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Toward integrated detection and graphene-based removal of contaminants in a lab-on-a-chip platform

Nano Research 2017年第7期10卷 2296-2310页

作者： Andrzej Chalupniak arben merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain ICREA Pg. Lluis Companys 23 08070 Barcelona Spain

A novel miniaturized microfluidic platform was developed for the simultaneous detection and removal of polybrominated diphenyl ethers （PBDEs）. The platform consists of a polydimethylsiloxane （PDMS） microfluidic chip for an immunoreaction step, a PDMS chip with an integrated screen-printed electrode （SPCE） for detection, and a PDMS-reduced graphene oxide （rGO） chip for physical adsorption and subsequent removal of PBDE residues. The detection was based on competitive immunoassay-linked binding between PBDE and PBDE modified with horseradish peroxidase （HRP-PBDE） followed by the monitoring of enzymatic oxidation of o-aminophenol （o-AP） using square wave anodic stripping voltammetry （SW-ASV）. PBDE was detected with good sensitivity and a limit of detection similar to that obtained with a commercial colorimetric test （0.018 ppb）, but with the advantage of using lower reagent volumes and a reduced analysis time. The use of microfluidic chips also provides improved linearity and a better reproducibility in comparison to those obtained with batch-based measurements using screen-printed electrodes. In order to design a detection system suitable for toxic compounds such as PBDEs, a reduced graphene oxide-PDMS composite was developed and optimized to obtain increased adsorption （based on both the hydrophobicity and rr-v~ stacking between rGO and PBDE molecules） compared to those of non-modified PDMS. To the best of our knowledge, this is the first demonstration of electrochemical detection of flame retardants and a novel application of the rGO-PDMS composite in a biosensing system. This system can be easily applied to detect any analyte using the appropriate immunoassay and it supports operation in complex matrices such as seawater.

关键词： electrochemistry,microfluidics,graphene oxide,flame retardants,lab on a chip,polydimethylsiloxane

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Tunable electrochemistry of gold-silver alloy nanoshells

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Nano Research 2018年第12期11卷 6336-6345页

作者： Lorenzo Russo Victor Puntes arben merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BISTCampus UABBellaterra08193BarcelonaSpain Universitat Autonoma de Barcelona (UAB) Campus UABBellaterra08193BarcelonaSpain Vail d'Hebron Institut de Recerca (VHIR) 08035BarcelonaSpain Institucio Catalana de Recerca i Estudis Avancats (ICREA) P Llub Companys 2308010BarcelonaSpain

The widespread and increasing interest in enhancing biosensing technologies by increasing their sensitivities and lowering their costs has led to the exploration and application of complex nanomaterials as signal transducers and enhancers. In this work, the electrochemical properties of monodispersed AuAg alloy nanoshells (NSs) with finely tunable morphology, composition, and size are studied to assess their potential as electroactive labels. The controlled corrosion of their silver content, caused by the oxidizing character of dissolved oxygen and chlorides of the electrolyte, allows the generation of a reproducible electrochemical signal that is easily measurable through voltammetric techniques. Remarkably, the underpotential deposition of dissolved Ag+ catalyzed on AuAg NS surfaces is observed and its dependence on the nanoparticle morphology, size, and elemental composition is studied, revealing a strong correlation between the relative amounts of the two metals. The highest catalytic activity is found at Au/Ag ratios higher than ≈ 10, showing how the synergy between both metals is necessary to trigger the enhancement of Ag+ reduction. The ability of AuAg NSs to generate an electrocatalytic current without the need for any strong acid makes them an extremely promising material for biosensing applications.

关键词： Au nanoshells nanoparticles surface chemistry underpotential deposition

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Bioluminescent nanopaper for rapid screening of toxic substances

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Nano Research 2018年第1期11卷 114-125页

作者： Jie Liu Eden Morales-Narvaez Jahir Orozco Teresa vicent Guohua Zhong arben merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and the Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Laboratory of Insect Toxicology Key Laboratory of Pesticide and Chemical Biology Ministry of Education South China Agricultural University Guangzhou 510642 China Departamentd'Enginyeria Quimica UniversitatAutOnoma de Barcelona Bellaterra Barcelona 08193 Spain ICREA Pg. Llufs Companys 23 08010 Barcelona Spain

Environmental pollution is threatening human health and ecosystems as a result of modern agricultural techniques and industrial progress. A simple nanopaper-based platform coupled with luminescent bacteria Aliivibrio Jischeri （A. Jischeri） as a bio-indicator is presented here, for rapid and sensitive evaluation of contaminant toxicity. When exposed to toxicants, the luminescence inhibition of A. Jischeri-decorated bioluminescent nanopaper （BLN） can be quantified and analyzed to classify the toxicity level of a pollutant. The BLN composite was characterized in terms of morphology and functionality. Given the outstanding biocompatibility of nanocellulose for bacterial proliferation, BLN achieved high sensitivity with a low cost and simplified procedure compared to conventional instruments for laboratory use only. The broad applicability of BLN devices to environmental samples was studied in spiked real matrices （lake and sea water）, and their potential for direct and in situ toxicity screening was demonstrated. The BLN architecture not only survives but also maintains its function during freezing and recycling processes, endowing the BLN system with competitive advantages as a deliverable, ready-to-use device for large-scale manufacturing. The novel luminescent bacteria-immobilized, nanocelullose-based device shows outstanding abilities for toxicity bioassays of hazardous compounds, bringing new possibilities for cheap and efficient environmental monitoring of potential contamination.

