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Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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Neural Regeneration Research 2015年第3期10卷 445-450页

作者： Peiman Alesheikh arezou mashoufi Hui-ling Tang Wei Zhang Bo Di Yang-yang Yan Peng-tao Li Yan-shu Pan Research Center of Natural Product Health North Khorasan University of Medical Science Department of Pathology Preclinical Medical SchoolBeijing University of Chinese Medicine Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

The Chinese herbal formula Tongluo fiunao, containing the active components Panax notogin- seng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control （Xuesai Tong, containing Panax notoginseng） or saline intraperitoneally to investigate the pathway involved in the action of TongIuo fiunao injection. 2,3,5-Triphenyltetrazolium chloride （TTC） staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo fiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo fiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/ tropomyosin-related kinase C pathway.

关键词： neural regeneration cerebral ischemia Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration

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The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury

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Neural Regeneration Research 2011年第12期6卷 885-891页

作者： Peiman Alesheikh Huiling Tang Pengtao Li Wei Zhang Yanshu Pan arezou mashoufi Liyun Zhao Runjun Wang Bo Di Yangyang Yan Department of Pathology Preclinical Medical School Beijing University of Chinese Medicine Beijing 100029 China Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700 China Department of Histology and Embryology Preclinical Medical School Beijing University of Chinese Medicine Beijing 100029 China

The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao （TLJN）, which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor （BDNF） and tropomyosin-related kinase B （TrkB） in a rat model of focal cerebral ischemic injury. Xue Sai Tong （XST）, comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST.

关键词： brain-derived neurotrophic factor tropomyosin-related kinase B Tongluo Jiunao injection ischemic stroke

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肝络通对门静脉高压症大鼠肝组织α7-烟碱样乙酰胆碱受体的影响

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世界科学技术-中医药现代化 2010年第3期12卷 383-386页

作者：姜俊杰杜庆红韩琳 arezou mashoufi 李澎涛北京中医药大学基础医学院北京100029

目的:分析肝络通对门静脉高压症大鼠肝组织中α7-烟碱样乙酰胆碱受体表达的影响特征,探讨肝络通治疗门静脉高压症的可能机制。方法:取体重240～260g的清洁级雄性SD大鼠40只,根据体重随机分为假手术组、2周模型组、2周肝络通组、4周模型... 详细信息

目的:分析肝络通对门静脉高压症大鼠肝组织中α7-烟碱样乙酰胆碱受体表达的影响特征,探讨肝络通治疗门静脉高压症的可能机制。方法:取体重240～260g的清洁级雄性SD大鼠40只,根据体重随机分为假手术组、2周模型组、2周肝络通组、4周模型组、4周肝络通组。模型组及给药组采用胆总管结扎术(CBDL)对大鼠进行造模,分别于造模2周、4周测量门静脉压力,并用免疫印迹法检测α7-烟碱样乙酰胆碱受体(nAchRα7)在肝组织中的表达。结果:胆总管结扎后2周和4周门静脉压力均显著升高,模型组nAchRα7的表达较假手术组明显增多,门静脉压力和nAchRα7的表达具有随术后时间延长而加重的一致性趋势。肝络通组门静脉压力显著低于模型组,术后4周作用最为显著;2周肝络通组nAchRα7的表达与2周模型组比较无显著差异,4周肝络通组较4周模型组显著减少。结论:肝组织nAchRα7的表达变化与门静脉压力变化具有一致性趋势,肝络通降低门静脉压力的作用可能与调节肝组织内nAchRα7的表达有关。

关键词：肝络通 α7-烟碱样乙酰胆碱受体门静脉高压症肝组织

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α1-烟碱样乙酰胆碱受体在门脉高压症发病机制中的作用分析

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现代生物医学进展 2010年第6期10卷 1055-1057,1054页

作者：姜俊杰杜庆红韩琳 arezou mashoufi 李澎涛北京中医药大学基础医学院北京100029

目的:探讨肝组织中的α1-烟碱样乙酰胆碱受体在胆汁性肝纤维化引起的门静脉高压症(PHT)发病机制中的作用。方法:取体重240-260g的清洁级雄性SD大鼠30只,根据体重随机分为假手术组、模型组。模型组采用胆总管结扎术(CBDL)对大鼠进行造模... 详细信息

目的:探讨肝组织中的α1-烟碱样乙酰胆碱受体在胆汁性肝纤维化引起的门静脉高压症(PHT)发病机制中的作用。方法:取体重240-260g的清洁级雄性SD大鼠30只,根据体重随机分为假手术组、模型组。模型组采用胆总管结扎术(CBDL)对大鼠进行造模,分别于2周、4周测门静脉压力,并用免疫组化和免疫印迹法对α1-烟碱样乙酰胆碱受体(nAchRα1)进行定位及定量的检测。结果:假手术组的门静脉压力是7.97±0.55mmHg,造模后2周和4周门静脉压力升高,分别为14.15±0.92mmHg;17.75±0.86mmHg。免疫组化显示nAchRα1主要表达在肝窦和汇管区。免疫印迹显示模型组nAchRα1的表达较假手术组明显增多。结论:nAchRα1可能通过活化肝星状细胞,进而形成肝窦毛细血管化,来参与门静脉高压症的发病机制。

