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Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner

Cellular & Molecular Immunology 2018年第1期15卷 38-47页

作者： Alexandra C Bolognese archna sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang Elmezzi Graduate School of Molecular Medicine Manhasset11030NYUSA Department of Surgery Hofstra Northwell School of MedicineManhasset11030NYUSA Center for Immunology and Inflammation The Feinstein Institute for Medical ResearchManhasset11030NYUSA

Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner.

关键词： CIRP immune response lymphocytes sepsis T-cell activation

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Radical Scavenging and Antioxidant Potential of Nuts and Leaves Extracts of <i>Semecarpus anacardium</i>(L.)

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American Journal of Plant Sciences 2013年第8期4卷 1679-1683页

作者： Nachiketa Barman archna sharma Ashwani Kumar Department of Botany Vedic Girls P. G. College University of Rajasthan Jaipur India Laboratory of Bioactive Compounds and Algal Biotechnology Department of Botany University of Rajasthan Jaipur India.

In the present investigation, antioxidant activity of the crude extracts from nuts and leaves of S. anacardium was carried out. The antioxidant potential of various extracts (ethanol, acetone and aqueous) of S. anacardium was determined by using DPPH assay, ABTS assay and metal chelating activity assay. Among the extracts the ethanol extract of nut showed significant scavenging activity (DPPH-88.73 ± 2.26;ABTS assay-81.65 ± 1.57 and metal chelating activity-72.37 ± 2.26) compared with antioxidant controls, ascorbic acid and BHA respectively. The findings of the present investigation suggest that the S. anacardium extracts can prove to be a potent source of biologically active compounds that can be further subjected to isolation of therapeutic antioxidant agents.

关键词： Semecarpus anacardium Anacardiaceae Antioxidant Activity

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Mass Disaster: Will Dental Records be Effectively Useful in Developing Nations?

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Journal of Forensic Science and Medicine 2015年第1期1卷 72-72页

作者： Gaurav sharma archna Nagpal Department of Oral Medicine and Radiology S.R.Dental CollegeFaridabadHaryana Department of Oral Medicine and Radiology PDM Dental College and Research InstituteBahadurgarhHaryanaIndia

Sir,Dentistry is growing at a rapid rate and now there is certainly an increased awareness of oral health care among the general population of developing *** are numerous studies conducted on the important role of forensic odontology in developing ***,I have always been intrigued about whether in case of a mass disaster,the records of the patients would actually be available to the concerned forensic odontologist or the forensics *** is a lack of any common record of the patients in resource‑constrained *** data is obtained by general dental practitioners but most of the time,the data is not recorded in either soft copy(through digital imaging)or conventional intraoral periapical film and is generally *** obvious reason for this is the lack of any archiving *** is no compulsion to keep the records of the patients and thus,valuable data is *** would like to recommend a system for archiving records that can be cited in a ***,there are certain practical difficulties involved such as the lack of any dental insurance scheme in emerging nations due to which the general dental practitioners may lack the motivation to archive records and place these records on a ***,the practitioners would feel uncomfortable placing their patients’records on a common website.

关键词： motivation disaster records

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Salivary gland disease in human immunodeficiency virus/acquired immunodeficiency syndrome: A review

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World Journal of Dermatology 2015年第1期4卷 57-62页

作者： Gaurav sharma archna Nagpal Department of Oral Medicine and Diagnosis Sudha Rustagi College of Dental Sciences and Research Faridabad 121002 Haryana India Department of Oral Medicine and Diagnosis Prabhu Dayal Memorial Dental College and Research Institute Bahadurgarh 124507 Haryana IndiaReader

The effect of human immunodeficiency virus(HIV) infection on salivary glands has diagnostic and prognostic significance. HIV-salivary gland disease(HIV-SGD) is comprehensively ascertained amongst the major critical acquired immunodeficiency syndrome(AIDS)-relatedoral manifestation and causes substantial morbidity. Parotid gland swelling due to sicca syndrome, parotid lipomatosis, sialadenitis, diffuse infiltrative lymphocytosis syndrome, benign lymphoepithelial lesions, neoplasms(benign or malignant) of salivary gland, parotid gland inflammation, diminished flow rates of saliva and xerostomia have been documented that also affects the health- associated characteristics of life in subjects infected with HIV. There is a necessity for health care researchers to diagnose it, particularly as it might worsen if left undiagnosed. The precise characteristic of alterations in dynamics of salivary gland structure and functionality with long-standing usage of highly active anti-retroviral therapy still remains unknown. HIV positive children also present with bilateral parotid enlargement and the syndrome state with classical clinical and cytological features of predominated lymphoid hyperplasia. Though various case reports and studies have been extensively published on different aspects of HIV-SGD, it has not been described solely, thus leading to occasional confusion of nomenclature and clinical presentation of HIV-SGD. This article reviews the pathogenesis of HIV-related SGD and its components and various other miscellaneous disorders affecting the salivary glands in HIV/AIDS.

关键词： Human immunodeficiency virus Acquired immunodeficiency syndrome Salivary gland diseases Antiretroviral therapy Highly active Xerostomia

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