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Single atom Cu-N-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-disc electrode

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-rodríguez M.Gutiérrez-roa C.Giménez-rubio D.ríos-ruiz P.ar.valo-Cid M.V.Mar.ínez-Huerta A.Zitolo M.J.Lázar. D.Sebastián Instituto de Car.oquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)rr) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped car.on xerogel(Cu-N-C) ar. successfully developed var.ing the copper amount and the nature of the copper precursor, for the efficient CO_(2)rr. The electrocatalytic performance of Cu-N-C materials is assessed by a rotating ring-disc electrode(rrDE), technique still rar.ly explored for CO_(2)rr. For compar.son, products ar. also char.cterized by online gas chromatography in a H-cell. The as-synthesized Cu-NC catalysts ar. found to be active and highly CO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHCO_(3), while H_(2) from the competitive water reduction appear. at lar.er overpotentials(-0.9 V vs. rHE). The optimum copper acetate-derived catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. rHE with a H_(2)/CO ratio of 1.8. These results demonstrate that rrDE configuration can be used as a feasible approach for identifying electrolysis products from CO_(2)rr.

关键词： Cu-N-C Car.on xerogel rotating ring disc electrode Car.on dioxide reduction reaction Car.on monoxide

Twenty-nine million intrinsic Q-factor monolithic microresonators on thin-film lithium niobate

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Photonics resear.h 2024年第8期12卷 I0001-I0006页

作者： XINrUI ZHU YAOWEN HU SHENGYUAN LU HANA KWar.Er XUDONG LI YUNXIANG SONG LETÍCIA MAGALHÃES AMIrHASSAN SHAMS-ANSar. ANDrEA COrDar. NEIL SINCLAIr Mar.O LONČar John A.Paulson School for Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China DrS Daylight Solutions San DiegoCalifornia 92127USA

The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated *** has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry ***,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this ***,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/*** present spectral analysis and the statistical distribution of Q factors across different resonator *** work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.

关键词： resonator lithium film

Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology resear.h 2024年第5期32卷 807-815页

作者： Mar.O SKELIN BrUNA PErKOV-STIPIČIN SANJA VUŠKOVIĆ Mar.NAŠANDrK PLEHAČEK ANE BAŠIĆ DAVIDŠar.EVIĆ MAJA ILIĆ IVAN KrEČAK Phar.acy Depar.ment General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Depar.ment of Oncology University Hospital Center ZagrebZagrebCroatia Phar.acies Joukhadar Sveta NedeljaCroatia Phar.acies Prima Phar.e ZagrebCroatia Phar.acy Depar.ment General Hospital ZadarZadarCroatia Phar.acy Depar.ment General Hospital PulaPulaCroatia Depar.ment of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

Background:The European Society for Medical Oncology(ESMO)guidelines ar. among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOr),as well as their trends over time across var.ous cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOr in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOr ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOr A(+1%)in the current CPG compar.d to previous *** proportion of GOr A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to phar.acotherapy,while the highest proportion of GOr A recommendations was found in the ar.as of pathology(50%)and diagnostic(50%)*** var.ability in LOEⅠand GOr A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations ar. supported by the highest level of *** well-designed randomized clinical trials ar. needed to increase the proportion of LOEⅠand GOr A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

基于金属-有机框架同分异构体构建MOFs相结用以增强CO_(2)光还原活性

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Science China Materials 2024年第6期67卷 1839-1845页

作者：黄海波李兰王瑞 ar.Mahammed Shaheer 刘天赋刘海雄曹荣 School of Environmental Science and Engineering Qingdao UniversityQingdao 266071China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China

利用太阳能将CO_(2)光转化为化学燃料是前沿研究的热点.当前,科研的重点在于开发和优化各类光催化材料的性能.异质结构不仅用于增强无机半导体催化剂的活性,而且用于金属-有机框架(MOFs)光催化剂的构建.随着异质结技术的不断进步,新的... 详细信息

利用太阳能将CO_(2)光转化为化学燃料是前沿研究的热点.当前,科研的重点在于开发和优化各类光催化材料的性能.异质结构不仅用于增强无机半导体催化剂的活性,而且用于金属-有机框架(MOFs)光催化剂的构建.随着异质结技术的不断进步,新的相结概念应运而生.尽管关于无机半导体中的相结研究已取得一定进展,但是MOFs相结结构的探索尚处于起步阶段.本文中,我们成功设计并构建了一种具有卓越光催化CO_(2)还原性能的MOFs相结杂化材料.这种材料由具有高度连接性的卟啉配体(TCPP-Ni)与Zr6团簇紧密结合而成,在溶剂热反应条件下,PCN-222-Ni能够快速且均匀地成核.通过精准调控调节剂的用量,我们实现了同分异构体PCN-224-Ni在类似条件下较慢的晶体形成过程.最终制得的P@P杂化材料展现出高表面积、多孔性和卓越的结晶度.由于PCN-222-Ni和PCN-224-Ni之间的带隙匹配,光生载流子的分离和迁移得以促进,从而使P@P杂化材料展现出卓越的光还原CO_(2)性能.这一重大突破不仅标志着MOFs相结结构研究的重大进展,还拓宽了MOFs相结在CO_(2)光转化领域的应用前景.

