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Biologics in the management of pediatric inflammatory bowel disease:When and what to choose

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World Journal of Clinical Pediatrics 2025年第1期14卷 21-45页

作者： Arghya Samanta Anshu srivastava Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

Pediatric inflammatory bowel disease(PIBD)is a chronic inflammatory disorder of the gastrointestinal tract,with rising global incidence and *** the past two decades,biologics have added to the therapeutic armamentarium and revolutionized the approach to treatment of inflammatory bowel *** available biologics include monoclonal antibodies which target inflammatory cytokines(anti-tumor necrosis factor alpha,anti-interleukin 12/23)or recruitment of leucocytes to the gastrointestinal tract(anti-alpha4beta7 integrin)and small molecules(Janus kinase inhibitors,sphingosine 1-phosphate-inhibitors)which modify the proinflammatory *** their potential disease-modifying ability,recent pediatric guidelines from the West have advocated upfront use of biologics in appropriate clinical scenarios as a top-down approach rather than the conventional step-up *** real-world studies are available regarding the clinical efficacy of biologics in PIBD,there is paucity of long-term outcome and safety data in ***,little information is available about the best approach in the newly industrialized-developing countries where PIBD is rising but at the same time,infections are prevalent and resources are *** this review,we summarize the efficacy and safety profile of biologics and small molecule drugs and discuss the challenges in the management of PIBD,especially in the developing world,and future directions.

关键词： Biologics Children Inflammatory bowel disease Therapeutic drug monitoring Dual biologic

Synthesis and enhanced photoluminescence properties of red emitting divalent ion(Ca^(2+))doped Eu:Y_(2)O_(3)nanophosphors for optoelectronic applications

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Journal of Rare Earths 2022年第8期40卷 1187-1198页

作者： Arpita Dwivedi Monika srivastava Ankur Dwivedi Amit srivastava Anurag Mishra S.K.srivastava Department of Physics Institute of ScienceBanaras Hindu University(BHU)Varanasi221005India School of Materials Science and Technology Indian Institute of Technology(BHU)Varanasi221005India Department of Mining Engineering Indian Institute of Technology(BHU)Varanasi221005India Department of Physics TDPG College VBS Purvanchal UniversityJaunpur222001India

This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion method for optoelectronic,display,and lighting *** X-ray diffraction(XRD)patterns of the proposed nanophosphor reveal its structural properties and crystalline *** transmission electron microscope(TEM)results confirm the change in the shape of the particle and aggregation of particles after co-doping with Ca^(2+).Fourier transform infrared spectroscopy(FTIR)and Raman vibrations also confirm the presence of Y-O vibration and subsequently explain the crystalline nature,structural properties,and purity of the *** the synthesized nanophosphors samples emit intense red emission at 613 nm(~5D_(0)→~7 F_(2))under excitation with 235,394 and 466 nm wavelengths of Eu^(3+)*** photoluminescence(PL)emission spectra excited with 235 nm illustrate the highest emission peak with two other emission peaks excited with 466 and 394 nm that is 1.4 times higher than 466 nm and 1.9 times enhanced by 394 nm wavelength,*** emission intensity of Y_(2)O_(3):Eu^(3+),χCa^(2+)(5 mol%)is increased 8-fold as compared to Eu:Y_(2)O_(3).Doping with Ca^(2+)ions enhances the emission intensity of Eu:Y_(2)O_(3)nanopho sphors due to an increase in energy transfer in Ca^(2+)→Eu^(3+)through asymmetry in the crystal field and by introduction of radiative defect centers through oxygen vacancies in the yttria *** is also observed that the optical band gap and the lifetime of the~5D_(0)level of Eu^(3+)ions in Y_(2)O_(3):Eu^(3+),xCa^(2+)nanophosphor sample gets changed with a doping conce ntration of Ca^(2+)*** also reveals high thermal stability and quantum yield as estimating activation energy of 0.25 eV and 81%,***,CCT,and color purity values(>98%)show an improved red-emitting nanophosphor in the warm region of light,which m

关键词： Red emission Photoluminescence(PL) Y_(2)O_(3):Eu^(3+),xCa^(2+) Rare earths Nanophosphors LEDs

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 788-806页

作者： Ankit srivastava Deeksha Rikhari Sameer srivastava Department of Biotechnology Motilal Nehru National Institute of TechnologyAllahabadUttar Pradesh 211004India

R-spondins are secretory proteins localized in the endoplasmic reticulum and Golgi bodies and are processed through the secretory *** the R-spondin family,RSPO2 has emanated as a novel regulator of Wnt signaling,which has now been acknowledged in numerous in vitro and in vivo *** is an abnormal growth of cells that proliferates and spreads uncontrollably due to the accumulation of genetic and epigenetic factors that constitutively activate Wnt signaling in various types of *** cancer (CRC) begins when cells in the colon and rectum follow an indefinite pattern of division due to aberrant Wnt activation as one of the key ***-long progress in research on R-spondins has demonstrated their oncogenic function in distinct cancer types,particularly *** a critical regulator of the Wnt pathway,it modulates several phenotypes of cells,such as cell proliferation,invasion,migration,and cancer stem cell ***,RSPO mutations,gene rearrangements,fusions,copy number alterations,and altered gene expression have also been identified in a variety of cancers,including *** this review,we addressed the recent updates regarding the recurrently altered R-spondins with special emphasis on the RSPO2 gene and its involvement in potentiating Wnt signaling in *** addition to the compelling physiological and biological roles in cellular fate and regulation,we propose that RSPO2 would be valuable as a potential biomarker for prognostic,diagnostic,and therapeutic use in CRC.

