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Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID

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Neuroprotection 2023年第2期1卷 170-175页

作者： Elizabeth Mendoza-Portillo Estefania Aleman-Navarro G.Aleph Prieto Yvonne Rosenstein Jose J.Lozano-Nuevo araceli perez-lopez Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de MéxicoMéxico Instituto de Biotecnología Universidad Nacional Autónoma de México(UNAM)CuernavacaMorelosMéxico Instituto de Neurobiología UNAM-JuriquillaQuerétaroMéxico Institute for Memory Impairments and Neurological Disorders University of California-IrvineIrvineCaliforniaUSA Hospital General de Ticomán Secretaría de Salud de la Ciudad de MéxicoCiudad de MéxicoMéxico Unidad de Investigación en Biomedicina Facultad de Estudios Superiores IztacalaUNAMTlalneplantlaEstado de MéxicoMéxico

More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute *** 76%of patients with long COVID experience neurological ***,patients who have survived COVID-19 have an increased risk of cerebral venous *** case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before *** initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet ***,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative *** this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with ***,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection.

关键词： cerebral venous thrombosis long COVID vaccine

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Laser-Welded Steel Foils with Sapphire Substrates

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Acta Metallurgica Sinica(English Letters) 2016年第7期29卷 683-688页

作者： araceli de Pablos-Martin Christian Grosse Andreas Cismak Thomas Hoche Fraunhofer Institute for Microstructure of Materials and Systems IMWS Walter-Htilse-Strage 1 06120 HalleGermany

A nanosecond pulsed laser was used to weld stainless steel foils of 10 ~tm thickness to the sapphire substrates. The microstructure of the bonded interface was studied. Both materials were partially ablated under the influence of the laser beam. An inhomogeneous distribution of the steel and sapphire along the bonded interface is observed. The electrical resistance of the steel foil was measured before and after laser welding, showing that the weld slightly increases the electrical resistance but still keeps the values acceptable for electrical contacts.

关键词： Laser welding Stainless steel Sapphire Electrical resistance

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The Effect of Brain Gym on Global Cognitive Function of Institutionalized Older People

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International Journal of Mental Health Promotion 2022年第3期24卷 375-383页

作者： araceli Cano-Estrada araceli Jimenez-Mendoza Denny Contreras-Guerrero Mario Hernandes-Alejandro Andres Salas-Casas Escuela Superior de Tlahuelilpan Universidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico Escuela Nacional de Enfermería y Obstetricia.Universidad Nacional Autónoma de México Mexico CityMéxico Departomento de Bioingenieria Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politecnico Nacional(UPIBIIPN)Mexico CityMexico Instituto de Ciencias de la Salud.Universidad Autónoma del Estado de Hidalgo.Pachuca Hidalgo.México.Scuela Superior de TlahuelilpanUniversidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico

Cognitive function of older adults is influenced by several factors such as age,sex,education,and physical activity so that it can impact the decrease in progressive cognitive *** is necessary to implement cognitive training in old people’s care to prevent or delay the onset of age-related cognitive *** gym is a series of simple motion exercises and is an alternative therapy that stimulates the *** study aims to evaluate the effect of brain gym as a cognitive training intervention on global cognitive functioning of institutionalized older *** study is a non-randomized quasi-experimental one using pre-and post-test control group *** participants of the study were 65 years old or older who had been part of gerontological centers from a local *** were divided into two groups:control and intervention,each one with 15 ***-Mental State Examination was applied to the sample before and after the cognitive *** brain gym training consists of bi-weekly group meeting for 12 weeks,lasting 50 min *** treated group had a significantly better global cognitive ***(memory),orientation and language skills were the domains with the most significant changes(p<0.05).On the other hand,no significant changes were found in the participants of control groups during post *** results suggest that cognitive training based in brain gym improves global cognitive function of institutionalized older people lease type your abstract *** of a research paper is typically 200 to 400 words in length,and 150 to 300 words for a review *** shall be running continuously(not structured)and shall not include reference *** that appear only once in the abstract should be defined in *** abbreviations appear more than once,the full definitions should be provided first before they can be used elsewhere.

