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Computational Prediction of Micro RNAs from Toxoplasma gondii Potentially Regulating the Hosts' Gene Expression

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 228-238页

作者： Müs?erref Duygu Saar Caner Bagc? Jens Allmer Molecular Biology and Genetics Izmir Institute of Technology Urla Izmir 35430 Turkey Biotechnology Izmir Institute of Technology Urla Izmir 35430 Turkey Bionia Incorporated IZTEKGEB A8 Urla Izmir 35430 Turkey

MicroRNAs （miRNAs） were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene reg- ulation. It may also regulate its hosts＇ gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.

关键词： Toxoplasma gondii MicroRNA Regulation Host interaction Parasite

Alluvial sedimentation and tectonostratigraphic evolution in a narrow extensional zigzag basin margin (northern Teruel Basin, Spain)

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Journal of Palaeogeography 2019年第4期8卷 368-392页

作者： Lope Ezquerro aránzazu Luzón José L.Simón Carlos L.Liesa Departamento de Ciencias de la Tierra Facultad de Ciencias Geotransfer Research Group and Instituto de Investigación en Ciencias Ambientales (IUCA) Universidad de Zaragoza

The northern part of the eastern margin of the extensional Neogene Teruel Basin(central-eastern Spain)consists of a non-linear,zigzag fault zone made of alternating ca.2 km long,NNW-SSE trending segments and shorter NNESSW *** outcrop conditions made possible a comprehensive integrated stratigraphic and structural study,especially focused on coarse clastic sediments deposited along the basin ***-exposed stratal relationships with boundary faults,allowed the analysis of tectonic influence on *** deformation includes growth faulting,rollover anticlines,and monoclines and associated onlap stratal terminations,angular unconformities,and other complex growth strata *** of them is the onlap-over-rollover bed arrangement described here for the first time,which reveals the competition between tectonic subsidence and sedimentary ***,the structural inheritance(dense Mesozoic fracture grid)and the dominant,nearly‘multidirectional’(σ1 vertical,σ2≈σ3),Pliocene extensional regime withσ3 close to E-W,are considered to have controlled the margin structure and ***-stratigraphic evolution includes:(i)reactivation of inherited NNW-SSE faults and development of W-SW-directed small alluvial fans(SAF)while NNE-SSW segments acted as gentle relay ramp zones;(ii)progressive activation of NNE-SSW faults and development of NW-directed very small alluvial fans(VSAF);during stages i and ii sediments were trapped close to the margin,avoiding widespread progradation;(iii)linking of NNW-SSE and NNE-SSW structural segments,overall basin sinking and widespread alluvial progradation;(iv)fault activity attenuation and alluvial *** particular structure and kinematic evolution of this margin controlled alluvial system *** of alluvial fans,directly set up at the border faults,was conditioned by the narrowness of the margin,small catchment areas,and proximity between faults,which prevented the development of l

关键词： Extensional basin Alluvial fan stratal stacking pattern structural inheritance Fault linkage

BANACH SPACES AND INEQUALITIES ASSOCIATED WITH NEW GENERALIZATION OF CESàRO MATRIX

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Acta Mathematica Scientia 2023年第4期43卷 1518-1536页

作者： Feyzi BASar Hadi ROOPAEI Department of Primary Mathematics Teacher Education Inonu University44280–MalatyaTurkiye Department of Mathematics and Statistics University of VictoriaVictoriaCanada

Let the triangle matrix A^(ru)be a generalization of the Cesàro matrix and U∈{c_(0),c,l_(∞)}.In this study,we essentially deal with the space U(A^(ru))defined by the domain of A^(ru)in the space U and give the bases,and determine the Kothe-Toeplitz,generalized K?theToeplitz and bounded-duals of the space U(A^(ru)).We characterize the classes(l_(∞)(A^(ru)):l_(∞)),(l_(∞)(A^(ru)):c),(c(A^(ru)):c),and(U:V(A^(ru)))of infinite matrices,where V denotes any given sequence ***,we also present a Steinhaus type *** an another result of this study,we investigate the l_(p)-norm of the matrix A^(ru)and as a result obtaining a generalized version of Hardy's inequality,and some inclusion ***,we compute the norm of well-known operators on the matrix domain l_(p)(A^(ru)).

关键词： matrix domain normed sequence space duals and matrix transformations

Opportunistic screening for atrial fibrillation with a single lead device in geriatric patients

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Journal of Geriatric Cardiology 2020年第3期17卷 149-154,I0008页

作者： Lennaert ar Zwart Rene WMM Jansen Jacob H Ruiter Tjeerd Germans Suat Simsek Martin EW Hemels Department of Geriatric Medicine North West ClinicsWilhelminalaanAlkmaarthe Netherlands Department of Geriatric Medicine Dijklander HospitalMaelsonstraatHoornthe Netherlands Department of Cardiology North West ClinicsWilhelminalaanAlkmaarthe Netherlands Department of Internal Medicine North West ClinicsWilhelminalaanAlkmaarthe Netherlands Department of Cardiology Rijnstate HospitalArnhemthe Netherlands Department of Cardiology Radboud University Medical CentreGeert Grooteplein ZuidNijmegenthe Netherlands

