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Toxoplasma gondii and human immunodeficiency virus co-infection in western Iran: A cross sectional study

Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 58-62页

作者： Naser Nazari arezoo bozorgomid Alireza Janbakhsh Farshid Bashiri Department of Medical Parasitology and Mycology Faculty of Medicine Kermanshah University of Medical Sciences Department of Microbiolgy Asadabad School of Medical Sciences Department of Infection Disease Faculty of Medicine Kermanshah University of Medical Sciences

Objective: To determine Toxoplasma gondii(T. gondii) as a cause of morbidity and mortality in human immunodeficiency virus(HIV) infected patients by ELISA method and to investigate toxoplasmosis-associated risk factors. Methods: This cross sectional study was conducted with 385 patients with HIV/AIDS referred to the behavior disease consultation center in Kermanshah, Iran between May 2012 and June 2013. Anti-Toxoplasma IgG and IgM antibodies were measured by using the ELISA method. Also, the relationship between the infection and age, gender, education, occupation, antiretroviral status, CD4+ cell counts and some other factors of the patients were assessed. P<0.05 was considered statistically significant. Results:Among the HIV-positive patients, 40.8%(157/358) and 2.6%(10/358) patients were positive for anti-T. gondii IgG and IgM antibodies, respectively. The mean CD4+ count in the patients with HIV was 327 cells/μL. A significant correlation was observed between the toxoplasmosis infections with the age group(P<0.05). Nevertheless, no statistically significant difference was found between gender, living area, educational level, occupational, marital status, antiretroviral status, prophylaxis, CD4+ cell count and toxoplasmosis. Conclusions: This study revealed that the patients with HIV infection were at the high risk of developing toxoplasmosis disease especially those patients who do not receive antiretroviral therapy and prophylaxis. The development and use of the effectiveness-based guidelines for controlling and the prevention reactivation of the latent T. gondii infection is required.

关键词： Seroepidemiology Toxoplasmosis HIV Iran

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Effect of tranexamic acid on the treatment of patients with upper gastrointestinal bleeding: A double-blinded randomized controlled clinical trial

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Journal of Acute Disease 2021年第2期10卷 57-61页

作者： Homayoon Bashiri Mehdi Hamzeii arezoo bozorgomid Infectious Diseases Research Center Health InstituteKermanshah University of Medical SciencesKermanshahIran Department of Internal Medicine School of MedicineKermanshah University of Medical SciencesKermanshahIran Clinical Research Development Center Imam Reza HospitalKermanshah University of Medical SciencesKermanshahIran

Objective:To determine the efficacy of tranexamic acid(TXA)in the management of acute upper gastrointestinal(GI)bleeding.Methods:A total of 70 patients with acute upper GI bleeding were included in this double-blinded randomized controlled clinical trial from September 2018 to December 2018.Patients were divided into the control group(received fluid therapy and intravenous infusion of pantoprazole,35 cases)and the TXA group(received intravenous TXA besides the treatment of control group,35 cases).Rebleeding,admission duration,and need for blood transfusion were compared between the two groups.Results:Fifteen patients(42.9%)in the TXA group and 10 patients(28.6%)in the control group stayed in hospital for more than 3 days during their admission(P=0.21).Rebleeding occurred in 8 patients(22.9%)and 5 patients(14.3%)of the TXA group and the control group,respectively(P=0.35).More patients in the TXA group(21 cases,60%)received blood transfusion than the control group(8 cases,22.9%)(P=0.02).Conclusions:TXA did not improve the outcome of patients with acute upper GI bleeding.

关键词： Tranexamic acid Gastrointestinal bleeding Emergent Treatment

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Association between community-acquired pneumonia and platelet indices: A case-control study

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Journal of Acute Disease 2021年第1期10卷 23-27页

作者： Hajar Motamed Homayoon Bashiri Farideh Yari Arezo bozorgomid Mosayeb Rostamian Yosef Azarakhsh Azam Hosseini Roya Chegene lorestani Department of Pathology School of MedicineKermanshah University of Medical SciencesKermanshahIran Infectious Diseases Research Center Kermanshah University of Medical SciencesKermanshahIran Clinical Research Development Center of Imam Reza Hospital Kermanshah University of Medical SciencesKermanshahIran Department of Basic Sciences and Pathobiology Faculty of Veterinary MedicineRazi UniversityIran Department of Microbiology Faculty of MedicineKermanshah University of Medical SciencesKermanshahIran

Objective:To examine whether the platelet index would be applicable for the diagnosis of community-acquired pneumonia(CAP).Methods:In this study,64 CAP patients(the case group)and 68 healthy children(the control group)were included from 2017 to 2018.Baseline variables were recorded including total white blood cells,neutrophils,lymphocytes,red blood cells,platelet,mean platelet volume,platelet distribution width,erythrocyte sedimentation rate,and C-reactive protein,and compared between the case group and the control group.The cutoff value,sensitivity,and specificity of neutrophil-to-lymphocyte ratio,platelet,neutrophils,lymphocytes,and platelet larger cell ratio were calculated by receiver-operating characteristic curves.Results:The median platelet count of the case group and the control group were(411.09±67.40)mm3 and(334.48±78.15)mm3,respectively(P=0.000).The median neutrophil count of the case group was higher than that of the control group,while the lymphocyte level of the case group was lower.Differences in other variables including the mean platelet volume,platelet distribution width,C-reactive protein,and erythrocyte sedimentation rate were not statistically significant between the two groups.Conclusions:Due to the different levels of platelet,neutrophil and lymphocyte indices in the case and the control group,these indices can be used simultaneously for the diagnosis of CAP.

关键词： Community-acquired pneumonia Platelet index Hematological profile

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