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Stool-based DNA testing,a new noninvasive method for colorectal cancer screening,the first report from Iran

World Journal of Gastroenterology 2007年第10期13卷 1528-1533页

作者： Mohammad Reza Abbaszadegan Alireza Tavasoli arash velayati Hamid Reza Sima Hassan Vosooghinia Mehdi Farzadnia Hamid Asadzedeh Mehran Gholamin Ezzat Dadkhah Azadeh Aarabi Mohammad Reza Abbaszadegan Division of Human GeneticsImmunology Research CenterBu-Ali Research InstituteMUMSMashhadIran Department of Surgery Ghaem HospitalMashhad University of Medical SciencesMashhadIran Department of Internal Medicine Imam Reza HospitalMUMSMashhadIran Department of Internal Medicine Ghaem HospitalMUMSMashhadIran Department of Pathology Imam Reza HospitalMUMSMashhadIran

AIM： To detect tumor-associated DNA changes in stool samples among Iranian patients with colorectal cancer （CRC） compared to healthy individuals using BAT-26, p16 hypermethylation and long DNA markers. METHODS： Stool DNA was isolated from 45 subjects including 25 CRC patients and 20 healthy individuals using a new, fast and easy extraction method. Long DNA associated with tumor was detected using polymerase chain reaction method. Microsatellite studies were performed utilizing denaturating polyacrylamide gel to determine the instability of BAT-26. Methylation status of p16 promoter was analyzed using methylation-specific PCR （MSP）. RESULTS： The results showed a significant difference in existence of long DNA （16 in patients vs 1 in controls, P 〈 0.001） and p16 （5 in patients vs none in controls, P = 0.043） in the stool samples of two groups. Long DNA was detected in 64% of CRC patients; whereas just one of the healthy individuals was positive for Long DNA. p16 methylation was found in 20% of patients and in none of healthy individuals. Instability of BATo26 was not detected in any of stool samples. CONCLUSION： We could detect colorectal cancer related genetic alterations by analyzing stool DNA with a sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively. A non- invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals. However, additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers.

关键词： Stool DNA Colorectal cancer Cancer screening Long DNA BAT-26 p16

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Recent advances in flat sheet mixed matrix membrane modified by Mg-based layered double hydroxides(LDHs)for salt and organic compound separations

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Journal of Magnesium and Alloys 2024年第6期12卷 2182-2200页

作者： Payam Veisi arash Fattah-alhosseini Mosab Kaseem Department of Materials Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedanIran Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea

Magnesium(Mg)is a widely used and attractive metal,known for its unique physical and chemical properties,and it has been employed in the manufacture of many practical *** Double Hydroxides(LDHs),particularly Mg-based LDHs,rank among the most prevalent two-dimensional materials utilized in separation processes,which include adsorption,extraction,and membrane *** high popularity of Mg-based LDHs in separation applications can be attributed to their properties,such as excellent hydrophilicity,high surface area,ion exchangeability,and adjustable interlayer ***,polymer membranes play a pivotal role in semi-industrial and industrial separation ***,the development of polymer membranes and the mitigation of their limitations have emerged as compelling topics for *** methods exist to enhance the separation performance and anti-fouling properties of polymer *** these,incorporating additives into the membrane polymer matrix stands out as a cost-effective,straightforward,readily available,and efficient *** use of Mg-based LDHs,either in combination with other materials or as a standalone additive in the polymer membrane matrix,represents a promising strategy to bolster the separation and anti-fouling efficacy of flat sheet mixed matrix polymer *** review highlights Mg-based LDHs as high-potential additives designed to refine flat sheet mixed matrix polymer membranes for applications in wastewater treatment and brackish water desalination.

