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Inhibitory Interaction and Pharmacological Analyses of Berries Phenolics Against Listeria monocytogenes Virulent Protein Internalin B

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 71-80页

作者： Abhishek Kumar archana vimal Awanish Kumar School of Agriculture Indira Gandhi National Open UniversityNew DelhiIndia Department of Bioengineering Integral University LucknowUttar PradeshIndia Department of Biotechnology National Institute of TechnologyRaipurChhattisgarhIndia

Background: Traditional plants, their parts, and phytochemicals obtained from them are beneficial for human beings. They are used as potent antimicrobials, but very little research is conducted on the use of traditional medicine against food-borne infection. Different berry plants are rich in phenolic compounds and conventionally known to have many properties such as antioxidants, anti-carcinogenic, anti-inflammatory, anti-bacterial, and anti-diabetics. However, only limited polyphenols are known for their antilisterial effect. The present study aimed to explore the antimicrobial efficacy of phenolic compounds of berries for the treatment of food-borne infection caused by the bacteria Listeria monocytogenes. Materials and Methods: Molecular docking studies employing the Swiss DOCK server were performed to evaluate the antimicrobial activity of phenolic compounds obtained from different varieties of berries. Internalin B(Inl B), a virulence protein of L. monocytogenes was selected as a target. The absorption, distribution, metabolism, excretion, and toxicity profiling of each test ligand was done through the Swiss ADME tool. Results: Among all the test ligands, p-coumaric acid, epicatechins, chlorogenic acid, and quercetin showed better binding efficiency with the target protein Inl B. The binding energy obtained for quercetin, p-coumaric acid, chlorogenic acid, and epicatechins was-8.93,-8.23,-8.18,-7.58, kcal/mol, respectively. Quercetin and p-coumaric acid were forming 4 H-bonds, whereas chlorogenic acid and epicatechins were forming 3-H bonds inside the binding pocket. Conclusion: In a nutshell, analyses indicated that identified ligands have the potential to block the virulent protein Inl B of L. monocytogenes and help combat Listeria infection. These phenolic compounds could be a substitute for synthetic antimicrobials and can be used in food preservation and combat food-borne diseases. However, future in-depth in vitro and in vivo analysis is needed to get mor

关键词： Berry plant internalin B Listeria monocytogenes pharmacological analyses phenolics potent inhibitor traditional medicine

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Recent progress in emerging BiPO_(4)-based photocatalysts:Synthesis,properties,modification strategies,and photocatalytic applications

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Journal of Materials Science & Technology 2022年第13期108卷 208-225页

作者： Rohit Kumar Pankaj Raizada Aftab Aslam Parwaz Khan Van-Huy Nguyen Quyet Van Le Suresh Ghotekar Rangabhashiyam Selvasembian vimal Gandhi archana Singh Pardeep Singh School of Advanced Chemical Sciences Shoolini UniversitySolan(Himachal Pradesh)-173212India Center of Excellence for Advanced Materials Research King Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Faculty of Biotechnology Binh Duong UniversityThu Dau MotVietnam. Department of Materials Science and Engineering Korea University145Anam-ro Seongbuk-guSeoul 02841South Korea Department of Chemistry Smt.Devkiba Mohansinhji Chauhan College of Commerce and ScienceSilvassa 396230University of MumbaiDadra and Nagar Haveli(UT)India Department of Chemistry S.N.ArtsD.J.M.Commerce and B.N.S.Science CollegeSangamner 422605Savitribai Phule Pune UniversityMaharashtraIndia Department of Biotechnology School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavur-613401TamilnaduIndia Department of Chemical Engineering Faculty of TechnologyDharmsinh Desai UniversityNadiad-387001GujaratIndia Advanced Materials and Processes Research Institute Hoshangabad RoadBhopal 462026India

In this perspective,we have highlighted the current literature and explained the synthesis,structure,morphology,modification strategies,and photocatalytic applications of emerging BiPO_(4)-based *** BiPO_(4)is a large bandgap photocatalyst,it uses UV light for the excitation of electrons,and also,the recombination of charge carriers is an issue in BiPO_(4).Various novel modification strategies of BiPO_(4)photocatalysts *** modifications,heterojunction formation,phase-junctions,surface plasmon resonance,Schottky junction have been successfully proposed and *** modifications enhance the light absorption and inhibit the recombination of charge carriers BiPO_(4)***,future aspects for further research on BiPO_(4)-based photocatalysts are also *** expects that BiPO_(4)-based photocatalysts represent a promising strategy for developing practical photocatalysts for energy and environmental remediation applications.

关键词： Photocatalysis Modification strategies Environmental remediation BiPO_(4)photocatalyst

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