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Radiotherapy,photodynamic therapy,and cryoablation‐induced abscopal effect:Challenges and future prospects

Cancer Innovation 2023年第5期2卷 323-345页

作者： Sadik Ali Mohammad Arshadul Hak Sunil V.Pogu aravind k.rengan Indian Institute of Technology Hyderabad KandiSangareddyTelanganaIndia

Local therapy modalities such as radiation therapy,photodynamic therapy,photothermal therapy,and cryoablation have been used to treat localized tumors for *** discovery of the abscopal effect causes a paradigm shift where local therapy also causes systemic effects and leads to the remission of nonirradiated *** abscopal effect of radiation therapy,alone or in combination with other treatments,has been extensively studied over the last six ***,the results are unsatisfactory in producing robust,reproducible,and long‐lasting systemic *** immunotherapy and radiation therapy are promising in producing the abscopal effect,the abscopal effect's mechanism is still unclear,owing to various factors such as irradiation type and dose and cancer *** article reviews the research progress,clinical and preclinical evidence of the abscopal effect by various local therapies alone and in combination with chemotherapy and immunotherapy,case reports,and the current challenges in producing the abscopal effect by various local therapies,focusing on radiotherapy,photodynamic therapy,cryoablation,and the prospects for obtaining a robust,reproducible,and long‐lasting abscopal effect.

关键词： abscopal effect local therapy radiotherapy photodynamic therapy cryoablation immunotherapy cancer

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Casein nanoformulations-Potential biomaterials in theranostics

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Food Bioscience 2022年第6期50卷 1430-1439页

作者： Sajmina khatun Tejaswini Appidi aravind kumar rengan Department of Biomedical Engineering IIT HyderabadKandiSangareddy502285TelanganaIndia

Casein is a milk protein emerging as a potential nanosystem for applications in therapy and *** consists of four major phosphoproteins with their homologous primary amino acid sequences into the following familiesαs1,αs2,β,andκ-*** the aqueous phase,casein forms micelles binding with colloidal calcium ***,high drug binding/encapsulation capability,potential to cross the blood-brain barrier,and targeted cellular uptake are a few of the properties of casein micelles,enabling their application in *** review discusses various components,properties,and functions of casein phosphoproteins and casein ***-specific cross-linking mechanisms and different synthesis approaches are also *** review extensively explores casein's structural and functional properties and its biomedical application:targeted drug delivery and tissue *** potential applications of casein-based complexes for treating iron deficiency anaemia and casein-derived peptides for inhibition of neuronal cognitive disorders are also discussed in this review.

关键词： Casein micelles Anticancer drug delivery Tissue engineering Iron deficiency anaemia Alzheimer's disease

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A comprehensive review of 3D cancer models for drug screening and translational research

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Cancer Innovation 2024年第1期3卷 61-78页

作者： karthikey Sharma Sreenath Dey Rounik karmakar aravind kumar rengan Department of Biomedical Engineering Indian Institute of Technology(IIT)HyderabadIndia

The 3D cancer models fill the discovery gap of 2D cancer models and play an important role in cancer *** addition to cancer cells,a range of other factors include the stroma,density and composition of extracellular matrix,cancer-associated immune cells(e.g.,cancer-associated fibroblasts cancer cell-stroma interactions and subsequent interactions,and a number of other factors(e.g.,tumor vasculature and tumor-like microenvironment in vivo)has been widely ignored in the 2D concept of *** this knowledge,the continued use of monolayer cell culture methods has led to the failure of a series of clinical *** review discusses the immense importance of tumor microenvironment(TME)recapitulation in cancer research,prioritizing the individual roles of TME elements in cancer *** TME provided by the 3D model fulfills the requirements of in vivo spatiotemporal arrangement,components,and is helpful in analyzing various different aspects of drug sensitivity in preclinical and clinical trials,some of which are discussed ***,it discusses models for the co-assembly of different TME elements in vitro and focuses on their synergistic function and responsiveness as ***,this review broadly describes of a handful of recently developed 3D models whose main focus is limited to drug development and their screening and/or the impact of this approach in preclinical and translational research.

关键词： 3D models cancer drug development translational research tumor microenvironment elements

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