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Management of obstructed colorectal carcinoma in an emergency setting:An update

World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： e.s.athios T Pavlidis Ioannis N Galanis Theodoros e Pavlidis 2nd Propedeutic Department of surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ile.s.may be the first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(CT),CT colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice.s.ould be either emergency surgery or endoscopic decompre.s.on by self-expen-dable metal stents or *** operative plan should be either one.s.age or two-stage ***-stage resection with on-table bowel decompre.s.on and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ile.s.omy).Primary anastomosis is more convenient but has incre.s.d risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is le.s.frequently performed since it can be.s.cce.s.ully substituted with endoscopic stenting or *** the le.s.common right-sided obstruction,one.s.age.s.rgical resection is more beneficial than endoscopic *** role of minimally invasive.s.rgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficulties in dissecting the distended colon and the risk of rup-ture and subsequent septic *** decompre.s.ng stent as a bridge to elective.s.rgery more.s.bstantially decre.s.s the risks of morbidity and mortality than emergency surgery for decompre.s.on and has equivalent medium-term overall survival and dise.s.-free.s.rvival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma emergency surgery Colectomy Intraluminal metal stents

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Phase.s.paration of s-RNase promotes self-incompatibility in Petunia hybrida

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Journal of Integrative Plant Biology 2024年第5期66卷 986-1006页

作者： Huayang Tian Hongkui Zhang Huaqiu Huang Yu'e Zhang Yongbiao Xue The.s.ate Key Laboratory of Plant Cell and Chromosome engineering Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China Unive.s.ty of the Chinese Academy of sciences Beijing 100049China Beiing Institute of Genomics Chinese Academy of SciencesNational Center for BioinformationBeijing 100101China

self-incompatibility(sI)is an intraspecific reproductive barrier widely present in *** sI system with the broadest occurrence in angiosperms is based on an s-RNase linked to a cluster of multiple.s.locus F-box(sLF)genes found in the.s.lanaceae,Plantaginaceae,Rosaceae,and *** studies reveal that non-self s-RNase is degraded by the.s.ip Cullin F-box(sCF)sLF-mediated ubiquitin–prote.s.me.s.stem in a collaborative manner in Petunia,but how self-RNase functions largely remains ***,we.s.ow that s-RNases form s-RNase conde.s.tes(sRCs)in the.s.lf-pollen tube cytoplasm through phase.s.paration and the disruption of sRC formation breaks sI in self-incompatible Petunia *** further find that the pistil sI factors of a small asparagine-rich protein HT-B and thioredoxin h together with a reduced state of the pollen tube all promote the expansion of sRCs,which then sequester several actin-binding proteins,including the actin polymerization factor PhABRACL,the actin polymerization activity of which is reduced by s-RNase in ***,we find that s-RNase variants lacking conde.s.tion ability fail to recruit PhABRACL and are unable to induce actin foci formation required for pollen tube growth *** together,our results demonstrate that phase.s.paration of s-RNase promotes sI response in ***,revealing a new mode of s-RNase action.

关键词： self-incompatibility s-RNase phase.s.paration

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Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yele.s.eva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate.s.hool and Unive.s.ty Center City University of New York10016 New YorkUSA al-Farabi Kazakh National Unive.s.ty 050040 AlmatyKazakhstan

We.s.udy radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to e1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O proce.s.with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the.s.factor with existing experimental and theoretical data is addre.s.d,and a re.s.nable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each proce.s.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

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Cavitation research with computational fluid dynamics:From euler-euler to euler-Lagrange approach

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Journal of Hydrodynamics 2024年第1期36卷 1-23页

作者： Bin Ji Zi-yang Wang Huai-yu Cheng Rickard e.Be.s.w state Key Laboratory of Water Resources engineering and Management Wuhan UniversityWuhan430072China Department of Mechanics and Maritime.s.iences Chalmers University of TechnologyGothenburgSweden

