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Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

Precision Clinical Medicine 2018年第2期1卷 75-87页

作者： archana sharma-oates Abeer M.Shaaban Ian Tomlinson Luke Wynne Jean-Baptiste Cazier Sudha Sundar Centre for Computational Biology Haworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesHaworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Department of Cellular Pathology University Hospitals Birmingham NHS Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152THUK Pan-Birmingham Gynaecological Cancer Centre City HospitalDudley RoadBirminghamWest MidlandsB187QHUK

Breast and ovarian cancers now account for one in three cancers in Indian women and their incidence is *** differences in the clinical presentation of breast and ovarian cancers exist between India and the United *** example,Indian patients with breast cancer typically present a decade earlier than in the *** for this could be multifactorial,including differences in underlying biology,environmental risks,and other systematic factors including access to *** possible explanation lies in variable incidence or penetrance of germline mutations in genes such as BRCA1 and *** performed a methodical database and literature review to investigate the prevalence and spectrum of high-risk cancer susceptibility genes in Indian patients with breast and ovarian *** identified 148 articles,but most studies were small,with inconsistent inclusion criteria and based on heterogeneous technologies,so that mutation frequency could not be reliably *** were also often lacking on penetrance,histopathology,and survival *** filtering out unsuitable studies,only 13 remained,comprising 1028 ***-scale research studies are urgently needed to determine mutation prevalence,spectra,and clinico-pathological features,and hence derive guidelines for screening,treatment,and prevention specific to the Indian population.

关键词： BRCA1 BRCA2 hereditary cancer sporadic cancer India breast cancer ovarian cancer

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Corrigendum to:Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

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Precision Clinical Medicine 2018年第3期1卷 134-134页

作者： archana sharma-oates Abeer M.Shaaban Ian Tomlinson Luke Wynne Jean-Baptiste Cazier Sudha Sundar 不详

This is a correction notice for article pby010(Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India;DOI:https://***/10.1093/pcmedi/pby010),published on 22 September *** authors were mistakenly listed as being affiliated with the following:‘Centre for Computational Biology,Institute of Cancer and Genomic Sciences,College of Medical and Dental Sciences,Haworth Building,University of Birmingham,Edgbaston,Birmingham,B152TT,UK.’Their affiliations should instead have been given as follows.

关键词： breast cancer susceptibility

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Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit SHUKLA archana sharma Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

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Urban greenways： Operationalizing design syntax and integrating mathematics and science in design

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Frontiers of Architectural Research 2015年第1期4卷 24-34页

作者： archana sharma Morgan State University School of Architecture and Planning CBEIS 1700 E. Cold Spring Lane BaltimoreMD 21251 USA

The ubiquitous sameness of urban greenways prompts questions on generative design grammar and syntax, whether creative, critical rethinking at that level might be lacking. However the design syntax of urban greenways is not explicitly discussed thus leaving a critical gap in knowledge. This paper begins tackling the larger question by acting on the fundamental subset of it, by operationatizing the design syntax of urban greenways. This is done through mathematics-based graph studies to analyze patterns and shapes, photography based thermal, material and morphology studies, and section analyses to make imagery-derived deductions on the design syntax. Recommendation on approaches to diversify and enrich the design syntax includes a more direct reference from ecosystem science theories such for siting and planning the urban greenways at macro- to meso-scale, a mixed-method approach, combining mathe- matics, photography and drawings based frames for analyses at meso- to micro-scale, and a turtle view scale for designing at meso- to micro-scale, with an emphasis on latter.

关键词： Design thinking Syntax Greenway Urban Ptanning Landscape STEM integrateddesgn Inter-discipLinary

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Spatio-temporal variation of trace elements distributed over surface water of Upper Ganga River Basin in Western Himalayan Region

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Journal of Mountain Science 2023年第1期20卷 145-162页

作者： Deepika DIMRI Ambika KUMAR DeepakKumar MISHRA archana sharma Doon University Dehradun248012India Bhagalpur National College Bhagalpur812007India

The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream *** metals flowed with river water can lead to serious impact on ecological system and human ***,the documentation on trace elements of Himalayan rivers is inadequately *** current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan *** samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological *** studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of ***,the highest values of HPI in hyporhithron zone correspond to poor water quality *** with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural *** Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water *** Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithr

关键词： Trace elements Spatial variation Temporal variation Surface water Ganga River Basin ICP-OES

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Vigna radiata var. GM4 Plant Growth Enhancement and Root Colonization by a Multi-Metal-Resistant Plant Growth-Promoting Bacterium Enterobacter sp. C1D in Cr(VI)-Amended Soils

