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CONCURRENT PRODUCT PORTFOLIO PLANNING AND MIXED PRODUCT ASSEMBLY LINE BALANCING

Chinese Journal of Mechanical Engineering 2007年第1期20卷 96-99页

作者： BRYAN april HU S Jack KOREN Yoram Department of Mechanical Engineering University of Michigan Ann Arbor USA

Reconfigurable products and manufacturing systems have enabled manufacturers to provide ＂cost effective＂ variety to the market. In spite of these new technologies, the expense of manufacturing makes it infeasible to supply all the possible variants to the market for some industries. Therefore, the determination of the right number of product variantsto offer in the product portfolios becomes an important consideration. The product portfolio planning problem had been independently well studied from marketing and engineering perspectives. However, advantages can be gained from using a concurrent marketing and engineering approach. Concurrent product development strategies specifically for reconfigurable products and manufacturing systems can allow manufacturers to select best product portfolios from marketing, product design and manufacturing perspectives. A methodology for the concurrent design of a product portfolio and assembly system is presented. The objective of the concurrent product portfolio planning and assembly system design problem is to obtain the product variants that will make up the product portfolio such that oversupply of optional modules is minimized and the assembly line efficiency is maximized. Explicit design of the assembly system is obtained during the solution of the problem. It is assumed that the demand for optional modules and the assembly times for these modules are known a priori. A genetic algorithm is used in the solution of the problem. The basic premise of this methodology is that the selected product portfolio has a significant impact on the solution of the assembly line balancing problem. An example is used to validate this hypothesis. The example is then further developed to demonstrate how the methodology can be used to obtain the optimal product portfolio. This approach is intended for use by manufacturers during the early design stages of product family design.

关键词： Product portfolio Assembly system design Assembly line balancing Concurrent design and manufacturing Optimization

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Online recognition of drainage type based on UV-vis spectra and derivative neural network algorithm

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Frontiers of Environmental Science & Engineering 2021年第6期15卷 447-455页

作者： Qiyun Zhu april Gu Dan Li Tianmu Zhang Lunhong Xiang Miao He School of Environment Tsinghua UniversityBeijing 100084China Department of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China

Optimizing sewage collection is important for water pollution control and wastewater treatment plants quality and efficiency ***,the urban drainage pipeline network is upgrading to improve its classification and collection ***,there is a lack of efficient online monitoring and identification ***-visible absorption spectrum probe is considered as a potential monitoring method due to its small size,reagent-free and fast *** the performance parameters of probe like optic resolution,dynamic interval and signal-to-noise ratio are weak and high turbidity of sewage raises the noise level,it is necessary to extract shape features from the turbidity disturbed drainage spectrum for classification *** this study,drainage network samples were online collected and tested,and four types were labeled according to sample sites and environment *** spectrum were adopted to amplify the shape features,while convolutional neural network algorithm was established to conduct nonlinear spectrum *** of input and network structure on classification accuracy was *** spectrum,first-order derivative spectrum and a combination of both were set to be three different *** neural network with or without convolutional layer were set be two different network *** results revealed a convolutional neural network combined with inputs of first and zero-order derivatives was proposed to have the best classification effect on domestic sewage,mixed rainwater,rainwater and industrial *** recognition rate of industrial wastewater was 100%,and the recognition rate of domestic sewage and rainwater mixing system were over 90%.

关键词： Drainage online recognition UV-vis spectra Derivative spectrum Convolutional neural network

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Inactivation, reactivation and regrowth of indigenous bacteria in reclaimed water after chlorine disinfection of a municipal wastewater treatment plant

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Journal of Environmental Sciences 2013年第7期25卷 1319-1325页

作者： Dan Li Siyu Zeng april Z. Gu Miao He Hanchang Shi Environmental Simulation and Pollution Control State Key Joint Laboratory School of Environment Tsinghua University Department of Civil and Environmental Engineering Northeastern University

Disinfection of reclaimed water prior to reuse is important to prevent the transmission of pathogens. Chlorine is a widely utilized disinfectant and as such is a leading contender for disinfection of reclaimed water. To understand the risks of chlorination resulting from the potential selection of pathogenic bacteria, the inactivation, reactivation and regrowth rates of indigenous bacteria were investigated in reclaimed water after chlorine disinfection. Inactivation of total coliforms, Enterococcus and Salmonella showed linear correlations, with constants of 0.1384, 0.1624 and 0.057 L/（mg·min） and R 2 of 0.7617, 0.8316 and 0.845, respectively. However, inactivation of total viable cells by measurement of metabolic activity typically showed a linear correlation at lower chlorine dose （0-22 （mg·min）/L）, and a trailing region with chlorine dose increasing from 22 to 69 （mg·min）/L. Reactivation and regrowth of bacteria were most likely to occur after exposure to lower chlorine doses, and extents of reactivation decreased gradually with increasing chlorine dose. In contrast to total coliforms and Enterococcus, Salmonella had a high level of regrowth and reactivation, and still had 2% regrowth even after chlorination of 69 （mg·min）/L and 24 hr storage. The bacterial compositions were also significantly altered by chlorination and storage of reclaimed water, and the ratio of Salmonella was significantly increased from 0.001% to 0.045% after chlorination of 69 （mg·min）/L and 24 hr storage. These trends indicated that chlorination contributes to the selection of chlorine-resistant pathogenic bacteria, and regrowth of pathogenic bacteria after chlorination in reclaimed water with a long retention time could threaten public health security during wastewater reuse.