Objective To determine the diagnostic yield of repeated screening for atrial fibrillation(AF)among geriatric *** A pragmatic prospective cohort study into applying opportunistic screening for AF with a handheld single lead ECG device(SLD)in a geriatric *** patients of 65 years old and older visiting the geriatric outpatient clinic were eligible for inclusion.A 12 lead ECG was performed,followed by measurements with the SLD during every visit to the geriatric outpatient clinic.A frailty index was based on the accumulation of deficits *** 478 patients were *** were excluded if they did not give informed consent(17 patients),had a pacemaker or implantable cardioverter defibrillator(20 patients),or had incomplete medical files(two patients).After exclusion,439 patients participated in this *** mean age was 78 years(range 65 to 100 years),54%were *** was known in 89 patients(20%),first detected on the baseline ECG in four patients(1%)and first detected with the SLD in 20 patients(5%)during follow up *** of the SLD was 90.0%,specificity 99.0%,negative predictive value 99.7%,and positive predictive value 73.5%.Most patients(82%)with AF were frail and 53%were severely *** Repeated screening in geriatric patients has a five times higher diagnostic yield than usual *** was easily combined with usual *** of the positive predictive value of 73.5%,it remains necessary to confirm AF with a 12 lead ECG or 24-h Holter monitoring.

关键词： Atrial fibrillation Frailty Geriatric patients Opportunistic screening The elderly

Optimal culture conditions and toxicity assessment of Fomitopsis feei(Fr.):a newly documented macro fungus from Philippines

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Studies in Fungi 2020年第1期5卷 491-507页

作者： De Leon AM Dulay ar Villanueva AL Kalaw SP Department of Biological Sciences College of ScienceCentral Luzon State UniversityScience City of MuñozNueva EcijaPhilippines Center for Tropical Mushroom Research and Development Central Luzon State UniversityScience City of MuñozNueva EcijaPhilippines

Mushrooms are known to be utilized by ethnic communities and Paracelis,Mountain Province is one of the places in Philippines inhabited by several of these native *** studies have been conducted on various macrofungi,however no studies have been reported about Fomitopsis feei in the Philippines particularly in Paracelis,Mountain *** is a brown-rot bracket fungus,belonging to the family Fomitopsidaceae,characterized by a sessile effuse-reflexed basidiomata,with its color ranging from white to pinkish or *** mushroom has been reported to have antimicrobial properties,hence optimization of its culture condition could lead to its mass production for its biopharmaceutical *** order to develop a mass cultivation protocol of this mushroom,this study was conducted to determine the optimum conditions for its mycelial *** effect of different culture media using local substrates and evaluating environmental factors such as pH,aeration,illumination,and temperature were *** conditions for the secondary mycelial growth of *** produced very thick and largest radial growth on coconut water gelatin(CWG)medium(83.57 mm)at pH 6.5(83.13 mm),in sealed(85 mm),dark conditions(85.00 mm)at room temperature(28-32℃)(81.96 mm).The most abundant mycelial growth was found in cracked corn as grain spawning *** study also determined the teratogenic and cytotoxic activity of the ethanol extract of *** against the zebra fish(Danio rerio)embryos and brine shrimp(artemia salina)*** feei exhibited teratogenic effects against the developing *** embryos wherein growth retardation,malformation of tail,yolk deformity,pericardial edema,curved body,scoliosis and little pigmentation were the notable teratogenic effects of the ethanol extract to the developing *** treated with≥1000 ppm recorded high mortality *** was most evident at lower concentrations≤750 *** terms of heartbeat,as the concentrat

关键词： cultivation cytotoxicity grain spawn local substrate media teratogenicity

Decentralized multi-agent reinforcement learning with networked agents: recent advances

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Frontiers of Information Technology & Electronic Engineering 2021年第6期22卷 802-814页

作者： Kaiqing ZHAng Zhuoran YAng Tamer BAŞar Coordinated Science Laboratory University of Illinois at Urbana-ChampaignIL 61801USA Department of Operations Research and Financial Engineering Princeton UniversityNJ 08544USA

Multi-agent reinforcement learning(MarL) has long been a significant research topic in both machine learning and control systems. Recent development of(single-agent) deep reinforcement learning has created a resurgence of interest in developing new MarL algorithms, especially those founded on theoretical analysis. In this paper, we review recent advances on a sub-area of this topic: decentralized MarL with networked *** this scenario, multiple agents perform sequential decision-making in a common environment, and without the coordination of any central controller, while being allowed to exchange information with their neighbors over a communication network. Such a setting finds broad applications in the control and operation of robots, unmanned vehicles, mobile sensor networks, and the smart grid. This review covers several of our research endeavors in this direction, as well as progress made by other researchers along the line. We hope that this review promotes additional research efforts in this exciting yet challenging area.