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Pedosphere 2018年第1期28卷 144-156页

作者： Gangavarapu SUBRAHMANYAM Rakesh Kumar sharma Gattupalli Naresh KUMAR Gattupalli archana Department of Microbiology and Biotechnology Centre The Maharaja Sayajirao University of Baroda Department of Biomedical Science Nitte University Center for Science Education and Research (NUCSER) Nitte University Central Muga Eri Research and Training Institute Central Silk Board Department of Biochemistry Faculty of Science The Maharaja Sayajirao University of Baroda

Contamination of agricultural soils by heavy metals has become a major concern due to their toxic effects on plant growth,symbiosis and consequently the yields of crops. In the present study, to enhance plant growth in Cr（VI）-amended soils, novel metalresistant plant growth-promoting bacteria（PGPB） were isolated from a soil contaminated with industrial waste effluent. One of the bacterial isolates, identified as Enterobacter sp. C1 D by 16 S r RNA gene sequencing, was found to be multi-metal resistant in nature with excellent plant growth-promoting（PGP） traits. Mung bean（Vigna radiata var. GM4） inoculation with Enterobacter sp.C1 D significantly（P ＆lt; 0.01） increased root and shoot length, shoot and root weight, and chlorophyll content in a range of Cr（VI）treatments. Plant tolerance towards Cr（VI） measured as effective concentration showed higher values with Enterobacter sp. C1 Dtreated plants compared to un-inoculated plants. Root colonization study was also carried out using green fluorescence protein-labeled Enterobacter sp. C1 D under a hydroponic system. Confocal laser scanning microscopy of the plant roots showed heavy bacterial loads on the surface of the plant root specifically at the root tip and the point of root hair/lateral root formation. The results of PGP traits showed that elevated indole acetic acid levels and 1-aminocyclopropane-1-carboxylate deaminase activity enabled Enterobacter sp. C1 D to enhance V. radiata growth in Cr（VI）-amended soils, whereby it significantly increased plant tolerance towards elevated Cr（VI） concentrations.

关键词： chromium(VI) Enterobacter sp C1D heavy metal metal toxicity plant tolerance

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Development and performance characterization of a compact plasma focus based portable fast neutron generator

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Plasma Science and Technology 2020年第11期22卷 127-135页

作者： Rishi VERMA Ekansh MISHRA Prosenjit DHANG Basanta Kumar DAS Manraj MEENA Lakshman RONGALI archana sharma Pulsed Power&Electromagnetics Division Bhabha Atomic Research Centre FacilityAtchutapuramVishakhapatnam 531011.India Homi Bhabha National Institute AnushaktinagarMumbai 400094India Raja Ramanna Centre for Advanced Technology Rajendra NagarIndore 452013India Variable Energy Cyclotron Centre BidhannagarKolkata 700064India

The design details and performance characterization results of a newly developed plasma focus based compact and portable system(0.5 m×0.5 m×1.2 m,weighing≈100 kg)that produces an average neutron yield of^2×10^8 neutrons/shot(of fast D-D neutrons with typical energy^2.45 Me V)at^1.8 k J energy discharge are *** the detailed analysis of the experimental characterization and simulation results of this system,it has been conclusively revealed that specifically in plasma focus devices with larger static inductance:(i)pinch current is a reliable and more valid neutron yield scaling parameter than peak current,(ii)the ratio of pinch/peak current improves as static inductance of the system reduces,(iii)the benign role of the higher static/pinch inductance ratio enables the supply of inductively stored energy in densely pinched plasma with a larger time constant and it is well depicted by the extended dip observed in the discharge current trace,(iv)there is the need to redefine existing index values of the pinch(Ipinch^4.7)and peak(Ipeak^3.9)currents in neutron yield scaling equations to higher values.

关键词： plasma focus neutrons time of flight pinch current peak current plasma pinch pseudospark switch

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On the photoevaporation,dust polarization and kinematics of two nebulae in Sh2-236

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Research in Astronomy and Astrophysics 2021年第4期21卷 157-167页

作者： archana Soam SOFIA Science Center Universities Space Research AssociationNASA Ames Research CenterM.S.N232-12Moffett FieldCA 94035USA

