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Open Journal of Gastroenterology 2012年第2期2卷 72-75页

作者： arezoo estakhri Ashraf Mohamadkhani Hosein Poustchi Ghodrat Montazeri Digestive Disease Research Institute(DDRI) Shariati Hospital Tehran University of Medical Sciences Tehran Iran

AIM: To evaluate the impact of combination therapy with Lamivudine and Adefovir for treatment of chronic hepatitis B in Lamivudine-resistant patients. METHODS: Among the 110 adult chronic hepatitis B Iranian patients whom were treated with Lamivudine, for 36 months, nineteen patients (17%) with no any biochemical and viral responses to Lamivudine alone, were selected and enrolled in the study. Due to resistancy, Adefovir was added to Lamivudine, and continued for 30 months. We measured HBV_DNA viral load and serum AST, ALT in 0, 12, 24, 30 and 0, 6, 12, 18, 24, 30 months, respectively. RESULTS: Between biochemical and viral characteristics, Repeated Measure analysis identified just biochemical markers— Aspartate Aminotransferase level (AST) (P = 0.002) and Alanine Aminotransferase level (ALT) (P = 0.007) —as predictors of response to treatment, while, viral marker—HBV DNA load—was not statistically significant (P = 0.128). CONCLUSIONS: Treatment for a long time, such as 21.5 ± 8.8 months, with Lami- vudine and Adefovir, can cause liver enzymes including AST and ALT, decreasing and being normal. But, this finding is not indicative, for HBV-DNA viral load.

关键词： Adefovir Dipivoxil Lamivudine-Resistant Chronic Hepatitis B Combination Treatment

The effect of NAFLD (non-alcoholic fatty liver disease) on long-term outcome of chronic hepatitis B in Iranian patients

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Open Journal of Gastroenterology 2012年第1期2卷 18-21页

作者： arezoo estakhri Ali Akbari Sari Sahar Naz Nedjat Marym Rohban Naser Rakhshani Seyed Mohammad Tavangar Reza Malekzadeh Ghodrat Montazeri Digestive Disease Research Center (DDRC) Shariati Hospital Tehran University of Medical Sciences Tehran Iran School of Public Health Knowledge Utilization Research Center Tehran University of Medical Sciences Tehran Iran

Background: The influence of Non-Alcoholic Fatty Liver Disease on the outcome of chronic hepatitis B disease, including viral, biochemical and histologic characteristics, in Iranian patients is not yet fully un- derstood. Aim: To evaluate the effect of Non-Alcoholic Fatty Liver Disease (NAFLD) on long-term histology- cal, biochemical and viral outcome of chronic he- pa-tictis B in Iranian patients. Methods: We retro- spec-tively evaluated 94 “e Ag” negative chronic hepatitis B patients (with NAFLD: 44, without NAFLD: 50). Non-Alcoholic Fatty Liver Disease was diagnosed based on liver biopsy according to Kleiner classifica-tion. Liver biopsy was done for all patients. Serologi-cal and biochemical variables were evaluated with repeated measure analysis. Results: Non-Alcoholic Fat- ty Liver Disease (NAFLD) was present in 47% of the patients (44 out of 94 patients). In the NAFLD group, increase in AST, ALT, stage (P = 0.002), grade, and total score of liver biopsy were independently related to non-alcoholic fatty liver disease, while HBV-DNA viral load did not correlate with the presence of a fatty liver. Conclusion: Abnormalities of liver enzymes and liver histopathology are more prevalent in concurrent chronic hepatitis B and Non-Alcoholic Fatty Liver Disease (NAFLD).

关键词： Non-Alcoholic Fatty Liver Disease Chronic Hepatitis B IMPACT Long-Term Prognosis Iranian

Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene Technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

Theoretical Study and NBO Analysis of the Decomposition Kinetics of Oxetane, 2-Methyloxetane and 2,2-Dimethyloxetane

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Chinese Journal of Structural Chemistry 2011年第5期30卷 697-705页

作者： arezoo Tahan Abolfazl Shiroudi Semnan Branch Islamic Azad University Chemistry Department Shahrood BranchIslamic Azad University