Unsteady cavitating flow often contains vapor structures with a wide range of different length scales,from micro-bubbles to large cavities,which issues a big challenge to precisely investigate its evolution mechanism by computational fluid dynamics(CFD)*** present work revie.s.the development of simulation methods for cavitation,especially the emerging euler-Lagrange ***,the progre.s.of the numerical investigation of hot and vital issues is discussed,including cavitation inception,cloud cavitation inner structure and its formation mechanism,cavitation erosion,and cavitation *** is indicated that the euler-Lagrange method can determine cavitation inception point *** cloud cavitation,the euler-Lagrange method can reveal the.s.urce of microbubbles and their distribution law inside the.s.edding *** method also has advantages and great potential in asse.s.ng cloud cavitation-induced erosion and *** the ever-growing demands of cavitation simulation accuracy in basic research and engineering applications,how to improve the euler-Lagrange method’s stability and applicability is still an open *** further promote the application of this advanced CFD simulation technology in cavitation research,some key issues are to be.s.lved and fe.s.ble.s.ggestions are put forward for further work.

关键词： numerical simulation euler-euler method euler-Lagrange method bubble dynamicsgy,Gothenburg,sweden

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When Fleeing Matte.s.Differences in escape Behaviours of Three Northe.s. Asian Anurans

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Asian Herpetological Research 2024年第1期15卷 41-48页

作者： Yoonjung YI Zoljargal PUReVDORJ Irina MAsLOVA Yikweon JANG Amaël BORZÉe Laboratory of Animal Behaviour and Conservation College of Life SciencesNanjing Forestry UniversityNanjing 210037JiangsuChina Division of ecoscience and Department of Life.s.iences Ewha Womans UniversitySeoul 03760Republic of Korea Department of Biology School of MathematicsMongolian State University of EducationUlaanbaatar 210648Mongolia Department of Forest and environmental Resources Chungnam National UniversityDaejeon 34134Republic of Korea Federal scientific Center of the e.s. Asia Terrestrial Biodive.s.ty Far Eastern Branch of Russian Academy of SciencesVladivostok 690022Russia

Prey species may have their own optimal escape.s.rategy to balance predation risks and the energetic cost of *** species have an advantage when maintaining a short fleeing distance,while othe.s.may favour an earlier escape based on microhabitat,size,or body ***,we examined the escape behaviour of the three.s.ntopic Northe.s. Asian anuran species:Mongolian toads(strauchbufo raddei),Amur brown frogs(Rana amure.s.s),and Japanese treefrogs(Dryophytes japonicus)in Mongolia,Russia,China and DPR *** examined flight initiation distance(FID;the distance from a potential predator to the point when the individual starts to flee)and distance fled(DF;distance between flight initiation and flight termination points)of each species and the effects of microhabitat,sex,and body *** raddei and *** had a longer FID than ***,and *** also had a longer DF than *** trends remained similar when dividing FID and DF by a size proxy(snout-vent length)for all *** suggests that the treefrog *** used a strategy to stay immobile even when they were detected,and the toad *** reacted quicker and more.s.nsitively to predators despite the presence of *** *** had a significantly longer FID than males suggesting that females are more.s.nsitive to predation risk in this species,but body size was not significant for any of the three *** results indicate that the three.s.mpatric species have different escaping strategies,likely related to differences in physiology and crypticity.

关键词： amphibian distance fled escape behaviour flight initiation distance predation

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experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics Letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar sánchez-López Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiinte.s. diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be e.s.ly reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

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Optimization of Cooperative RelayingMolecular Communications for Nanomedical Applications

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Computer Modeling in engineering & sciences 2024年第2期138卷 1259-1275页

作者： eman s.Attia Ashraf A.M.Khalaf Fathi e.Abd el-samie.s.ied M.Abd el-atty Konstantinos A.Lizos Osama Alfarraj Heba M.el-Hoseny Department of electrical engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of electronics and electrical Communications engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-syste.s.based on molecular communications via diffusion(MCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDs)***,because the MCvD is unreliable and there exists molecular noise and inter symbol interference(IsI),cooperative nano-relays can acquire the reliability for drug delivery to targeted dise.s.d cells,especially if the.s.paration distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by theModified Central Force Optimization(MCFO)*** the previous work,the probability of bit error is expre.s.d in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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The transcriptional landscape of the developmental switch from regular pollen maturation towards microspore-derived plant regeneration in barley