关键词： Mg-based layered double hydroxides(LDHs) Mixed matrix membrane Polymeric membrane Water and wastewater treatment Brackishwater desalination

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Commentary on"Speed and surface steepness affect internal tibial loading during running"

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Journal of Sport and Health Science 2024年第1期13卷 125-126页

作者： Michael Baggaley arash Khassetarash Faculty of Kinesiology University of CalgaryCalgaryAB T2N 1N4Canada McCaig Institute for Bone and Joint Health University of CalgaryCalgaryAB T2N 4Z6Canada

It is a pleasure to write a commentary on the work of *** Rice and colleagues,l who have advanced our understanding of how the mechanical loading environment of the tibia changes as a function of running grade and *** is important that we understand how the tibia is loaded during conditions that an individual is likely to encounter when running as it is these internal loads which we believe are responsible for the development of bone-stress injuries.

关键词： loading injuries likely

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In search of optimal building behavior models for model predictive control in the context of flexibility

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Building Simulation 2024年第1期17卷 71-91页

作者： arash Erfani Tohid Jafarinejad Staf Roels Dirk Saelens KU Leuven Department of Civil EngineeringBuilding Physics and Sustainable Design SectionKasteelpark Arenberg 40 Bus 24473001 HeverleeBelgium EnergyVille Thor Park 8310Genk 3600Belgium

Model predictive control(MPC)is an advanced control *** has been deployed to harness the energy flexibility of a *** requires a dynamic model of the building to achieve such an ***,developing a suitable predictive model is the main challenge in MPC implementation forflexibility *** studyfocuses on the application of key performance indicators(KPls)to evaluate the suitability of MPC models via feature *** this end,multiple models were developed for two houses.A feature selection method was developed to select an appropriate feature space to train the *** predictive models were then quantified based on one-step ahead prediction error(OSPE),a standard KPI used in multiple studies,and a less-often KPl:multi-step ahead prediction error(MSPE).An MPC workflow was designed where different models can serve as the predictive *** showed that MSPE better demonstrates the performance of predictive models used for flexibility *** revealed that up to 57% of the flexibility potential and 48% of energy use reduction are not exploited if MSPE is not minimized while developing a predictive model.

关键词： building flexibility model predictive control for building building behaviour identification smart home

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Surface growth of novel MOFs on AZ31 Mg alloy coated via plasma electrolytic oxidation for enhanced corrosion protection and photocatalytic performance

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Journal of Magnesium and Alloys 2024年第6期12卷 2413-2432页

作者： Ananda Repycha Safira arash Fattah-alhosseini Mosab Kaseem Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea Department of Materials Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedanIran

In the pursuit of multifunctional coatings,the controlled growth of materials on stationary platforms holds paramount importance for achieving superior corrosion protection and optimal photocatalytic *** study introduces a cutting-edge approach,intertwining bifunctional metal-organic frameworks(MOFs)seamlessly into defective MgO layers produced by the anodic oxidation of AZ31 *** metallic oxides of Zn,Sn,and V take center stage as metallic sources for MOF formation,complemented by the organic prowess of L-Tryptophan as anα-amino acid *** the electronic structure of metallic oxides reacting with tryptophan molecules,controlled morphologies with distinct characteristics are induced on the defective surface of the MgO layer,enabling the precise modulation of surface *** hybrid composite demonstrates an adaptive microstructure in diverse aqueous environments,offering dual functionality with electrochemical stability and visible light photocatalytic activity for crystal violet *** the samples,the SnOF complex exhibited remarkable electrochemical stability with a low corrosion current density of 7.50×10^(−10)A·cm^(−2),along with a 94.56%degradation efficiency after 90 min under visible light *** VOF complex,under similar visible light conditions,demonstrated exceptional performance with a higher degradation efficiency of 97.79%and excellent electrochemical stability characterized by a corrosion current density of 3.26×10^(−9)A·cm^(−2).Additionally,Density Functional Theory(DFT)computations shed light on the basic bonding patterns between MOFs and inorganic components,providing electronic understanding of their electrochemical and photocatalytic activities.