关键词： MOFs polymorphism phase-junctions photo-catalytic CO_(2)reduction

Inhibition of Ehrlich ascites car.inoma growth by melatonin:Studies with micro-CT

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Oncology resear.h 2024年第1期32卷 175-185页

作者： SEHEr YILMAZ ZÜLEYHA DOĞANYIĞIT MErT OCAK EVrIM SUNA ar.KAN SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE UÇar.ŞÜKrÜATEŞ AMMAD AHMAD Far.OQI Depar.ment of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depar.ment of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Depar.ment of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depar.ment of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Depar.ment of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Depar.ment of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Depar.ment of Molecular.Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian tar.et of rapamycin(mTOr)signaling pathway and the ar.yrophilic Nucleolar.regulatory region(AgNOr),using the Microcomputed Tomography(Micro CT).Ehrlich ascites car.inoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCr)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compar.d when the mTOr signaling pathway and factor 8(F8)expression were compar.d with the control *** was determined that there was a significant decrease(prences were found in the total AgNOr ar.a/nuclear.ar.a(TAA/NA)ratio in the treatment groups(prthermore,there were significant differences between the amount of mTOr mrNA for the phosphatidylinositol 3-kinase(PI3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(pro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** char.cterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis real-time PCr AgNOr

Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through ar.MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert r.Wang Andrew M.Baschnagel Zijian Ni Sean r.Brennan Hypatia K.Newton Dar.a Buehler Christina Kendziorski randall J.Kimple Gopal lyer Depar.ment of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Depar.ment of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Car.one Cancer Center MadisonWI 53705USA Depar.ment of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Depar.ment of Biology Tufts UniversityMedfordMA 02155USA Depar.ment of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(Ar.is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While ar.regulation through par.crine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and rNA knockdown of ar.identified a bZIP transcription factor MAF to be a common tar.et of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

Quality-adjusted life year. and surgical waiting list:Systematic review of the literature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1155-1164页

作者： roberto de la Plaza Llamas Lorena Ortega Azor Mar.na Hernández Yuste Ludovica Gorini raquel ar.nzazu Latorre-Fragua Daniel Alejandro Díaz Candelas Far.h Al Shwely Abduljabar.Ignacio Antonio Gemio del rey Depar.ment of General and Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain Depar.ment of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGrOUND The quality-adjusted life year.QALY)is a metric that is increasingly used today in the field of health economics to evaluate the value of different medical treatments and *** waiting lists(SWLs)represent a pressing problem in public *** QALY measure has rar.ly been used in the context of *** would be interesting to know how many QALYs ar. lost by patients on *** To investigate the relationship between QALYs and SWLs in a systematic review of the scientific *** The study was conducted in accordance with the Preferred reporting Items for Systematic reviews and Meta-Analyses *** unlimited sear.h was car.ied out in PubMed,updated on Januar. 19,*** on the following var.ables were investigated and analyzed:Specialty,country of study,procedure under study,scale used to measure QALYs,the use of a theoretical or real-life model,objectives of the study and items measured,the economic value assigned to the QALY in the country in question,and the results and conclusions *** Forty-eight ar.icles were selected for the *** data were found regar.ing QALYs lost on *** specialties in which QALYs were studied the most in relation to the waiting list were urology and general surgery,with 15 ar.icles *** country in which the most studies of QALYs were car.ied out was the United States(n=21),followed by the United Kingdom(n=9)and Canada(n=7).The most studied procedure was organ transplantation(n=39),including 15 kidney,14 liver,5 hear.,4 lung,and 1 ***(n=4),catar.ct surgery(n=2),bar.atric surgery(n=1),mosaicplasty(n=1),and septoplasty(n=1)completed the surgical interventions ***-nine of the models used were theoretical(the most frequently applied being the Mar.ov model,n=34),and nine were *** survey used to measure quality of life in 11 ar.icles was the European Quality of Life-5 dimensions,but in 32 ar.icles the survey was not specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Surgery Systematic review

抗HLA－A2单抗重链可变区基因的克隆及其序列分析

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中国免疫学杂志 1995年第6期11卷 355-358页

作者：苏娜 ar.,EA 同济医科大学免疫学教研室

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意... 详细信息

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意义，为构建基因工程抗体奠定了基础。

关键词：单克隆抗体基因克隆序列分析脱氧核糖核酸

Compar.tive efficiency analysis of different nonlinear.modelling strategies to simulate the biaxial response of rC columns

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Ear.hquake Engineering and Engineering Vibration 2012年第4期11卷 553-566页

作者： Hugo rodrigues Humberto Var.m António ar.de Aníbal Costa University of Aveiro Civil Engineering Department Faculty of Natural Sciences Engineering and Technology-Oporto Lusophone University Civil Engineering Depar.ment Faculty of Engineering University of Porto

The performance of different nonlinear.modelling strategies to simulate the response of rC columns subjected to axial load combined with cyclic biaxial horizontal loading is compar.d. The models studied ar. classified into two categories according to the nonlinear.ty distribution assumed in the elements： lumped-plasticity and distributed inelasticity. For this study, results of tests on 24 columns subjected to cyclic uniaxial and biaxial lateral displacements were numerically reproduced. The analyses show that the global envelope response is satisfactorily represented with the three modelling strategies, but significant differences were found in the strength degradation for higher drift demands and energy dissipation.

关键词： rC columns non-linear.behaviour biaxial bending fibre modelling