关键词： inactivation regrowth reactivation indigenous bacteria reclaimed water

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Comparing the effects of isoleucine and leucine supplementation at different dosage on the growth and metabolism of Torulaspora delbrueckii Biodiva during soy whey fermentation

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Food Bioscience 2022年第6期50卷 71-83页

作者： Jian-Yong Chua april Huang Shao-Quan Liu Department of Food Science and Technology National University of Singapore2 Science Drive 2Singapore117542Singapore Department of Food Science College of Agriculture and Life SciencesCornell UniversityStocking HallIthacaNYUSA14853USA National University of Singapore (Suzhou) Research Institute 377 Lin Quan StreetSuzhou Industrial ParkJiangsu215213China

Soy whey is a liquid by-product generated from tofu production and it is often discarded as wastewater after it is *** studies have shown that out of the three branched-chain amino acids,isoleucine was found to have an inhibitory effect on Torulaspora delbrueckii Biodiva during soy whey *** this study,a comparison between isoleucine and leucine was carried out to ascertain how these two structural isomers could affect the growth and metabolism of *** Biodiva at various concentrations(40,80 and 160 mg nitrogen/L).In general,amino acid supplementation sped up the fermentation process relative to unsupplemented *** though glycerol and ethanol production were enhanced in all isoleucine supplemented samples in comparison to unsupplemented samples,isoleucine supplementation resulted in slower yeast growth at day 1 and slower sucrose hydrolysis regardless of the concentration *** for leucine supplementation,there was no impact on yeast growth,glycerol and ethanol production but sucrose hydrolysis was enhanced in comparison to the unsupplemented *** isoleucine and leucine supplementation resulted in corresponding increase in active amyl alcohol and isoamyl alcohol production respectively,but isoleucine had a stimulating effect on increasing the production of other higher alcohols while leucine had an inhibitory effect on the production of other higher ***,even though isoleucine and leucine are structural isomers with the positional difference of only one methyl group,the impact on the yeast metabolism and growth is visibly different.

关键词： Soy whey Leucine supplementation Isoleucine supplementation Torulaspora delbrueckii

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Current advances in using neurotrophic factors to treat neurodegenerative disorders

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Translational Neurodegeneration 2012年第1期1卷 103-111页

作者： april M Weissmiller Chengbiao Wu Department of Neurosciences University of California San DiegoSchool of MedicineLa JollaCA 92093-0649USA Department of Neurosciences University of California San DiegoGeorge Palade Labs(GPL)Room 337 MC-06499500 Gilman DriveLa JollaCA 92093USA

Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous *** strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative ***,significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic *** article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.

关键词： Neurotrophin Neurotrophic factor BDNF NGF Gene delivery Mimetics

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《第一与第二语言语境中的语用变异：方法论问题》介绍

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当代语言学 2017年第1期19卷 146-149页

作者： j.césar félix-brasdefer dale april koike 佴云国不详山东省青岛市宁夏路308号266071 青岛大学公共外语教育学院

1．前言《第一与第二语言语境中的语用变异：方法论问题》（Pragmatic Variation inFirst and Second Language Contexts： Methodological Issues）2012年由JohnBen—jamins出版社出版，*** Felix-Brasdefer和Dale april Koike主编。该书集中反映了当前语用变异研究领域的最新探索和发展趋势，并重点探讨多种第一和第二语言语境下语料的收集和分析方法问题。除开篇导言，全书共11章。

关键词：语用变异语言语境方法论 Language Dale 发展趋势方法问题出版社

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Efficient training of ANN potentials by including atomic forces via Taylor expansion and application to water and a transition-metal oxide

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npj Computational Materials 2020年第1期6卷 1205-1218页

作者： april M.Cooper Johannes Kästner Alexander Urban Nongnuch Artrith School of Chemistry University of St AndrewsSt AndrewsUK Institute for Theoretical Chemistry University of StuttgartStuttgartGermany Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

Artificial neural network(ANN)potentials enable the efficient large-scale atomistic modeling of complex materials with near firstprinciples *** molecular dynamics simulations,accurate energies and interatomic forces are a prerequisite,but training ANN potentials simultaneously on energies and forces from electronic structure calculations is computationally ***,we introduce an efficient alternative method for the training of ANN potentials on energy and force information,based on an extrapolation of the total energy via a Taylor *** translating the force information to approximate energies,the quadratic scaling with the number of atoms exhibited by conventional force-training methods can be avoided,which enables the training on reference datasets containing complex atomic structures.