A theoretical study of the thermal decomposition kinetics of oxetane （1）, 2-methyloxetane （2）, and 2,2-dimethyloxetane （3） has been carried out at the B3LYP/6-311＋G＊＊, B3PW91/6-311＋G＊＊, and MPW1PW91/6-311＋G＊＊ levels of theory. The MPW1PW91/6-311＋G＊＊ method was found to give a reasonable good agreement with the experimental kinetics and thermodynamic parameters. The decomposition reaction of compounds 1～3 yields formaldehyde and the corresponding substituted olefin. Based on the optimized ground state geometries using MPW1PW91/6-311＋G＊＊ method, the natural bond orbital （NBO） analysis of donor-acceptor （bond-antibond） interactions revealed that the stabilization energies associated with the electronic delocalization from σC3-C4 bonding to σ＊O1-C2 antibonding orbitals decrease from compounds 1 to 3. The σC3-C4→σO1-C2 resonance energies for compounds 1～3 are 2.63, 2.59 and 2.45 kcal mol-1, respectively. Further, the results showed that the energy gaps between σC3-C4 bonding and σ＊O1-C2 antibonding orbitals decrease from compounds 1 to 3. Also, the decomposition process in these compounds are controlled by σ→σ＊ resonance energies. Moreover, the obtained order of energy barriers could be explained by the number of electron-releasing methyl groups substituted to the Csp3 atom （which is attached to oxygen atom）. NBO analysis shows that the occupancies of σCsp3-O bonds decrease for compounds 1～3 as 3〈2〈1, and those of σCsp3-O bonds increase in the opposite order （3 〉 2 〉 1）. This fact illustrates a comparatively easier thermal decomposition of the sCsp3-O bond in compound 3 compared to compound 2, and in compound 2 compared to compound 1. NBO results indicate that these reactions are occurring through a concerted and asynchronous four-membered cyclic transition state type of mechanism.

关键词： unimolecular ab initio molecular modeling decomposition DFT NBO

Transient gene expression in western white pine using agroinfiltration

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Journal of Forestry Research 2020年第5期31卷 1823-1832页

作者： Zhenguo Ma Jun-Jun Liu arezoo Zamany Holly Williams Canadian Forest Service Natural Resources Canada506 West Burnside RoadVictoriaBC V8Z 1M5Canada

A method for transient gene expression was developed for western white pine(WWP,Pinus monticola *** ***)using reporter gene uidA encodingβ-glucuronidase(GUS).GUS was transiently expressed in cross sections of primary and secondary needles,cotyledons,and current and second year stems of WWP via vacuum-infiltration with Agrobacterium *** assays of cross sections of secondary needles showed stronger blue color indicating GUS expression at day 1 and 2 than on other days post agroinfiltration(dpa).GUS activity expressed inside WWP cells was confirmed using light *** fluorometric assays,GUS expression was high at 1 dpa and lasted until 4 dpa in detached secondary needles,while similarly high expression levels only lasted until 2 dpa in attached secondary needles then dropped *** the length of GUS-staining zones varied among different WWP organs and between growth and dormant seasons,all tested WWP tissues using the protocol had high levels of transient GUS ***,heterologous candidate genes or endogenous silencing can be expressed in various WWP tissues or organs using this agroinfiltration *** current protocol for efficient transient gene expression will aid functional genomics study of WWP and its pathogens and related conifer species.

关键词： Agrobacterium Agroinfiltration β-glucuronidase Transient gene expression Western white pine

Applications of stem cells in orthodontics and dentofacial orthopedics:Current trends and future perspectives

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World Journal of Stem Cells 2018年第6期10卷 66-77页

作者： Shiva Safari arezoo Mahdian Saeed Reza Motamedian Department of Orthodontics School of Dentistry Shahid Beheshti University of Medical Sciences

A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and future applications of stem cells(SCs) in orthodontics and dentofacial orthopedics have been discussed. For craniofacial anomalies, SCs have been applied to regenerate hard tissue(such as treatment of alveolar cleft) and soft tissue(such as treatment of hemifacial macrosomia). Several attempts have been done to reconstruct impaired temporomandibular joint. Also, SCs with or without bone scaffolds and growth factors have been used to regenerate bone following distraction osteogenesis of mandibular bone or maxillary expansion. Current evidence shows that SCs also have potential to be used to regenerate infrabony alveolar defects and move the teeth into regenerated areas. Future application of SCs in orthodontics could involve accelerating tooth movement, regenerating resorbed roots and expanding tooth movement limitations. However, evidence supporting these roles is weak and further studies are required to evaluate the possibility of these ideas.

