javaid ali Armando Ciancio Kashif ali Khan Nauman Raza Haci Mehmet Baskonus Muhammad Luqman Zafar-Ullah Khan Department of Mathematics Govt.Graduate College TownshipLahore54770Pakistan Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy Department of Mathematics University of Engineering and TechnologyLahore54890Pakistan Department of Mathematics University of the PunjabLahore54590Pakistan Mathematics Research Center Near East University TRNCMersin 10Nicosia99138Turkey Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Department of Dermatology Rashid Latif Medical CollegeLahore54600Pakistan

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic(CCE)*** underlying CCE model lacks a closed-form exact *** solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties,such as positivity,boundedness,and ***,the development of structure-preserving semi-analytical approaches is always *** research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization ***-free safe Padérational functions approximate the mathematical shape of state variables,while the model’s physical requirements are treated as problem *** primary model of the governing differential equations is imposed to minimize the error between approximate *** evolutionary algorithm,the Genetic Algorithm with Multi-Parent Crossover(GA-MPC),executes the optimization *** resulting method is the Evolutionary Safe PadéApproximation(ESPA)*** proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical *** performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padéapproximants.

关键词： Nonlinear cervical cancer epidemic non-singular Padéapproximants approximate solutions computational biology

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