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大环内酯类抗生素25年应用总结--面向常见病的应用进展

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中国实用内科杂志 2009年第10期29卷 903-905页

作者： arata azuma 安云霞(翻译) 张放(审校) 康健(审校) 日本医科大学呼吸感染肿瘤部门东京113-8602 不详

大环内酯类抗生素(MA)可显著改善弥漫性泛细支气管炎(DPB)的预后。同时对慢性副鼻窦炎、绿脓杆菌感染等均产生显著疗效,提示着MA除抗菌作用以外还具有抗炎作用,这种抗炎作用不仅对宿主,对致病菌本身也发挥着重要作用。近年来逐渐认识到M... 详细信息

大环内酯类抗生素(MA)可显著改善弥漫性泛细支气管炎(DPB)的预后。同时对慢性副鼻窦炎、绿脓杆菌感染等均产生显著疗效,提示着MA除抗菌作用以外还具有抗炎作用,这种抗炎作用不仅对宿主,对致病菌本身也发挥着重要作用。近年来逐渐认识到MA对慢性阻塞性肺疾病(COPD)、流感病毒感染等常见病也发挥了显著疗效,减缓了疾病的进展和抑制了病情的加重。[第一段]

关键词：大环内酯类抗生素弥漫性泛细支气管炎红霉素

Risk Factors for Postoperative Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Surgery for Primary Lung Cancer

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Open Journal of Respiratory Diseases 2014年第2期4卷 48-54页

作者： Toru Tanaka Shinji Abe Hiroki Hayashi Koichiro Kamio Yoshinobu Saito Jiro Usuki arata azuma Iwao Mikami Shuji Haraguchi Kiyoshi Koizumi Jitsuo Usuda Akihiko Gemma Department of Pulmonary Medicine and Oncology Nippon Medical School Tokyo Japan Department of Thoracic Surgery Graduate School of Medicine Nippon Medical School Tokyo Japan

Objective: Postoperative acute exacerbation of idiopathic interstitial pneumonia (IIP) is a serious complication in patients with lung cancer. This study was aimed to investigate risk factors for postoperative acute exacerbation of IIP in surgery for primary lung cancer. Method: We evaluated retrospectively 37 IIP patients combined with primary lung cancer who underwent lung resection for lung cancer from January 2006 and March 2010. Preoperative and perioperative clinical data were collected and analyzed. Results: Ten of 37 patients (27.0%) developed acute exacerbation of IIP after surgery for primary lung cancer and five patients (13.5%) died of progressive respiratory failure. There was no significant difference in preoperative clinical factors between acute exacerbation (AE) group and non-acute exacerbation (non-AE) group. In perioperative factors, the duration of anesthesia is significantly longer in AE group than in non-AE group. Conclusion: These data suggest that it is unable to predict postoperative acute exacerbation of IIP from preoperative clinical data. Perioperative and postoperative management might be important to prevent acute exacerbation of IIP combined lung cancer.

关键词： Postoperative Acute Exacerbation Idiopathic Interstitial Pneumonia Lung Cancer

Solving composite scheduling problems using the hybrid genetic algorithm

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 953-958页

作者： azuma OKAMOTO Mitsumasa SUGAWARA Faculty of Software and Information Science Iwate Prefectural University

This paper dealt with composite scheduling problems which combine manufacturing scheduling problems and/or transportation routing *** scheduling models were formulated as the elements of the composite scheduling model,and the composite model was formulated composing these models with indispensable additional constraints.A hybrid genetic algorithm was developed to solve the composite scheduling *** improved representation based on random keys was developed to search permutation space.A genetic algorithm based dynamic programming approach was applied to select *** proposed technique and a previous technique are compared by three types of *** results indicate that the proposed technique is superior to the previous one.

关键词： Composite scheduling Manufacturing scheduling Transportation routing Hybrid genetic algorithm

Robust network structures for conserving total activity in Boolean networks

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Control Theory and Technology 2020年第2期18卷 143-147页

作者： Shun-ichi azuma Graduate School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya464-8603Japan

One of the typical properties of biological systems is the law o f conservation o f mass,that is,the property that the mass must remain constant over time in a closed chemical reaction ***,it is known that Boolean networks,which are a promising model of biological networks,do not always represent the conservation *** paper thus addresses a kind of conservation law as a generic property of Boolean *** particular,we consider the problem of finding network structures on which,for any Boolean operation on nodes,the number of active nodes,*** nodes whose state is one,is constant over *** a solution to the problem,we focus on the strongly-connected network structures and present a necessary and sufficient condition.

