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Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease:the PINK1/CHCHD4 interplay

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Neural Regeneration Research 2021年第11期16卷 2222-2224页

作者： Giuseppe arena Nazanine Modj.ahedi Rej.o Kruger Translational Neuroscience group Luxembourg Centre for Systems Biomedicine(LCSB)University of LuxembourgEsch-sur-AlzetteLuxembourg UniversitéParis-Saclay Gustave Roussy InstituteCNRSMetabolic and systemic aspects of oncogenesis for new therapeutic approachesVillejuifFrance Parkinson Research Clinic Centre Hospitalier du Luxembourg(CHL)Esch-sur-AlzetteLuxembourg Transversal Translational Medicine Luxembourg Institute of Health(LIH)Esch-sur-AlzetteLuxembourg

Parkinson’s disease(PD)is a common movement disorder of the elderly caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the *** environmental and genetic factors pointed out mitochondrial dysfunction as a maj.r cause of neurodegeneration in *** studies using mitochondrial toxins revealed their ability to trigger dopaminergic cell death and irreversible parkinsonism in different animal models(Poewe et al.,2017).Typical features of mitochondrial dysfunction have been also observed in the human brain of idiopathic PD cases,showing alterations of respiratory chain complex I and IV activity,accumulation of mtDNA deletions and increased oxidative stress(Bender et al.,2006).Moreover,a number of genes found mutated in familial PD forms encode for proteins involved in the maintenance of mitochondrial homeostasis and quality *** these,the PINK1 gene encodes a mitochondrial serine/threonine kinase implicated in key neuroprotective functions,including mitophagy,regulation of mitochondrial transport,control of the mitochondria/endoplasmic reticulum crosstalk and calcium homeostasis(Brunelli et al.,2020).

关键词： PINK1 homeostasis protective

Cardiac rehabilitation and exercise therapy in the elderly： Should we invest in the aged？

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j.urnal of Geriatric Cardiology 2012年第1期9卷 68-75页

作者： Arthur R Menezes Carl j.Lavie Richard V Milani Ross A arena Timothy S Church Department of Cardiovascular Diseases John Ochsner Heart and Vascular Institute Ochsner Clinical School The University of Queensland School ofMedicine 1514 Jefferson Highway New Orleans LA 70121 USA Department of Orthopaedics Physical Therapy Program and Division of Cardiology Department of Internal Medicine University of New MexicoAlbuquerque NM87131 USA Department of Preventive Medicine Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA 70808 USA

Coronary heart disease （CHD） is the leading cause of death worldwide and becomes increasingly prevalent among patients aged 65 years and *** patients are at a higher risk for complications and accelerated physical deconditioning after a cardiovascular event,especially compared to their younger *** last few decades were privy to multiple studies that demonstrated the beneficial effects of cardiac rehabilitation （CR） and exercise therapy on mortality,exercise capacity,psychological risk factors,inflammation,and obesity among patients with ***,a significant portion of the available data in this field pertains to younger patients.A viable explanation is that older patients are grossly underrepresented in these programs for multiple reasons starting with the patient and extending to the *** this article,we will review the benefits of CR programs among the elderly,as well as some of the barriers that hinder their participation.

关键词： Cardiac rehabilitation Exercise therapy Elderly patients Exercise capacity

What is the role of adolescent body mass index and physical activity on adult health risk behaviors?