关键词： Alveolar bone grafting Dentofacial deformities Distraction osteogenesis Guided tissue regeneration Orthodontics Orthodontic tooth movement Orthognathic surgery Periodontitis Root resorption Stem cells

Toxoplasma gondii and human immunodeficiency virus co-infection in western Iran: A cross sectional study

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 58-62页

作者： Naser Nazari arezoo Bozorgomid Alireza Janbakhsh Farshid Bashiri Department of Medical Parasitology and Mycology Faculty of Medicine Kermanshah University of Medical Sciences Department of Microbiolgy Asadabad School of Medical Sciences Department of Infection Disease Faculty of Medicine Kermanshah University of Medical Sciences

Objective: To determine Toxoplasma gondii(T. gondii) as a cause of morbidity and mortality in human immunodeficiency virus(HIV) infected patients by ELISA method and to investigate toxoplasmosis-associated risk factors. Methods: This cross sectional study was conducted with 385 patients with HIV/AIDS referred to the behavior disease consultation center in Kermanshah, Iran between May 2012 and June 2013. Anti-Toxoplasma IgG and IgM antibodies were measured by using the ELISA method. Also, the relationship between the infection and age, gender, education, occupation, antiretroviral status, CD4+ cell counts and some other factors of the patients were assessed. P<0.05 was considered statistically significant. Results:Among the HIV-positive patients, 40.8%(157/358) and 2.6%(10/358) patients were positive for anti-T. gondii IgG and IgM antibodies, respectively. The mean CD4+ count in the patients with HIV was 327 cells/μL. A significant correlation was observed between the toxoplasmosis infections with the age group(P<0.05). Nevertheless, no statistically significant difference was found between gender, living area, educational level, occupational, marital status, antiretroviral status, prophylaxis, CD4+ cell count and toxoplasmosis. Conclusions: This study revealed that the patients with HIV infection were at the high risk of developing toxoplasmosis disease especially those patients who do not receive antiretroviral therapy and prophylaxis. The development and use of the effectiveness-based guidelines for controlling and the prevention reactivation of the latent T. gondii infection is required.

关键词： Seroepidemiology Toxoplasmosis HIV Iran

Selective laser trabeculoplasty in patients with pseudoexfoliative glaucoma vs primary open angle glaucoma： a one-year comparative study

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 406-410页

作者： arezoo Miraftabi Naveed Nilforushan Nariman Nassiri Kouros Nouri-Mahdavi Eye Research Center Hazrat Rasoul Akram Hospital Iran University of Medical Sciences Tehran *** lran Jules Stein Eye Institute University of California Los Angeles Los Angeles 90095 California USA

AIM：To compare the efficacy of single-session 360-degree selective laser trabeculoplasty（SLT） for reduction of intraocular pressure（IOP） in patients with pseudoexfoliative glaucoma（PXFG） and primary open angle glaucoma（POAG）.· METHODS：This is a single-center,prospective,nonrandomized comparative *** older than 18 years of age with uncontrolled PXFG or POAG eyes requiring additional therapy while on maximally tolerated IOP-lowering medications were *** primary outcome measure changed in IOP from *** was defined as IOP reduction ≥20%from baseline without any additional IOP-lowering *** patients were examined at 1d,1wk,1,3,6,9,12 mo after SLT.· RESULTS：Nineteen patients（20 eyes） with PXFG and27 patients（28 eyes） with POAG were included in the *** the visual fields mean deviation was-2.88（±1.67）in the POAG and-3.1（±1.69） in the PXFG groups（P=0.3）.The mean（±SD） IOP was 22.9（±3.7） mm Hg in the POAG group and 25.7（±4.4） mm Hg in the PXFG group at baseline and decreased to 18.4（±3.2） and 18.0（±3.9） mm Hg in the POAG group（P〈0.001 and P=0.02）,and to 17.9（±4.0） and 21.0（±6.6） mm Hg in the PXFG group（P〈0.001 and P=0.47） at 6 and 12 mo,*** number of medications was 2.6（±0.8） in the POAG group and 2.5（±0.8） in the PXFG group at baseline,and did not change at all follow-up visits in both groups（P =0.16 in POAG and 0.57 in PXFG）.Based on Kaplan-Meier survival analysis,the success rate was 75%in the POAG group compared to 94.1%in the PXFG group（P=0.08;Log-rank test） at 6mo,and 29.1%and 25.0%at 12 mo,respectively（P=0.9;Log-rank）.· CONCLUSION：The 360-degree SLT is an effective and well-tolerated therapeutic modality in patients with POAG and PXFG by reducing IOP without any change in number of *** response was more pronounced early in the postoperative period in patients with PXFG whereas there was no statistically significant difference at 12-month follow-up. 〈/tr〉

