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Osteoporosis in adult Sri Lankan inflammatory bowel disease patients

World Journal of Gastroenterology 2009年第28期15卷 3528-3531页

作者： Arjuna Priyadarsin de Silva aranjan lionel karunanayake Thalahitiya Gamaralalage Iruka Dissanayaka Anuradha Supun Dassanayake Hewa Kattadi Kankanamgae Tilak Duminda Arunasalam Pathmeswaran Ananda Rajitha Wickramasinghe Hithanadura Janaka de Silva Department of Medicine Culty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka Department of Anatomy Faculty of Medicine University of Kelaniya PO Box 6Thalagolla Road Ragama GQ11010 Sri Lanka Department of Pharmacology Faculty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka Department of Public Health Faculty of Medicine University of Kelaniya PO Box 6Thalagolla Road Ragama GQ11010 Sri Lanka Faculty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka

AIM： To determine if inflammatory bowel disease （IBD） is a risk factor for osteoporosis in adult Sri Lankans. METHODS： We identified eligible subjects from among consecutive patients diagnosed with IBD who attended our outpatient clinic. We included only patients aged between 20 and 70 years. Patients who were pregnant, had significant comorbidity, or were on calcium supplements or treatment for osteoporosis within the past 6 mo, were excluded. Healthy, ageand sex-matched controls were also recruited, in a control to patient ratio of 3：1. Both groups were screened for osteoporosis using peripheral dual energy X-ray absorptiometry scanning. RESULTS： The study population consisted of 111 IBD patients （male：female = 43：68; mean age 42.5 years） and 333 controls （male：female = 129：204; mean age 43.8 years）. The occurrence of osteoporosis among IBD patients （13.5%） was significantly higher than among controls （4.5%）（P = 0.001）. The frequency of osteoporosis was not significantly different between ulcerative colitis （14.45%） and Crohn＇s disease （10.7%）. However, on multivariate analysis, only age （P = 0.001）, menopause （P = 0.024） and use of systemic steroids （P 〈 0.001） were found to be associated independently with the occurrence of osteoporosis, while IBD, severity of disease, number of relapses, duration of illness or treatment other than systemic steroids were not. CONCLUSION： IBD does not appear to be an independent risk factor for the occurrence of osteoporosis in this population. However, the use of systemic steroids was a risk factor.

关键词： Osteoporosis Inflammatory bowel disease Asians Crohn's disease Ulcerative colitis

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