关键词： CRC Gene fusion R-Spondins RSPO2 Therapeutics Wnt signaling

Largest Ediacaran discs from the Jodhpur Sandstone, Marwar Supergroup, India: Their palaeobiological significance

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Geoscience Frontiers 2014年第2期5卷 183-191页

作者： Purnima srivastava Centre of Advanced Study in Geology Lucknow University

Ediacaran discs from the Jodhpur Sandstone of the Marwar Supergroup, Rajasthan, exhibit a wide size ranging from a few millimetres to 75 cm in diameter. Exceptionally large size of the discs in these rocks represent the largest reported so far from any Ediacaran assemblage. Although, larger medu-soid discs have been reported from USA, they are from the middle Cambrian and even younger rocks. Presence of microbial mats and weed-like structures with well preserved hold fasts and horizontal rhizome-like structures in association with some of these large-sized discs support their animal affinity, which probably feed on this weed-like vegetations. This association also supports their benthic habitat. Unlike the general trend of sudden increase in size of organisms in Ediacaran period and further decrease in size during Cambrian, these discs continued increasing in size in Cambrian also.

关键词： Ediacaran discs Jodhpur Sandstone Marwar Supergroup Rajasthan India

Production and characterisation of new bioresorbable radiopaque Mg–Zn–Y alloy to improve X-ray visibility of polymeric scaffolds

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Journal of Magnesium and Alloys 2022年第6期10卷 1694-1703页

作者： Alok srivastava Naresh Bhatnagar Mechanical Engineering Department Indian Institute of TechnologyDelhiIndia

For the medical diagnosis,radiopaque materials(RM)made from high specific gravity elements like Pt,Au,Ta,Iodine,Bromine are either attached or blended or coated on an implant to makes it detectable under X-ray/Fluoroscopy/*** facilitate the surgeon in an operation theatre to position an implant during the ***,RM are non-degradable,thus in case of biodegradable implants,it may detach from the body and accumulate in vital organ cause serious health ***,a new bioresorbable radiopaque material(BRM)was produced by alloying the high specific gravity elements Zn(35%w/w)and Y(4%w/w)with Mg *** this alloy,three main phases were identified,alpha Mg,Mg_(7)Zn_(3)and icosahedral quasicrystalline I-phase Mg3Zn6Y,which reinforce the Mg ***,BRM was powdered to a size of less than 25 microns and blended in different ratios with bioresorbable poly-L-lactic acid(PLLA)for fabricating PLLA/BRM *** microparticles were uniformly distributed and interfacial bonded with the *** X-ray was passed through bio-composite to captureμCT radiograph for evaluating linear attenuation co-efficient(μ)and optical density(OD).Thermal analysis reveals that BRM particles act as a nucleating site and enhance the crystallinity of the polymeric *** the In Vitro accelerated degradation study,the alkaline nature of BRM neutralise the acidity of PLLA and balance the pH of the body fluid to reduce the inflammatory reactions,but this compromises the stability of the polymer as it increases the decomposition rate.

关键词： Magnesium alloys X-ray Quasicrystal Polymer matrix composites Radiopacity

Synthesis of malachite@clay nanocomposite for rapid scavenging of cationic and anionic dyes from synthetic wastewater

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Journal of Environmental Sciences 2017年第1期29卷 97-110页

作者： Varsha srivastava Mika Sillanpää Laboratory of Green Chemistry School of Engineering ScienceLappeenranta University of TechnologySammonkatu 12FI 50130MikkeliFinland

Synthesis of malachite@clay nanocomposite was successfully carried out for the removal of cationic（Methylene Blue,MB） and anionic dyes（Congo Red,CR） from synthetic *** was characterized by TEM,SEM,FT-IR,EDS analysis and zeta *** analysis indicated that the particle diameter of nanocomposite was in the range of 14 to23 *** important parameters *** time,concentration of dyes,nanocomposite dosage,temperature and solution pH were optimized to achieve maximum adsorption *** the case of MB,removal decreased from 99.82%to 93.67%while for CR,removal decreased from 88.55%to 75.69%on increasing dye concentration from 100 to 450 mg/*** study confirmed the higher removal of CR in acidic range while MB removal was higher in alkaline *** study revealed the applicability of pseudo-second-order model for the adsorption of both *** values of AG0 for both systems suggested the feasibility of dye removal and support for spontaneous adsorption of CR and MB on *** showed 277.77 and 238.09 mg/g Langmuir adsorption capacity for MB and CR *** of dyes from the dye loaded nanocomposite was easily carried out with *** results indicate that the prepared malachite@clay nanocomposite is an efficient adsorbent with high adsorption capacity for the aforementioned dyes.