In the work presented here,the impact of magnetic field on the dynamical evolution of cometary globules Sim 129 and Sim 130 in the Sh2-236 HⅡregion and the ionized gas streaming out of their surfaces is *** magnetic field morphology in the region associated with these globules is inferred using optical polarization measurements with the Sampurnanand Telescope at *** nebular emission is probed through radio continuum mapping at 1.4 GHz with the archival National Radio Astronomy Observatory(NRAO)Very Large Array(VLA)Sky Survey(NVSS)*** correlation of these measurements suggests that photoevaporated gas from the surfaces of Sim 129 and Sim 130 accumulates in clouds and starts streaming along the magnetic field *** ^(12)CO(J=1-0)molecular line observations are performed towards NGC 1893 from the 14-m single dish radio telescope in Taeduk Radio Astronomy Observatory(TRAO).The velocity dispersion in the ^(12)CO(J=1-0)molecular line and the dispersion in polarization angles are considered in the Davis-Chandrasekhar-Fermi formulation to estimate the magnetic field strength towards two Sim *** average value of field strength is found to be~60μG with uncertainty of 0.5 times the estimated value.

关键词： ISM:general polarization:nebulae

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Forensic Analysis of Sexual Dimorphism from Facial Photographs

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Journal of Forensic Science and Medicine 2024年第3期10卷 196-208页

作者： Prachi Panwar Tina sharma archana Gautam Mahipal Singh Sankhla Department of Forensic Science University Institute of Allied Health SciencesChandigarh UniversityMohaliPunjabIndia University Centre for Research and Development Chandigarh UniversityMohaliPunjabIndia

Background:Techniques for identifying facial features and proving the individuality of a person’s facial features are used in forensic *** and Objectives:Acommon method in this area is cranial anthropometry,which has uses in facial reconstruction,locating unidentified remains,and identifying criminal *** and Methods:A study analyzed 200 standard full-face photographs of 50 males and 50 females to compare frontal and lateral facial images and identify male and female facial *** located landmarks and measured the distances between *** data were analyzed using statistical tests like t-tests and analysis of variance(ANOVA)***:The results showed that in 100%of the suggested measurements for both males and females,there were no statistically significant differences(P>0.05)between frontal and lateral *** ANOVA test,however,showed that all suggested measurements showed differences in the lateral aspect,while only 76.92%of them showed differences between the male and female groups in the frontal ***:In conclusion,statistically significant differences were found,rejecting the null hypothesis of equal means,when the level of significance(α)was lower than the P value(0.05).On the other hand,the null hypothesis was accepted when statistically insignificant differences were found and the level of significance was higher than the P *** there were differences between males and females in different views,the distances between landmarks in frontal and lateral views of the same person were generally *** taken in the lateral aspect were more accurate and displayed greater sexual dimorphism variation compared to those taken in the frontal aspect.

关键词： Anthropometry craniofacial facial feature landmarks personal identification somatic measurements

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Preparation, characterization and luminescence behavior of some samarium complexes

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Rare Metals 2021年第9期40卷 2618-2626页

作者： archana Chauhan Ritu Langyan Department of Chemistry Kurukshetra UniversityKurukshetra 136119India

The synthesis of luminescent complexes of Sm(III) with the general formula [Sm(L)_(3)·(X)] was done in powder form. In the formula, L is 6-methyl-4-oxo-4 H-1-benzopyran-3-carboxaldehyde and X represents 2H_(2)O(C1), 1,10-phenanthroline(C2), 2,20-bipyridine(C3);bathophenanthroline(C4) and neocuproine(C5). The complexes were characterized by using various analytical and spectroscopic tools like elemental analysis, electrospray ionization mass spectrometry(ESI–MS+), Fourier transform infrared spectroscopy(FTIR), ultraviolet–visible(UV–Vis) spectroscopy, thermo-gravimetric analysis/differential thermal gravimetric analysis(TGA/DTG), field emission scanning electron microscopy(FESEM), powder X-ray diffraction(XRD), and photoluminescence(PL)studies. TGA/DTG showed high thermal stability of synthesized complexes. Powder XRD depicts that the average particle size lies in the nano-range. On monitoring at the excitation wavelength of 370 nm, the complexes display characteristic luminescence peaks of Sm(III) at ~564,~600 and ~647 nm assigned to^(4)G_(5/2)→^(6)H_(5/2),^(4)G_(5/2)→^(6)H_(7/2), and ^(4)G_(5/2)→6H9/2 transitions, respectively, with the most intense transition at ~600(orange emission) and~647 nm(bright red emission) in liquid and powder state, respectively. The investigations demonstrate that the synthesized novel complexes might be practically useful in electroluminescent devices, bio-assays, and liquid lasers due to their attractive photoluminescent properties.

关键词： Samarium complexes Luminescence Thermal analysis Quantum yield

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