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Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus

Neuroprotection 2024年第2期2卷 167-178页

作者： aravind parthasarathy Ramesha Hanumanthappa Sarojini R.Bulbule Kiran P.C. Hemalatha Nanjaiah Gopinath G. Siddaiah B.M. David Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoology Karnatak UniversityDharwadIndia

Backgrounds:Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living *** have previously explored the overexpression of calcium-binding protein genes in a reactive oxygen and nitrogen species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze gene expression of major calcium-binding proteins(calcineurin,calmodulin,calsyntenin,synaptotagmin,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(glutamate receptor ionotropic[GluN]GluN1,GluN2A,and GluN2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assigned to two stress induction groups and a control group without stress(n=6).Stress was induced by using H_(2)O_(2)(3%in water)or by immobilization(using a sticky mat)over a period of 30 *** of calcium-binding protein genes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of genes encoding calcium-binding proteins calcineurin,calsyntenin,synaptotagmin and NMDA receptor subunit GluN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,p<0.05,2.05±0.08vs.1.03±0.02,p<0.005;2.2±0.4 vs.1.02±0.03,p<0.05,1.98±0.07 vs.1.02±0.03,p<0.005;1.4±0.6 vs.1.15±0.09,p<0.05,1.39±0.05 vs.1.15±0.09,p<0.005),*** stress-induced rats,neurons in the CA2 region of the hippocampus were fewer and appeared disorganized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxygen and nitrogen species(RONS)can also lead to stress in rats by affecting their calcium signaling,buffering capacity in the neurons leading to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

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