关键词： Cognitive function brain gymnastic older people gerontological center physical activity

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Rodent management in Aotearoa New Zealand: approaches and challenges to landscape-scale control

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Integrative Zoology 2024年第1期19卷 8-26页

作者： John G.INNES Grant NORBURY araceli SAMANIEGO Susan WALKER Deborah J.WILSON Manaaki Whenua-Landcare Research HamiltonNew Zealand Manaaki Whenua-Landcare Research AlexandraNew Zealand Manaaki Whenua-Landcare Research AucklandNew Zealand Manaaki Whenua-Landcare Research DunedinNew Zealand

Aotearoa—New Zealand has only four rodent species,all *** order of arrival,they are Pacific rat Rattus exulans,brown rat ***,house mouse Mus musculus,and black rat *** management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases,as is usual *** describe four major“regimes”and one major vision for rodent control in New Zealand to meet ecological restoration *** challenges for island eradications are for large islands that are remote or populated by *** 1080 is the only large-scale(tens of thousands of hectares)option for black rat control,but its application requires adjustment to counter subsequent rapid black rat ***“ecosanctuaries”(mean 720 ha)use ground-based traps and poisons to target mainly black rats and face constant *** with mammal-resistant fences(up to 3500 ha)limit reinvasion and target more pest species and have enabled the return of previously extirpated taxa to the main *** Free 2050 aims to eradicate the rat species(but not mice)plus some other introduced mammals from New Zealand by *** vision is not attainable with current tools,but research and experimental management is exploring techniques and *** large scale(to 100000 ha)at which black rats are now targeted for control to extremely low abundance seems to be unique to New Zealand.

关键词： black rat brown rat eradication house mouse rodent control

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Secondary male hypogonadism： a prevalent but overlooked comorbidity of obesity

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Asian Journal of Andrology 2018年第6期20卷 531-538页

作者： Maria Molina-Vega araceli Mufioz-Garach Miguel Damas-Fuentes JosO Carlos Fernfindez-Garcia Francisco J inahones Department of Endocrinology and Nutrition Virgen de la Victoria Universitary HospitalMalaga 29010Spain Institute of Biomedical Research in Malaga（IBIMA） Virgen de la Victoria Universitary HospitalMalaga 29010Spain CIBER Pathophysiology of Obesity and Nutrition（CB06/003） Institute of Health Carlos III（ISClII）Madrid 28029Spain.

Male hypogonadism associated with obesity is a very prevalent condition and is increasing in parallel with the epidemic prevalence of obesity. Low testosterone levels promote higher fat mass with reduced lean mass. Male hypogonadism is related to an increase in associated cardiometabolic complications, such as hypertension, type 2 diabetes mellitus, the metabolic syndrome, and cardiovascular disease. Its influence as a comorbidity of obesity is becoming more evident and should be evaluated and treated in at-risk patients. Mechanisms involved in this relationship include body composition changes, the presence of adipokines, insulin resistance, and other factors, some of which are still unknown. Weight loss and treatment to replace testosterone levels improve the metabolic profile and quality of life in patients with obesity and hypogonadism; these beneficial effects depend on treatment modality and duration of therapy. The use of testosterone replacement therapy may be indicated, as it has not been shown to increase cardiovascular risk, and retrospective studies suggest a reduction in events in men with metabolic syndrome and type 2 diabetes.

关键词： adipose tissue male hypogonadism obesity testosterone

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Estimation of endogenous protein and amino acid ileal losses in weaned piglets by regression analysis using diets with graded levels of casein

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Journal of Animal Science and Biotechnology 2014年第1期5卷 74-79页

作者： Tércia Cesária Reis de Souza araceli Aguilera Barreyro Gerardo Mariscal-Landín Facultad de Ciencias Naturales Universidad Autónoma de QuerétaroSantiago de Querétaro Av. De las Ciencias s/n Juriquilla 76000 QuerétaroQuerétaro México Centro Nacional de Investigación en Fisiología Animal Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Km 1Carretera a Colón Ajuchitlán Colón Querétaro 76280 México

