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LC-HRMS Based Non-Targeted Metabolomic Profiling of Wheat (<I>Triticum aestivum</I>L.) under Post-Anthesis Drought Stress

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American Journal of Plant Sciences 2017年第12期8卷 3024-3061页

作者： Mohammad Atikur Rahman Masum Akond Md Ali babar Chris Beecher John Erickson kayla Thomason Felice A De Jong Richard Esten Mason Agronomy Department IFAS University of Florida Gainesville FL USA Southeast Center for Integrated Metabolomics (SECIM) University of Florida Gainesville FL USA IROA Technologies LLC Ann Arbor MI USA Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA

Drought stress at the reproductive stage causes severe damage to productivity of wheat. However, little is known about the metabolites associated with drought tolerance. The objectives of this study were to elucidate changes in metabolite levels in wheat under drought, and to identify potential metabolites associated with drought stress through untargeted metabolomic profiling using a liquid chromatography-high resolution mass spectrometry (LC-HRMS)-based technique called Isotopic Ratio Outlier Analysis. Metabolomic analysis was performed on flag leaves of drought-stressed and control (well-watered) plants after 18 days of post-anthesis drought stress at three-hour intervals over a 24-hour period. Out of 723 peaks detected in leaves, 221 were identified as known metabolites. Sixty known metabolites were identified as important metabolites by 3 different methods, PLS-DA, RF and SAM. The most pronounced accumulation due to drought stress was demonstrated by tryptophan, proline, pipecolate and linamarin, whereas the most pronounced decrease was demonstrated by serine, trehalose, N-acetyl-glutamic acid, DIBOA-glucoside etc. Three different patterns of metabolite accumulation were observed over 24-hour period. The increased accumulated metabolites remained higher during all 8 time points in drought stressed leaves. On the contrary, metabolites that showed decreased level remained significantly lower during all or the most time points. However, the levels of some decreased metabolites were lower during the day, but higher during night in drought stressed leaves. Both univariate and multivariate analyses predicted that N-acetyl-glutamic acid, proline, pipecolate, linamarin, tryptophan, and DIBOA-glucoside could be potential metabolite biomarkers, and their levels could serve as indicators of drought tolerance in wheat.

关键词： Drought Post-Anthesis Wheat Metabolites LC-MS

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A new candidate as predictor of acute renal allograft rejection:notch receptor-1

A new candidate as predictor of acute renal allograft reject...

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2012中国器官移植大会

作者： kai Zheng,weizhen Wu,shunliang Yang,jinquan Cai,em Yang,TZ Xu,jianming Tan Organ Transplant Institute,Fuzhou General Hospital,No.156 Xierhuan North Road,Fuzhou,350025,China.

【Background】The early identification of renal transplant recipients of enhanced risk of developing acute rejection(ar) would allow individualized adjustment of immunosuppression before functional graft injury occurs and may be helpful for renal graft survival.A recent addition to the list of molecules at work during T cell activation are the Notch receptors and their ligands,which are expressed widely by different cells of the central and peripheral immune *** Notch receptors,

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IMPROVemENT IN ParAMETRIC AND RELIABILITY PERFORMANCE OF 90NM DUAL-DAMASCENE INTERCONNECTS USING ar+PUNCHTHRU PVD BarRIER PROCESS Reprinted with permission as presented at SemICON China 2005

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集成电路应用 2005年第9期22卷 43-49页

作者： N.kumar S.Chu D.L.Diehl k.Maekawa k.Mori k.kobayashi M.Yoneda Applied Materials Inc. Thin Films Group Applied Materials Japan Inc. Thin Films Group Process Development Department Process Technology Development DivisionProduction and Technology UnitRenesas Technology Corp.

As interconnects shrink beyond 90nm node, the presence of etch residues can createhigh via resistance and void nucleation during stress migration (SM) testing. Physical ar+ preclean is effectivein removing residues, but early SM failures have been seen due to Cu resputter from underlying *** preclean methods show promise in reducing CuOx and cleaning Si, N, F, C,O etch residues inpresence of H+, H* species. In this paper, reactive preclean and PVD PunchThru process (deposit-etch-deposit) is proposed as solution to conventional *** PunchThru process reduces via resistance, improves SM and protects dual-damascene beveland unlanded vias from Cu diffusion by presence of thin Ta deposition step. In addition, the U-shaped interface,which minimizes electron crowding and localized heating effects, increases the mean time to failureby electromigration. Consistent, repeatable blanket film property and good parametric electrical test resultshave proven the production worthiness of this process.

关键词：集成电路芯片制造工艺封装技术

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颈动脉内膜中层厚度测量未改善高血压患者心血管风险预测

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中华高血压杂志 2014年第6期22卷 599-599页

作者： Bots ML Groenewegen kA erson TJ Britton ar Dekker JM Engstrm G Evans GW de Graaf J Grobbee DE Hedblad B Hofman A Holewijn S Ikeda A kavousi M kitagawa k kitamura A Ikram MA Lonn em Lorenz MW Mathiesen EB Nijpels G Okazaki S O'Leary DH Polak JF Price JF Robertson C Rembold CM Rosvall M Rundek T Salonen JT Sitzer M Stehouwer CD Franco OH Peters SA den Ruijter HM 赵狄

颈动脉内膜中层厚度（carotid intima-media thickness,CIMT）是心血管风险的标志。目前仍不清楚颈总动脉CIMT测量能否改善高血压患者10年内首发心肌梗死或脑卒中的风险预测。研究人员获取正在进行的大规模荟萃分析：USE-IMT研究中的高... 详细信息

颈动脉内膜中层厚度（carotid intima-media thickness,CIMT）是心血管风险的标志。目前仍不清楚颈总动脉CIMT测量能否改善高血压患者10年内首发心肌梗死或脑卒中的风险预测。研究人员获取正在进行的大规模荟萃分析：USE-IMT研究中的高血压参与者（收缩压≥140和舒张压≥90 mm Hg,1mm Hg=0.133kPa）数据进行分析。

关键词：颈动脉内膜中层厚度高血压患者心血管风险风险预测厚度测量心肌梗死颈总动脉荟萃分析

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螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究

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中华高血压杂志 2018年第3期26卷 299-299页

作者： krieger em Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira ar Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB krieger JE ReHOT Investigators 赵狄练桂丽

该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者（定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制... 详细信息

该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者（定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制）随机给予螺内酯（12.5～50 mg/d）或可乐定（0.1～0．3mg，2次／d）继续治疗12周。

关键词：难治性高血压随机研究治疗药物可乐定螺内酯最佳治疗药物治疗依从性多中心随机试验

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