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Open j.urnal of Preventive Medicine 2012年第1期2卷 72-78页

作者： j.nnifer A. Pintar Kristi L. Storti Vincent C. arena Robert j. Robertson Elizabeth F. Nagle Andrea M. Kriska Department of Human Performance and Exercise Science Youngstown State University Youngstown USA

Introduction: A high prevalence of modifiable risk factors exists among adolescents that may lead to increased levels of morbidity and mortality in adulthood. This study sought to determine whether higher levels of physical activity (PA) and/or having a healthy body weight in adolescence influences future health risk behaviors (HRB) in young adulthood. Methods: Complete data were gathered for 536 participants from a prospective study and a follow-up survey conducted 10 years apart. At both time points, the questionnaires included information about HRB, PA, and health status. Results: Males who engaged in HRB during adolescence were more likely to continue these same risk behaviors during adulthood. Using multivariate models, only HRB in adolescence predicted HRB in adulthood for drinking, binge drinking and smoking among males, and for binge drinking and smoking among females. Conclusions: It appears that for males, once a health-risk behavior is initiated, it will likely continue into young adulthood, regardless of the presence of other healthy behaviors such as the proper maintenance of body weight and higher levels of PA. Similarly for females, binge drinking and smoking in adolescence is predictive of the same behavior in adulthood.

关键词： Smoking Drinking Binge Drinking

Exercise recommendations for stroke survivors

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中华物理医学与康复杂志 2014年第11期36卷 858-858页

作者： Billinger SA arena R Bernhardt j

BACKGROUND AND OBj.CTIVE As of 2010,an estimated seven million adults in the United States were living with sequelae of a *** number is predicted increase to 11 million by *** updated scientific statement was produced as an overall guide for practitioners prescribing exercise for stroke *** Members of the American Heart Association's Stroke Council performed a systematic review of clinical studies and public

关键词：幸存者中风运动从业人员后遗症成年人

Dewlap size in male water anoles associates with consistent inter-individual variation in boldness

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Current Zoology 2019年第2期65卷 189-195页

作者： Breanna j. PUTMAN Kylee R. AZURE Lindsey SWIERK Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095-1606 USA Section of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles County Los Angeles CA 90007 USA Environmental Science Department Aaniiih Nakoda College Harlem MT 59526 USA dSchool of Forestry and Environmental Studies Yale University New Haven CT 06511 USA

Male sexually selected signals can indicate competitive ability by honestly signaling fitnessrelevant traits such as condition or performance. However, behavior can also influence contest outcomes;in particular, boldness often predicts dominance rank and mating success. Here, we sought to determi ne whether male ornament size is associated with consiste nt in dividual differences in boldness in water anoles Anol is aquaticus. We measured the relative size of the dewlap, a flap of skin under the chin that is a sexually selected ornament in Anolis lizards, and tested for associations with responses to a novel and potentially risky environment: time to emerge from a refuge into an arena and number of head sea ns post-emergence. We found that in dividuals con siste ntly differed in both time to emerge and head sea nning (i.e., in dividual resp on ses were repeatable), and that dewlap size was negatively related to nu mber of head sea ns. This suggests that orname nt size could indicate male boldness if seanning represents antipredator vigilance. We found that males that had larger relative dewlaps were also in better body condition, but boldness (i.e., head scann ing) was not related to condition. Lastly, we found con siste nt d iff ere nces in behavior betwee n trials, showing that anoles were becoming habituated or sensitized to the testing arena. Overall, our study shows that in additi on to indicating con dition and perform a nee, dewlap size could also honestly indicate male boldness in Anolis lizards.

关键词： Anolis aquaticus behavioral syndrome mating success personality signal sexual selection temperament

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心力衰竭患者通气分级系统的发展

世界核心医学期刊文摘(心脏病学分册) 2007年第9期 36-37页

作者： arena R. Myers j. Abella j. 徐永城 Department of Physical Therapy Virginia Common wealth University VA 23298-0224 Health Sciences Campus Richmond United States

背景:通气效率通常用每分通气量(VE)与二氧化碳产量(VCO2)斜率来评估,该指标对于心力衰竭人群是有效的预后指标。本研究旨在通过建立关联VE/VCO2界值与心脏相关事件的通气分级系统,明确VE/VCO2斜率的诊断价值。方法和结果:研究纳入了448例