关键词： Reinforcement learning Multi-agent systems Networked systems Consensus optimization Distributed optimization Game theory

The Future of ASEAN as A Regional Organization

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The Future of ASEAN as A Regional Organization

作者： MD ar-RIFA’IE PD HALBI 山东大学

学位级别：硕士

With the exception of the European Union（EU）,the Association of Southeast Asian Nations（ASEAN）is certainly the most successful example of a regional grouping in the *** of ten states in a region that is typified by an extensive difference of ethnicities with different norms,values,religions and languages,ASEAN has successfully attained economic success and peace in a region that has a rich history of *** its initial establishment and potential role and influence were undermined by external observers,ASEAN has definitely proven its doubters wrong throughout its 50-year existence,with the Association managing to adjust to the varying circumstances in geopolitics and economics,becoming a calming force in advocating peace and security,as well as helping to boost the economic growth of its *** addition to this,ASEAN,as a regional organization,also saw a milestone in its integration process,with the establishment of the ASEAN Community in 2015,which is based on three pillars pertaining to economy,political-security,and ***,in spite of these successes,the integration process in ASEAN still goes through much debate by external observers and scholars alike,and rightfully *** is because the integration process in ASEAN has been mainly steered by the self-interests of states,such as sovereignty,security,and regime survival,instead of a shared goal of regional *** forms of integration in the region,such as the establishment of the AFT A and the ASEAN Community,although showing the steps ASEAN has taken to integrate its members,have been considerably limited with the Association still upholding the same principles that guided it through the 20th to the 21st *** example,in terms of the principle of conflict avoidance,although ensuring stability in the short term,these unresolved conflicts have the potential to destabilize integration in the future,thus weakening ASEAN in the ***,the

关键词： A REGIONAL ORGANIZATION FUTURE ASEAN

Efficiency Performances of LVDC Supplies for Residential Building

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Computer Systems Science & Engineering 2023年第5期45卷 2171-2186页

作者： Anis Ammous Ammar Alsaedi Ahmed N.M.Alahmadi Fahad Alharbi Kaiçar Ammous Department of Electrical Engineering College of Engineering and Islamic ArchitectureUmm Al Qura UniversityMakkahKSA

The Low Voltage Direct Current(LVDC)architecture gives higher benefits over the classic low-voltage alternating current(LVAC)supply *** has fewer energy conversion stages,is compatible with renewable energy sources,and is easier to integrate with *** this paper,an LVDC supply concept is proposed and compared with currently used conventional photovoltaic(PV)systems in terms of *** new LVDC photovoltaic system behavior is validated using LTspice modeling *** findings of this work prove that the concept of LVDC supply is highly attractive when the electricity produced by the photovoltaic is used onsite in the *** carry out an efficient system,the PV power mounted in the houses should be precisely rated with respect to the magnitude of the load energy *** proposed three house examples to verify the superiority of our proposed system in comparison with the traditional LVDC PV *** annual analysis of the energy saved by the studied systems was carried *** main benefit of the suggested LVDC supply is the short way taken by the energy generated by the photovoltaic system to supply DC loads within daytime *** registered increase in system efficiency reached more than 20%for the proposed LVDC system.

关键词： Sustainable energy energy saving power conversion solar PV system

Tuberculosis:an experience from Mycobacterium smears and culture analysis

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 47-53页

作者： Zeehaida M Siti Asma H Siti Hawa H Zaidah ar Norbanee TH Department of Medical Microbiology and Parasitology School of Medical SciencesUniversiti Sains MalaysiaKubang KerianKelantanMalaysia

Objective:Simple tests like direct smear of the acid fast bacilli(AFB) and Mycobacterium culture could assist the diagnosis of *** study is aimed at reviewing the outcome of smears,culture results and contamination rate among specimens requested for AFB smear and Mycobacterium ***:Retrospective laboratory data analysis requesting for Mycobacterium culture from January 2005 till December 2006 was done in a tertiary teaching hospital of Universiti Sains Malaysia,Kubang Kerian,Kelantan,***: Four hundred and sixty seven(36.6%) isolates grew from 1 277 *** these isolates,314 (67.2%) grew Mycobacterium tuberculosis,23(4.9%) grew Mycobacterium other than tuberculosis and 38 (8.1%) grew *** the *** cultures,165(52.5%) had growth of more than 100 confluent colonies,whereas 39 cultures(12.4%) had growth of less than 19 *** smear for AFB among smear positive cases showed presence of more than 50 bacilli/line in 231(49.5%) cases and smear negative cases accounted for 63(13.5%).Among smear positive cases,291(94.5%) cultures grew Mycobacterium species and another 17(5.5%) cultures grew *** smear negative cases,32(62.7%) cultures grew Mycobacterium species and 19(37.3%) cultures grew ***:The results from data analysis of the Mycobacterium cultures should be critically utilized in order to review the laboratory performance and to improve its services in the *** of the data is also useful to the administrators of the hospital in terms of estimating the risk of occupational hazard faced by the health care workers.

关键词： Tuberculosis Mycobacterium tuberculosis Culture Acid fast bacilli Smear Contamination