关键词： Boolean network robust network structure structural analysis conservation law

Fukuititan nipponensis,A New Titanosauriform Sauropod from the Early Cretaceous Tetori Group of Fukui Prefecture,Japan

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Acta Geologica Sinica(English Edition) 2010年第3期84卷 454-462页

作者： Yoichi azuma Masateru SHIBATA Fukui Prefectural Dinosaur Museum 51-11 TeraoMurokoKatsuyamaFukui 911-8601Japan

A titanosauriform dinosaur： Fukuititan nipponensis gen. et sp. nov. is erected based on the incomplete skeleton. It is characterized by elongated asymmetric tooth crown with a weak or absent labial groove and without lingual concavity; stalk-like epipophysis of cervical vertebra; the transverse width of the proximal end of the humerus approximately 32% of the humerus length; metacarpal longer, approximately 48 % of the radius and the distal end of the ischia slightly expanded. It represents the first relatively complete titanosauriform skeleton found from Japan. The discovery of Fukuititan indicates that the diversity and geographical distribution of Titanosauriformes are much higher than the previous thought.

关键词： Fukuititan Titanosauriformes Early Cretaceous Japan

A New Iguanodontian Dinosaur from the Lower Cretaceous Khok Kruat Formation,Nakhon Ratchasima in Northeastern Thailand

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Acta Geologica Sinica(English Edition) 2011年第5期85卷 969-976页

作者： Masateru SHIBATA Pratueng JINTASAKUL Yoichi azuma Fukui Prefectural Dinosaur Museum 51-11 TeraoMurokoKatsuyamaFukui 911-8601Japan Northeastern Research Institute of Petrified Wood and Mineral Resources Nakhon Ratchasima Rajabhat University184 Moo 7 Suranaree SubdistictMuangNakhon Ratchasima 30000Thailand

Here we report a new iguanodontian dentary found from the Lower Cretaceous Khok Kruat Formation,Nakhon Ratchasima,northeast Thailand.A unique character,which is an elongated and flat shape of the dentary ramus,makes it possible to assign the specimen to the new genus of non-hadrosaurid iguanodontian,Ratchasimasaurus suranareae *** *** shows both primitive and derived characters,such as a caudally inclined coronoid process and alveolar trough with a primitive crown impression,and a derived buccal shelf between tooth row and coronoid *** discovery of a new iguanodontian from the Indochina Terrene,considering that the previously reported 'Probactrosaurus-like' iguanodontian,points out a great diversity of this group in the late Early Cretaceous in Thailand,and corresponds to the Asian iguanodontian diversity at that time.

关键词： Ratchasimasaurus iguanodontia dentary Early Cretaceous Thailand

Initiation of plate tectonics in the Hadean: Eclogitization triggered by the ABEL Bombardment

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Geoscience Frontiers 2018年第4期9卷 1033-1048页

作者： Shigenori Maruyama M.Santosh Shintaro azuma Earth-Life Science Institute Tokyo Institute of Technology Institute for Study of the Earth’s Interior Okayama University Centre for Tectonics Resources and ExplorationDepartment of Earth SciencesUniversity of Adelaide School of Earth Sciences and Resources China University of Geosciences Beijing Faculty of Science Kochi University