关键词：心力衰竭 VCO 分级系统最佳控制系统心肺运动试验患者

心肺运动试验在男性与女性心力衰竭患者中预测价值的比较

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 40-41页

作者： Guazzi M. arena R. Myers j. 郭俊 Department of Physical Therapy Virginia Commonwealth University Box 980224 Richmond VA 23298- 0224 United States

背景:心肺运动试验(CPX)对心力衰竭(HF)人群确实具有预测价值。旨在探讨CPX在HF个体中预测价值的研究一直以来主要以男性人群作为试验对象。本研究旨在检查CPX在女性HF人群中的预测价值。方法:研究纳入已诊断为HF的75例女性和337例男性受试

关键词：预测价值心肺运动试验心力衰竭男性患者女性

心力衰竭患者运动试验中呼气末二氧化碳分压的预后价值

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 51-52页

作者： arena R. Guazzi M. Myers j. 马超 Department of Physical Therapy Virginia Commonwealth University Box 980224 Health Sciences Campus Richmond VA 23298- 0224 United States

背景:现已证实,通气阈值(VT)时的呼气末二氧化碳分压(PETCO2)与心力衰竭(H F)患者运动期间的心输出量具强相关,但关于其预后预测价值的资料很少。目的:该研究旨在评估PETCO2预测H F受试者心脏相关事件的效力。方法:130例代偿性H F受试... 详细信息

背景:现已证实,通气阈值(VT)时的呼气末二氧化碳分压(PETCO2)与心力衰竭(H F)患者运动期间的心输出量具强相关,但关于其预后预测价值的资料很少。目的:该研究旨在评估PETCO2预测H F受试者心脏相关事件的效力。方法:130例代偿性H F受试者接受心肺运动试验(CPX)。确定受试者的峰值耗氧量(VO2)、每分通气量/二氧化碳产生量(VE/VCO2)斜率以及PETCO2。

关键词：运动试验预后价值每分通气量心输出量通气阈预后预测耗氧量强相关临床评估特异度

Recall of past activity levels in young adults is predictive of adolescent activity levels

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Open j.urnal of Preventive Medicine 2013年第3期3卷 280-284页

作者： Kristi L. Storti Emily R. Lawrentz Vincent C. arena Robert j. Robertson Elizabeth F. Nagle Andrea M. Kriska Department of Biostatistics University of Pittsburgh Graduate School of Public Health Pittsburgh USA Department of Epidemiology University of Pittsburgh Graduate School of Public Health Pittsburgh USA Department of Physical Activity and Health University of Pittsburgh Pittsburgh USA

Purpose: To determine whether a global physical activity question (GPAq) administered in young adulthood can be used to accurately rank former physical activity levels (PA) relative to peers of the same age and sex during adolescence. Methods: Data were obtained from the Physical Activity in Young Adults Study, a 10- year follow-up study of 12 - 16 year old adolescents. Five hundred twenty-eight young adults, mean age 24.5 (±1.0) years, completed a GPAq regarding current and past (adolescent) PA. GPAq answers were used to determine whether young adults could accurately rank their past (adolescent) PA levels relative to peers of the same age and sex. GPAq responses were compared with actual self-reported PA levels assessed by the Modifiable Activity Questionnaire for Adolescents (MAQ-A;collected during adolescence). For adolescent PA, an average of 4 years of activity from the MAQ-A 1990-1993, was used. Results: Regardless of gender, j.nckheere-Terpstra tests for trend (p < 0.0001) suggest significant linear trends across categories of PA level for the MAQ-A. Higher perceived PA tracked with greater past PA activity and lower perceived PA tracked with lower past PA activity. Conclusions: Young adults who classified themselves as more active as an adolescent were found to be relatively more active based upon self-reported activity from recall questionnaires collected during that time. These findings suggest that young adults can reasonably estimate relative PA levels during their adolescent years with GPAq. Global physical activity questions may be valid for the assessment and classification of previous PA levels.

关键词： Recall Adolescent Self-Report Modifiable Activity Questionnaire for Adolescents