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Pencil-beam scanning catheter for intracoronary optical coherence tomography

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Opto-Electronic Advances 2022年第3期5卷 69-75页

作者： Jiqiang kang Rui Zhu yunxu Sun Jianan Li kenneth k.y.wong School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China International Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055China Shenzhen Vivolight Medical Device&Technology Co. Ltd.Shenzhen 518055China State key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongChina Advanced Biomedical Instrumentation Centre Hong Kong Science ParkShatinNew TerritoriesHong KongChina

Current gradient-index(GRIN)lens based proximal-driven intracoronary optical coherence tomography(ICOCT)probes consist of a spacer and a GRIN lens with large gradient *** design provides great flexibility to control beam profiles,but the spacer length should be well controlled to obtain desired beam profiles and thus it sets an obstacle in mass catheter ***,although GRIN lens with large gradient constant can provide tight focus spot,it has short depth of focus and fast-expanded beam which leads to poor lateral resolution for deep *** this paper,a type of spacer-removed probe is demonstrated with a small gradient constant GRIN *** design simplifies the fabrica-tion process and is suitable for mass *** output beam of the catheter is a narrow nearly collimated light beam,referred to as pencil beam *** full width at half maximum beam size varies from 35.1μm to 75.3μm in air over 3-mm *** design principles are elaborated with probe/catheter fabrication and performance *** in vivo imaging of the catheter was verified by a clinical ICOCT *** results prove that this novel pencil-beam scanning catheter is potentially a good choice for ICOCT systems.

关键词： optical coherence tomography endoscopic imaging intravascular imaging fiber optics imaging

Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array

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Light(Science & Applications) 2020年第1期9卷 1914-1924页

作者： yu-Xuan Ren Jianglai Wu Queenie T.k.Lai Hei Ming Lai Dickson M.D.Siu Wutian Wu kenneth k.y.wong kevin k.Tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongSAR 999077China Department of Physics University of CaliforniaBerkeleyCA 94720USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongSAR 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong KongSAR 999077China GHM Institute of CNS Regeneration Jinan University601 Huangpu Avenue WestGuangzhou 510632China Re-Stem Biotechnology Suzhou 215007China

Parallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional(3D)visualization of dynamical biological processes with minimal ***,the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three *** hereby develop a novel fluorescence imaging approach,called coded light-sheet array microscopy(CLAM),which allows complete parallelized 3D imaging without mechanical *** the concept of an“infinity mirror”,CLAM generates a light-sheet array with controllable sheet density and degree of ***,CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/***,the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged *** demonstrate the utility of CLAM in different imaging scenarios,including a light-scattering medium,an optically cleared tissue,and microparticles in fluidic *** can maximize the signal-to-noise ratio and the spatial duty cycle,and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging *** flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research.

关键词： scattering light mirror

Breathing dissipative soliton explosions in a bidirectional ultrafast fiber laser

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Photonics Research 2020年第10期8卷 1566-1572页

作者： yI ZHOU yU-XUAN REN JIAWEI SHI kENNETH k.y.wong Department of Eectrical and Electronic Engineering The University of Rong KongHong KongChina

Soliton explosions,among the most exotic dynamics,have been extensively studied on parameter invariant stationary ***,the explosion dynamics are still largcly unexplored in breathing dissipative solitons as a dynamic solution to many nonlincar ***,we report on the first observation of a breathing dissipative soliton explosion in a nct-normal-dispersion bidirectional ultrafast fiber *** breathing soliton explos ionscould be stimulated by the soliton buildup process or alteration of polarization *** breathing soliton pairs with intensive repulsion that is sensitive to initial conditions can also be triggered by multiple soliton explosions in the soliton buildup process instead of being triggered by varying polarization *** high bchavior similarity also exists in the breathing soliton buildup and explosion process owing to the common gain and loss *** addition,dissipative rogue waves were detected in the breathing soliton explosion,and the collision of breathing soliton significantly enhanced the amplitude of rogue waves,which is characteristic of the breathing solitons in a bidirectional fiber *** results shed new insights into complex dissipative soliton dynamics.

关键词： dynamics. soliton dissipative

Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content

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eLight 2022年第1期2卷 68-74页

作者： Jiawei Shi Mingsheng Li Huajun Tang Jiqiang kang Najia Sharmin Amir Rosenthal kenneth k.y.wong Department of Electrical and Electronic Engineering The University of Hong kong Pokfulam RoadHong KongChina.2 Department of Electrical EngineeringTechnion–Israel Institute of TechnologyTechnion City32000 HaifaIsrael Advanced Biomedical Instrumentation Centre Hong Kong Science ParkShatinNew TerritoriesHong KongChina

Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively,such as leveraging the vibrational absorption peak of the O-H ***,due to the lack of an efficient laser source,it was challenging to image the water content in the deep tissue with micron-level spatial *** address this problem,we develop a high-power hybrid optical parametrically-oscillating emitter(HOPE)at 1930 nm,at which the vibrational absorption peak of the O-H bond *** maximum pulse energy is over 1.74μJ with a pulse repetition rate of 50 kHz and a pulse width of 15 *** employ this laser source in the optical-resolution photoacoustic microscopy(OR-PAM)system to image the water content in the phantom and the biological tissue in *** 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution,deep penetration depth,improved sensitivity,and suppressed artifact signal of the lipid.