关键词： α1-烟碱样乙酰胆碱受体门静脉高压症肝组织

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Strongly Clean Matrix Rings over a Skew Monoid Ring

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代数集刊:英文版 2023年第3期30卷 361-370页

作者： arezou Karimimansoub Mohammad-Reza(Rafsanjani)Sadeghi Department of Mathematics and Computer Science Amirkabir University of TechnologyTehranP.O.Box ***Iran

Let R be a ring with an endomorphismσ,F∪{0}the free monoid generated by U={u1,…,ut}with 0 added,and M a factor of F obtained by setting certain monomials in F to 0 such that M^(n)=0 for some *** we can form the non-semiprime skew monoid ring R[M;σ].A local ring R is called bleached if for any j∈J(R)and any u∈U(R),the abelian group endomorphisms l_(u)−r_(j) and l_(j)−r_(u) of R are *** R[M;σ],we provide various classes of both bleached and non-bleached local *** of the main problems concerning strongly clean rings is to characterize the rings R for which the matrix ring M_(n)(R)is strongly *** investigate the strong cleanness of the full matrix rings over the skew monoid ring R[M;σ].

关键词： skew monoid rings strongly clean rings matrix rings

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Application of different CFD multiphase models to investigate effects of baffles and nanoparticles on heat transfer enhancement

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 320-329页

作者： Ali SHAHMOHAMMADI arezou JAFARI Chemical Engineering Department Tarbiat Modares University Tehran 114-14115 Iran

In this work, the effect of baffles in a pipe on heat transfer enhancement was studied using computa- tional fluid dynamics （CFD） in the presence of Al2O3 nanoparticles which are dispersed into water. Fluid flow through the horizontal tube with uniform heat flux was simulated numerically and three dimensional governing partial differential equations were solved. To find an accurate model for CFD simulations, the results obtained by the single phase were compared with those obtained by three different multiphase models including Eulerian, mixture and volume of fluid （VOF） at Reynolds numbers in range of 600 to 3000, and two different nanoparticle concentrations （1% and 1.6%）. It was found that multi- phase models could better predict the heat transfer in nanofluids. The effect of baffles on heat transfer of nanofluid flow was also investigated through a baffled geometry. The numerical results show that at Reynolds numbers in the range of 600 to 2100, the heat transfer of nanofluid flowing in the geometry without baffle is greater than that of water flowing through a tube with baffle, whereas the difference between these effects （nanofluid and baffle） decreases with increasing the Reynolds number. At higher Reynolds numbers （2100-3000） the baffle has a greater effect on heat transfer enhancement than the nanofluid.

关键词： CFD simulation heat transfer nanofluid,baffle single phase model multiphase model

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H_∞ Consensus Control of Discrete-Time Multi-Agent Systems Under Network Imperfections and External Disturbance

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 667-675页

作者： arezou Elahi Alireza Alfi Hamidreza Modares IEEE the Faculty of Electrical and Robotic Engineering Shahrood University of Technology the Department of Mechanical Engineering at Michigan State University

This paper presents a distributed control protocol for consensus control of multi-agent systems(MASs) under external disturbances and network imperfections, including communication delay and random packet dropout. To comply with the discrete nature of networked systems, in contrast to most of the existing work for MASs under network imperfections,the agents are modeled by discrete-time dynamics. The communication network is considered to be undirected, its delay is considered to be time-varying but bounded, and its packet dropout is modeled by a Bernoulli distributed white *** conditions in terms of linear matrix inequalities(LMIs)for asymptotic mean-square consensus stability are derived under network imperfections without considering external disturbances.A desired disturbance attenuation level in the presence of both external disturbances and network imperfections is also provided.A simulation example is given to verify the effectiveness of the proposed approach in coping with network imperfection and disturbances.

关键词： Consensus distributed control H∞ control packet dropout stability time delay

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Temperature effect on performance of nanoparticle/surfactant flooding in enhanced heavy oil recovery

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Petroleum Science 2019年第6期16卷 1387-1402页

作者： Sajjad Mahmoudi arezou Jafari Soheila Javadian Department of Petroleum Engineering Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran Department of Physical Chemistry Faculty of Basic ScienceTarbiat Modares UniversityP.O.Box 14115-175TehranIran

