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A Meta-Analysis of the Genome-Wide Association Studies on Two Genetically Correlated Phenotypes Suggests Four New Risk Loci for Headaches

引用

Phenomics 2023年第1期3卷 64-76页

作者： Weihua Meng Parminder S.Reel Charvi Nangia aravind lathika rajendrakumar Harry L.Hebert Qian Guo Mark J.Adams Hua Zheng Zen Haut Lu Me Research Team Debashree Ray Lesley A.Colvin Colin N.A.Palmer Andrew M.McIntosh Blair H.Smith Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100China Division of Population Health and Genomics Ninewells Hospital and Medical SchoolUniversity of DundeeDundee DD24BFUK Division of Psychiatry Edinburgh Medical SchoolUniversity of EdinburghEdinburgh EH105HFUK Department of Anaesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China PAPRSB Institute of Health Sciences Universiti Brunei DarussalamBandar Seri Begawan BE1410Brunei Darussalam andMe Inc.SunnyvaleCA 94086USA Department of Epidemiology Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA Department of Biostatistics Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA

Headache is one of the commonest complaints that doctors need to address in clinical *** genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically *** this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(N=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly *** LDL receptor related protein 1(LRP1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of *** One Cut homeobox 2(ONECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of *** study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for *** study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.

关键词： Headache Migraine Unified Score-based Association Test Correlated phenotypes Meta-analysis Genome-wide association study

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