Background： Many studies have investigated endogenous loss of proteins and amino acids （AAs） at the ileal level in growing pigs. However, only a few studies have researched this subject in piglets. Knowledge regarding AA ileal digestibility in piglets would be helpful during the formulation of diets for weaning piglets, rather than just using coefficients obtained in growing pigs. Therefore, in this study, we sought to estimate endogenous protein and AA ileal losses in piglets. Furthermore, apparent and true ileal digestibility （AID and TID） of protein and AAs from casein were measured. Results： The average flow of protein was 20.8 g/kg of dry matter intake （DMI）. Basal protein loss, as estimated by regression, was 16.9 g/kg DMI. Glutamic acid, arginine, and aspartic acid （2.2, 1.4, and 1.2 g/kg DMI, respectively） were the AAs for which greater losses were seen. The AID of protein and AAs increased as the protein level in the diet increased. A higher increment in AID was observed between diets with 80 and160 g CP/kg of feed; this finding was mainly attributable to increases in glycine and arginine （46.1% and 18%, respectively）. The TID of protein was 97.8, and the TID of AAs varied from 93.9 for histidine to 100.2 for phenylalanine. Conclusions： The basal endogenous protein loss in piglets was 16.9 g/kg DMI. Endogenous protein was rich in glutamic acid, aspartic acid, and arginine, which represented 32.7% of endogenous protein loss in weaning piglets. The TID of casein was high and varied from 93.0 for histidine to 100.2 for phenylalanine.

关键词： Amino acid loss Ileal digestibility Protein loss Weaned piglets

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Morphometric and kinematic sperm subpopulations in split ejaculates of normozoospermic men

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Asian Journal of Andrology 2016年第6期18卷 831-834页

作者： Pilar Santolaria Caries Soler Pilar Recreo Teresa Carretero araceli Bono Jose M Berne Jesus L Yaniz TECNOGAM research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences University of Zaragoza Huesca Spain Department of Functionat 8iotogy and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Valencia Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Departament of Human Anatomy and Histolosy Faculty of Health and Sport Sciences of Huesca PLaza Universidad 3 22002 Huesca Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Hospital General San Jorge de Huesca Area de Urologia Av. Martinez de Velasco 36 22004 Huesca Spain

This study was designed to analyze the sperm kinematic and morphometric subpopulations in the different fractions of the ejaculate in normozoospermic men. Ejaculates from eight normozoospermic men were collected by masturbation in three fractions after 3-5 days of sexual abstinence. Analyses of sperm motility by computer-assisted sperm analysis （CASA-Mot）, and of sperm morphometry by computer-assisted sperm morphometry analysis （CASA-Morph） using fluorescence were performed. Clustering and discriminant procedures were performed to identify sperm subpopulations in the kinematic and morphometric data obtained. Clustering procedures resulted in the classification of spermatozoa into three kinematic subpopulations （slow with low ALH [35.6% of all motile spermatozoa], with circular trajectories [32.0%], and rapid with high ALH [32.4%]）, and three morphometric subpopulations （large-round [33.9% of all spermatozoa], elongated [32.0%], and small [34.10%]）. The distribution of kinematic sperm subpopulations was different among ejaculate fractions （P 〈 0.001）, with higher percentages of spermatozoa exhibiting slow movements with low ALH in the second and third portions, and with a more homogeneous distribution of kinematic sperm subpopulations in the first portion. The distribution of morphometric sperm subpopulations was also different among ejaculate fractions （P〈 0.001）, with more elongated spermatozoa in the first, and of small spermatozoa in the third, portion. It is concluded that important variations in the distribution of kinematic and morphometric sperm subpopulations exist between ejaculate fractions, with possible functional implications.

