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Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-Ct

Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIt MERt OCAK EvRIM SUNA arIKAN SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE UÇar ŞÜkrÜAtEŞ AMMAD AHMAD FarOOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mtOR)signaling pathway and the argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed tomography(Micro Ct).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-Ct imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-Ct *** the IHC analysis,the groups treated with tumor+100 mg/kg melatonin were compared when the mtOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(pt differences were found in the total AgNOR area/nuclear area(tAA/NA)ratio in the treatment groups(pthermore,there were significant differences between the amount of mtOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKt Serine/threonine Kinase(PKB/AKt)genes(ptosis was evaluated with Annexin v in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

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Present Status of NIRS ECR Ion Sources

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Chinese Physics C 2007年第S1期31卷 60-62页

作者： M.Muramatsu A.Kitagawa Y.Iwata K.Yamamoto H.Ogawa S.Hojo Y.Sakamoto t.Honma W.takasugi M.Wakaisami Y.Yoshida t.Kubo Y.Kato S.Biri A.G.Drentje Graduate school of Engineering Toyo UniversityJapan National Institute of Radiological Sciences4-9-1 AnagawaInageChiba 263-8555Japan National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan Accelerator Engineering Corporation Ltd.2-13-I KonakadaiInageChiba 263-0043Japan Department of Mechanical Engineering Toyo University2100 KujiraiKawagoeSaitarna 350-0815Japan Osaka University 2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute of Nuclear Research (AtOMKI) H-4026 DebrecenBen ter 18/cHungary National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan K.V.I.University of GroningenZernikelaan 259747AA GroningenNetherlands

Four ECR ion sources have been operated in National Institute of Radiological Sciences(NIRS). two ECR ion sources supply various ion species for the Heavy Ion Medical Accelerator in Chiba(HIMAC). the 10GHz NIRS-ECR ion source mainly produces C^(2+) ions for the heavy-ion *** of Si,ar,Fe,kr and Xe are usually produced by the 18GHz NIRS-HEC ion source for physical and biological *** other two compact ECR ion sources with all permanent magnet configuration have been developed for the new generation carbon therapy *** of these,the Kei-source,is a prototype which has been installed to the NIRS-930 cyclotron for axial *** other source,Kei2-source,is a demonstration source and utilized for the new generation *** addition,both Kei sources have been used to study fundamental properties. In this paper,present status of the ion sources and recent developments are reported.

关键词： heavy ion therapy ECR

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