关键词： Adsorption Bentonite Dyes Kinetic study Methylene blue Congo red

Effect of N2 and O2 on OH radical production in an atmospheric helium microwave plasma jet

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Plasma Science and Technology 2019年第11期21卷 17-28页

作者： Nimisha srivastava Chuji WANG Department of Physics&Astronomy Mississippi State UniversityStarkvilleMS39762United States of America Currently with Intel Corporation PortlandOR97124United States of America

UV-pulsed laser cavity ringdown spectroscopy of the hydroxyl radical OH(A–X)(0–0)band in the wavelength range of 306–310 nm was employed to determine absolute number densities of OH in the atmospheric helium plasma jets generated by a 2.45 GHz microwave plasma *** effect of the addition of molecular gases N2 and O2 to He plasma jets on OH generation was *** emission spectroscopy was simultaneously employed to monitor reactive plasma *** broadening of the hydrogen Balmer emission line(Hβ)was used to estimate the electron density ne in the *** both He/N2 and He/O2 jets,ne was estimated to be on the order of 10^15 cm^?*** effects of plasma power and gas flow rate were also *** increase in N2 and O2 flow rates,ne tended to *** temperature in the He/O2 plasma jets was elevated compared to the temperatures in the pure He and He/N2 plasma *** highest OH densities in the He/N2 and He/O2 plasma jets were determined to be 1.0×10^16 molecules/cm^3 at x=4 mm(from the jet orifice)and 1.8×10^16 molecules/cm^3 at x=3 mm,*** impact dissociation of water and water ion dissociative recombination were the dominant reaction pathways,respectively,for OH formation within the jet column and in the downstream and far downstream *** presence of strong emissions of the N2^+ bands in both He/N2 and He/O2 plasma jets,as against the absence of the N2^+ emissions in the Ar plasma jets,suggests that the Penning ionization process is a key reaction channel leading to the formation of N2^+ in these He plasma jets.

关键词： helium plasma jet OH radical CRDS microwave plasma

A Review of Heat Transfer Enhancement through Flow Disruption in a Microchannel

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Journal of Thermal Science 2015年第3期24卷 203-214页

作者： Anupam Dewan Pankaj srivastava Department of Applied Mechanics Indian Institute of Technology Delhi Hauz Khas New Delhi - 110016 India Instruments R & D Establishment Defence R & D Organisation Dehradun (UK) - 248008 India

In this paper a comprehensive review of heat transfer enhancement through microchannels has been presented. Over the past few years due to multifunetion, shrinking package size and high power dissipation, the heat flux per unit area has increased significantly. Microchannels, with their large heat transfer surface to volume ratio and their small volumes, have shown a good thermal performance. Microchannels have been proven to be a high per- formaace cooling technique which is able to dissipate heat flux effectively from localized hot spots over small surface area. A good amount of heat transfer augmentation techniques have been reported on flow disruption through microchannel. These techniques promote free stream separation at the leading edge which results in boundary layer development and enhanced mixing leading to increased heat transfer. Flow disruption can be achieved through passive surface modifications, such as, shape of channel, dimple surfaces, ribs, cavities, groove structures, porous medium, etc. Combined effects of these geometrical configurations in heat transfer augmenta- tion are also reported in the literature. In this paper recent developments in experimental and numerical simula- tions of single-phase liquid cooled microchannel have been discussed to analyze the pressure drop, friction and heat transfer characteristics due to different flow conditions, roughness structure and passive surface modifica- tions. It has been observed that the flow disruption techniques are effective for heat transfer enhancement with lower penalties of increased pressure drop. The review concludes with suggestions for future research in this area.

关键词： Microchannel heat transfer enhancement boundary-layer pressure drop dimple surface cavitiesand ribs

A New Class of Generalized Close-to-Starlike Functions Defined by the srivastava-Attiya Operator

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Acta Mathematica Sinica,English Series 2013年第5期29卷 833-840页

作者： H.M.srivastava Dorina RADUCANU Grigore S.SLGEAN Department of Mathematics and Statistics University of Victoria Faculty of Mathematics and Computer Science Transilvania University of Brasov Faculty of Mathematics and Computer Science Babe s-Bolyai University

In this paper, we consider a new class CS＊s,b of generalized close-to-starlike functions, which is defined by means of the srivastava-Attiya operator Js,b involving the Hurwitz-Lerch Zeta function φ（z, s, a）. Basic results such as inclusion relations, coefficient inequalities and other interesting properties of this class are investigated. Relevant connections of some of the results presented here with those that were obtained in earlier investigations are pointed out briefly.

关键词： Analytic functions starlike functions convex functions close-to-starlike functions srivastava-Attiya operator inclusion results coefficient bounds coefficient inequalities hadamard product (or convolution)