关键词： Fiber optical parametric oscillator Thulium-doped fiber laser Photoacoustic microscopy

High-contrast,fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

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Light(Science & Applications) 2020年第1期9卷 1775-1786页

作者： Cihang kong Christian Pilger Henning Hachmeister Xiaoming Wei Tom H.Cheung Cora S.W.Lai Nikki P.Lee kevin k.Tsia kenneth k.y.wong Thomas Huser Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongChina Biomolecular Photonics Department of PhysicsUniversity of BielefeldUniversitatsstr2533615 BielefeldGermany Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Department of Physiology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Department of Surgery The University of Hong KongPokfulam RoadHong KongChina Division of Engineering and Applied Science California Institute of Technology1200 East California BoulevardPasadenaCA 91125USA

Coherent Raman scattering(CRS)microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast,high spatial and spectral resolution,and high ***,the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large *** fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging,as previous implementations have suffered from high intensity noise,a narrow tuning range and low power,resulting in low image qualities and slow imaging ***,we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability(improved by 50 dB),timing jitter(24.3 fs),average power fluctuation(20 dB)and pulse width variation(y of the laser source enables,for the first time,high-contrast,fast CRS imaging without complicated noise reduction via balanced detection *** capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail,kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence,which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical *** work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies.

关键词： scattering tuning fibre

Enhanced depth resolution in optical scanning holography using a configurable pupil

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Photonics Research 2014年第2期2卷 64-70页

作者： Haiyan Ou Ting-Chung Poon kenneth k.y.wong Edmund y.Lam Department of Electrical and Electronic Engineering University of Hong KongPokfulamHong KongChina Institute of Applied Physics University of Electronic Science and Technology of China610054ChengduChina Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVirginia 24061USA

The optical scanning holography(OSH)technique can capture all the three-dimensional volume information of an object in a hologram via a single raster *** digital hologram can then be processed to reconstruct individual sectional images of the *** this paper,we present a scheme to reconstruct sectional images in OSH with enhanced depth resolution,where a spatial light modulator(SLM)is adopted as a configurable point *** switching the SLM between two states,different Fresnel zone plates(FZPs)are generated based on the same optical *** extra information provided by different FZPs,a depth resolution at 0.7μm can be achieved.

关键词： resolution sectional Fresnel

High-energy all-fiber gain-switched thulium-doped fiber laser for volumetric photoacoustic imaging of lipids

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Photonics Research 2020年第2期8卷 160-164页

作者： CAN LI JIAWEI SHI XIATIAN WANG BOQUAN WANG XIAOJING GONG LIANG SONG kENNETH k.y.wong Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

We demonstrate a high-energy all-fiber short wavelength gain-switched thulium-doped fiber laser for volumetric photoacoustic(PA)imaging of *** laser cavity is constructed by embedding a short piece of gain fiber between a pair of fiber Bragg gratings(FBGs).Through using three pairs of FBGs with operation wavelengths at1700,1725,and 1750 nm,three similar lasers are realized with a cavity length of around 25 *** a maximum pump energy of 300μJ at 1560 nm,laser pulse energies of 58.2,66.8,and 75.3μJ are,respectively,achieved with a minimum pulse width ofy system incorporated with the newly developed source,and a lateral resolution of 18.8μm and an axial resolution of 172.9μm are ***,the higher shooting speed of the developed source can potentially allow for increasing at twice the frame rate of current intravascular PA imaging.

关键词： fiber switched laser

QUASI-INTERPOLATING OPERATORS AND THEIR APPLICATIONS IN HyPERSINGULAR INTEGRALS

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Journal of Computational Mathematics 1998年第4期16卷 337-344页

作者： wong, RH Lu, y Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

The purpose of this paper is to propose and study a class of quasi-interpolating operators in multivariate spline space S-1/2(Delta(mn)(2*)) on non-uniform type-2 triangulation. Based on the operators, we construct cubature formula for two-dimensional hypersingular integrals. Some computing work have been done and the results are quite satisfactory.

关键词： hypersingular integral finite-part integral quasi-interpolating operator non-uniform type-2 triangulation

Obesity in children and adolescents:Overview of the diagnosis and management

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Chronic Diseases and Translational Medicine 2023年第2期9卷 122-133页

作者： Joanna y.L.Tung Grace W.k.Poon Juan Du kenneth k.y.wong Department of Paediatrics and Adolescent Medicine The University of Hong KongPokfulamHong KongChina Department of Paediatrics and Adolescent Medicine Hong Kong Children's HospitalHong KongChina Department of Endocrinology Jilin Province People's HospitalJilinChina The Paediatric Precision Medicine Centre Children's Hospital of ChangchunJilinChina Department of Surgery The University of Hong KongPokfulamHong KongChina

Childhood obesity is one of the biggest public health challenges *** is associated with various adverse health consequences throughout *** and early intervention represent the most reasonable and costeffective *** progress has been achieved in the management of obesity in children and adolescents;yet,implementation in the real world remains a *** article aimed to present an overview of the diagnosis and management of obesity in children and adolescents.

关键词： adolescent children diagnosis management obesity