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Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections

World Journal of Hepatology 2016年第31期8卷 1295-1308页

作者： Daniel Fuster arantza sanvisens Ferran Bolao Inmaculada Rivas Jordi Tor Robert Muga Department of Internal Medicine Addiction Unit Hospital Univer-sitari Germans Trias i Pujol Department of Internal Medicine Hospital Univer-sitari de Bellvitge IDIBELL Municipal Center for Substance Abuse Treatment (Centro Delta) IMSP

Alcohol use disorder(AUD) and hepatitis C virus(HCV) infection frequently co-occur. AUD is associated with greater exposure to HCV infection, increased HCV infection persistence, and more extensive liver damage due to interactions between AUD and HCV on immune responses, cytotoxicity, and oxidative stress. Although AUD and HCV infection are associated with increased morbidity and mortality, HCV antiviral therapy is less commonly prescribed in individuals with both conditions. AUD is also common in human immunodeficiency virus(HIV) infection, which negatively impacts proper HIV care and adherence to antiretroviral therapy, and liver disease. In addition, AUD and HCV infection are also frequent within a proportion of patients with HIV infection, which negatively impacts liver disease. This review summarizes the current knowledge regarding pathological interactions of AUD with hepatitis C infection, HIV infection, and HCV/HIV co-infection, as well as relating to AUD treatment interventions in these individuals.

关键词： Hepatitis C virus Human immunodeficiency virus Hepatitis C virus/human immunodeficiency virus co-infection Liver Alcohol

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Monitoring hepatitis C virus treatment rates in an Opioid Treatment Program:A longitudinal study

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World Journal of Gastroenterology 2020年第38期26卷 5874-5883页

作者： arantza sanvisens Inmaculada Rivas Eva Faure Néstor Espinach Anna Hernandez-Rubio Xavier Majó Joan Colom Robert Muga Department of Internal Medicine Hospital Universitari Germans Trias i PujolBadalona 08916Spain Mental Health and Addiction Service Badalona Serveis Assistencials-BSABadalona 08911Spain Department of Internal Medicine Hospital Universitari Germans Trias i PujolUniversitat Autònoma de BarcelonaBadalona 08916Spain Program on HIV STIs and Viral Hepatitis-PCAVIHV Public Health Agency of CataloniaGeneralitat de CatalunyaBarcelona 08005Spain

BACKGROUND Direct-acting antivirals(DAAs)are recommended for the treatment of hepatitis C virus(HCV)infection in patients treated with methadone or *** To assess HCV treatment rates in an Opioid Treatment Program(OTP).METHODS This longitudinal study included 501 patients(81.4%men,median age:45 years;interquartile range:39-50 years)enrolled in an OTP between October 2015 and September *** were followed until September *** on sociodemographics,substance use,HCV infection,human immunodeficiency virus(HIV)infection and laboratory parameters were collected at *** analyzed medical records to evaluate HCV ***-Meier methods and Cox regression models were used to analyze the DAA treatment uptake and to identify treatment *** Prevalence of HCV and HIV infection was 70%and 34%,*** anti-HCV-positive(n=336)patients,47.2%,41.3%,and 31.9%used alcohol,cannabis,and cocaine,***-RNA tests were positive in 233(69.3%)*** patients(8.3%)cleared the infection,and 59/308(19.1%)had received interferon-based treatment regimens before *** 249 patients eligible,111(44.6%)received *** rates significantly increased over time from 7.8/100 person-years(p-y)(95%CI:5.0-12.3)in 2015 to 18.9/100 p-y(95%CI:11.7-30.3)in *** a multivariate analysis,patients with HIV co-infection were twice as likely to receive DAAs(HR=1.94,95%CI:1.21-3.12)than patients with HCV *** drug use was an independent risk factor for not receiving treatment against infection(HR=0.48,95%CI:0.29-0.80).CONCLUSION HCV treatment is evolving in patients with HCV-HIV *** drug use while in an OTP might negatively impact the readiness to treat infection.

关键词： Direct-acting antiviral agents Opioid Treatment Program Opioid agonist therapy Hepatitis C virus infection Human immunodeficiency virus infection Drug use

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