When plate tectonics began on the Earth has been long debated and here we argue this topic based on the records of Earth-Moon geology and asteroid belt to conclude that the onset of plate tectonics was during the middle Hadean（4.37-4.20 Ga）. The trigger of the initiation of plate tectonics is the ABEL Bombardment, which delivered oceanic and atmospheric components on a completely dry reductive Earth, originally comprised of enstatite chondrite-like materials. Through the accretion of volatiles, shock metamorphism processed with vaporization of both CI chondrite and supracrustal rocks at the bombarded location, and significant recrystallization went through under wet conditions, caused considerable eclogitization in the primordial continents composed of felsic upper crust of 21 km thick anorthosite, and 50 km or even thicker KREEP lower crust. Eclogitization must have yielded a powerful slab-pull force to initiate plate tectonics in the middle Hadean. Another important factor is the size of the bombardment. By creating Pacific Ocean class crater by 1000 km across impactor, rigid plate operating stagnant lid tectonics since the early Hadean was severely destroyed, and oceanic lithosphere was generated to have bi-modal lithosphere on the Earth to enable the operation of plate *** the importance of the ABEL Bombardment event which initiated plate tectonics including the appearance of ocean and atmosphere, we propose that the Hadean Eon can be subdivided into three periods：（1） early Hadean（4.57-4.37 Ga）,（2） middle Hadean（4.37-4.20 Ga）, and（3） late Hadean（4.20-4.00 Ga）.

关键词： Initiation of plate tectonics ABEL Bombardment Eclogitization Stagnant lid tectonics Primordial continents

Optimum sintering conditions for optical properties of translucent aluminum nitride ceramics

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Chinese Science Bulletin 2009年第5期54卷 842-845页

作者： KANECHIKA Yukihiro azuma Masanobu FUKUSHIMA Hiroshi Tokuyama Corp. Graduate School of Engineering Hiroshima University

High translucency is one of the excellent properties of AlN ceramics because of its wide optical band gap energy of 6.2 eV. We have achieved success in producing AlN ceramic tube of 98% total visible light transmittance at 0.6 mm thick tube wall by applying an improved sintering technique. This AlN ceramic was produced by sintering at 1880℃ using Ca3Al2O6 as a sintering additive and in reduction atmosphere to remove the sintering additive from the final sintered material. After the sintering, the annealing with Al2O3 was carried out to improve the transmittance of AlN ceramics. The amount of metal impurities and carbon were 27ppm and 100ppm, respectively. It is noteworthy that the amount of oxygen in AlN ceramics after the annealing was 0.36wt% which was higher than the 0.07wt% of the as-sintered AlN ceramics. Therefore, total transmittance was improved by the oxygen doping. On the other hand, thermal conductivity of AlN after the annealing was lowered by 35% compared with that of as-sintered AlN. Positron Annihilation Lifetime (PAL) measurement was applied to investigation of a relationship between the total transmittance and lattice defects. The present PAL results confirms the presence of negatively charged atomic-size vacancies that is aluminum site vacancies and also sug-gests the increase in the concentration of the vacancies after the annealing compared with that of the as-sintered material. However, it can be concluded that there is no relation between aluminum site va-cancies and the light transmittance of AlN ceramics.

关键词：陶器阳电子湮没铝氮化物半透明性光学性能

Analysis of value of flexibility in Japan’s power system with increased VRE

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Clean Energy 2018年第1期2卷 37-44页

作者： Sumie Nakayama Hitoshi azuma Suguru Fukutome Kazuhiko Ogimoto J-POWER/Electric Power Development Co. Ltd.6-15-1GinzaChuo-kuTokyo 104-8165Japan JP Business Service Corporation 2-2-18FukagawaKoto-kuTokyo 135-8451Japan Institute of Industrial Science Collaborative Research Center for Energy EngineeringThe University of Tokyo4-6-1KomabaMeguro-kuTokyo153-8585Japan

The growth of renewable energy has accelerated globally toward a low-carbon economy since the Paris Agreement entered into force in *** a result of the increase of variable renewable energy(VRE),namely solar PV and wind,power systems require more flexibility from conventional power plants with less power generation to regulate increased *** are sources of flexibility other than conventional power plants,including enhanced power networks,storage capacity and demand *** maximize economic utilization of VRE power generation,it is necessary to use the flexibility potential from all these *** Japan,the share of VRE has increased since the introduction of a feed-in tariff(FIT)and,in parallel,power market reform is *** has a unique power system of nine grids connected like a fish bone,making the uptake of an increasing share of VRE *** paper assesses the value of flexibility by source in Japan’s power system in *** analysis of different VRE scenarios is undertaken based on a newly developed production cost *** result of the simulation shows the quantitative impact of each source of flexibility to the generation cost and VRE curtailment and demonstrates the mechanism by which flexibility works to impact VRE curtailment.

关键词： component power demand and supply renewable energy flexibility Japan’s power system produc-tion cost model analysis