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Interleukin-15 is a significant predictor of sarcopenia in human immunodeficiency virus infected patients on antiretroviral therapy:A cross-sectional study

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Asian Pacific Journal of Tropical Medicine 2022年第8期15卷 361-366页

作者： aprianta agus Somia agus Aryana Suka Internal Medicine Education Program Faculty of MedicineUdayana UniversityDenpasarBaliIndonesia Tropical Infectious Disease Division Department of Internal MedicineSanglah General HospitalDenpasarBaliIndonesia Geriatric Division Department of Internal MedicineSanglah General HospitalDenpasarBaliIndonesia

Objective:To identify the relationship between interleukin(IL)-15 levels and sarcopenia in human immunodeficiency virus(HIV)-infected patients who have received antiretroviral ***:This study was a cross-sectional design with 70 participants conducted from January to March *** the participants were assessed for sarcopenia and the IL-15 *** was established based on the the Asian Working Group for Sarcopenia(AWGS)2019 *** IL-15 was *** analysis was carried out by means of 2×2 tabulation and the statistical test used is ***:Seventy patients received antiretroviral therapy>6 months and showed a good clinical *** them,36(51.4%)took zidovudine-based antiretroviral therapy with a median duration of illness of 5 *** proportion of sarcopenia in patients with HIV infection was 32.9%.The median CD4 cell count was 395.5 cells/L(range:203-937 cells/L).Logistic regression analysis revealed that age>50 years(aOR 8.3,95%CI 1.6-44.5),underweight(aOR 7.7,95%CI 1.5-40.5),IL-15≥150.5 ng/L(aOR 4.9,95%CI 1.3-19.0)and female(aOR 4.8,95%CI 1.2-18.3 were significant and independent adverse predictors of sarcopenia in subjects with HIV ***:There is an association between high levels of IL-15 and sarcopenia in HIV-infected patients on antiretroviral therapy for more than 6 months with good clinical response.

关键词： Antiretroviral therapy HIV IL-15 Inflammatory Sarcopenia Underweight

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