关键词： man sperm morphometry by computer-assisted sperm morphometry analysis sperm motility by computer-assisted spermanalysis sperm subpopulations split ejaculate

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Vinyl sulfonyl chemistry-driven unidirectional transport of a macrocycle through a[2]rotaxane

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Organic Chemistry Frontiers 2022年第3期9卷 633-642页

作者： Arthur H.G.David Pablo García-Cerezo araceli G.Campaña Francisco Santoyo-González Victor Blanco Departamento de Química Orgánica Facultad de CienciasUnidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente(UEQ)Universidad de Granada(UGR)Avda.Fuente Nueva S/N18071 GranadaSpain

By applying a combination of the coupling-and-decoupling(CAD)chemistry of the vinyl sulfonate group with the click thia-Michael addition to the vinyl sulfone group(MAVS)we performed the irreversible unidirectional transportation of the ring through the linear component in a[2]rotaxane by a chemically and pHdriven flashing energy ratchet mechanism.

关键词： mechanism unidirectional chemistry

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Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity

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Neural Regeneration Research 2020年第3期15卷 557-568页

作者： Megumi Hirose-Ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda araceli Espinosa-Jeffrey Intellectual and Developmental Disabilities Research Center Jane and Terry Semel Institute for Neuroscience and Human BehaviorDepartments of NeurobiologyPsychiatry&Biobehavioral SciencesUniversity of CaliforniaLos AngelesCAUSA Department of Human Genetics David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA

The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no ***,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive *** the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly *** replacement therapy is often considered a viable option to replace progenitors that die due to glutamate *** previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter *** that purpose,we used a well-established model of glutamate excitotoxic ***-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain *** and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also *** found that OLPs did not survive in the excitotoxic environment when grafted *** contrast,when combined with TSC1,survival and integration of grafted OLPs was ***,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by *** proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to *** changes were reversed in the presence of TSC1 and ubiquitination was *** results obtained i

关键词： myelin regeneration myelination oligodendrocytes periventricular leukomalacia premature birth proteomics trophic factors white matter injury

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Comparison of different statistical approaches to evaluate morphometric sperm subpopulations in men

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Asian Journal of Andrology 2016年第6期18卷 819-823页

作者： Jesus L Yaniz Sandra Vicente-Fiel Caries Soler Pilar Recreo Teresa Carretero araceli Bono Jose M Berne Pilar Santolaria TECNOGAM research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences Higher Polytechnic School University of Zaragoza Ctra. Cuarte S/N 22071 Huesca Spain Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Valencia Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Departament of Human Anatomy and Histology Faculty of Health and Sport Sciences of Huesca Plaza Universidad 3 22002 Huesca Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Hospital General San Jorge de Huesca Area de Urologla Av. Martfnez de Velasco 36 22004 Huesca Spain

This study was designed to characterize morphometric sperm subpopulations in normozoospermic men by using different statistical methods and examining their suitability to classify correctly different sperm nuclear morphologies present in human ejaculates. Ejaculates from 21 normozoospermic men were collected for the study. After semen collection and analysis, samples were prepared for morphometric determination. At least 200 spermatozoa per sample were assessed for sperm morphometry by computer-assisted sperm morphometry analysis （CASA-Morph） using fluorescence. Clustering and discriminant procedures were performed to identify sperm subpopulations from the morphometric data obtained. Clustering procedures resulted in the classification of spermatozoa into three morphometric subpopulations （large-round 30.4%, small-round 46.6%, and large-elongated 22.9%）. In the second analysis, using discriminant methods, the classification was made independently of size and shape. Three morphological categories according to nuclear size （small 〈10.90 μm^2, intermediate 10.91-13.07 μm^2, and large 〉13.07 μm^2） and four categories were defined on 400 canonical cells （100 × 4） from 10 men according to sperm nuclear shape （oval, pyriform, round, and elongated）. Thereafter, the resulting classification functions were used to categorize 4200 spermatozoa from 21 men. Differences in the class distribution were observed among men from both clustering and discriminant procedures. It was concluded that the combination of CASA-Morph fluorescence-based technology with multivariate cluster or discriminant analyses provides new information on the description of different morphometric sperm subpopulations in normal individuals, and that important variations in the distribution of morphometric sperm subpopulations may exist between men, with possible functional implications.

关键词： computer-assisted sperm morphometry analysis man sperm subpopulations

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