Recently,nanoparticles have been used along with surfactants for enhancing oil *** the recent studies show that oil recovery is enhanced using nanoparticle/surfactant solutions,some effective parameters and mechanisms involved in the oil recovery have not yet been ***,the temperature effect on the stability of nanoparticle/surfactant solutions and ultimate oil recovery has been studied in this work,and the optimal concentrations of both SiO2 nanoparticle and surfactant(sodium dodecyl sulfate)have been determined by the Central Composite Design *** addition,the simultaneous effects of parameters and their interactions have been *** of the stability of the injected solutions indicates that the nanoparticle concentration is the most important factor affecting the solution *** surfactant makes the solution more stable if used in appropriate concentrations below the *** to the micromodel flooding results,the most effective factor for enhancing oil recovery is temperature compared to the nanoparticle and surfactant ***,in floodings with higher porous medium temperature,the oil viscosity reduction is considerable,and more oil is *** addition,the surfactant concentration plays a more effective role in reservoirs with higher *** other words,at a surfactant concentration of 250 ppm,the ultimate oil recovery is improved about 20%with a temperature increase of 20°***,when the surfactant concentration is equal to 750 ppm,the temperature increase enhances the ultimate oil recovery by only about 7%.Finally,the nanoparticle and surfactant optimum concentrations determined by Design-Expert software were equal to 46 and 159 ppm,*** is worthy to note that obtained results are validated by the confirmation test.

关键词： Enhanced heavy oil recovery Nanoparticle Surfactant Temperature High salinity brine Stability Micromodel Experimental design

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Wettability alteration analysis of smart water/novel functionalized nanocomposites for enhanced oil recovery

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Petroleum Science 2020年第5期17卷 1318-1328页

作者： Sara Habibi arezou Jafari Zahra F.akhroueian Chemical Engineering Faculty Tarbiat Modares UniversityTehranIran School of Chemical Engineering College of EngineeringInstitute of Petroleum EngineeringUniversity of TehranTehranIran

Smart water flooding,as a popular method to change the wettability of carbonate rocks,is one of the interesting and challenging issues in reservoir *** addition,the recent studies show that nanoparticles have a great potential for application in EOR ***,little research has been conducted on the use of smart water with nanoparticles in enhanced oil *** this study,stability,contact angle and IFT measurements and multi-step core flooding tests were designed to investigate the effect of the ionic composition of smart water containing SO4^2- and Ca^2+ ions in the presence of nanofluid on EOR *** amine/organosiloxane@Al2O3/SiO2(AOAS) nanocomposite previously synthesized using co-precipitation-hydrothermal method has been used ***,for the first time the application of this nanocomposite along with smart water has been studied in this *** show that by increasing the concentrations of calcium and sulfate ions in smart water,oil recovery is improved by 9% and 10%,respectively,compared to *** addition,the use of smart water and nanofluids simultaneously is very effective on increasing oil ***,the best performance was observed in smart water containing two times of sulfate ions concentration(SW2 S) with nanofluids,showing increased efficiency of about 7.5%.

关键词： Smart water Nanofluid Wettability alteration Contact angle Stability Enhanced oil recovery

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Nanoparticles assisted microwave radiation:Fluid-rock interactions in oil reservoirs

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Petroleum Science 2021年第6期18卷 1797-1812页

作者： Hamzeh Shamsi Armandi arezou Jafari Reza Gharibshahi Faculty of Chemical Engineering Tarbiat Modares UniversityTehranIran

Recently,many researchers have focused on the usage of electromagnetic waves in oil production and well stimulation,but so far the effect of these waves on the fluid and rock interaction and its simultaneous effect with nanoparticles have not been ***-rock interaction is one of the most important factors affecting fluid distribution in the *** this study,the oil reservoir rock wettability alteration under electromagnetic heating and the presence of nanoparticles has been *** nanoparticles of TiO_2,Fe_(3)O_(4),and TiO_2/Fe_(3)O_(4)have been ***_2 nanoparticles are commercially available,and the other mentioned nanoparticles are synthesized via a co-precipitation *** acid has been used to modify surfaces of nanoparticles and stabilize them in water as the base ***,the adsorption of the nanoparticles on the rock surface has been *** the next step,the amount of oil outflow from the rock has been measured and reported as the external fluid *** this process,the nanoparticle performance in wettability alteration was investigated using pH and inductively coupled plasma(ICP)*** better understand the governing mechanisms,oil viscosity was measured by mixing the oil with nanoparticles and put under *** results reveal that the microwave has a great ability to reduce oil contact angle with carbonate *** the presence of0.2 wt%Fe_(3)O_(4)nanoparticles,the contact angle was reduced from 155°to 19°after 28 min of irradiation,indicating strong rock ***,microwave irradiation on Fe_(3)O_(4)nanofluid extracts75%of the oil from the *** microwave radiation,the pH of the nanofluid increases and hence,more nanoparticles are adsorbed on the rock which subsequently causes more rock *** viscosity change results prove that there is an optimal irradiation time of 5 min in which oil viscosity reduces from 481 cP to 410 cP and then increases to 827

关键词： Microwave radiation Wettability alteration Nanoparticle adsorption Rock-fluid interaction

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