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世界核心医学期刊文摘(神经病学分册) 2006年第10期 57-58页

作者： Pillon B. ardouin c. Dujardin K. M. Vidailhet 高宗强 Department of Neurology Saint Antoine Hospital INSERM U 679 184 Faubourg Saint Antoine 75571 Paris Cedex 12 France Dr.

Objec.ive: To assess the effec.s of bilateral pallidal deep brain stimulation (DBS) on mood and c.gnitive performanc. in patients with dystonia before surgery (at baseline, while patients rec.ived their usual treatment) and 12 months postoperatively (while patients rec.ived neurostimulation and their medic.tions) in a multic.nter prospec.ive study. Methods: Twenty- two patients with primary generalized dystonia were evaluated with tests foc.sed on exec.tive func.ions. The authors c.nsidered the patients' severe disability and selec.ed the following tests: Raven Progressive Matric.s 38, Similarities and Arithmetic.subtests of the Wec.sler Adult Intelligenc. Sc.le- R, Grober and Busc.ke, Wisc.nsin c.rd Sorting Test (Wc.T), verbal fluenc., Trail Making Test, and the Bec. Depression Inventory. Median age at surgery was 30 years (range = 14 to 54 years), median duration of disease was 18.5 years (range = 4 to 37 years). Results: Before surgery, no patients showed c.gnitive dec.ine or depression. The surgic.l proc.dure appeared to be benign c.gnitively. One year after surgery, free rec.ll improved. There was a signific.nt reduc.ion in the number of errors in the Wc.T. No behavioral or mood c.anges were found. c.nc.usions: Bilateral pallidal stimulation has a good benefit- to- risk ratio as it did not negatively affec. c.gnitive performanc. and mood in primary dystonia, while a signific.nt motor improvement was obtained. Moreover, a signific.nt mild improvement in exec.tive func.ions was observed, whic. may have been related either to the surgic.l treatment or to the marked dec.ease in antic.olinergic.drugs.

关键词：苍白球认知功能肌张力患者障碍

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