关键词： Electrochemical stability Defective layer Metal-organic framework Photocatalytic activity DFT

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Novel interface engineering of LDH-based materials on Mg alloy for efficient photocatalytic systems considering the geometrical linearity of condensed phosphates

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Journal of Magnesium and Alloys 2024年第1期12卷 267-280页

作者： Mosab Kaseem Ananda Repycha Safira arash Fattah-alhosseini Department of Nanotechnology and Advanced Materials Engineering Corrosion and Electrochemistry LaboratorySejong UniversitySeoul 05006Republic of Korea Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran

This study presents a facile and rapid method for synthesizing novel Layered Double Hydroxide(LDH)nanoflakes,exploring their application as a photocatalyst,and investigating the influence of condensed phosphates'geometric linearity on their photocatalytic ***,the Mg O film,obtained by plasma electrolysis of AZ31 Mg alloys,was modified by growing an LDH film,which was further functionalized using cyclic sodium hexametaphosphate(CP)and linear sodium tripolyphosphate(LP).CP acted as an enhancer for flake spacing within the LDH structure,while LP changed flake dispersion and ***,CP@LDH demonstrated exceptional efficiency in heterogeneous photocatalysis,effectively degrading organic dyes like Methylene blue(MB),Congo red(CR),and Methyl orange(MO).The unique cyclic structure of CP likely enhances surface reactions and improves the catalyst's interaction with dye ***,the condensed phosphate structure contributes to a higher surface area and reactivity in CP@LDH,leading to its superior photocatalytic performance compared to LP@***,LP@LDH demonstrated notable degradation efficiencies of 93.02%,92.89%,and 88.81%for MB,MO,and CR respectively,over a 40 min *** highest degradation efficiencies were observed in the case of the CP@LDH sample,reporting 99.99%for MB,98.88%for CR,and 99.70%for *** underscores the potential of CP@LDH as a highly effective photocatalyst for organic dye degradation,offering promising prospects for environmental remediation and water detoxification applications.

关键词： Plasma electrolysis Layered Double Hydroxide Condensed phosphates Adsorption capacity Photocatalytic efficiency

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Advancements in enhancing corrosion protection of Mg alloys:A comprehensive review on the synergistic effects of combining inhibitors with PEO coating

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Journal of Magnesium and Alloys 2024年第2期12卷 465-489页

作者： arash Fattah-alhosseini Abdelhameed Fardosi Minoo Karbasi Mosab Kaseem Department of Materials Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedanIran Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Magnesium(Mg)alloys are lightweight materials with excellent mechanical properties,making them attractive for various applications,including aerospace,automotive,and biomedical ***,the practical application of Mg alloys is limited due to their high susceptibility to *** electrolytic oxidation(PEO),or micro-arc oxidation(MAO),is a coating method that boosts Mg alloys'corrosion ***,despite the benefits of PEO coatings,they can still exhibit certain limitations,such as failing to maintain long-term protection as a result of their inherent *** address these challenges,researchers have suggested the use of inhibitors in combination with PEO coatings on Mg *** are chemical compounds that can be incorporated into the coating or applied as a post-treatment to further boost the corrosion resistance of the PEO-coated Mg *** inhibitors,whether organic or inorganic,can act by forming a protective barrier,hindering the corrosion process,or modifying the surface properties to reduce susceptibility to *** can be made of various materials,including polyelectrolyte shells,layered double hydroxides,polymer shells,and mesoporous inorganic *** corrosion inhibitors in containers fully compatible with the coating matrix and substrate is a promising approach for their *** studies of the combination of inhibitors with PEO coatings on Mg alloys have shown promising results,demonstrating significant corrosion mitigation,extending the service life of Mg alloy components in aggressive environments,and providing self-healing *** general,this review presents available information on the incorporation of inhibitors with PEO coatings,which can lead to improved performance of Mg alloy components in demanding environments.