关键词： bacterial nanocellulose,nanopaper,Aliivibrio jqscheri,bioluminescent device,toxicity bioassay

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Nanoparticles-based nanochannels assembled on a plastic flexible substrate for label-free immunosensing

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Nano Research 2015年第4期8卷 1180-1188页

作者： Alfredo de la Escosura-Muniz Marisol Espinoza-Castaneda Madoka Hasegawa Laetitia Philippe arben merkoci ICN2-Nanobioelectronics & Biosensors Group Institut Catala de Nanociencia i Nanotecnologia Campus UAB 08193 Bellaterra (Barcelona) Spain EMPA Swiss Federal Laboratories for Materials Science and Technology Feuerwerkerstrasse 39 3602Thun Switzerland ICREA-Institucio Catalana de Recerca i Esrudis Avan@ats 08010 Barcelona Spain

便宜地，可处理、单个使用的基于 nanoparticles 的 nanochannel 站台为没有标签的 immunosensing 在灵活底层上装配了的一篇小说被介绍。这个察觉到的平台被 carboxylated 聚苯乙烯 nanospheres PS 的同类、装配的单层的 dip-coating ... 详细信息

便宜地，可处理、单个使用的基于 nanoparticles 的 nanochannel 站台为没有标签的 immunosensing 在灵活底层上装配了的一篇小说被介绍。这个察觉到的平台被 carboxylated 聚苯乙烯 nanospheres PS 的同类、装配的单层的 dip-coating 形成， 200 和 500 到灵活的打印屏幕的铟锡氧化物 / 聚乙烯 terephthalate ITO/PET 电极的工作区域上缩放 nm。在自我装配的 nanospheres 之间的空格分别地产生秩序井然的 nanochannels，与约 65 和 24 nm 的 inter-PS 粒子距离。形成的 nanochannels 基于监视被用于抗体和随后的蛋白质察觉的有效固定[FeCN 6 ] 通过在在 immunocomplex 之上的微分脉搏 voltammetric 信号的散开和减少的 4 流动形成。获得的察觉到的系统是依赖的 nanochannel 尺寸并且允许选择为在 580 ng/mL 的层次要检测的模型 analyte 的人的免疫球蛋白 G IgG。系统也对在真实样品在场的另外的蛋白质展出优秀特性并且与一件人的尿样品显示出好性能。发达设备表示以前报导的基于 nanochannels 的途径和罐头的限制克服许多的一个综合、简单的 biodetection 系统在未来被扩大到几另外的免疫和 DNA 察觉系统。

关键词：免疫复合物纳米通道纳米粒子柔性基板无标记传感蛋白质检测检测系统

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Triple lines gold nanoparticle-based lateral flow assay for enhanced and simultaneous detection of Leishmania DNA and endogenous control

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Nano Research 2015年第11期8卷 3704-3714页

作者： Lourdes Rivas Alfredo de la Escosura-Muniz Lorena Serrano Laura Altet Olga Francino ArmandSanchez arben merkoci ICN2-Nanobioelectronics & Biosensors Group Institut Catala de Nanociencia i Nanotecnologia Campus UAB 08193 Bellaterra (Barcelona) Spain Autonomous University of Barcelona Campus UAB 08193 Bellaterra (Barcelona) Spain Vetgenomics Edifici Eureka Parc de Recerca UAB 08193 Bellaterra (Barcelona) Spain Centre for Research in Agricultural Genomics-CSIC-IRTA-UAB-UB Campus UAB 08193 Cerdanyola del Varies Catalonia Spain ICREA - Institucio Catalana de Recerca i Estudis A vancats 08010 Barcelona Spain

一个新奇三元组在狗血样品为利什曼原虫 infantum DNA 的察觉与提高的敏感衬里侧面流动的试金(LFA ) 被设计并且成功地适用。提高的 LFA 方法论利用结合到 polyclonal 的金 nanoparticle 标签(AuNPs ) 第二等的抗体，它认出 anti-FITC ... 详细信息

一个新奇三元组在狗血样品为利什曼原虫 infantum DNA 的察觉与提高的敏感衬里侧面流动的试金(LFA ) 被设计并且成功地适用。提高的 LFA 方法论利用结合到 polyclonal 的金 nanoparticle 标签(AuNPs ) 第二等的抗体，它认出 anti-FITC 抗体。第二等的抗体的 polyclonal 性质允许多重绑定到主要抗体，导致提高了 AuNP plasmonics 信号。而且，由放大的狗 18S rRNA 基因组成的内长的控制被介绍避免假 negatives。用这策略， 0.038 每 DNA 扩大反应(DNA 样品的 1 parasite/100 L ) 刺了利什曼原虫寄生虫被检测。LFA 的察觉限制被发现比常规技术的低。在摘要，我们的新奇 LFA 设计是能被扩大到几种另外的 biosensing 情形的一种通用、简单的察觉到的选择。

关键词： DNA检测同时检测原虫控制纳米金多克隆抗体金纳米粒子基础

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