关键词： KEYWORDS: primary open angle glaucoma pseudoexfoliative glaucoma selective laser trabeculoplasty

Zataria multiflora and its constituent,carvacrol,counteract sepsis-induced aortic and cardiac toxicity in rat:Involvement of nitric oxide and oxidative stress

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Animal Models and Experimental Medicine 2023年第3期6卷 221-229页

作者： Mahmoud Hosseini Zohreh Arab Farimah Beheshti Akbar Anaeigoudari Farzaneh Shakeri arezoo Rajabian Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Neuroscience Research Center Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran Natural Products and Medicinal Plants Research Center North Khorasan University of Medical SciencesBojnurdIran Department of Physiology and Pharmacology School of MedicineNorth Khorasan University of Medical SciencesBojnurdIran Department of Internal Medicine Faculty of MedicineMashhad University of Medical SciencesMashhadIran

Background:Zataria multiflora and carvacrol showed various pharmacological prop-erties including anti-inflammatory and anti-oxidant ***,up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac ***,this study aimed to investigate the effects of *** and carvacrol on nitric oxide(NO)and oxidative stress indicators in lipopolysaccharide(LPS)-induced aortic and cardiac ***:Adult male Wistar rats were assigned to:Control,lipopolysaccharide(LPS)(1 mg/kg,intraperitoneal(i.p.)),and *** hydro-ethanolic extract(ZME,50–200 mg/kg,oral)-and carvacrol(25–100 mg/kg,oral)-treated *** was in-jected daily for 14 *** with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS *** the end of the study,the levels of malondialdehyde(MDA),NO,thiols,and antioxidant enzymes were ***:Our findings showed a significant reduction in the levels of superoxide dis-mutase(SOD),catalase(CAT),and thiols in the LPS group,which were restored by ZME and ***,ZME and carvacrol decreased MDA and NO in car-diac and aortic tissues of LPS-injected ***:The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO ***,additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

关键词： carvacrol lipopolysaccharide nitric oxide oxidative injury sepsis Z.multiflora

Effects of nitric oxide on the prefrontal cortex in stressed rats

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Neural Regeneration Research 2010年第14期5卷 1096-1099页

作者： Batoul Ebadi Mehdi Mehdizadeh arezoo Nahavandi Tabandeh Shariati Sara Soleimani Asl Hamdolah Delaviz Department of Radiology Iran University of Medical Sciences Cellular and Molecular Research Center Department of AnatomyIran University of Medical Sciences Department of Physiology Iran University of Medical Sciences Department of Anatomy Hammedan University of Medical Sciences Department of Anatomy Yasuj University of Medical Sciences

BACKGROUND： Nitric oxide （NO） exhibits both protective and detrimental effects in the central nervous system. OBJECTIVE： To investigate the effect of NO on the prefrontal cortex in neonatal stressed rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal study was performed at the Anatomical Department of Iran University of Medical Sciences from May 2007 to August 2008. MATERIALS; Forty-eight male, Wistar rats were obtained from Pasteur＇s Institute, Tehran, Iran. METHODS： Rat stress models were established by immobilization and randomly received intraperitoneal injection of 2 mL physiological saline, L-arginine （200 mg/kg） as a NO precursor, N（G）-nitro-L-arginine methyl ester （20 mg/kg）, or subcutaneous injection of 7-nitroindazole （25 mg/kg） as a NO synthase inhibitor. MAIN OUTCOME MEASURES： After the rats were treated for 4 weeks, the frontal cortex was harvested for histological observation and NO detection. RESULTS： Subcutaneous administration of N（G）-nitro-L-arginine methyl ester or 7-nitroindazole resulted in significantly lower prefrontal cortex thickness and NO production compared with subcutaneous administration of L-arginine （P 〈 0.05）. Prefrontal cortex thickness significantly increased in rats following L-arginine treatment, compared with physiological saline intervention （P 〈 0.05）. CONCLUSION： NO exhibited protective effects on the prefrontal cortex of stressed rats.

关键词： nitric oxide prefrontal cortex thickness nerve cell stress rats neural regeneration