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The Crop Journal 2024年第4期12卷 1064-1080页

作者： Anna Nowicka Martin Kovacik Anna Maksylewicz Przemysław Kopec ewa Dubas Monika Krze.s.a Agnieszka springer Robert e.Hoffie Diaaeldin s.Daghma Zbynek Milec Ales Pecinka Jochen Kumlehn Iwona Zur The Franciszek Górski Institute of Plant Physiology Polish Academy of sciences Niezapominajek 2130-239 KrakówPoland Institute of experimental Botany of the Czech Academy of sciences Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic Department of Cell Biology and Genetics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Malopolska Centre of Biotechnology Jagiellonian University30-387 KrakówPoland Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gate.s.eben Corrensstraße 306466 Stadt SeelandGermany Institute for Breeding Research on Horticultural Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Global Change Research Institute Czech Academy of sciences Beˇlidla 986/4a60300 BrnoCzech Republic

Plant formation from in vitro-cultivated microspores involves a complex network of internal and environmental ***/doubled haploids(DHs)derived from in vitro-cultured microspores are widely used in plant breeding and genetic ***,the mechanism underlying the developmental switch from regular pollen maturation towards microspore-derived plant regeneration remains poorly ***,RNA-sequencing was employed to elucidate the transcriptional landscapes of four early stages of microspore embryogenesis(Me)in barley cultivars Golden Promise and Igri,which exhibit contrasting responsivene.s.to microspore-derived plant *** experiments revealed fundamental regulatory networks,specific groups of genes,and transcription factor(TF)families potentially regulating the developmental *** identified a set of candidate genes crucial for genotype-dependent responsivene.s.recalcitrance to *** high-resolution temporal transcriptome atlas provides an important resource for future functional studies on the genetic control of microspore developmental transition.

关键词： Hordeum vulgare Marker gene Microspore embryogenesis stre.s.response Transcriptome analysis

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Preliminary results of lithological and palynological study of svobodny,ancient man’s parking relic in Amur region,Russia

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Global Geology 2024年第3期27卷 121-131页

作者： Kovalenko s.V. Kezina T.V. Kryuchko e.I. Mironov M.A. Center for the Preservation of Historical and Cultural Heritage of the Amur Region Blagoveshchensk 675000Russia Amur state Unive.s.ty Blagoveshchensk 675027Russia

A single-layer monument svobodny,ancient man's parking lot-1,discovered in 2021 as part of archaeological work to study the zone of economic development of the Amur region was investigated lithologically and *** on the results of geomorphological analysis of the territory,the.s.udy of artifacts,palynological data,as well as analogy with previously identified and sufficiently studied relics in the region,the existence of the Osinooze.s. late Neolithic culture in this territory is *** time of its expansion in the Amur region is determined within the framework of the.s.cond half of the IV millennium BC to the first half of the II millennium *** preliminary results of palynological analysis suggest the existence of a temperate climate here,was close to the modern one,which does not contradict the reconstructed paleoclimate and environments of the region during the Holocene period.

关键词： Osinooze.s. culture palynological spectra Zeya River paleoclimate

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editor-in-Chief articles of choice and comments at the year-end of 2023

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World Journal of Gastroenterology 2024年第1期30卷 1-8页

作者： Andrzej s Tarnawski Department of Gastroenterology Research University of California Irvine and the Veterans Administration Long Beach Healthcare SystemLong BeachCA 90822United States

As the editor-in-Chief of World Journal of Gastroenterology,every week prior to a new issue.s.online publication,I perform a careful review of all encompassed articles,including the title,clinical and/or research importance,originality,novelty,and ratings by the peer *** on this review,I select the pape.s.of choice and suggest pertinent changes(e.g.,in the title)to the Company editors responsible for *** proce.s.while time-consuming,is very important for assuring the quality of publications and highlighting important articles that Reade.s.may revisit.

关键词： Pape.s.of choice Careful weekly review suggested changes/revisions Hepatocellular carcinoma Pancreatic cancer Liver cirrhosis Liver injury Gastric cancer Colorectal cancer Inflammatory bowel dise.s.s

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