关键词： Inhibitor Mg alloy Self-healing coating Plasma electrolytic oxidation(PEO) Corrosion protection

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An inter-semiotic analysis of ideational meaning in text-prompted AI-generated images

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Language and Semiotic Studies 2024年第1期10卷 17-42页

作者： arash Ghazvineh Department of Art Research Faculty of ArtsTarbiat Modares UniversityTehranIran

This paper explores the inter-semiotic analysis of the ideational meaning in images generated by the text-to-image AI tool,Bing Image *** adopts Kress and Van Leeuwen’s Grammar of Visual Design as its theoretical framework as the original grounding of the framework in systemic functional grammar(SFG)ensures a solid theoretical basis for undertaking analyses that involve the incorporation of textual and visual *** integration of an AI generative model within the analytical framework enables a systematic connection between language and visual *** incorporation offers the potential to generate well-regulated pictorial representations that are systematically grounded in controlled textual *** approach introduces a novel avenue for re-examining inter-semiotic processes,leveraging the power of AI *** paper argues that visual representations possess unique structural devices that surpass the limitations of verbal or written communication as they readily accommodate larger amounts of information in contrast to the limitations of the linear nature of alphabetic ***,this paper extends its contribution by critically evaluating specific aspects of the Grammar of Visual Design.

关键词： inter-semiotic analysis AI text-to-image generator systemic functional linguistics grammar of visual designs

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Enhanced electrochemical and photocatalytic performance achieved through dual incorporation of SnO_(2)and WO_(3)nanoparticles into LDH layer fabricated on PEO-coated AZ31 Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1880-1898页

作者： Muhammad Ali Khan Ananda Repycha Safira Mosab Kaseem arash Fattah-alhosseini Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea Department of Materials Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedanIran

This study explores the potential of LDH flakes decorated with metallic oxide nanoparticles to function as both anti-corrosion barriers against chloride anions and heterogeneous photocatalysts for tetracycline degradation under visible *** process involves modifying the primarily MgO-based inorganic porous film by growing a MgFe LDH film,followed by the individual and dual incorporation of SnO_(2)and WO_(3)*** dual incorporation of these nanoparticles into the LDH matrix leads to synergistic interactions,effectively sealing pre-existing defects within LDH flakes and facilitating the in-situ formation of catalytic sites through oxidation and the induction of surface oxygen vacancy defects,which synergistically contribute to the enhancement of both electrochemical and photocatalytic *** enhanced electrochemical stability is reflected in a significant reduction in corrosion current density by 4 orders of magnitude compared to unmodified porous ***,the decorated film demonstrates sustained photocatalytic functionality,achieving significant degradation(95.5%)of tetracycline within two *** study presents a novel approach,highlighting the dual effectiveness of LDHs decorated by dual metal oxides as an anti-corrosive agent and photocatalyst,with promising implications for environmental remediation and wastewater purification.

关键词： Porous film LDH film Anti corrosive Photocatalysis Oxygen vacancy Tetracycline

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Innovative approach to boosting the chemical stability of AZ31 magnesium alloy using polymer-modified hybrid metal oxides

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Journal of Magnesium and Alloys 2024年第3期12卷 1068-1081页

作者： Mosab Kaseem Ananda Repycha Safira Mohammad Aadil Tehseen Zehra Muhammad Ali Khan arash Fattah-alhosseini Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran

Meeting the demands of complex and advanced applications requires the development of high-performance hybrid materials with unique ***,the integration of polymeric frameworks with MgO/WO_(3) composite layers faces challenges due to the lack of understanding of the formation mechanism and the challenge of determining the impact of self-assembled architecture on anticorrosive *** this study,we aimed to enhance the corrosion resistance of the MgO layer produced by plasma electrolysis(PE)of AZ31 Mg alloy by incorporating WO_(3) with partially phosphorated poly(vinyl alcohol)(PPVA).Two types of porous MgO layers were produced using the PE process with an alkaline-phosphate electrolyte,one with and one without WO_(3) nanoparticles,which were subsequently immersed in an aqueous solution of *** PPVA into the WO_(3)-MgO layer resulted in hybrids being deposited in a fragmented manner,creating a“laminar reef-like structure”that sealed most of the structural defects in the *** PPVA-sealed WO_(3)-based coating exhibited superior corrosion resistance compared to the other *** analyses were employed to explore the mechanism underlying the formation of PPVA/WO_(3) hybrids on the MgO *** findings suggest that PPVA-WO_(3)-MgO hybrid coatings can potentially improve corrosion resistance in various fields.

关键词： Plasma electrolysis Poly(vinyl alcohol) Tungsten trioxide Sealing Corrosion DFT.

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