关键词： forces enable atomic

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Evaluation of the infectivity,gene and antigenicity persistence of rotaviruses by free chlorine disinfection

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Journal of Environmental Sciences 2011年第10期23卷 1691-1698页

作者： Dan Li april Z. Gu Siyu Zeng Wan Yang Miao He Hanchang Shi Environmental Simulation and Pollution Control （ESPC） State Key Joint Laboratory School of Environment Tsinghua University Beijing 100084 China Department of Civil and Environmental Engineering Northeastern University Boston MA 02115 USA

The effects of free chlorine disinfection of tap water and wastewater effluents on the infectivity, gene integrity and surface antigens of rotaviruses were evaluated by a bench-scale chlorine disinfection experiments. Plaque assays, integrated cell culture-quantitative RT- PCR （ICC-RT-qPCR）, RT-qPCR, and enzyme-linked immunosorbent assays （ELISA）, respectively, were used to assess the influence of the disinfectant on virus infectivity as well as genetic and antigenic integrity of simian rotavirus SA11 as a surrogate for human rotaviruses. The ICC-RT-qPCR was able to detect rotaviruses survival from chlorine disinfection at chlorine dose up to 20 mg/L （60 min contact）, which suggested a required chlorine dose of 5 folds （from 1 to 5 mg/L） higher than that indicated by the plaque assay to achieve 1.8 log10 reductions in tap water with 60 rain exposing. The VP7 gene was more resistant than the infectivity and existed at chlorine dose up to 20 mg/L （60 min contact）, while the antigencity was undetectable with chlorine dose more than 5 mg/L （60 min contact）. The water quality also impacted the inactivation efficiencies, and rotaviruses have a relatively higher resistant in secondary effluents than in the tap water under the same chlorine disinfection treatments. This study indicated that rotaviruses have a higher infectivity, gene and antigencity resistance to chlorine than that previously indicated by plaque assay only, which seemed to underestimate the resistance of rotaviruses to chlorine and the risk of rotaviruses in environments. Present results also suggested that re-evaluation of resistance of other waterborne viruses after disinfections by more sensitive infectivity detection method （such as ICC-RT-qPCR） may be necessary, to determine the adequate disinfectant doses required for the inactivation of waterborne viruses.

关键词： rotaviruses free chlorine disinfection infectivity genes antigenicity ICC-RT-qPCR

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Blue Electrogenerated Chemiluminescence from Halide Perovskite Nanocrystals

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Journal of Analysis and Testing 2019年第2期3卷 125-133页

作者： Yiliyasi Wusimanjiang Jeetika Yadav Victoria Arau april ESteen Nathan IHammer Shanlin Pan Department of Chemistry and Biochemistry The University of AlabamaTuscaloosaAL 35487USA Chemistry and Biochemistry The University of MississippiOxfordMS 38677USA

Electrogenerated chemiluminescence(ECL)has been extensively used in ultrasensitive electroanalysis because it can be generated electrochemically without using expensive optics and light *** ECL emission can be obtained with a reasonable quantum yield and *** ECL is rare and often suffers from stability and poor quantum *** ECL emission at 473 nm from organometallic halide perovskite nanocrystals(PNCs),CH_(3)NH_(3)PbCl_(1.08)Br_(1.92),is reported here for the first time using tripropylamine(TPrA)as *** blue ECL emission peak resembles its photoluminescence peak *** addition to this blue emission peak,the ECL spectra of CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs also showed a broad ECL peak at 745 *** of the second ECL peak at 745 nm from CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs was can be explained by the existence of surface trap states on as-synthesized PNC due to incomplete surface *** anion tunability of ECL emission from CH3NH3PbX3(X:Cl,Br,I)PNCs is also *** fluorescence microscopy image of single PNC and stability of selected single PNCs are presented in this with simultaneous acquisition of fluorescence spectra using 405-nm laser *** photoluminescence(PL)decay was described by PL lifetime(τ)of 1.2 *** effect of the addition of surfactants(oleic acid and n-octylamine)on the fluorescence intensity and stability of CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs is also discussed.

关键词： ECL(electrogenerated chemiluminescence) Photoluminescence(PL) Perovskite nanocrystals(PNCs) Blue light emission Photoluminescence quantum yield(PLQY) Surfactants

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Placebo Effects and Research in Alternative and Conventional Medicine

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Chinese Journal of Integrative Medicine 1996年第2期2卷 141-148页

作者： A White Paper from the Placebo Working Group of the NIH Office of Alternative MedicineAlternative Medicine Research Methodology Conference,april 26 - 28, 1995. 不详

Abstract The placebo effect is a very powerful and unpredictable aspect of any medical treatment. Assuch, it dramatically complicates efforts at convincingly demonstrating the effectiveness of specitic effects inmedicine, conventional or alternative. This review provides a tlieoretical overview of tlie placebo effect toassist researchers in designing trials, controlled or otliereise, so that more convincing demoiistrations of spe-cific effects can be achieved.

关键词： Placebo Effects and Research in Alternative and Conventional Medicine

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