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Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

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Neural Regeneration Research 2014年第21期9卷 1884-1890页

作者： aras adem bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat Department of Neurosurgery ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Neurology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Medical Biochemistry Ondokuz May?s UniversitySamsunTurkey Deparment of Histology and Embryology Faculty of MedicineRecep Tayyip Erdo?an UniversityRizeTurkey Department of Pharmacology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey

There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.

关键词： nerve regeneration syringaldehyde brain ischemia neuroprotective effects inflammatory oxidative stress apoptosis neural regeneration

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Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

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Neural Regeneration Research 2015年第1期10卷 146-152页

作者： adem bozkurt aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar Department of Neurosurgery Canakkale Onsekiz Mart University Department of Neurology Canakkale Onsekiz Mart University Department of Medical Biochemistry Ministry of HealthAdministration of Public Health Deparment of Histology and Embryology Recep Tayyip Erdo?an UniversityFaculty of Medicine Department of Pharmacology Canakkale Onsekiz Mart University

Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery oc- clusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administra- tion; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the afore- mentioned hypothesis.

关键词： nerve regeneration brain ischemia stroke daidzein oxidative stress apoptosis superoxidedismutase malondialdehyde nuclear respiratory factor 1 neural regeneration

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