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Effect of aqueous seed extract of Mucuna pruriens on arsenic-induced testicular toxicity in mice

Asian pacific Journal of Reproduction 2020年第2期9卷 77-82页

作者： Preethi Concessao Laxminarayana Kurady Bairy archana parampalli raghavendra Department of Physiology Melaka Manipal Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacology RAK College of Medical SciencesRAK Medical and Health Sciences UniversityRas Al KhaimahUnited Arab Emirates

Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino ***:Thirty-six male albino mice were divided into six groups,with 6 mice in each *** 1 received drinking water as the normal *** 2 to 6 received sodium arsenite(40 mg/L)in drinking *** 3 received sodium arsenite(40 mg/L)and 300 mg/kg body weight(b.w.)of *** 4 received sodium arsenite(40 mg/L)and 500 mg/kg *** *** 5 received sodium arsenite(40 mg/L)and 1000 mg/kg *** *** 6 received sodium arsenite(40 mg/L)and 2000 mg/kg *** ***.N-acetylcysteine and *** were administered orally once a *** were subjected to the above treatments for 45 *** were sacrificed with overdose of ketamine 24 h following drug *** testis was used for biochemical estimations(lipid peroxidation and glutathione),and the epididymis was used to determine the sperm count and ***:Sodium arsenite significantly decreased(P<0.01)the sperm count and glutathione levels of the *** significantly increased(P<0.01)the abnormal architecture of the spermatozoa and lipid peroxidation *** with *** significantly increased the sperm count and the glutathione levels[500 mg/kg *** 1000 mg/kg b.w.(P<0.01)].A significant decrease in sperm abnormality and lipid peroxidation levels[500 mg/kg *** 1000 mg/kg b.w.(P<0.01)]was also ***:The perturbed sperm parameters and antioxidant levels of the arsenic insulted testis are attenuated by 500 mg/kg *** 1000 mg/kg ***.

关键词： Sodium arsenite Mucuna pruriens Sperm morphology Sperm count Testis

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Effect of Different Diet Level on the Physiological Adaptability, Biochemical and Endocrine Responses and Relative Hepatic HSP70 and HSP90 Genes Expression in Osmanabadi Kids

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Journal of Agricultural Science and Technology(A) 2015年第9期5卷 755-769页

作者： Veerasamy Sejian Madiajagan Bagath Sivashanmugam Parthipan Gundallahalli Bayyappa Manjunathareddy Sellappan- Selvaraju Santanahalli Siddalingappa archana Nira Manik Soren Somu Bala Nageswara Rao Kandalam Giridhar Janivara Parameswaraiah Ravindra raghavendra Bhatta Animal Physiology Division ICAR-National Institute of Animal Nutrition and Physiology Adugodi Bengaluru 560030 India Animal Nutrition Division ICAR-National Institute of Animal Nutrition and Physiology Adugodi Bengaluru 560030 lndia ICAR-National Institute of Veterinary Epidemiology and Disease Informatics Yelahanka Bengaluru 560064 India Knowledge Management and Biostatistics Section ICAR-National Institute of Animal Nutrition and Physiology AdugodiBengaluru 560030 lndia ICAR-National Institute of Animal Nutrition and Physiology Adugodi Bengaluru 560030 India

The study was conducted to investigate the impact of different levels of feed on the adaptive capability based on physiological, blood biochemical, endocrine and molecular mechanisms in growing Osmanabadi kids. The primary objective of the study was to identify if HSP70 and HSP90 can be a nutritional stress marker for goat. The study was conducted for a period of two months. The animals were randomly divided into three groups as GI （n = 6; ad libitum feeding）, GII （n = 6; 20% less than ad libitum） and GIII （n = 6; 40% less than ad libitum）. The animals were fed with feed consisting of 50% roughage and 50% concentrate. Blood collection was carried out at fortnightly intervals. Body weights were recorded at weekly interval. Physiological responses, biochemical responses, plasma tri-iodo-thyronine （T3）, thyroxin （＇1＂4） and cortisol were recorded at fortnightly interval. At the end of study period, only GI and Gill animals were slaughtered and different organs were collected for histopathological studies as well as for hepatic HSP70 and HSP90 mRNA transcript expression. Body weight recorded showed significant （P 〈 0.01） differences between the groups. Physiological responses showed significant （P 〈 0.01） variation among the groups. Among the biochemical parameters, plasma glucose and total plasma protein and globulin showed significant （P 〈 0.01） differences between the groups. Plasma T3 （P 〈 0.01）, T4 （P 〈 0.01） and cortisol （P 〈 0.05） also differed significantly between the groups. The relative hepatic HSP70 mRNA transcript expression was significantly （P 〈 0.05） higher in Gill （2.8 fold） as compared to GI （1 fold） kids. Similar result was obtained for hepatic HSP90 mRNA transcript expression. From the results, it can be concluded that Osmanabadi kids possessed the ability to alter their adaptive mechanisms to maintain homeostasis. Further, the study revealed the significance of providing the optimum nutrition for these animals to adapt to existing environmental condi

关键词： Adaptation cortisol goat HSP70 HSP90 nutritional stress.

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